rabbit anti nav1 7  (Alomone Labs)


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    Name:
    Anti Nav1 7 SCN9A Antibody
    Description:
    Anti NaV1 7 SCN9A Antibody ASC 008 is a highly specific antibody directed against an epitope of the rat protein The antibody can be used in western blot immunohistochemistry and immunocytochemistry applications It has been designed to recognize NaV1 7 from rat human and mouse samples
    Catalog Number:
    ASC-008
    Price:
    397.0
    Category:
    Primary Antibody
    Applications:
    Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
    Purity:
    Affinity purified on immobilized antigen.
    Immunogen:
    Synthetic peptide
    Size:
    25 mcl
    Antibody Type:
    Polyclonal Primary Antibodies
    Format:
    Lyophilized Powder
    Host:
    Rabbit
    Isotype:
    Rabbit IgG
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    Structured Review

    Alomone Labs rabbit anti nav1 7
    Anti Nav1 7 SCN9A Antibody
    Anti NaV1 7 SCN9A Antibody ASC 008 is a highly specific antibody directed against an epitope of the rat protein The antibody can be used in western blot immunohistochemistry and immunocytochemistry applications It has been designed to recognize NaV1 7 from rat human and mouse samples
    https://www.bioz.com/result/rabbit anti nav1 7/product/Alomone Labs
    Average 93 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    rabbit anti nav1 7 - by Bioz Stars, 2021-09
    93/100 stars

    Images

    1) Product Images from "α-lipoic acid suppresses neuronal excitability and attenuates colonic hypersensitivity to colorectal distention in diabetic rats"

    Article Title: α-lipoic acid suppresses neuronal excitability and attenuates colonic hypersensitivity to colorectal distention in diabetic rats

    Journal: Journal of Pain Research

    doi: 10.2147/JPR.S135017

    ALA downregulated NaV1.7 and NaV1.8 expression. Notes: (A) Western blots for NaV1.7 of T13-L2 DRGs from NS- and ALA-treatment rats. Bar graph showed mean density relative to GAPHD for NaV1.7. ALA treatment greatly reduced expressions of NaV1.7 (n=4 for each group, ** p
    Figure Legend Snippet: ALA downregulated NaV1.7 and NaV1.8 expression. Notes: (A) Western blots for NaV1.7 of T13-L2 DRGs from NS- and ALA-treatment rats. Bar graph showed mean density relative to GAPHD for NaV1.7. ALA treatment greatly reduced expressions of NaV1.7 (n=4 for each group, ** p

    Techniques Used: Expressing, Western Blot

    2) Product Images from "Modulation of Voltage-Gated Sodium Channel Activity in Human Dorsal Root Ganglion Neurons by Herpesvirus Quiescent Infection"

    Article Title: Modulation of Voltage-Gated Sodium Channel Activity in Human Dorsal Root Ganglion Neurons by Herpesvirus Quiescent Infection

    Journal: Journal of Virology

    doi: 10.1128/JVI.01823-19

    Expression of Nav1.7 in HD10.6 cells. (A and B) The expression of Nav1.7 protein and mRNA was assessed by Western blotting (A) and qRT-PCR (B), respectively. (A) Lane 1, control; lane 2, latent cells; lane 3, control plus TSA; lane 4, latent cells plus TSA. (B) The asterisk (*) indicates a statistically significant difference ( P
    Figure Legend Snippet: Expression of Nav1.7 in HD10.6 cells. (A and B) The expression of Nav1.7 protein and mRNA was assessed by Western blotting (A) and qRT-PCR (B), respectively. (A) Lane 1, control; lane 2, latent cells; lane 3, control plus TSA; lane 4, latent cells plus TSA. (B) The asterisk (*) indicates a statistically significant difference ( P

    Techniques Used: Expressing, Western Blot, Quantitative RT-PCR

    3) Product Images from "Efficacy of Anti-NaV1.7 Antibody on the Sensory Nervous System in a Rat Model of Lumbar Intervertebral Disc Injury"

