skf96365  (Alomone Labs)


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    Alomone Labs skf96365
    Cholinergic-associated shift in the timing of firing on ramp is mediated by TRP channels, but notably not TRPC channels. A. Voltage traces recorded in the soma for a two second triangular current ramp injected in the soma in control (A1), CCh (2 μM, A2), and CCh + FFA (100 μM, A3) applied subsequently to the same cell. Current traces and instantaneous frequency plots are just below voltage traces. Red dotted line marks the middle of the ramp. Summary data (A4) of the adaptation index for control, CCh, and CCh + FFA (n = 9). B. Same as in A, but for dendritic injection and recordings. Summary data (B4) of the adaptation index for control, CCh, and CCh + FFA (n = 9). Open circles connected by dashed lines represent indices for individual cells, over all three treatments. Black squares with error bars represent group averages ± SEM. C. Voltage traces recorded in the soma for a two second triangular current ramp injected in the soma in control (C1), CCh (2 μM, C2), and CCh + <t>SKF96365</t> (50 μM, C3) applied subsequently to the same cell. Current traces and instantaneous frequency plots are just below voltage traces. Red dotted line marks the middle of the ramp. Summary data (C4) of the adaptation index for control, CCh, and CCh + SKF96365 (n = 8). D. Same as in C, but for dendritic injection and recordings. Summary data (D4) of the adaptation index for control, CCh, and CCh + SKF96365 (n = 8). *** p
    Skf96365, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/skf96365/product/Alomone Labs
    Average 94 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    skf96365 - by Bioz Stars, 2022-12
    94/100 stars

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    1) Product Images from "Cholinergic Modulation Shifts the Response of CA1 Pyramidal Cells to Depolarizing Ramps via TRPM4 Channels with Implications for Place Field Firing"

    Article Title: Cholinergic Modulation Shifts the Response of CA1 Pyramidal Cells to Depolarizing Ramps via TRPM4 Channels with Implications for Place Field Firing

    Journal: bioRxiv

    doi: 10.1101/2022.10.24.513511

    Cholinergic-associated shift in the timing of firing on ramp is mediated by TRP channels, but notably not TRPC channels. A. Voltage traces recorded in the soma for a two second triangular current ramp injected in the soma in control (A1), CCh (2 μM, A2), and CCh + FFA (100 μM, A3) applied subsequently to the same cell. Current traces and instantaneous frequency plots are just below voltage traces. Red dotted line marks the middle of the ramp. Summary data (A4) of the adaptation index for control, CCh, and CCh + FFA (n = 9). B. Same as in A, but for dendritic injection and recordings. Summary data (B4) of the adaptation index for control, CCh, and CCh + FFA (n = 9). Open circles connected by dashed lines represent indices for individual cells, over all three treatments. Black squares with error bars represent group averages ± SEM. C. Voltage traces recorded in the soma for a two second triangular current ramp injected in the soma in control (C1), CCh (2 μM, C2), and CCh + SKF96365 (50 μM, C3) applied subsequently to the same cell. Current traces and instantaneous frequency plots are just below voltage traces. Red dotted line marks the middle of the ramp. Summary data (C4) of the adaptation index for control, CCh, and CCh + SKF96365 (n = 8). D. Same as in C, but for dendritic injection and recordings. Summary data (D4) of the adaptation index for control, CCh, and CCh + SKF96365 (n = 8). *** p
    Figure Legend Snippet: Cholinergic-associated shift in the timing of firing on ramp is mediated by TRP channels, but notably not TRPC channels. A. Voltage traces recorded in the soma for a two second triangular current ramp injected in the soma in control (A1), CCh (2 μM, A2), and CCh + FFA (100 μM, A3) applied subsequently to the same cell. Current traces and instantaneous frequency plots are just below voltage traces. Red dotted line marks the middle of the ramp. Summary data (A4) of the adaptation index for control, CCh, and CCh + FFA (n = 9). B. Same as in A, but for dendritic injection and recordings. Summary data (B4) of the adaptation index for control, CCh, and CCh + FFA (n = 9). Open circles connected by dashed lines represent indices for individual cells, over all three treatments. Black squares with error bars represent group averages ± SEM. C. Voltage traces recorded in the soma for a two second triangular current ramp injected in the soma in control (C1), CCh (2 μM, C2), and CCh + SKF96365 (50 μM, C3) applied subsequently to the same cell. Current traces and instantaneous frequency plots are just below voltage traces. Red dotted line marks the middle of the ramp. Summary data (C4) of the adaptation index for control, CCh, and CCh + SKF96365 (n = 8). D. Same as in C, but for dendritic injection and recordings. Summary data (D4) of the adaptation index for control, CCh, and CCh + SKF96365 (n = 8). *** p

