nav1 7  (Alomone Labs)


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    Structured Review

    Alomone Labs nav1 7
    Keratinocyte biomarker immunolabeling. Epidermal keratinocyte biomarkers are significantly increased among PDPN patients compared with control biopsies. The panels depict representative images of immunolabeling for (A) Nav1.6, (B) <t>Nav1.7,</t> and (C) CGRP along with DAPI fluorescence from PRE and POST treatment biopsies, along with half-sized grayscale images used for pixel intensity measures, from age-matched female and male PDPN patients compared to a male control. (D) There was a significant increase in PRE-treatment Nav1.6, Nav1.7, and CGRP immunolabeling among PDPN patients compared with control (brackets indicate significant differences). (E) Topical lidocaine treatment acted to decrease keratinocyte biomarker levels of Nav1.6, Nav1.7, and CGRP among PDPN patients such that no differences were found among the groups POST-treatment.
    Nav1 7, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/nav1 7/product/Alomone Labs
    Average 93 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    nav1 7 - by Bioz Stars, 2022-05
    93/100 stars

    Images

    1) Product Images from "Keratinocyte Biomarkers Distinguish Painful Diabetic Peripheral Neuropathy Patients and Correlate With Topical Lidocaine Responsiveness"

    Article Title: Keratinocyte Biomarkers Distinguish Painful Diabetic Peripheral Neuropathy Patients and Correlate With Topical Lidocaine Responsiveness

    Journal: Frontiers in Pain Research

    doi: 10.3389/fpain.2021.790524

    Keratinocyte biomarker immunolabeling. Epidermal keratinocyte biomarkers are significantly increased among PDPN patients compared with control biopsies. The panels depict representative images of immunolabeling for (A) Nav1.6, (B) Nav1.7, and (C) CGRP along with DAPI fluorescence from PRE and POST treatment biopsies, along with half-sized grayscale images used for pixel intensity measures, from age-matched female and male PDPN patients compared to a male control. (D) There was a significant increase in PRE-treatment Nav1.6, Nav1.7, and CGRP immunolabeling among PDPN patients compared with control (brackets indicate significant differences). (E) Topical lidocaine treatment acted to decrease keratinocyte biomarker levels of Nav1.6, Nav1.7, and CGRP among PDPN patients such that no differences were found among the groups POST-treatment.
    Figure Legend Snippet: Keratinocyte biomarker immunolabeling. Epidermal keratinocyte biomarkers are significantly increased among PDPN patients compared with control biopsies. The panels depict representative images of immunolabeling for (A) Nav1.6, (B) Nav1.7, and (C) CGRP along with DAPI fluorescence from PRE and POST treatment biopsies, along with half-sized grayscale images used for pixel intensity measures, from age-matched female and male PDPN patients compared to a male control. (D) There was a significant increase in PRE-treatment Nav1.6, Nav1.7, and CGRP immunolabeling among PDPN patients compared with control (brackets indicate significant differences). (E) Topical lidocaine treatment acted to decrease keratinocyte biomarker levels of Nav1.6, Nav1.7, and CGRP among PDPN patients such that no differences were found among the groups POST-treatment.

    Techniques Used: Biomarker Assay, Immunolabeling, Fluorescence

    2) Product Images from "Smooth muscle and neural mechanisms contributing to the downregulation of neonatal rat spontaneous bladder contractions during postnatal development"

    Article Title: Smooth muscle and neural mechanisms contributing to the downregulation of neonatal rat spontaneous bladder contractions during postnatal development

    Journal: American journal of physiology. Regulatory, integrative and comparative physiology

    doi: 10.1152/ajpregu.00779.2006

    Upregulation of BK-α subunit during the first 6 postnatal weeks. A , top : RT-PCR of BK-α subunit in bladders of different ages. The RT-PCR product of GAPDH is shown as a loading control. Bottom : mRNA levels of the α subunit between 3 days and 6 wk ( n = 5). Values are expressed as means (SD). * P
    Figure Legend Snippet: Upregulation of BK-α subunit during the first 6 postnatal weeks. A , top : RT-PCR of BK-α subunit in bladders of different ages. The RT-PCR product of GAPDH is shown as a loading control. Bottom : mRNA levels of the α subunit between 3 days and 6 wk ( n = 5). Values are expressed as means (SD). * P

    Techniques Used: Reverse Transcription Polymerase Chain Reaction

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  • 93
    Alomone Labs nav1 7
    Keratinocyte biomarker immunolabeling. Epidermal keratinocyte biomarkers are significantly increased among PDPN patients compared with control biopsies. The panels depict representative images of immunolabeling for (A) Nav1.6, (B) <t>Nav1.7,</t> and (C) CGRP along with DAPI fluorescence from PRE and POST treatment biopsies, along with half-sized grayscale images used for pixel intensity measures, from age-matched female and male PDPN patients compared to a male control. (D) There was a significant increase in PRE-treatment Nav1.6, Nav1.7, and CGRP immunolabeling among PDPN patients compared with control (brackets indicate significant differences). (E) Topical lidocaine treatment acted to decrease keratinocyte biomarker levels of Nav1.6, Nav1.7, and CGRP among PDPN patients such that no differences were found among the groups POST-treatment.
    Nav1 7, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/nav1 7/product/Alomone Labs
    Average 93 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    nav1 7 - by Bioz Stars, 2022-05
    93/100 stars
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    Keratinocyte biomarker immunolabeling. Epidermal keratinocyte biomarkers are significantly increased among PDPN patients compared with control biopsies. The panels depict representative images of immunolabeling for (A) Nav1.6, (B) Nav1.7, and (C) CGRP along with DAPI fluorescence from PRE and POST treatment biopsies, along with half-sized grayscale images used for pixel intensity measures, from age-matched female and male PDPN patients compared to a male control. (D) There was a significant increase in PRE-treatment Nav1.6, Nav1.7, and CGRP immunolabeling among PDPN patients compared with control (brackets indicate significant differences). (E) Topical lidocaine treatment acted to decrease keratinocyte biomarker levels of Nav1.6, Nav1.7, and CGRP among PDPN patients such that no differences were found among the groups POST-treatment.

    Journal: Frontiers in Pain Research

    Article Title: Keratinocyte Biomarkers Distinguish Painful Diabetic Peripheral Neuropathy Patients and Correlate With Topical Lidocaine Responsiveness

    doi: 10.3389/fpain.2021.790524

    Figure Lengend Snippet: Keratinocyte biomarker immunolabeling. Epidermal keratinocyte biomarkers are significantly increased among PDPN patients compared with control biopsies. The panels depict representative images of immunolabeling for (A) Nav1.6, (B) Nav1.7, and (C) CGRP along with DAPI fluorescence from PRE and POST treatment biopsies, along with half-sized grayscale images used for pixel intensity measures, from age-matched female and male PDPN patients compared to a male control. (D) There was a significant increase in PRE-treatment Nav1.6, Nav1.7, and CGRP immunolabeling among PDPN patients compared with control (brackets indicate significant differences). (E) Topical lidocaine treatment acted to decrease keratinocyte biomarker levels of Nav1.6, Nav1.7, and CGRP among PDPN patients such that no differences were found among the groups POST-treatment.

    Article Snippet: Primary antibodies were diluted in PBS-T and separate slides from each biopsy were immunolabeled for the pan-neuronal enzyme PGP (rabbit polyclonal, 1:800, UltraClone Ltd.) to visualize and quantify total cutaneous innervation, and for Nav1.6 (rabbit polyclonal, 1:100; Alomone Labs), Nav1.7 (rabbit polyclonal, 1:100; Alomone Labs), and CGRP (sheep polyclonal, 1:500, Abcam), to determine epidermal keratinocyte immunolabeling.

    Techniques: Biomarker Assay, Immunolabeling, Fluorescence

    Upregulation of BK-α subunit during the first 6 postnatal weeks. A , top : RT-PCR of BK-α subunit in bladders of different ages. The RT-PCR product of GAPDH is shown as a loading control. Bottom : mRNA levels of the α subunit between 3 days and 6 wk ( n = 5). Values are expressed as means (SD). * P

    Journal: American journal of physiology. Regulatory, integrative and comparative physiology

    Article Title: Smooth muscle and neural mechanisms contributing to the downregulation of neonatal rat spontaneous bladder contractions during postnatal development

    doi: 10.1152/ajpregu.00779.2006

    Figure Lengend Snippet: Upregulation of BK-α subunit during the first 6 postnatal weeks. A , top : RT-PCR of BK-α subunit in bladders of different ages. The RT-PCR product of GAPDH is shown as a loading control. Bottom : mRNA levels of the α subunit between 3 days and 6 wk ( n = 5). Values are expressed as means (SD). * P

    Article Snippet: The resolved proteins were transferred from the gel to a nitrocellulose membrane (0.45-µm pore size; Bio-Rad Laboratories) for 1 h at room temperature with a constant voltage of 100 V. The membrane was blocked with 1% (wt/vol) milk in Tris-buffered saline-Tween [TBST; 0.05% (vol/vol) Tween-20, 25 mM Tris, 140 mM sodium chloride, 2.7 mM potassium chloride, pH 7.5] at room temperature for 1 h. The membrane was then incubated with 1:500 rabbit anti-BK channel α subunit antibody (Alomone Laboratories, Jerusalem, Israel) at 4°C overnight.

    Techniques: Reverse Transcription Polymerase Chain Reaction