    Article Title: Efficacy of Anti-NaV1.7 Antibody on the Sensory Nervous System in a Rat Model of Lumbar Intervertebral Disc Injury

    Journal: Yonsei Medical Journal

    doi: 10.3349/ymj.2016.57.3.748

    Ratio of FG-labeled/CGRP-IR DRG neurons to FG-labeled DRG neurons in the non-puncture, puncture+saline, and puncture+anti-NaV1.7 antibody groups on day 14. The ratio at levels L1 to L6 in the puncture+saline group was significantly greater than in the non-puncture and the puncture+NaV1.7 antibody groups ( * p
    Figure Legend Snippet: Ratio of FG-labeled/CGRP-IR DRG neurons to FG-labeled DRG neurons in the non-puncture, puncture+saline, and puncture+anti-NaV1.7 antibody groups on day 14. The ratio at levels L1 to L6 in the puncture+saline group was significantly greater than in the non-puncture and the puncture+NaV1.7 antibody groups ( * p

    Techniques Used: Labeling

    Ratio of FG-labeled/CGRP-IR DRG neurons to FG-labeled DRG neurons in the non-puncture, puncture+saline, and puncture+anti-NaV1.7 antibody groups on day 7. The ratio at levels L1 to L6 in the puncture+saline group was significantly greater than the non-puncture and the puncture+NaV1.7 antibody groups ( * p
    Figure Legend Snippet: Ratio of FG-labeled/CGRP-IR DRG neurons to FG-labeled DRG neurons in the non-puncture, puncture+saline, and puncture+anti-NaV1.7 antibody groups on day 7. The ratio at levels L1 to L6 in the puncture+saline group was significantly greater than the non-puncture and the puncture+NaV1.7 antibody groups ( * p

    Techniques Used: Labeling

    FG-labeled (A, B, and C) and CGRP-IR (D, E, and F) DRG neurons among 3 group. FG-labeled (A) and CGRP-IR (D) DRG neurons in the non-puncture group. FG-labeled (B) and CGRP-IR (E) DRG neurons in the puncture+saline group. FG-labeled (C) and CGRP-IR (F) DRG neurons in the puncture+anti-NaV1.7 antibody group. Arrowheads indicate FG-labeled/CGRP-IR DRG neurons. Magnification rate is ×400. FG, Fluoro-Gold; CGRP-IR, calcitonin gene-related peptide-immunoreactive; DRG, dorsal root ganglion; NaV, voltage-gated sodium.
    Figure Legend Snippet: FG-labeled (A, B, and C) and CGRP-IR (D, E, and F) DRG neurons among 3 group. FG-labeled (A) and CGRP-IR (D) DRG neurons in the non-puncture group. FG-labeled (B) and CGRP-IR (E) DRG neurons in the puncture+saline group. FG-labeled (C) and CGRP-IR (F) DRG neurons in the puncture+anti-NaV1.7 antibody group. Arrowheads indicate FG-labeled/CGRP-IR DRG neurons. Magnification rate is ×400. FG, Fluoro-Gold; CGRP-IR, calcitonin gene-related peptide-immunoreactive; DRG, dorsal root ganglion; NaV, voltage-gated sodium.

    Techniques Used: Labeling

    4) Product Images from "Efficacy of Anti-NaV1.7 Antibody on the Sensory Nervous System in a Rat Model of Lumbar Intervertebral Disc Injury"

    Article Title: Efficacy of Anti-NaV1.7 Antibody on the Sensory Nervous System in a Rat Model of Lumbar Intervertebral Disc Injury

    Journal: Yonsei Medical Journal

    doi: 10.3349/ymj.2016.57.3.748

    Ratio of FG-labeled/CGRP-IR DRG neurons to FG-labeled DRG neurons in the non-puncture, puncture+saline, and puncture+anti-NaV1.7 antibody groups on day 14. The ratio at levels L1 to L6 in the puncture+saline group was significantly greater than in the non-puncture and the puncture+NaV1.7 antibody groups ( * p
    Figure Legend Snippet: Ratio of FG-labeled/CGRP-IR DRG neurons to FG-labeled DRG neurons in the non-puncture, puncture+saline, and puncture+anti-NaV1.7 antibody groups on day 14. The ratio at levels L1 to L6 in the puncture+saline group was significantly greater than in the non-puncture and the puncture+NaV1.7 antibody groups ( * p

