α dendrotoxin  (Alomone Labs)


Bioz Verified Symbol Alomone Labs is a verified supplier
Bioz Manufacturer Symbol Alomone Labs manufactures this product  
  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
  • 94
    Name:
    alpha Dendrotoxin
    Description:
    A Blocker of KV1 1 KV1 2 KV1 6 and ASIC Channels
    Catalog Number:
    D-350
    Price:
    2275.0
    Category:
    Toxin
    Source:
    Natural peptide isolated from Dendroaspis angusticeps (Eastern green mamba).
    Applications:
    0
    Purity:
    >98% (HPLC)
    Size:
    1 Vials containing 0 14 mg each
    Format:
    Lyophilized powder.
    Formula:
    C305H481N99O84S6
    Molecular Weight:
    7048
    Molecule Name:
    alpha-Dendrotoxin, Venom basic protease inhibitor 1 homolog, Toxin C13S2C3, alpha-DTX
    Buy from Supplier


    Structured Review

    Alomone Labs α dendrotoxin
    alpha Dendrotoxin
    A Blocker of KV1 1 KV1 2 KV1 6 and ASIC Channels
    https://www.bioz.com/result/α dendrotoxin/product/Alomone Labs
    Average 94 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    α dendrotoxin - by Bioz Stars, 2021-09
    94/100 stars

    Images

    1) Product Images from "Parvalbumin-Positive Basket Interneurons in Monkey and Rat Prefrontal Cortex"

    Article Title: Parvalbumin-Positive Basket Interneurons in Monkey and Rat Prefrontal Cortex

    Journal: Journal of Neurophysiology

    doi: 10.1152/jn.90396.2008

    Properties of the first evoked spike in monkey and rat basket cells. A : first suprathreshold response to the depolarizing current was significantly delayed in rat, but not in monkey basket cells. B : spike threshold was considerably lower in monkey basket cells than that in rat (APs are truncated). C : spikes evoked by rectangular current pulses with the latency of 8 ms still had more negative threshold in monkey ( n = 15) basket cells than that in rat ( n = 14). D : threshold of the 1st spikes and 8-ms-latency spikes is lower in monkeys than that in rats. Error bars represent SE. E : α-dendrotoxin (α-DTX) decreased spike threshold for the 1st spikes evoked in monkey ( n = 4) and rat basket cells ( n = 5).
    Figure Legend Snippet: Properties of the first evoked spike in monkey and rat basket cells. A : first suprathreshold response to the depolarizing current was significantly delayed in rat, but not in monkey basket cells. B : spike threshold was considerably lower in monkey basket cells than that in rat (APs are truncated). C : spikes evoked by rectangular current pulses with the latency of 8 ms still had more negative threshold in monkey ( n = 15) basket cells than that in rat ( n = 14). D : threshold of the 1st spikes and 8-ms-latency spikes is lower in monkeys than that in rats. Error bars represent SE. E : α-dendrotoxin (α-DTX) decreased spike threshold for the 1st spikes evoked in monkey ( n = 4) and rat basket cells ( n = 5).

    Techniques Used: Mass Spectrometry

    Related Articles

    other:

    Article Title: Activity-dependent tuning of intrinsic excitability in mouse and human neurogliaform cells
    Article Snippet: In certain experiments (see results section for details) the extracellular solution was supplemented with one or a combination of the following drugs; 50 μM picrotoxin (Millipore Sigma; Cat. No. 80410), 2–5 μM CGP556845A (Abcam; Cat. No. ab120337), 5–10 μM bicuculline methobromide (Abcam; Cat. No. ab120109), 100 μM or 1–3 mM 4-aminopyridine (Millipore Sigma; Cat. No. A78403), 100–200 nM α -DTX (Alomone Labs; Cat No.D-350), 200 or 500 nM AmmTx3 (Alomone Labs; Cat No.STA-305).

    Article Title: Molecular correlates of muscle spindle and Golgi tendon organ afferents
    Article Snippet: After the identification of their firing pattern, neurons were exposed to 20 nM of DTXα (Alomone D-350) in extracellular solution for 3–5 min, and firing responses were recorded during and after washout.

    Article Title: LGI1 downregulation increases neuronal circuit excitability
    Article Snippet: 1μM α-Dendrotoxin (Alomone Lab) was dissolved in 0.1% BSA and acutely applied to the slice.

