Journal: Molecular and cellular neurosciences

Article Title: Sympathomimetics Regulate Neuromuscular Junction Transmission through TRPV1, P/Q- and N-type Ca 2+ Channels

doi: 10.1016/j.mcn.2019.01.007

Figure Lengend Snippet: MEPP recordings in 3 μM ω-conotoxin GIVA (a) or 3 μM ω-conotoxin GIVA plus 1μM clenbuterol (b). EPPs recorded in 3 μM ω-conotoxin GIVA or 3 μM ω-conotoxin GIVA plus 1 μM clenbuterol followed the stimulation frequency, and no major differences in amplitude or kinetics were observed (c). The thin and thick arrows show the stimulation artefact and EPP, respectively.

Article Snippet: Salbutamol and clenbuterol concentrations used in this study are within those reported in the literature for the treatment of asthmatic patients. ( Jacobson et al., 2003 ; Yamamoto et al., 1985 ) ω-conotoxin GIIIB (a.k.a. myotoxin II, geographutoxin II, GTx-II; Alomone, cat. C270), a selective blocker of skeletal muscle Nav1.4 channels, was used at a concentration of 1μM. ω-conotoxin GVIA (a.k.a.

Techniques:

Journal: Molecular and cellular neurosciences

Article Title: Sympathomimetics Regulate Neuromuscular Junction Transmission through TRPV1, P/Q- and N-type Ca 2+ Channels

doi: 10.1016/j.mcn.2019.01.007

Figure Lengend Snippet: ω-conotoxin GVIA prevents clenbuterol-enhanced neuromuscular transmission

Article Snippet: Salbutamol and clenbuterol concentrations used in this study are within those reported in the literature for the treatment of asthmatic patients. ( Jacobson et al., 2003 ; Yamamoto et al., 1985 ) ω-conotoxin GIIIB (a.k.a. myotoxin II, geographutoxin II, GTx-II; Alomone, cat. C270), a selective blocker of skeletal muscle Nav1.4 channels, was used at a concentration of 1μM. ω-conotoxin GVIA (a.k.a.

Techniques: Significance Assay