    Techniques Used: Labeling

    Ratio of FG-labeled/CGRP-IR DRG neurons to FG-labeled DRG neurons in the non-puncture, puncture+saline, and puncture+anti-NaV1.7 antibody groups on day 7. The ratio at levels L1 to L6 in the puncture+saline group was significantly greater than the non-puncture and the puncture+NaV1.7 antibody groups ( * p
    Figure Legend Snippet: Ratio of FG-labeled/CGRP-IR DRG neurons to FG-labeled DRG neurons in the non-puncture, puncture+saline, and puncture+anti-NaV1.7 antibody groups on day 7. The ratio at levels L1 to L6 in the puncture+saline group was significantly greater than the non-puncture and the puncture+NaV1.7 antibody groups ( * p

    Techniques Used: Labeling

    FG-labeled (A, B, and C) and CGRP-IR (D, E, and F) DRG neurons among 3 group. FG-labeled (A) and CGRP-IR (D) DRG neurons in the non-puncture group. FG-labeled (B) and CGRP-IR (E) DRG neurons in the puncture+saline group. FG-labeled (C) and CGRP-IR (F) DRG neurons in the puncture+anti-NaV1.7 antibody group. Arrowheads indicate FG-labeled/CGRP-IR DRG neurons. Magnification rate is ×400. FG, Fluoro-Gold; CGRP-IR, calcitonin gene-related peptide-immunoreactive; DRG, dorsal root ganglion; NaV, voltage-gated sodium.
    Figure Legend Snippet: FG-labeled (A, B, and C) and CGRP-IR (D, E, and F) DRG neurons among 3 group. FG-labeled (A) and CGRP-IR (D) DRG neurons in the non-puncture group. FG-labeled (B) and CGRP-IR (E) DRG neurons in the puncture+saline group. FG-labeled (C) and CGRP-IR (F) DRG neurons in the puncture+anti-NaV1.7 antibody group. Arrowheads indicate FG-labeled/CGRP-IR DRG neurons. Magnification rate is ×400. FG, Fluoro-Gold; CGRP-IR, calcitonin gene-related peptide-immunoreactive; DRG, dorsal root ganglion; NaV, voltage-gated sodium.

    Techniques Used: Labeling

    5) Product Images from "Modulation of Voltage-Gated Sodium Channel Activity in Human Dorsal Root Ganglion Neurons by Herpesvirus Quiescent Infection"

    Article Title: Modulation of Voltage-Gated Sodium Channel Activity in Human Dorsal Root Ganglion Neurons by Herpesvirus Quiescent Infection

    Journal: Journal of Virology

    doi: 10.1128/JVI.01823-19

    Expression of Nav1.7 in HD10.6 cells. (A and B) The expression of Nav1.7 protein and mRNA was assessed by Western blotting (A) and qRT-PCR (B), respectively. (A) Lane 1, control; lane 2, latent cells; lane 3, control plus TSA; lane 4, latent cells plus TSA. (B) The asterisk (*) indicates a statistically significant difference ( P
    Figure Legend Snippet: Expression of Nav1.7 in HD10.6 cells. (A and B) The expression of Nav1.7 protein and mRNA was assessed by Western blotting (A) and qRT-PCR (B), respectively. (A) Lane 1, control; lane 2, latent cells; lane 3, control plus TSA; lane 4, latent cells plus TSA. (B) The asterisk (*) indicates a statistically significant difference ( P

    Techniques Used: Expressing, Western Blot, Quantitative RT-PCR

    6) Product Images from "The alarmins S100A8 and S100A9 mediate acute pain in experimental synovitis"

    Article Title: The alarmins S100A8 and S100A9 mediate acute pain in experimental synovitis