    Article Title: Regulation of Nociceptive Glutamatergic Signaling by Presynaptic Kv3.4 Channels in the Rat Spinal Dorsal Horn
    Article Snippet: Tetraethylammonium-Cl (TEA; Sigma-Aldrich), 4-aminopyridine (Sigma-Aldrich), α-dendrotoxin (α-DTX; Alomone Laboratories), iberiotoxin (IbTX; Smartox), and 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX disodium salt; Alomone Laboratories) were dissolved in deionized water and XE991 (Alomone) was dissolved in DMSO.

    Article Title: Molecular tuning of electroreception in sharks and skates
    Article Snippet: Iberiotoxin, α-dendrotoxin, margatoxin, UK78282, and Guangxitoxin-1E were from Alamone Labs.

    Article Title: μ Opioid Receptors Modulate Action Potential Kinetics and Firing Frequency in Neocortical Interneurons
    Article Snippet: Saline controls were done alternately with drug condition recordings throughout the course of the experiments. α-Dendrotoxin (αDTX) was purchased from Alomone Labs (Jerusalem, Israel).

    Article Title: Deep sequencing of somatosensory neurons reveals molecular determinants of intrinsic physiological properties
    Article Snippet: First, α-dendrotoxin (Alomone Labs), which is highly selective for Kv1.1, Kv1.2, and Kv1.6 channels , was applied at 100 nM.

    Similar Products

  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
  • 94
    Alomone Labs α dendrotoxin
    Properties of the first evoked spike in monkey and rat basket cells. A : first suprathreshold response to the depolarizing current was significantly delayed in rat, but not in monkey basket cells. B : spike threshold was considerably lower in monkey basket cells than that in rat (APs are truncated). C : spikes evoked by rectangular current pulses with the latency of 8 ms still had more negative threshold in monkey ( n = 15) basket cells than that in rat ( n = 14). D : threshold of the 1st spikes and 8-ms-latency spikes is lower in monkeys than that in rats. Error bars represent SE. E : <t>α-dendrotoxin</t> (α-DTX) decreased spike threshold for the 1st spikes evoked in monkey ( n = 4) and rat basket cells ( n = 5).
    α Dendrotoxin, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/α dendrotoxin/product/Alomone Labs
    Average 94 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    α dendrotoxin - by Bioz Stars, 2021-09
    94/100 stars
      Buy from Supplier

    Image Search Results


    Properties of the first evoked spike in monkey and rat basket cells. A : first suprathreshold response to the depolarizing current was significantly delayed in rat, but not in monkey basket cells. B : spike threshold was considerably lower in monkey basket cells than that in rat (APs are truncated). C : spikes evoked by rectangular current pulses with the latency of 8 ms still had more negative threshold in monkey ( n = 15) basket cells than that in rat ( n = 14). D : threshold of the 1st spikes and 8-ms-latency spikes is lower in monkeys than that in rats. Error bars represent SE. E : α-dendrotoxin (α-DTX) decreased spike threshold for the 1st spikes evoked in monkey ( n = 4) and rat basket cells ( n = 5).

    Journal: Journal of Neurophysiology

    Article Title: Parvalbumin-Positive Basket Interneurons in Monkey and Rat Prefrontal Cortex

    doi: 10.1152/jn.90396.2008

    Figure Lengend Snippet: Properties of the first evoked spike in monkey and rat basket cells. A : first suprathreshold response to the depolarizing current was significantly delayed in rat, but not in monkey basket cells. B : spike threshold was considerably lower in monkey basket cells than that in rat (APs are truncated). C : spikes evoked by rectangular current pulses with the latency of 8 ms still had more negative threshold in monkey ( n = 15) basket cells than that in rat ( n = 14). D : threshold of the 1st spikes and 8-ms-latency spikes is lower in monkeys than that in rats. Error bars represent SE. E : α-dendrotoxin (α-DTX) decreased spike threshold for the 1st spikes evoked in monkey ( n = 4) and rat basket cells ( n = 5).

    Article Snippet: During some of the experiments, gabazine (4.5–6 μM; Sigma, St. Louis, MO) was added to the bath to block GABAA receptors. d -2-Amino-5-phospho-pentanoic acid (APV, 50 μM; Sigma) and 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX, 20 μM; Sigma) were included in the bath to block N -methyl- d -aspartate (NMDA) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, respectively. α-Dendrotoxin (α-DTX, 150–200 nM; Alomone Labs, Jerusalem, Israel) was used to block Kv1 channels and 4-( N -ethyl- N -phenylamino-1,2-dimethyl-6-methylamino)pyrimidinium chloride (ZD7288, 20 μM; Alomone Labs) was used to block I h channels.

    Techniques: Mass Spectrometry