Rigosertib, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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1) Product Images from "Glucocorticoids improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels"
Article Title: Glucocorticoids improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels
Journal: International Journal of Biological Sciences
Figure Legend Snippet: Activation of ACE2 expression and inhibition of IL-6 secretion in macrophages using glucocorticoids or other chemicals. A ) Several glucocorticoids and candidate agonists activated ACE2 expression in M0 macrophages, whereas only glucocorticoids imparted an activating effect on M1 macrophages. B) Low-dose hydrocortisone within the range of 10 to 100 nm is sufficient in activating ACE2 expression in macrophages. C) All glucocorticoids imparted a suppressive effect on IL-6 secretion. Dexamethasone revealed the strongest activating effect, followed by hydrocortisone, methylprednisolone, triamcinolone, and prednisolone. The chemical rigosertib showed a suppressive effect on IL-6 production to some extent. D) Low-dose hydrocortisone within the range of 50 to 100 nm is sufficient in suppressing IL-6 secretion in M1 macrophages. “*” represents a significant difference compared to the “control” or “0 nm” group. *P
Techniques Used: Activation Assay, Expressing, Inhibition