Journal: BMC Neuroscience

Article Title: Synergistic effect of CART (cocaine- and amphetamine-regulated transcript) peptide and cholecystokinin on food intake regulation in lean mice

doi: 10.1186/1471-2202-9-101

Figure Lengend Snippet: Administration of compounds in mice, in food intake Experiment 1 and 2

Article Snippet: Cholecystokinin octapeptide (CCK-8, Asp-Tyr(SO 3 H)-Met-Gly-Trp-Met-Asp-Phe-NH 2 , NeoMPS, Strasbourg, France), CCK-A receptor antagonist devazepide (L364,718) or CCK-B receptor antagonist L365,260 (gift from ML Laboratories, Liverpool, UK) and CART(61-102) (Bachem, Bubendorf, Switzerland) were used in the experiments.

Techniques:

Journal: BMC Neuroscience

Article Title: Synergistic effect of CART (cocaine- and amphetamine-regulated transcript) peptide and cholecystokinin on food intake regulation in lean mice

doi: 10.1186/1471-2202-9-101

Figure Lengend Snippet: Dose-related inhibition of food intake in 17-h fasted mice after administration of: A/ CCK-8 (0.4 and 4 μg/kg, i.p.) or i.c.v. saline, CART(61-102) (0.1 and 0.5 μg/mouse, i.c.v.), CCK-8 (0.4 and 4 μg/kg, i.p.) plus CART(61-102) (0.1 and 0.5 μg/mouse, i.c.v.), or B/ i.p. devazepide (1 mg/kg) alone or followed by i.c.v. CART(61-102) (0.1 and 0.5 μg/mouse) and i.p. L365,260 (1 mg/kg) alone or followed by i.c.v. CART(61-102) (0.5 μg/mouse). Food intake is expressed in grams of food consumed in the first 30 min after presentation of food (n = 6–8 mice per group). ** P < 0.01, *** P < 0.001 vs. saline-treated group, + P < 0.05 vs. CART(61-102) 0.1 μg/mouse, ++ P < 0.05 vs. CART(61-102) 0.5 μg/mouse [ANOVA, F 12,78 = 13.88]. CART – CART(61-102), dev – devazepide, L365 – L365,260.

Article Snippet: Cholecystokinin octapeptide (CCK-8, Asp-Tyr(SO 3 H)-Met-Gly-Trp-Met-Asp-Phe-NH 2 , NeoMPS, Strasbourg, France), CCK-A receptor antagonist devazepide (L364,718) or CCK-B receptor antagonist L365,260 (gift from ML Laboratories, Liverpool, UK) and CART(61-102) (Bachem, Bubendorf, Switzerland) were used in the experiments.

Techniques: Inhibition, CCK-8 Assay

Journal: BMC Neuroscience

Article Title: Synergistic effect of CART (cocaine- and amphetamine-regulated transcript) peptide and cholecystokinin on food intake regulation in lean mice

doi: 10.1186/1471-2202-9-101

Figure Lengend Snippet: Food intake of 17-h fasted mice during first 30 min measured (maximal effect) in Experiment 1 and 2

Article Snippet: Cholecystokinin octapeptide (CCK-8, Asp-Tyr(SO 3 H)-Met-Gly-Trp-Met-Asp-Phe-NH 2 , NeoMPS, Strasbourg, France), CCK-A receptor antagonist devazepide (L364,718) or CCK-B receptor antagonist L365,260 (gift from ML Laboratories, Liverpool, UK) and CART(61-102) (Bachem, Bubendorf, Switzerland) were used in the experiments.

Techniques:

Journal: BMC Neuroscience

Article Title: Synergistic effect of CART (cocaine- and amphetamine-regulated transcript) peptide and cholecystokinin on food intake regulation in lean mice

doi: 10.1186/1471-2202-9-101

Figure Lengend Snippet: Behavioral activity of fed mice (open field test, total distance traveled for 10 min) after i.p. administration of CCK-8 (4 μg/kg) or devazepide (1 mg/kg), after i.c.v. administration of saline, CART(61-102) (0.1 and 0.5 μg/mouse), or after combined injection of i.p. CCK-8 or devazepide followed by i.c.v. CART(61-102). ** P < 0.01 vs. saline-treated group [ANOVA, F 6,38 = 6.29]. CART – CART(61-102), dev – devazepide, L365 – L365,260.

Article Snippet: Cholecystokinin octapeptide (CCK-8, Asp-Tyr(SO 3 H)-Met-Gly-Trp-Met-Asp-Phe-NH 2 , NeoMPS, Strasbourg, France), CCK-A receptor antagonist devazepide (L364,718) or CCK-B receptor antagonist L365,260 (gift from ML Laboratories, Liverpool, UK) and CART(61-102) (Bachem, Bubendorf, Switzerland) were used in the experiments.

Techniques: Activity Assay, CCK-8 Assay, Injection