tta p2  (Alomone Labs)


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    Name:
    TTA P2
    Description:
    TTA P2 blocks T type currents in DRGs with IC50 of 100 nM and 22 nM in thalamocortical and reticular neurons
    Catalog Number:
    T-155
    Price:
    143.0
    Category:
    Small Molecule
    Source:
    Synthetic
    Applications:
    0
    Purity:
    >96% (HPLC)
    Size:
    5 mg
    Format:
    Lyophilized/solid.
    Formula:
    C21H29Cl2FN2O2
    Molecular Weight:
    431
    Molecule Name:
    3,5-dichloro-N-[1-(2,2-dimethyl-tetrahydro-pyran-4-ylmethyl)-4-fluoro-piperidin-4-ylmethyl]-benzamide. Racemic mixture.
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    Structured Review

    Alomone Labs tta p2
    TTA P2
    TTA P2 blocks T type currents in DRGs with IC50 of 100 nM and 22 nM in thalamocortical and reticular neurons
    https://www.bioz.com/result/tta p2/product/Alomone Labs
    Average 94 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    tta p2 - by Bioz Stars, 2021-09
    94/100 stars

    Images

    1) Product Images from "Dopamine Inhibition Differentially Controls Excitability of Substantia Nigra Dopamine Neuron Subpopulations through T-Type Calcium Channels"

    Article Title: Dopamine Inhibition Differentially Controls Excitability of Substantia Nigra Dopamine Neuron Subpopulations through T-Type Calcium Channels

    Journal: The Journal of Neuroscience

    doi: 10.1523/JNEUROSCI.0117-17.2017

    T-type Ca 2+ channels contribute to rebound spike timing. A , Rebound spikes (top) and rebound Ca 2+ (bottom) before (black) and after (red) TTA-P2 application. Scale bars: top, 20 mV, 100 ms; bottom, 0.05 dG / Gs , 100 ms. B , Time course of TTA-P2 application
    Figure Legend Snippet: T-type Ca 2+ channels contribute to rebound spike timing. A , Rebound spikes (top) and rebound Ca 2+ (bottom) before (black) and after (red) TTA-P2 application. Scale bars: top, 20 mV, 100 ms; bottom, 0.05 dG / Gs , 100 ms. B , Time course of TTA-P2 application

    Techniques Used:

    Related Articles

    Crocin Bleaching Assay:

    Article Title: TRPM4 conductances in thalamic reticular nucleus neurons generate persistent firing during slow oscillations
    Article Snippet: .. NBQX, apamin, nimodipine, TTX, 2-Aminoethoxydiphenylborane (2-APB), flufenamic acid (FFA), 9-phenthranol, glibenclamide, 4-Chloro-2-[[2-(2-chlorophenoxy)acetyl]amino]benzoic acid (CBA), JNJ 16259685, MTEP hydrochloride, and atropine were obtained from R & D Systems. ω-conotoxin MVII and TTA-P2 were obtained from Alomone labs. ..

    Article Title: TRPM4 Conductances in Thalamic Reticular Nucleus Neurons Generate Persistent Firing during Slow Oscillations
    Article Snippet: .. NBQX, apamin, nimodipine, TTX, 2-aminoethoxydiphenylborane (2-APB), flufenamic acid (FFA), 9-phenthranol, glibenclamide, 4-chloro-2-[[2-(2-chlorophenoxy)acetyl]amino]benzoic acid (CBA), JNJ 16259685, MTEP hydrochloride, and atropine were obtained from R & D Systems. ω-Conotoxin MVII and TTA-P2 were obtained from Alomone Labs. ..

    other:

    Article Title: Cellular and Molecular Properties of Neurons: Adrenergic agonist induces rhythmic firing in quiescent cardiac preganglionic neurons in nucleus ambiguous via activation of intrinsic membrane excitability
    Article Snippet: TTA-P2 and TTX were purchased from Alomone Laboratories.

