Molnupiravir, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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1) Product Images from "Discovery of host-directed modulators of virus infection by probing the SARS-CoV-2-host protein-protein interaction network"
Article Title: Discovery of host-directed modulators of virus infection by probing the SARS-CoV-2-host protein-protein interaction network
Figure Legend Snippet: Dose-response matrix of SARS-CoV-2-infected 293TAT cells when combining molnupiravir (MPV, EIDD-1931) with either (A) MPA or (B) merimepodib. The maximum synergistic area (MSA, dotted-line square) and the Bliss synergy score were calculated with SynergyFinder v2.0, both for efficacy (virus infection) and viability (toxic effect on non-infected cells). Selective efficacy quantifies the difference in inhibition of virus-infected and mock-infected cells. A selective efficacy of 100 means that the drug combination inhibits 100% of the virus-infected cells and does not affect the mock-infected, drug-treated cells, while a selective efficacy of 0 means the drug kills both the virus and mock-infected cells. The selective efficacies of 46% and 35% for combinations of molnupiravir with MPA and merimepodib, respectively, indicate relatively high selective suppression of virus infection only. This is also seen in minimal co-inhibition of the viability of non-infected cells (right).
Techniques Used: Infection, Inhibition