    Techniques Used: Injection

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    Alomone Labs skf96365
    Cholinergic-associated shift in the timing of firing on ramp is mediated by TRP channels, but notably not TRPC channels. A. Voltage traces recorded in the soma for a two second triangular current ramp injected in the soma in control (A1), CCh (2 μM, A2), and CCh + FFA (100 μM, A3) applied subsequently to the same cell. Current traces and instantaneous frequency plots are just below voltage traces. Red dotted line marks the middle of the ramp. Summary data (A4) of the adaptation index for control, CCh, and CCh + FFA (n = 9). B. Same as in A, but for dendritic injection and recordings. Summary data (B4) of the adaptation index for control, CCh, and CCh + FFA (n = 9). Open circles connected by dashed lines represent indices for individual cells, over all three treatments. Black squares with error bars represent group averages ± SEM. C. Voltage traces recorded in the soma for a two second triangular current ramp injected in the soma in control (C1), CCh (2 μM, C2), and CCh + <t>SKF96365</t> (50 μM, C3) applied subsequently to the same cell. Current traces and instantaneous frequency plots are just below voltage traces. Red dotted line marks the middle of the ramp. Summary data (C4) of the adaptation index for control, CCh, and CCh + SKF96365 (n = 8). D. Same as in C, but for dendritic injection and recordings. Summary data (D4) of the adaptation index for control, CCh, and CCh + SKF96365 (n = 8). *** p
    Skf96365, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/skf96365/product/Alomone Labs
    Average 94 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    skf96365 - by Bioz Stars, 2022-12
    94/100 stars
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    Cholinergic-associated shift in the timing of firing on ramp is mediated by TRP channels, but notably not TRPC channels. A. Voltage traces recorded in the soma for a two second triangular current ramp injected in the soma in control (A1), CCh (2 μM, A2), and CCh + FFA (100 μM, A3) applied subsequently to the same cell. Current traces and instantaneous frequency plots are just below voltage traces. Red dotted line marks the middle of the ramp. Summary data (A4) of the adaptation index for control, CCh, and CCh + FFA (n = 9). B. Same as in A, but for dendritic injection and recordings. Summary data (B4) of the adaptation index for control, CCh, and CCh + FFA (n = 9). Open circles connected by dashed lines represent indices for individual cells, over all three treatments. Black squares with error bars represent group averages ± SEM. C. Voltage traces recorded in the soma for a two second triangular current ramp injected in the soma in control (C1), CCh (2 μM, C2), and CCh + SKF96365 (50 μM, C3) applied subsequently to the same cell. Current traces and instantaneous frequency plots are just below voltage traces. Red dotted line marks the middle of the ramp. Summary data (C4) of the adaptation index for control, CCh, and CCh + SKF96365 (n = 8). D. Same as in C, but for dendritic injection and recordings. Summary data (D4) of the adaptation index for control, CCh, and CCh + SKF96365 (n = 8). *** p

    Journal: bioRxiv

    Article Title: Cholinergic Modulation Shifts the Response of CA1 Pyramidal Cells to Depolarizing Ramps via TRPM4 Channels with Implications for Place Field Firing

    doi: 10.1101/2022.10.24.513511

    Figure Lengend Snippet: Cholinergic-associated shift in the timing of firing on ramp is mediated by TRP channels, but notably not TRPC channels. A. Voltage traces recorded in the soma for a two second triangular current ramp injected in the soma in control (A1), CCh (2 μM, A2), and CCh + FFA (100 μM, A3) applied subsequently to the same cell. Current traces and instantaneous frequency plots are just below voltage traces. Red dotted line marks the middle of the ramp. Summary data (A4) of the adaptation index for control, CCh, and CCh + FFA (n = 9). B. Same as in A, but for dendritic injection and recordings. Summary data (B4) of the adaptation index for control, CCh, and CCh + FFA (n = 9). Open circles connected by dashed lines represent indices for individual cells, over all three treatments. Black squares with error bars represent group averages ± SEM. C. Voltage traces recorded in the soma for a two second triangular current ramp injected in the soma in control (C1), CCh (2 μM, C2), and CCh + SKF96365 (50 μM, C3) applied subsequently to the same cell. Current traces and instantaneous frequency plots are just below voltage traces. Red dotted line marks the middle of the ramp. Summary data (C4) of the adaptation index for control, CCh, and CCh + SKF96365 (n = 8). D. Same as in C, but for dendritic injection and recordings. Summary data (D4) of the adaptation index for control, CCh, and CCh + SKF96365 (n = 8). *** p

    Article Snippet: Carbachol, 9-phenanthrol, and CBA were purchased from Tocris, CGP55845 from Abcam (Cambridge, MA), DL-APV from HelloBio (Princeton, NJ), NBQX, Gabazine, and SKF96365 from Alomone Labs (Jerusalem, Israel), and acetylcholine, flufenamic acid, and K4-BAPTA from Sigma (St. Louis, MO).

    Techniques: Injection