    Article Title: Diurnal properties of voltage-gated Ca2+ currents in suprachiasmatic nucleus and roles in action potential firing
    Article Snippet: Drugs were used at final concentrations of 1 μM tetrodotoxin (TTX; Alomone Labs, Jerusalem, Israel; T-550), 10 μM Nimodipine (Alomone Labs, Jerusalem, Israel; N150), 10 μM dantrolene (Dan; Sigma, Darmstadt, Germany; D9175), 1 μM cyclopiazonic acid (CPA; Alomone Labs, Jerusalem, Israel; C-750), 3 μM ω-conotoxin GVIA (ConoGVIA; Alomone Labs, Jerusalem, Israel; C-300), 3 μM ω-conotoxin MVIIC (ConoMVIIC; Alomone Labs, Jerusalem, Israel; C-150), 200 nM ω-agatoxin IVA (AgaIVA;Alomone Labs, Jerusalem, Israel; STA-500), 1 μM TTA-P2, (TTAP2;Alomone Labs, Jerusalem, Israel; T-155), 200 μM CdCl2 (Cd2+ ; Sigma; 529575), 30 μM NiCl2 (Ni2+ ; Sigma; 22387), and 5 μM Bay K8644 (Bay K; Sigma, Darmstadt, Germany; B133).

    Article Title: IL-6 induced upregulation of T-type Ca2+ currents and sensitization of DRG nociceptors is attenuated by MNK inhibition
    Article Snippet: In experiments testing the effect of TTA-P2, the drug was directly applied to the patched cell for 2–4 min after baseline recordings were obtained.

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  • 94
    Alomone Labs tta p2
    T-type Ca 2+ channels contribute to rebound spike timing. A , Rebound spikes (top) and rebound Ca 2+ (bottom) before (black) and after (red) <t>TTA-P2</t> application. Scale bars: top, 20 mV, 100 ms; bottom, 0.05 dG / Gs , 100 ms. B , Time course of TTA-P2 application
    Tta P2, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/tta p2/product/Alomone Labs
    Average 94 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    tta p2 - by Bioz Stars, 2021-09
    94/100 stars
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    Alomone Labs anti etb receptor antibody
    T-type Ca 2+ channels contribute to rebound spike timing. A , Rebound spikes (top) and rebound Ca 2+ (bottom) before (black) and after (red) <t>TTA-P2</t> application. Scale bars: top, 20 mV, 100 ms; bottom, 0.05 dG / Gs , 100 ms. B , Time course of TTA-P2 application
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    Alomone Labs rat kv3 1b channel subunit
    T-type Ca 2+ channels contribute to rebound spike timing. A , Rebound spikes (top) and rebound Ca 2+ (bottom) before (black) and after (red) <t>TTA-P2</t> application. Scale bars: top, 20 mV, 100 ms; bottom, 0.05 dG / Gs , 100 ms. B , Time course of TTA-P2 application
    Rat Kv3 1b Channel Subunit, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/rat kv3 1b channel subunit/product/Alomone Labs
    Average 95 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    rat kv3 1b channel subunit - by Bioz Stars, 2021-09
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    Alomone Labs anti kv3 1b
    T-type Ca 2+ channels contribute to rebound spike timing. A , Rebound spikes (top) and rebound Ca 2+ (bottom) before (black) and after (red) <t>TTA-P2</t> application. Scale bars: top, 20 mV, 100 ms; bottom, 0.05 dG / Gs , 100 ms. B , Time course of TTA-P2 application
    Anti Kv3 1b, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/anti kv3 1b/product/Alomone Labs
    Average 94 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    anti kv3 1b - by Bioz Stars, 2021-09
    94/100 stars
      Buy from Supplier

    Image Search Results


    T-type Ca 2+ channels contribute to rebound spike timing. A , Rebound spikes (top) and rebound Ca 2+ (bottom) before (black) and after (red) TTA-P2 application. Scale bars: top, 20 mV, 100 ms; bottom, 0.05 dG / Gs , 100 ms. B , Time course of TTA-P2 application

    Journal: The Journal of Neuroscience

    Article Title: Dopamine Inhibition Differentially Controls Excitability of Substantia Nigra Dopamine Neuron Subpopulations through T-Type Calcium Channels

    doi: 10.1523/JNEUROSCI.0117-17.2017

    Figure Lengend Snippet: T-type Ca 2+ channels contribute to rebound spike timing. A , Rebound spikes (top) and rebound Ca 2+ (bottom) before (black) and after (red) TTA-P2 application. Scale bars: top, 20 mV, 100 ms; bottom, 0.05 dG / Gs , 100 ms. B , Time course of TTA-P2 application

    Article Snippet: To ensure that this increase in rebound delay was not due to a change in I h , the voltage sag was also monitored and was not affected by TTA-P2 (control, 92 ± 13%; TTA-P2, 99 ± 8.2%; Mann–Whitney U test, p = 0.84; B , bottom).

    Techniques: