navarixin  (MedChemExpress)


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    Structured Review

    MedChemExpress navarixin
    CAFs-derived CXCL5 reinforces exosomal HSPC111 excretion in CRC cells and promotes CRLM progression. Western blot showed the protein levels of HSPC111, CXCR2 and EMT-relative genes in CAFs CM-incubated HCT116 ( A ) and SW480 cells ( B ). Migration of HCT116 ( C ) and SW480 cells ( D ) were analyzed by transwell assay after CAFs CM treatment. Scale bar = 200 μm. Western blot showed the protein levels of HSPC111, CXCR2 and EMT-relative genes in CAFs CM- and CXCL5 neutralizing antibody-incubated HCT116 ( E ) and SW480 cells ( F ). G Migration of HCT116 cells were analyzed by wound-healing assay after CAFs CM and CXCL5 neutralizing antibody treatment. Scale bar = 100 μm. Western blot showed the protein levels of HSPC111, CXCR2 and EMT-relative genes in CAFs CM- and CXCR2 inhibitor <t>(navarixin)-incubated</t> HCT116 ( H ) and SW480 cells ( I ). J Migration of HCT116 cells were analyzed by wound-healing assay after CAFs CM and CXCR2 inhibitor (navarixin) treatment. Scale bar = 100 μm. K IVIS imaging on experimental liver metastasis of indicated mice treated with Exo HCT116 KD or their relative control and with/without navarixin. Luciferase-labeled HCT116 cells were used to perform experimental liver metastasis model ( n = 3). L Representative pictures and quantitative results of HE staining of liver tissue sections from indicated mice. Scale bar = 500 μm. Each experiment was performed in triplicate. Data are shown as mean ± SD. * P
    Navarixin, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/navarixin/product/MedChemExpress
    Average 94 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    navarixin - by Bioz Stars, 2022-05
    94/100 stars

    Images

    1) Product Images from "Cancer-derived exosomal HSPC111 promotes colorectal cancer liver metastasis by reprogramming lipid metabolism in cancer-associated fibroblasts"

    Article Title: Cancer-derived exosomal HSPC111 promotes colorectal cancer liver metastasis by reprogramming lipid metabolism in cancer-associated fibroblasts

    Journal: Cell Death & Disease

    doi: 10.1038/s41419-022-04506-4

    CAFs-derived CXCL5 reinforces exosomal HSPC111 excretion in CRC cells and promotes CRLM progression. Western blot showed the protein levels of HSPC111, CXCR2 and EMT-relative genes in CAFs CM-incubated HCT116 ( A ) and SW480 cells ( B ). Migration of HCT116 ( C ) and SW480 cells ( D ) were analyzed by transwell assay after CAFs CM treatment. Scale bar = 200 μm. Western blot showed the protein levels of HSPC111, CXCR2 and EMT-relative genes in CAFs CM- and CXCL5 neutralizing antibody-incubated HCT116 ( E ) and SW480 cells ( F ). G Migration of HCT116 cells were analyzed by wound-healing assay after CAFs CM and CXCL5 neutralizing antibody treatment. Scale bar = 100 μm. Western blot showed the protein levels of HSPC111, CXCR2 and EMT-relative genes in CAFs CM- and CXCR2 inhibitor (navarixin)-incubated HCT116 ( H ) and SW480 cells ( I ). J Migration of HCT116 cells were analyzed by wound-healing assay after CAFs CM and CXCR2 inhibitor (navarixin) treatment. Scale bar = 100 μm. K IVIS imaging on experimental liver metastasis of indicated mice treated with Exo HCT116 KD or their relative control and with/without navarixin. Luciferase-labeled HCT116 cells were used to perform experimental liver metastasis model ( n = 3). L Representative pictures and quantitative results of HE staining of liver tissue sections from indicated mice. Scale bar = 500 μm. Each experiment was performed in triplicate. Data are shown as mean ± SD. * P
    Figure Legend Snippet: CAFs-derived CXCL5 reinforces exosomal HSPC111 excretion in CRC cells and promotes CRLM progression. Western blot showed the protein levels of HSPC111, CXCR2 and EMT-relative genes in CAFs CM-incubated HCT116 ( A ) and SW480 cells ( B ). Migration of HCT116 ( C ) and SW480 cells ( D ) were analyzed by transwell assay after CAFs CM treatment. Scale bar = 200 μm. Western blot showed the protein levels of HSPC111, CXCR2 and EMT-relative genes in CAFs CM- and CXCL5 neutralizing antibody-incubated HCT116 ( E ) and SW480 cells ( F ). G Migration of HCT116 cells were analyzed by wound-healing assay after CAFs CM and CXCL5 neutralizing antibody treatment. Scale bar = 100 μm. Western blot showed the protein levels of HSPC111, CXCR2 and EMT-relative genes in CAFs CM- and CXCR2 inhibitor (navarixin)-incubated HCT116 ( H ) and SW480 cells ( I ). J Migration of HCT116 cells were analyzed by wound-healing assay after CAFs CM and CXCR2 inhibitor (navarixin) treatment. Scale bar = 100 μm. K IVIS imaging on experimental liver metastasis of indicated mice treated with Exo HCT116 KD or their relative control and with/without navarixin. Luciferase-labeled HCT116 cells were used to perform experimental liver metastasis model ( n = 3). L Representative pictures and quantitative results of HE staining of liver tissue sections from indicated mice. Scale bar = 500 μm. Each experiment was performed in triplicate. Data are shown as mean ± SD. * P

