sodium ion channel antagonist tetrodotoxin  (Alomone Labs)


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    Alomone Labs sodium ion channel antagonist tetrodotoxin
    ( A ) Representative trace of the amplitude of an action potential during time, detected by one electrode from one well populated with line 37E. ( B ) MEA recordings of the MFR and number of network bursts of different iPSC-derived neuronal lines upon treatments with different receptor inhibitors. Values were acquired in four consecutive readings, that is, before (read 1) and after addition of GABA receptor inhibitor PTX (read 2), after addition of AMPA receptor inhibitor CNQX (read 3), and after addition of <t>sodium</t> <t>channel</t> blocker TTX (read 4). At least 60 min recovery was allowed after each reading, which were performed 5–10 min after treatment with neurotoxins. 6–8 wells were recorded for each group at week 8 PNI. Values are presented as mean ± SD from a single experiment; *p<0.05 between n/t and CNQX for all samples; PTX, Picrotoxin; CNQX, 6-Cyano-7-nitroquinoxaline-2,3-dione; TTX, <t>Tetrodotoxin;</t> n/t, not treated; μV, microvolt; Hz, hertz; ctrl, control; mut, mutant.
    Sodium Ion Channel Antagonist Tetrodotoxin, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/sodium ion channel antagonist tetrodotoxin/product/Alomone Labs
    Average 91 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    sodium ion channel antagonist tetrodotoxin - by Bioz Stars, 2023-02
    91/100 stars

    Images

    1) Product Images from "CNTN5 - /+ or EHMT2 - /+ human iPSC-derived neurons from individuals with autism develop hyperactive neuronal networks"

    Article Title: CNTN5 - /+ or EHMT2 - /+ human iPSC-derived neurons from individuals with autism develop hyperactive neuronal networks

    Journal: eLife

    doi: 10.7554/eLife.40092

    ( A ) Representative trace of the amplitude of an action potential during time, detected by one electrode from one well populated with line 37E. ( B ) MEA recordings of the MFR and number of network bursts of different iPSC-derived neuronal lines upon treatments with different receptor inhibitors. Values were acquired in four consecutive readings, that is, before (read 1) and after addition of GABA receptor inhibitor PTX (read 2), after addition of AMPA receptor inhibitor CNQX (read 3), and after addition of sodium channel blocker TTX (read 4). At least 60 min recovery was allowed after each reading, which were performed 5–10 min after treatment with neurotoxins. 6–8 wells were recorded for each group at week 8 PNI. Values are presented as mean ± SD from a single experiment; *p<0.05 between n/t and CNQX for all samples; PTX, Picrotoxin; CNQX, 6-Cyano-7-nitroquinoxaline-2,3-dione; TTX, Tetrodotoxin; n/t, not treated; μV, microvolt; Hz, hertz; ctrl, control; mut, mutant.
    Figure Legend Snippet: ( A ) Representative trace of the amplitude of an action potential during time, detected by one electrode from one well populated with line 37E. ( B ) MEA recordings of the MFR and number of network bursts of different iPSC-derived neuronal lines upon treatments with different receptor inhibitors. Values were acquired in four consecutive readings, that is, before (read 1) and after addition of GABA receptor inhibitor PTX (read 2), after addition of AMPA receptor inhibitor CNQX (read 3), and after addition of sodium channel blocker TTX (read 4). At least 60 min recovery was allowed after each reading, which were performed 5–10 min after treatment with neurotoxins. 6–8 wells were recorded for each group at week 8 PNI. Values are presented as mean ± SD from a single experiment; *p<0.05 between n/t and CNQX for all samples; PTX, Picrotoxin; CNQX, 6-Cyano-7-nitroquinoxaline-2,3-dione; TTX, Tetrodotoxin; n/t, not treated; μV, microvolt; Hz, hertz; ctrl, control; mut, mutant.