    Journal: Arthritis Research & Therapy

    doi: 10.1186/s13075-020-02295-9

    Of a panel of activation markers, ATF3, NAV1.7, and GAP43 are differentially expressed in DRG of arthritis WT versus S100A9 −/− mice. Three neuronal activation markers showed a significant increase in WT mice after SCW injection: NAV1.7 ( a ), ATF3 ( b ), and GAP43( c ). These differences were found only 1 day after the injection of SCW. In S100a9 −/− mice, no increase in these markers were found, for ATF3 even a small decrease. At day 7, protein level NAV1.7 also seemed lower in S100a9 −/− compared to saline-injected mice, whereas in WT mice, the expression seemed increased ( d ; magnification × 200). This was quantified, and protein expression was lower at day 7 in S100a9 −/− mice, compared to WT ( e ). Significance was tested using a two-way ANOVA at n = 5 per group. A Tukey post hoc test was performed to identify significantly different means (* p
    Figure Legend Snippet: Of a panel of activation markers, ATF3, NAV1.7, and GAP43 are differentially expressed in DRG of arthritis WT versus S100A9 −/− mice. Three neuronal activation markers showed a significant increase in WT mice after SCW injection: NAV1.7 ( a ), ATF3 ( b ), and GAP43( c ). These differences were found only 1 day after the injection of SCW. In S100a9 −/− mice, no increase in these markers were found, for ATF3 even a small decrease. At day 7, protein level NAV1.7 also seemed lower in S100a9 −/− compared to saline-injected mice, whereas in WT mice, the expression seemed increased ( d ; magnification × 200). This was quantified, and protein expression was lower at day 7 in S100a9 −/− mice, compared to WT ( e ). Significance was tested using a two-way ANOVA at n = 5 per group. A Tukey post hoc test was performed to identify significantly different means (* p

    Techniques Used: Activation Assay, Mouse Assay, Injection, Expressing

    7) Product Images from "Sodium channel Nav1.7 in vascular myocytes, endothelium, and innervating axons in human skin"

    Article Title: Sodium channel Nav1.7 in vascular myocytes, endothelium, and innervating axons in human skin

    Journal: Molecular Pain

    doi: 10.1186/s12990-015-0024-3

    Digital fluorescence images of Nav1.7 immunolabeling (IL) of arterioles (Ar), arteriole-venule shunts (AVS) and associated innervation in normal human glabrous skin biopsies from the plantar foot (A,C,D) and palmar hand (B) . All sections are labeled with an Alomone (A,C) or Yale (B,D) rabbit anti-rat Nav1.7 antibody revealed by a donkey anti-rabbit Cy3-conjugated secondary antibody (red fluorescence). Secondary antibodies conjugated to Alexa 488 (green fluorescence) were used to assess co-labeling for peptidergic sensory innervation revealed with a sheep anti-human CGRP antibody (A,B) or noradrenergic sympathetic innervation revealed with a sheep anti-human NPY antibody (C,D) . Cell nuclei are labeled with DAPI (blue fluorescence). The left images in each panel show only the red fluorescence, the middle images only the green, and the right images the triple label combinations. Areas outlined in large white rectangles are 2X enlargement of the areas in the small rectangles. A-D . Nav1.7-IL is expressed on the endothelial cells of the tunica intima (red arrowheads) and on smooth muscle cells of the tunica media (tm). A , B . Peptidergic sensory innervation co-expresses Nav1.7-IL and CGRP-IL (yellow straight arrows). Other innervation labeled only with Nav1.7 (red curved arrows) is likely the noradrenergic sympathetic innervation that expresses NPY-IL as shown in C and D . C , D . Noradrenergic sympathetic innervation co-expresses Nav1.7-IL and NPY-IL (yellow curved arrows). Other innervation labeled with only Nav1.7 (red straight arrows) is likely the peptidergic sensory innervation that expresses CGRP-IL as shown in A and B . Scale Bar = 150 μm in A and B , 100 μm in C and D .
    Figure Legend Snippet: Digital fluorescence images of Nav1.7 immunolabeling (IL) of arterioles (Ar), arteriole-venule shunts (AVS) and associated innervation in normal human glabrous skin biopsies from the plantar foot (A,C,D) and palmar hand (B) . All sections are labeled with an Alomone (A,C) or Yale (B,D) rabbit anti-rat Nav1.7 antibody revealed by a donkey anti-rabbit Cy3-conjugated secondary antibody (red fluorescence). Secondary antibodies conjugated to Alexa 488 (green fluorescence) were used to assess co-labeling for peptidergic sensory innervation revealed with a sheep anti-human CGRP antibody (A,B) or noradrenergic sympathetic innervation revealed with a sheep anti-human NPY antibody (C,D) . Cell nuclei are labeled with DAPI (blue fluorescence). The left images in each panel show only the red fluorescence, the middle images only the green, and the right images the triple label combinations. Areas outlined in large white rectangles are 2X enlargement of the areas in the small rectangles. A-D . Nav1.7-IL is expressed on the endothelial cells of the tunica intima (red arrowheads) and on smooth muscle cells of the tunica media (tm). A , B . Peptidergic sensory innervation co-expresses Nav1.7-IL and CGRP-IL (yellow straight arrows). Other innervation labeled only with Nav1.7 (red curved arrows) is likely the noradrenergic sympathetic innervation that expresses NPY-IL as shown in C and D . C , D . Noradrenergic sympathetic innervation co-expresses Nav1.7-IL and NPY-IL (yellow curved arrows). Other innervation labeled with only Nav1.7 (red straight arrows) is likely the peptidergic sensory innervation that expresses CGRP-IL as shown in A and B . Scale Bar = 150 μm in A and B , 100 μm in C and D .

    Techniques Used: Fluorescence, Immunolabeling, Labeling

    Nav1.7 immunolabeling (IL) of arterioles and associated innervation in normal human palmar glabrous skin biopsies, in alternating sections cut parallel to and through lumen (*) of branched arteriole (A-C) and parallel to arteriole, skimming the interface between tunica media (tm) and tunica adventitia (ta) (D,E) . All sections are labeled with Abcam anti-human Nav1.7 antibody (red). Secondary antibodies conjugated to Alexa 488 (green) were used to assess co-labeling for: smooth muscle cells revealed with mouse anti-α−smooth muscle actin antibody (αSMA, A ); peptidergic sensory innervation revealed with sheep anti-CGRP antibody (yellow straight arrows, B , D ); and noradrenergic sympathetic innervation revealed with sheep anti-NPY antibody (yellow curved arrows, C , E ): Nuclei are labeled with DAPI (blue). Left images in each panel show only the red fluorescence, middle images only green, and right images the triple-label combinations. Areas outlined in large white rectangles (A-C) are 2X enlargements of areas in small rectangles. A-E . A . Nav1.7-IL is expressed on endothelial cells of tunica intima (red arrowheads) and smooth muscle cells of tm as confirmed by double-labeling with anti-αSMA. Nav1.7-IL is expressed on innervation (arrows) in ta, near and at the border with tm. B , D . Peptidergic sensory innervation co-expresses Nav1.7-IL and CGRP-IL (yellow straight arrows). Other innervation labeled only with Nav1.7 (red curved arrows) is likely noradrenergic sympathetic innervation that expresses NPY-IL (C,E) . C , E . Noradrenergic sympathetic innervation co-expresses Nav1.7-IL and NPY-IL (yellow curved arrows). Other innervation labeled with only Nav1.7 (red straight arrows) is likely peptidergic sensory innervation that expresses CGRP-IL as shown in B and D . Scale bar = 100 μm in A-C , 50 μm in D and E .
    Figure Legend Snippet: Nav1.7 immunolabeling (IL) of arterioles and associated innervation in normal human palmar glabrous skin biopsies, in alternating sections cut parallel to and through lumen (*) of branched arteriole (A-C) and parallel to arteriole, skimming the interface between tunica media (tm) and tunica adventitia (ta) (D,E) . All sections are labeled with Abcam anti-human Nav1.7 antibody (red). Secondary antibodies conjugated to Alexa 488 (green) were used to assess co-labeling for: smooth muscle cells revealed with mouse anti-α−smooth muscle actin antibody (αSMA, A ); peptidergic sensory innervation revealed with sheep anti-CGRP antibody (yellow straight arrows, B , D ); and noradrenergic sympathetic innervation revealed with sheep anti-NPY antibody (yellow curved arrows, C , E ): Nuclei are labeled with DAPI (blue). Left images in each panel show only the red fluorescence, middle images only green, and right images the triple-label combinations. Areas outlined in large white rectangles (A-C) are 2X enlargements of areas in small rectangles. A-E . A . Nav1.7-IL is expressed on endothelial cells of tunica intima (red arrowheads) and smooth muscle cells of tm as confirmed by double-labeling with anti-αSMA. Nav1.7-IL is expressed on innervation (arrows) in ta, near and at the border with tm. B , D . Peptidergic sensory innervation co-expresses Nav1.7-IL and CGRP-IL (yellow straight arrows). Other innervation labeled only with Nav1.7 (red curved arrows) is likely noradrenergic sympathetic innervation that expresses NPY-IL (C,E) . C , E . Noradrenergic sympathetic innervation co-expresses Nav1.7-IL and NPY-IL (yellow curved arrows). Other innervation labeled with only Nav1.7 (red straight arrows) is likely peptidergic sensory innervation that expresses CGRP-IL as shown in B and D . Scale bar = 100 μm in A-C , 50 μm in D and E .

    Techniques Used: Immunolabeling, Labeling, Fluorescence

    Nav1.7 immunolabeling (IL) of arterioles (Ar), arteriole-venule shunts (AVS) and associated innervation in normal human plantar glabrous skin with Alomone (A, B) or Yale (C) Nav1.7 antibodies (red). Co-labeling of innervation (arrows) as marked with anti-PGP 9.5 (PGP, green, A ) or smooth muscle cells in tunica media (tm) as marked with anti α-smooth muscle actin antibody (αSMA, green, B , C ). Nuclei are DAPI-labeled (blue). Left images (each panel) show only red fluorescence, middle images green; right images show triple-label combinations. Large white rectangles are 2X-enlargements of small rectangles. A-C . Nav1.7-IL is expressed on endothelial cells of tunica intima (red arrowheads) and tm smooth muscle cells as confirmed by double-labeling with anti-αSMA (B, C) . Nav1.7-IL is expressed on virtually all vascular innervation (arrows) in tunica adventitia (ta) as confirmed by anti-PGP 9.5 double-labeling ( A , yellow arrows). N=nerve. D-E . Nav1.7-IL on arteriole endothelial cells shown as 2X-enlargements of areas indicated by white rectangles in B , C . First images (each panel) show Nav1.7-IL on smooth muscle cells in tm and endothelial cells (red arrowheads). The second images show α-SMA co-labeling of only the smooth muscle cells of tm (green). The third images show merge of first and second images with DAPI (blue). Sections re-labeled with anti-PECAM (green) to show co-labeling with Nav1.7 on endothelial cells (yellow arrowheads, fourth and fifth images). F-G . Background Cy3 fluorescence is limited with no primary antibody in arteriole deep in dermis (F) , epidermis (Ep) and upper-dermis (UD) (G) . In F , broken line shows tm perimeter with dotted line around arteriole lumen. In G , broken line indicates basement membrane of epidermis and dotted line indicates boundary of dead and live superficial keratinocyte layers (stratum corneum, sc and stratum granulosum, sg, respectively). Stratum spinosum, ss; stratum basalis, sb; dermal papilla (dp). Scale bars=150μm (A); 100μm (B ,C, F, G) ; 50μm in D , E .
    Figure Legend Snippet: Nav1.7 immunolabeling (IL) of arterioles (Ar), arteriole-venule shunts (AVS) and associated innervation in normal human plantar glabrous skin with Alomone (A, B) or Yale (C) Nav1.7 antibodies (red). Co-labeling of innervation (arrows) as marked with anti-PGP 9.5 (PGP, green, A ) or smooth muscle cells in tunica media (tm) as marked with anti α-smooth muscle actin antibody (αSMA, green, B , C ). Nuclei are DAPI-labeled (blue). Left images (each panel) show only red fluorescence, middle images green; right images show triple-label combinations. Large white rectangles are 2X-enlargements of small rectangles. A-C . Nav1.7-IL is expressed on endothelial cells of tunica intima (red arrowheads) and tm smooth muscle cells as confirmed by double-labeling with anti-αSMA (B, C) . Nav1.7-IL is expressed on virtually all vascular innervation (arrows) in tunica adventitia (ta) as confirmed by anti-PGP 9.5 double-labeling ( A , yellow arrows). N=nerve. D-E . Nav1.7-IL on arteriole endothelial cells shown as 2X-enlargements of areas indicated by white rectangles in B , C . First images (each panel) show Nav1.7-IL on smooth muscle cells in tm and endothelial cells (red arrowheads). The second images show α-SMA co-labeling of only the smooth muscle cells of tm (green). The third images show merge of first and second images with DAPI (blue). Sections re-labeled with anti-PECAM (green) to show co-labeling with Nav1.7 on endothelial cells (yellow arrowheads, fourth and fifth images). F-G . Background Cy3 fluorescence is limited with no primary antibody in arteriole deep in dermis (F) , epidermis (Ep) and upper-dermis (UD) (G) . In F , broken line shows tm perimeter with dotted line around arteriole lumen. In G , broken line indicates basement membrane of epidermis and dotted line indicates boundary of dead and live superficial keratinocyte layers (stratum corneum, sc and stratum granulosum, sg, respectively). Stratum spinosum, ss; stratum basalis, sb; dermal papilla (dp). Scale bars=150μm (A); 100μm (B ,C, F, G) ; 50μm in D , E .

    Techniques Used: Immunolabeling, Labeling, Fluorescence

    Digital fluorescence images of Nav1.7 (red) and PGP 9.5 (green) immunolabeling (IL) in the epidermis (Ep) and upper dermis (UD) biopsies of normal human palmar glabrous skin ( A , Abcam anti-Nav1.7) and normal human plantar glabrous skin ( B , Alomone anti-Nav1.7). Stratum corneum, sc; stratum granulosum, sg; stratum spinosum (ss); stratum basalis (sb), dermal papilla (dp). Straight arrows indicate epidermal sensory endings, curved arrows indicate small nerves and individual axons or endings in the upper dermis. The areas enclosed in the large rectangles are 2X enlargements of those in the smaller rectangles. Of all the innervation revealed by anti-PGP 9.5, only some express Nav1.7-IL (yellow straight and curved arrows) whereas other only express PGP 9.5-IL (green straight and curved arrows). Aβ-fiber innervation of a Meissner corpuscle (MC) has little if any Nav1.7-IL. Kertinocytes especially in stratum granulosum label for Nav1.7 (arrowheads) which has a more membranous distribution with the Alomone anti-Nav1.7 antibody, but more diffuse labeling with the Abcam anti-Nav1.7 antibody. Scale bar = 100 μm.
    Figure Legend Snippet: Digital fluorescence images of Nav1.7 (red) and PGP 9.5 (green) immunolabeling (IL) in the epidermis (Ep) and upper dermis (UD) biopsies of normal human palmar glabrous skin ( A , Abcam anti-Nav1.7) and normal human plantar glabrous skin ( B , Alomone anti-Nav1.7). Stratum corneum, sc; stratum granulosum, sg; stratum spinosum (ss); stratum basalis (sb), dermal papilla (dp). Straight arrows indicate epidermal sensory endings, curved arrows indicate small nerves and individual axons or endings in the upper dermis. The areas enclosed in the large rectangles are 2X enlargements of those in the smaller rectangles. Of all the innervation revealed by anti-PGP 9.5, only some express Nav1.7-IL (yellow straight and curved arrows) whereas other only express PGP 9.5-IL (green straight and curved arrows). Aβ-fiber innervation of a Meissner corpuscle (MC) has little if any Nav1.7-IL. Kertinocytes especially in stratum granulosum label for Nav1.7 (arrowheads) which has a more membranous distribution with the Alomone anti-Nav1.7 antibody, but more diffuse labeling with the Abcam anti-Nav1.7 antibody. Scale bar = 100 μm.

