rigosertib  (MedChemExpress)


Bioz Verified Symbol MedChemExpress is a verified supplier
Bioz Manufacturer Symbol MedChemExpress manufactures this product  
  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
  • 92

    Structured Review

    MedChemExpress rigosertib
    Activation of ACE2 expression and inhibition of IL-6 secretion in macrophages using glucocorticoids or other chemicals. A ) Several glucocorticoids and candidate agonists activated ACE2 expression in M0 macrophages, whereas only glucocorticoids imparted an activating effect on M1 macrophages. B) Low-dose hydrocortisone within the range of 10 to 100 nm is sufficient in activating ACE2 expression in macrophages. C) All glucocorticoids imparted a suppressive effect on IL-6 secretion. Dexamethasone revealed the strongest activating effect, followed by hydrocortisone, methylprednisolone, triamcinolone, and prednisolone. The chemical <t>rigosertib</t> showed a suppressive effect on IL-6 production to some extent. D) Low-dose hydrocortisone within the range of 50 to 100 nm is sufficient in suppressing IL-6 secretion in M1 macrophages. “*” represents a significant difference compared to the “control” or “0 nm” group. *P
    Rigosertib, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/rigosertib/product/MedChemExpress
    Average 92 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    rigosertib - by Bioz Stars, 2022-05
    92/100 stars

    Images

    1) Product Images from "Glucocorticoids improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels"

    Article Title: Glucocorticoids improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels

    Journal: International Journal of Biological Sciences

    doi: 10.7150/ijbs.47652

    Activation of ACE2 expression and inhibition of IL-6 secretion in macrophages using glucocorticoids or other chemicals. A ) Several glucocorticoids and candidate agonists activated ACE2 expression in M0 macrophages, whereas only glucocorticoids imparted an activating effect on M1 macrophages. B) Low-dose hydrocortisone within the range of 10 to 100 nm is sufficient in activating ACE2 expression in macrophages. C) All glucocorticoids imparted a suppressive effect on IL-6 secretion. Dexamethasone revealed the strongest activating effect, followed by hydrocortisone, methylprednisolone, triamcinolone, and prednisolone. The chemical rigosertib showed a suppressive effect on IL-6 production to some extent. D) Low-dose hydrocortisone within the range of 50 to 100 nm is sufficient in suppressing IL-6 secretion in M1 macrophages. “*” represents a significant difference compared to the “control” or “0 nm” group. *P
    Figure Legend Snippet: Activation of ACE2 expression and inhibition of IL-6 secretion in macrophages using glucocorticoids or other chemicals. A ) Several glucocorticoids and candidate agonists activated ACE2 expression in M0 macrophages, whereas only glucocorticoids imparted an activating effect on M1 macrophages. B) Low-dose hydrocortisone within the range of 10 to 100 nm is sufficient in activating ACE2 expression in macrophages. C) All glucocorticoids imparted a suppressive effect on IL-6 secretion. Dexamethasone revealed the strongest activating effect, followed by hydrocortisone, methylprednisolone, triamcinolone, and prednisolone. The chemical rigosertib showed a suppressive effect on IL-6 production to some extent. D) Low-dose hydrocortisone within the range of 50 to 100 nm is sufficient in suppressing IL-6 secretion in M1 macrophages. “*” represents a significant difference compared to the “control” or “0 nm” group. *P

    Techniques Used: Activation Assay, Expressing, Inhibition

    Similar Products

  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
  • 92
    MedChemExpress rigosertib
    Activation of ACE2 expression and inhibition of IL-6 secretion in macrophages using glucocorticoids or other chemicals. A ) Several glucocorticoids and candidate agonists activated ACE2 expression in M0 macrophages, whereas only glucocorticoids imparted an activating effect on M1 macrophages. B) Low-dose hydrocortisone within the range of 10 to 100 nm is sufficient in activating ACE2 expression in macrophages. C) All glucocorticoids imparted a suppressive effect on IL-6 secretion. Dexamethasone revealed the strongest activating effect, followed by hydrocortisone, methylprednisolone, triamcinolone, and prednisolone. The chemical <t>rigosertib</t> showed a suppressive effect on IL-6 production to some extent. D) Low-dose hydrocortisone within the range of 50 to 100 nm is sufficient in suppressing IL-6 secretion in M1 macrophages. “*” represents a significant difference compared to the “control” or “0 nm” group. *P
    Rigosertib, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/rigosertib/product/MedChemExpress
    Average 92 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    rigosertib - by Bioz Stars, 2022-05
    92/100 stars
      Buy from Supplier

    Image Search Results


    Activation of ACE2 expression and inhibition of IL-6 secretion in macrophages using glucocorticoids or other chemicals. A ) Several glucocorticoids and candidate agonists activated ACE2 expression in M0 macrophages, whereas only glucocorticoids imparted an activating effect on M1 macrophages. B) Low-dose hydrocortisone within the range of 10 to 100 nm is sufficient in activating ACE2 expression in macrophages. C) All glucocorticoids imparted a suppressive effect on IL-6 secretion. Dexamethasone revealed the strongest activating effect, followed by hydrocortisone, methylprednisolone, triamcinolone, and prednisolone. The chemical rigosertib showed a suppressive effect on IL-6 production to some extent. D) Low-dose hydrocortisone within the range of 50 to 100 nm is sufficient in suppressing IL-6 secretion in M1 macrophages. “*” represents a significant difference compared to the “control” or “0 nm” group. *P

    Journal: International Journal of Biological Sciences

    Article Title: Glucocorticoids improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels

    doi: 10.7150/ijbs.47652

    Figure Lengend Snippet: Activation of ACE2 expression and inhibition of IL-6 secretion in macrophages using glucocorticoids or other chemicals. A ) Several glucocorticoids and candidate agonists activated ACE2 expression in M0 macrophages, whereas only glucocorticoids imparted an activating effect on M1 macrophages. B) Low-dose hydrocortisone within the range of 10 to 100 nm is sufficient in activating ACE2 expression in macrophages. C) All glucocorticoids imparted a suppressive effect on IL-6 secretion. Dexamethasone revealed the strongest activating effect, followed by hydrocortisone, methylprednisolone, triamcinolone, and prednisolone. The chemical rigosertib showed a suppressive effect on IL-6 production to some extent. D) Low-dose hydrocortisone within the range of 50 to 100 nm is sufficient in suppressing IL-6 secretion in M1 macrophages. “*” represents a significant difference compared to the “control” or “0 nm” group. *P

    Article Snippet: Kinetin riboside, cilomilast, rigosertib, PMA, and LPS were purchased from MCE Co. IFN-γ was from PeproTech (New Jersey, USA).

    Techniques: Activation Assay, Expressing, Inhibition