    Techniques Used: Derivative Assay, Mutagenesis

    sodium ion channel antagonist tetrodotoxin  (Alomone Labs)


    Bioz Verified Symbol Alomone Labs is a verified supplier
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  • 91

    Structured Review

    Alomone Labs sodium ion channel antagonist tetrodotoxin
    ( A ) Representative trace of the amplitude of an action potential during time, detected by one electrode from one well populated with line 37E. ( B ) MEA recordings of the MFR and number of network bursts of different iPSC-derived neuronal lines upon treatments with different receptor inhibitors. Values were acquired in four consecutive readings, that is, before (read 1) and after addition of GABA receptor inhibitor PTX (read 2), after addition of AMPA receptor inhibitor CNQX (read 3), and after addition of <t>sodium</t> <t>channel</t> blocker TTX (read 4). At least 60 min recovery was allowed after each reading, which were performed 5–10 min after treatment with neurotoxins. 6–8 wells were recorded for each group at week 8 PNI. Values are presented as mean ± SD from a single experiment; *p<0.05 between n/t and CNQX for all samples; PTX, Picrotoxin; CNQX, 6-Cyano-7-nitroquinoxaline-2,3-dione; TTX, <t>Tetrodotoxin;</t> n/t, not treated; μV, microvolt; Hz, hertz; ctrl, control; mut, mutant.
    Sodium Ion Channel Antagonist Tetrodotoxin, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/sodium ion channel antagonist tetrodotoxin/product/Alomone Labs
    Average 91 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    sodium ion channel antagonist tetrodotoxin - by Bioz Stars, 2023-02
    91/100 stars

    Images

    1) Product Images from "CNTN5 - /+ or EHMT2 - /+ human iPSC-derived neurons from individuals with autism develop hyperactive neuronal networks"

    Article Title: CNTN5 - /+ or EHMT2 - /+ human iPSC-derived neurons from individuals with autism develop hyperactive neuronal networks

    Journal: eLife

    doi: 10.7554/eLife.40092

    ( A ) Representative trace of the amplitude of an action potential during time, detected by one electrode from one well populated with line 37E. ( B ) MEA recordings of the MFR and number of network bursts of different iPSC-derived neuronal lines upon treatments with different receptor inhibitors. Values were acquired in four consecutive readings, that is, before (read 1) and after addition of GABA receptor inhibitor PTX (read 2), after addition of AMPA receptor inhibitor CNQX (read 3), and after addition of sodium channel blocker TTX (read 4). At least 60 min recovery was allowed after each reading, which were performed 5–10 min after treatment with neurotoxins. 6–8 wells were recorded for each group at week 8 PNI. Values are presented as mean ± SD from a single experiment; *p<0.05 between n/t and CNQX for all samples; PTX, Picrotoxin; CNQX, 6-Cyano-7-nitroquinoxaline-2,3-dione; TTX, Tetrodotoxin; n/t, not treated; μV, microvolt; Hz, hertz; ctrl, control; mut, mutant.
    Figure Legend Snippet: ( A ) Representative trace of the amplitude of an action potential during time, detected by one electrode from one well populated with line 37E. ( B ) MEA recordings of the MFR and number of network bursts of different iPSC-derived neuronal lines upon treatments with different receptor inhibitors. Values were acquired in four consecutive readings, that is, before (read 1) and after addition of GABA receptor inhibitor PTX (read 2), after addition of AMPA receptor inhibitor CNQX (read 3), and after addition of sodium channel blocker TTX (read 4). At least 60 min recovery was allowed after each reading, which were performed 5–10 min after treatment with neurotoxins. 6–8 wells were recorded for each group at week 8 PNI. Values are presented as mean ± SD from a single experiment; *p<0.05 between n/t and CNQX for all samples; PTX, Picrotoxin; CNQX, 6-Cyano-7-nitroquinoxaline-2,3-dione; TTX, Tetrodotoxin; n/t, not treated; μV, microvolt; Hz, hertz; ctrl, control; mut, mutant.

