fw1256  (MedChemExpress)


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    MedChemExpress fw1256
    LOX1 promotes HF after MI through activation of the NF-κB p65/Caspase-9 signaling. (A) Western blot detection of p65 phosphorylation and Caspase-9 protein expression in rat myocardial tissues; (B) Staining intensity of phos-p65 and caspase-9 in rat myocardial tissues by immunohistochemical staining; (C) Western blot detection of the activation level of NF-κB p65/Caspase-9 signaling pathway in H9C2 cells; (D) Subcellular localization of phosphorylated NF-κB p65 in H9C2 cells by immunofluorescence detection. NF-κB p65 inhibitor <t>FW1256</t> or DMSO was applied to OGD-treated cardiomyocytes. (E) Apoptosis level of H9C2 cells by flow cytometry; (F) EdU staining for H9C2 cell activity; (G) Immunofluorescence detection of α-SMA and FN-1 expression in cells. For (A and B) each group contained 6 rats (one-way ANOVA and Tukey’s multiple comparison test). Error bars represent the mean ± SD. ** P
    Fw1256, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/fw1256/product/MedChemExpress
    Average 93 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    fw1256 - by Bioz Stars, 2022-05
    93/100 stars

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    1) Product Images from "Exosomes released from mesenchymal stem cells overexpressing microRNA-30e ameliorate heart failure in rats with myocardial infarction"

    Article Title: Exosomes released from mesenchymal stem cells overexpressing microRNA-30e ameliorate heart failure in rats with myocardial infarction

    Journal: American Journal of Translational Research

    doi:

    LOX1 promotes HF after MI through activation of the NF-κB p65/Caspase-9 signaling. (A) Western blot detection of p65 phosphorylation and Caspase-9 protein expression in rat myocardial tissues; (B) Staining intensity of phos-p65 and caspase-9 in rat myocardial tissues by immunohistochemical staining; (C) Western blot detection of the activation level of NF-κB p65/Caspase-9 signaling pathway in H9C2 cells; (D) Subcellular localization of phosphorylated NF-κB p65 in H9C2 cells by immunofluorescence detection. NF-κB p65 inhibitor FW1256 or DMSO was applied to OGD-treated cardiomyocytes. (E) Apoptosis level of H9C2 cells by flow cytometry; (F) EdU staining for H9C2 cell activity; (G) Immunofluorescence detection of α-SMA and FN-1 expression in cells. For (A and B) each group contained 6 rats (one-way ANOVA and Tukey’s multiple comparison test). Error bars represent the mean ± SD. ** P
    Figure Legend Snippet: LOX1 promotes HF after MI through activation of the NF-κB p65/Caspase-9 signaling. (A) Western blot detection of p65 phosphorylation and Caspase-9 protein expression in rat myocardial tissues; (B) Staining intensity of phos-p65 and caspase-9 in rat myocardial tissues by immunohistochemical staining; (C) Western blot detection of the activation level of NF-κB p65/Caspase-9 signaling pathway in H9C2 cells; (D) Subcellular localization of phosphorylated NF-κB p65 in H9C2 cells by immunofluorescence detection. NF-κB p65 inhibitor FW1256 or DMSO was applied to OGD-treated cardiomyocytes. (E) Apoptosis level of H9C2 cells by flow cytometry; (F) EdU staining for H9C2 cell activity; (G) Immunofluorescence detection of α-SMA and FN-1 expression in cells. For (A and B) each group contained 6 rats (one-way ANOVA and Tukey’s multiple comparison test). Error bars represent the mean ± SD. ** P

    Techniques Used: Activation Assay, Western Blot, Expressing, Staining, Immunohistochemistry, Immunofluorescence, Flow Cytometry, Activity Assay

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    • fw1256  (MedChemExpress)
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    MedChemExpress fw1256
    LOX1 promotes HF after MI through activation of the NF-κB p65/Caspase-9 signaling. (A) Western blot detection of p65 phosphorylation and Caspase-9 protein expression in rat myocardial tissues; (B) Staining intensity of phos-p65 and caspase-9 in rat myocardial tissues by immunohistochemical staining; (C) Western blot detection of the activation level of NF-κB p65/Caspase-9 signaling pathway in H9C2 cells; (D) Subcellular localization of phosphorylated NF-κB p65 in H9C2 cells by immunofluorescence detection. NF-κB p65 inhibitor <t>FW1256</t> or DMSO was applied to OGD-treated cardiomyocytes. (E) Apoptosis level of H9C2 cells by flow cytometry; (F) EdU staining for H9C2 cell activity; (G) Immunofluorescence detection of α-SMA and FN-1 expression in cells. For (A and B) each group contained 6 rats (one-way ANOVA and Tukey’s multiple comparison test). Error bars represent the mean ± SD. ** P
    Fw1256, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/fw1256/product/MedChemExpress
    Average 93 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    fw1256 - by Bioz Stars, 2022-05
    93/100 stars
    		  Buy from Supplier

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    LOX1 promotes HF after MI through activation of the NF-κB p65/Caspase-9 signaling. (A) Western blot detection of p65 phosphorylation and Caspase-9 protein expression in rat myocardial tissues; (B) Staining intensity of phos-p65 and caspase-9 in rat myocardial tissues by immunohistochemical staining; (C) Western blot detection of the activation level of NF-κB p65/Caspase-9 signaling pathway in H9C2 cells; (D) Subcellular localization of phosphorylated NF-κB p65 in H9C2 cells by immunofluorescence detection. NF-κB p65 inhibitor FW1256 or DMSO was applied to OGD-treated cardiomyocytes. (E) Apoptosis level of H9C2 cells by flow cytometry; (F) EdU staining for H9C2 cell activity; (G) Immunofluorescence detection of α-SMA and FN-1 expression in cells. For (A and B) each group contained 6 rats (one-way ANOVA and Tukey’s multiple comparison test). Error bars represent the mean ± SD. ** P

    Journal: American Journal of Translational Research

    Article Title: Exosomes released from mesenchymal stem cells overexpressing microRNA-30e ameliorate heart failure in rats with myocardial infarction

    doi:

    Figure Lengend Snippet: LOX1 promotes HF after MI through activation of the NF-κB p65/Caspase-9 signaling. (A) Western blot detection of p65 phosphorylation and Caspase-9 protein expression in rat myocardial tissues; (B) Staining intensity of phos-p65 and caspase-9 in rat myocardial tissues by immunohistochemical staining; (C) Western blot detection of the activation level of NF-κB p65/Caspase-9 signaling pathway in H9C2 cells; (D) Subcellular localization of phosphorylated NF-κB p65 in H9C2 cells by immunofluorescence detection. NF-κB p65 inhibitor FW1256 or DMSO was applied to OGD-treated cardiomyocytes. (E) Apoptosis level of H9C2 cells by flow cytometry; (F) EdU staining for H9C2 cell activity; (G) Immunofluorescence detection of α-SMA and FN-1 expression in cells. For (A and B) each group contained 6 rats (one-way ANOVA and Tukey’s multiple comparison test). Error bars represent the mean ± SD. ** P

    Article Snippet: Alternatively, following OGD treatment, H9C2 cells were incubated with 100 µM NF-κB specific inhibitor FW1256 (HY-121955, MedChemExpress, Monmouth Junction, NJ, USA) or dimethylsulfoxide (DMSO) and collected after 24 h for subsequent experiments.

    Techniques: Activation Assay, Western Blot, Expressing, Staining, Immunohistochemistry, Immunofluorescence, Flow Cytometry, Activity Assay