retigabine  (Alomone Labs)

Journal: Alcohol (Fayetteville, N.Y.)

Article Title: Differential Potassium Channel Gene Regulation in BXD Mice Reveals Novel Targets for Pharmacogenetic Therapies to Reduce Heavy Alcohol Drinking

doi: 10.1016/j.alcohol.2016.05.007

Figure Lengend Snippet: The Kv7 channel positive modulator, retigabine, reduced ethanol consumption in high-drinking, but not low-drinking male C57BL/6J mice ( A ) Average weekly ethanol consumption and ( B ) intra-strain variability of 24 hr ethanol consumption in C57BL/6J mice during week 7 of the intermittent access model. ( C ) Despite the large between-subjects variation, the coefficient of variance during 7 weeks of access to ethanol in the intermittent model indicates increased within-subject stability (n = 19 mice, * p

Article Snippet: On test days, mice were injected with retigabine (RTG, dihydrochloride, Alomone Labs; 0, 5, 10 mg/kg – doses reflect the base, IP, 10 ml/kg in sterile saline) approximately 30 min prior to bottle access in a repeated measures fashion (i.e., each animal received each dose across a 3 week testing period in a counterbalanced order).

Techniques: Mouse Assay

Journal: Neuron

Article Title: Hyper-SUMOylation of the Kv7 Potassium Channel Diminishes the M-Current Leading to Seizures and Sudden Death

doi: 10.1016/j.neuron.2014.07.042

Figure Lengend Snippet: Prevention of Acoustics-Induced Seizures and AV Block in SENP2 fxN/fxN Mice with Retigabine

Article Snippet: SENP2fxN/fxN mice (6 weeks old) were administrated atropine (1 mg/kg; Sigma) or propranolol (4 mg/kg; Sigma) for selective parasympathetic or sympathetic blockade and retigabine (10 mg/kg; Alomone labs) for seizure blockade.

Techniques: Blocking Assay, Mouse Assay