    Techniques Used: Derivative Assay, Mutagenesis

    cnqx  (Alomone Labs)


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  • 91

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    Alomone Labs cnqx
    Cnqx, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/cnqx/product/Alomone Labs
    Average 91 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    cnqx - by Bioz Stars, 2023-02
    91/100 stars

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    sodium ion channel antagonist tetrodotoxin  (Alomone Labs)


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  • 91

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    Alomone Labs sodium ion channel antagonist tetrodotoxin
    Sodium Ion Channel Antagonist Tetrodotoxin, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/sodium ion channel antagonist tetrodotoxin/product/Alomone Labs
    Average 91 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    sodium ion channel antagonist tetrodotoxin - by Bioz Stars, 2023-02
    91/100 stars

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    sodium ion channel antagonist tetrodotoxin  (Alomone Labs)


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  • 91

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    Alomone Labs sodium ion channel antagonist tetrodotoxin
    Sodium Ion Channel Antagonist Tetrodotoxin, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/sodium ion channel antagonist tetrodotoxin/product/Alomone Labs
    Average 91 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    sodium ion channel antagonist tetrodotoxin - by Bioz Stars, 2023-02
    91/100 stars

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    ampa kainate blocker cnqx  (Alomone Labs)


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    Alomone Labs ampa kainate blocker cnqx
    Ampa Kainate Blocker Cnqx, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/ampa kainate blocker cnqx/product/Alomone Labs
    Average 91 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    ampa kainate blocker cnqx - by Bioz Stars, 2023-02
    91/100 stars

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    cnqx  (Alomone Labs)


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    Alomone Labs cnqx
    Cnqx, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/cnqx/product/Alomone Labs
    Average 91 stars, based on 1 article reviews
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    cnqx - by Bioz Stars, 2023-02
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    cnqx  (Alomone Labs)


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    Alomone Labs cnqx
    Cnqx, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/cnqx/product/Alomone Labs
    Average 91 stars, based on 1 article reviews
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    Alomone Labs sodium ion channel antagonist tetrodotoxin
    ( A ) Representative trace of the amplitude of an action potential during time, detected by one electrode from one well populated with line 37E. ( B ) MEA recordings of the MFR and number of network bursts of different iPSC-derived neuronal lines upon treatments with different receptor inhibitors. Values were acquired in four consecutive readings, that is, before (read 1) and after addition of GABA receptor inhibitor PTX (read 2), after addition of AMPA receptor inhibitor CNQX (read 3), and after addition of <t>sodium</t> <t>channel</t> blocker TTX (read 4). At least 60 min recovery was allowed after each reading, which were performed 5–10 min after treatment with neurotoxins. 6–8 wells were recorded for each group at week 8 PNI. Values are presented as mean ± SD from a single experiment; *p<0.05 between n/t and CNQX for all samples; PTX, Picrotoxin; CNQX, 6-Cyano-7-nitroquinoxaline-2,3-dione; TTX, <t>Tetrodotoxin;</t> n/t, not treated; μV, microvolt; Hz, hertz; ctrl, control; mut, mutant.
    Sodium Ion Channel Antagonist Tetrodotoxin, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/sodium ion channel antagonist tetrodotoxin/product/Alomone Labs
    Average 91 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    sodium ion channel antagonist tetrodotoxin - by Bioz Stars, 2023-02
    91/100 stars
      Buy from Supplier