    Techniques Used: Derivative Assay, Western Blot, Incubation, Migration, Transwell Assay, Wound Healing Assay, Imaging, Mouse Assay, Luciferase, Labeling, Staining

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    MedChemExpress navarixin
    CAFs-derived CXCL5 reinforces exosomal HSPC111 excretion in CRC cells and promotes CRLM progression. Western blot showed the protein levels of HSPC111, CXCR2 and EMT-relative genes in CAFs CM-incubated HCT116 ( A ) and SW480 cells ( B ). Migration of HCT116 ( C ) and SW480 cells ( D ) were analyzed by transwell assay after CAFs CM treatment. Scale bar = 200 μm. Western blot showed the protein levels of HSPC111, CXCR2 and EMT-relative genes in CAFs CM- and CXCL5 neutralizing antibody-incubated HCT116 ( E ) and SW480 cells ( F ). G Migration of HCT116 cells were analyzed by wound-healing assay after CAFs CM and CXCL5 neutralizing antibody treatment. Scale bar = 100 μm. Western blot showed the protein levels of HSPC111, CXCR2 and EMT-relative genes in CAFs CM- and CXCR2 inhibitor <t>(navarixin)-incubated</t> HCT116 ( H ) and SW480 cells ( I ). J Migration of HCT116 cells were analyzed by wound-healing assay after CAFs CM and CXCR2 inhibitor (navarixin) treatment. Scale bar = 100 μm. K IVIS imaging on experimental liver metastasis of indicated mice treated with Exo HCT116 KD or their relative control and with/without navarixin. Luciferase-labeled HCT116 cells were used to perform experimental liver metastasis model ( n = 3). L Representative pictures and quantitative results of HE staining of liver tissue sections from indicated mice. Scale bar = 500 μm. Each experiment was performed in triplicate. Data are shown as mean ± SD. * P
    Navarixin, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/navarixin/product/MedChemExpress
    Average 94 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    navarixin - by Bioz Stars, 2022-05
    94/100 stars
      Buy from Supplier

    94
    MEDCHEMEXPRESS CO LTD cxcr1 2 inhibitor navarixin
    CAFs-derived CXCL5 reinforces exosomal HSPC111 excretion in CRC cells and promotes CRLM progression. Western blot showed the protein levels of HSPC111, CXCR2 and EMT-relative genes in CAFs CM-incubated HCT116 ( A ) and SW480 cells ( B ). Migration of HCT116 ( C ) and SW480 cells ( D ) were analyzed by transwell assay after CAFs CM treatment. Scale bar = 200 μm. Western blot showed the protein levels of HSPC111, CXCR2 and EMT-relative genes in CAFs CM- and CXCL5 neutralizing antibody-incubated HCT116 ( E ) and SW480 cells ( F ). G Migration of HCT116 cells were analyzed by wound-healing assay after CAFs CM and CXCL5 neutralizing antibody treatment. Scale bar = 100 μm. Western blot showed the protein levels of HSPC111, CXCR2 and EMT-relative genes in CAFs CM- and CXCR2 inhibitor <t>(navarixin)-incubated</t> HCT116 ( H ) and SW480 cells ( I ). J Migration of HCT116 cells were analyzed by wound-healing assay after CAFs CM and CXCR2 inhibitor (navarixin) treatment. Scale bar = 100 μm. K IVIS imaging on experimental liver metastasis of indicated mice treated with Exo HCT116 KD or their relative control and with/without navarixin. Luciferase-labeled HCT116 cells were used to perform experimental liver metastasis model ( n = 3). L Representative pictures and quantitative results of HE staining of liver tissue sections from indicated mice. Scale bar = 500 μm. Each experiment was performed in triplicate. Data are shown as mean ± SD. * P
    Cxcr1 2 Inhibitor Navarixin, supplied by MEDCHEMEXPRESS CO LTD, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/cxcr1 2 inhibitor navarixin/product/MEDCHEMEXPRESS CO LTD
    Average 94 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    cxcr1 2 inhibitor navarixin - by Bioz Stars, 2022-05
    94/100 stars
      Buy from Supplier

