cnqx  (Alomone Labs)


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  • 93
    Name:
    CNQX
    Description:
    AMPA Kainate receptor antagonist The concentrations that inhibit 50 of AMPA binding IC50 for CNQX in dorsal horn neurons and motoneurons are 300 nM 1 3 muM It was about one fifth as effective at kainate binding sites The association of AMPA receptors with TARPs converts CNQX from an antagonist to a weak partial agonist CNQX binds with high affinity to both high and low affinity AMPA binding sites in rat brain CNQX is a potent antagonist in electrophysiological responses mediated by non NMDA receptors Effects at NMDA receptors are much weaker
    Catalog Number:
    C-140
    Price:
    41.0
    Category:
    Small Molecule
    Source:
    Synthetic
    Applications:
    0
    Purity:
    >98%
    Size:
    5 mg
    Format:
    Lyophilized/solid.
    Formula:
    C9H4N4O4
    Molecular Weight:
    232.2
    Molecule Name:
    6-Cyano-7-nitroquinoxaline-2,3-dione.
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    Structured Review

    Alomone Labs cnqx
    CNQX
    AMPA Kainate receptor antagonist The concentrations that inhibit 50 of AMPA binding IC50 for CNQX in dorsal horn neurons and motoneurons are 300 nM 1 3 muM It was about one fifth as effective at kainate binding sites The association of AMPA receptors with TARPs converts CNQX from an antagonist to a weak partial agonist CNQX binds with high affinity to both high and low affinity AMPA binding sites in rat brain CNQX is a potent antagonist in electrophysiological responses mediated by non NMDA receptors Effects at NMDA receptors are much weaker
    https://www.bioz.com/result/cnqx/product/Alomone Labs
    Average 93 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    cnqx - by Bioz Stars, 2021-09
    93/100 stars

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    Related Articles

    other:

    Article Title: CB1-Dependent Long-Term Depression in Ventral Tegmental Area GABA Neurons: A Novel Target for Marijuana
    Article Snippet: CNQX (10 μ m ) was purchased from Alomone Labs.

    Article Title: Cocaine Dysregulates Dynorphin Modulation of Inhibitory Neurotransmission in the Ventral Pallidum in a Cell-Type-Specific Manner
    Article Snippet: Dynorphin A and NorBNI (Abcam) were first dissolved in water and then added to aCSF solution containing also CNQX (Alomone Labs).

    Article Title: Differential Regulation of NMDA Receptor-Mediated Transmission by SK Channels Underlies Dorsal-Ventral Differences in Dynamics of Schaffer Collateral Synaptic Function
    Article Snippet: In these experiments, slices were bathed in CNQX (Alomone Labs; 20 μ m ) and picrotoxin and pyramidal cells were voltage-clamped at 40 mV.

    Article Title: Increased Ca2+ signaling in NRXN1α+/− neurons derived from ASD induced pluripotent stem cells
    Article Snippet: Chemicals were added to the ACSF as required, i.e., Na+ channel blocker TTX (Alomone Labs T-550), AMPA/Kainate receptor blocker CNQX (Alomone Labs C-140), NMDA receptor blocker DL-AP5 (Alomone Labs D-140), L-type VGCC blocker Nifedipine (Alomone Labs N-120), P/Q-type VGCC blocker agatoxin (Alomone Labs STA-500), glutamate (Sigma, G8415), ionomycin (Sigma I0634), or γ-aminobutyric acid (Sigma A2129).

    Conditioned Place Preference:

    Article Title: Ion channel expression patterns in glioblastoma stem cells with functional and therapeutic implications for malignancy
    Article Snippet: .. Drugs Drugs used for this study included: tetrodotoxin (TTX, voltage-gated Na+ channel blocker, Tocris, #1078), tetraethylammonium hydroxide (TEA, non-inactivating K+ channel blocker, Sigma-Aldrich, #T6393), 4-Aminopyridine (4-AP, transient/A-type K+ channel blocker, Sigma-Aldrich, #275875), 3-((±)2-carboxypiperazin-4yl)propyl-1-phosphate (CPP, NMDA receptor antagonist, Tocris, #0173), 6-Cyano-7-nitroquinoxaline-2,3-dione (CNQX, AMPA/kainate receptor antagonist, Alomone Labs, #C-140, diluted in DMSO), ω-Conotoxin MVIIC (N-, P/Q-type Ca2+ channel blocker, Alomone Labs, #C-150), cadmium chloride (CdCl2 , non-selective voltage-gated Ca2+ channel blocker, Sigma-Aldrich, #C3141), Gabazine (GABAA receptor blocker, Tocris, #1262), Picrotoxin (PTX, GABAA receptor blocker, Sigma-Aldrich, #P1675, diluted in DMSO). ..

    Blocking Assay:

    Article Title: Chrna5 is Essential for a Rapid and Protected Response to Optogenetic Release of Endogenous Acetylcholine in Prefrontal Cortex
    Article Snippet: .. CNQX (20 μ m ; Alomone Labs), APV (50 μ m ; Alomone Labs), and picrotoxin (50 μ m , Alomone Labs) were used to block glutamate and GABAA receptors. ..

    Article Title: Lysophosphatidic acid receptor type 2 activation contributes to secondary damage after spinal cord injury in mice
    Article Snippet: .. The MCM was supplemented with 30 μM CNQX (6-cyano-7-nitroquinoxaline-2,3-dione) (Alomone Labs, Jerusalem, Israel) or 50 nM BBG (Brillian Blue G) (Sigma Aldrich) to block the AMPA/Kainate and P2X7 receptors in oligodendrocytes, respectively. ..

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  • 93
    Alomone Labs cnqx
    Cnqx, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/cnqx/product/Alomone Labs
    Average 93 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    cnqx - by Bioz Stars, 2021-09
    93/100 stars
      Buy from Supplier

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