    91
    Alomone Labs cnqx
    ( A ) Representative trace of the amplitude of an action potential during time, detected by one electrode from one well populated with line 37E. ( B ) MEA recordings of the MFR and number of network bursts of different iPSC-derived neuronal lines upon treatments with different receptor inhibitors. Values were acquired in four consecutive readings, that is, before (read 1) and after addition of GABA receptor inhibitor PTX (read 2), after addition of AMPA receptor inhibitor CNQX (read 3), and after addition of <t>sodium</t> <t>channel</t> blocker TTX (read 4). At least 60 min recovery was allowed after each reading, which were performed 5–10 min after treatment with neurotoxins. 6–8 wells were recorded for each group at week 8 PNI. Values are presented as mean ± SD from a single experiment; *p<0.05 between n/t and CNQX for all samples; PTX, Picrotoxin; CNQX, 6-Cyano-7-nitroquinoxaline-2,3-dione; TTX, <t>Tetrodotoxin;</t> n/t, not treated; μV, microvolt; Hz, hertz; ctrl, control; mut, mutant.
    Cnqx, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/cnqx/product/Alomone Labs
    Average 91 stars, based on 1 article reviews
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    cnqx - by Bioz Stars, 2023-02
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    Alomone Labs ampa kainate blocker cnqx
    ( A ) Representative trace of the amplitude of an action potential during time, detected by one electrode from one well populated with line 37E. ( B ) MEA recordings of the MFR and number of network bursts of different iPSC-derived neuronal lines upon treatments with different receptor inhibitors. Values were acquired in four consecutive readings, that is, before (read 1) and after addition of GABA receptor inhibitor PTX (read 2), after addition of AMPA receptor inhibitor CNQX (read 3), and after addition of <t>sodium</t> <t>channel</t> blocker TTX (read 4). At least 60 min recovery was allowed after each reading, which were performed 5–10 min after treatment with neurotoxins. 6–8 wells were recorded for each group at week 8 PNI. Values are presented as mean ± SD from a single experiment; *p<0.05 between n/t and CNQX for all samples; PTX, Picrotoxin; CNQX, 6-Cyano-7-nitroquinoxaline-2,3-dione; TTX, <t>Tetrodotoxin;</t> n/t, not treated; μV, microvolt; Hz, hertz; ctrl, control; mut, mutant.
    Ampa Kainate Blocker Cnqx, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/ampa kainate blocker cnqx/product/Alomone Labs
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    ( A ) Representative trace of the amplitude of an action potential during time, detected by one electrode from one well populated with line 37E. ( B ) MEA recordings of the MFR and number of network bursts of different iPSC-derived neuronal lines upon treatments with different receptor inhibitors. Values were acquired in four consecutive readings, that is, before (read 1) and after addition of GABA receptor inhibitor PTX (read 2), after addition of AMPA receptor inhibitor CNQX (read 3), and after addition of sodium channel blocker TTX (read 4). At least 60 min recovery was allowed after each reading, which were performed 5–10 min after treatment with neurotoxins. 6–8 wells were recorded for each group at week 8 PNI. Values are presented as mean ± SD from a single experiment; *p<0.05 between n/t and CNQX for all samples; PTX, Picrotoxin; CNQX, 6-Cyano-7-nitroquinoxaline-2,3-dione; TTX, Tetrodotoxin; n/t, not treated; μV, microvolt; Hz, hertz; ctrl, control; mut, mutant.

    Journal: eLife

    Article Title: CNTN5 - /+ or EHMT2 - /+ human iPSC-derived neurons from individuals with autism develop hyperactive neuronal networks

    doi: 10.7554/eLife.40092

    Figure Lengend Snippet: ( A ) Representative trace of the amplitude of an action potential during time, detected by one electrode from one well populated with line 37E. ( B ) MEA recordings of the MFR and number of network bursts of different iPSC-derived neuronal lines upon treatments with different receptor inhibitors. Values were acquired in four consecutive readings, that is, before (read 1) and after addition of GABA receptor inhibitor PTX (read 2), after addition of AMPA receptor inhibitor CNQX (read 3), and after addition of sodium channel blocker TTX (read 4). At least 60 min recovery was allowed after each reading, which were performed 5–10 min after treatment with neurotoxins. 6–8 wells were recorded for each group at week 8 PNI. Values are presented as mean ± SD from a single experiment; *p<0.05 between n/t and CNQX for all samples; PTX, Picrotoxin; CNQX, 6-Cyano-7-nitroquinoxaline-2,3-dione; TTX, Tetrodotoxin; n/t, not treated; μV, microvolt; Hz, hertz; ctrl, control; mut, mutant.

    Article Snippet: After the last reading, each well was treated with three synaptic antagonists: GABA A receptor antagonist picrotoxin (PTX; Sigma) at 100 μM, AMPA receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dion (CNQX; Sigma) at 60 μM, and sodium ion channel antagonist tetrodotoxin (TTX; Alomone labs) at 1 μM.

    Techniques: Derivative Assay, Mutagenesis