    Image Search Results


    CAFs-derived CXCL5 reinforces exosomal HSPC111 excretion in CRC cells and promotes CRLM progression. Western blot showed the protein levels of HSPC111, CXCR2 and EMT-relative genes in CAFs CM-incubated HCT116 ( A ) and SW480 cells ( B ). Migration of HCT116 ( C ) and SW480 cells ( D ) were analyzed by transwell assay after CAFs CM treatment. Scale bar = 200 μm. Western blot showed the protein levels of HSPC111, CXCR2 and EMT-relative genes in CAFs CM- and CXCL5 neutralizing antibody-incubated HCT116 ( E ) and SW480 cells ( F ). G Migration of HCT116 cells were analyzed by wound-healing assay after CAFs CM and CXCL5 neutralizing antibody treatment. Scale bar = 100 μm. Western blot showed the protein levels of HSPC111, CXCR2 and EMT-relative genes in CAFs CM- and CXCR2 inhibitor (navarixin)-incubated HCT116 ( H ) and SW480 cells ( I ). J Migration of HCT116 cells were analyzed by wound-healing assay after CAFs CM and CXCR2 inhibitor (navarixin) treatment. Scale bar = 100 μm. K IVIS imaging on experimental liver metastasis of indicated mice treated with Exo HCT116 KD or their relative control and with/without navarixin. Luciferase-labeled HCT116 cells were used to perform experimental liver metastasis model ( n = 3). L Representative pictures and quantitative results of HE staining of liver tissue sections from indicated mice. Scale bar = 500 μm. Each experiment was performed in triplicate. Data are shown as mean ± SD. * P

    Journal: Cell Death & Disease

    Article Title: Cancer-derived exosomal HSPC111 promotes colorectal cancer liver metastasis by reprogramming lipid metabolism in cancer-associated fibroblasts

    doi: 10.1038/s41419-022-04506-4

    Figure Lengend Snippet: CAFs-derived CXCL5 reinforces exosomal HSPC111 excretion in CRC cells and promotes CRLM progression. Western blot showed the protein levels of HSPC111, CXCR2 and EMT-relative genes in CAFs CM-incubated HCT116 ( A ) and SW480 cells ( B ). Migration of HCT116 ( C ) and SW480 cells ( D ) were analyzed by transwell assay after CAFs CM treatment. Scale bar = 200 μm. Western blot showed the protein levels of HSPC111, CXCR2 and EMT-relative genes in CAFs CM- and CXCL5 neutralizing antibody-incubated HCT116 ( E ) and SW480 cells ( F ). G Migration of HCT116 cells were analyzed by wound-healing assay after CAFs CM and CXCL5 neutralizing antibody treatment. Scale bar = 100 μm. Western blot showed the protein levels of HSPC111, CXCR2 and EMT-relative genes in CAFs CM- and CXCR2 inhibitor (navarixin)-incubated HCT116 ( H ) and SW480 cells ( I ). J Migration of HCT116 cells were analyzed by wound-healing assay after CAFs CM and CXCR2 inhibitor (navarixin) treatment. Scale bar = 100 μm. K IVIS imaging on experimental liver metastasis of indicated mice treated with Exo HCT116 KD or their relative control and with/without navarixin. Luciferase-labeled HCT116 cells were used to perform experimental liver metastasis model ( n = 3). L Representative pictures and quantitative results of HE staining of liver tissue sections from indicated mice. Scale bar = 500 μm. Each experiment was performed in triplicate. Data are shown as mean ± SD. * P

    Article Snippet: For studies of CXCR2 inhibitor in vivo, mice were treated with 50 mg/kg navarixin (CXCR2 inhibitor) (MCE, China) or vehicle (1% methyl cellulose) orally once daily for 4 weeks.

    Techniques: Derivative Assay, Western Blot, Incubation, Migration, Transwell Assay, Wound Healing Assay, Imaging, Mouse Assay, Luciferase, Labeling, Staining