    Techniques Used: Fluorescence, Immunolabeling, Labeling

    Nav1.7 expression in smooth muscle cells of deep dermis arterioles within skin from lateral malleolus of three healthy subjects. Smooth muscle cells (arrowheads) of the arteriole tunica media exhibit robust Nav1.7 (red) immunolabeling (antibody Nav1.7 Y ), which is co-localized with alpha smooth muscle actin (green). Skin samples from 3 healthy subjects (Subject 1: A ; Subject 2: B , C ; Subject 3: D ) display similar patterns of Nav1.7 labeling in the smooth muscle cells of the dermal arterioles. Co-localization of Nav1.7 and alpha smooth muscle actin is yellow in the merged panels. E . Sections incubated without primary antibodies followed by secondary antibodies displayed background levels of immunofluorescence in skin vasculature.
    Figure Legend Snippet: Nav1.7 expression in smooth muscle cells of deep dermis arterioles within skin from lateral malleolus of three healthy subjects. Smooth muscle cells (arrowheads) of the arteriole tunica media exhibit robust Nav1.7 (red) immunolabeling (antibody Nav1.7 Y ), which is co-localized with alpha smooth muscle actin (green). Skin samples from 3 healthy subjects (Subject 1: A ; Subject 2: B , C ; Subject 3: D ) display similar patterns of Nav1.7 labeling in the smooth muscle cells of the dermal arterioles. Co-localization of Nav1.7 and alpha smooth muscle actin is yellow in the merged panels. E . Sections incubated without primary antibodies followed by secondary antibodies displayed background levels of immunofluorescence in skin vasculature.

    Techniques Used: Expressing, Immunolabeling, Labeling, Incubation, Immunofluorescence

    8) Product Images from "Antihyperalgesic effects of ProTx-II, a Nav1.7 antagonist, and A803467, a Nav1.8 antagonist, in diabetic mice"

    Article Title: Antihyperalgesic effects of ProTx-II, a Nav1.7 antagonist, and A803467, a Nav1.8 antagonist, in diabetic mice

    Journal: Journal of Experimental Pharmacology

    doi: 10.2147/JEP.S79973

    The protein levels of Nav1.7 ( A ) and Nav1.8 ( B ) in the dorsal root ganglion of nondiabetic and diabetic mice. Notes: Immunoblots are representative of the results for Nav1.7 and Nav1.8. The immunoblots of Nav1.7 and Nav1.8 were normalized by GAPDH. Each column represents the mean with standard error of eight mice.
    Figure Legend Snippet: The protein levels of Nav1.7 ( A ) and Nav1.8 ( B ) in the dorsal root ganglion of nondiabetic and diabetic mice. Notes: Immunoblots are representative of the results for Nav1.7 and Nav1.8. The immunoblots of Nav1.7 and Nav1.8 were normalized by GAPDH. Each column represents the mean with standard error of eight mice.

    Techniques Used: Mouse Assay, Western Blot

    9) Product Images from "Novel SCN9A missense mutations contribute to congenital insensitivity to pain: Unexpected correlation between electrophysiological characterization and clinical phenotype"

    Article Title: Novel SCN9A missense mutations contribute to congenital insensitivity to pain: Unexpected correlation between electrophysiological characterization and clinical phenotype

    Journal: Molecular Pain

    doi: 10.1177/1744806920923881

    Novel compound heterozygous SCN9A mutations identified and the images of damaged tissues in the proband with CIP and anosmia. (a) Family pedigree. The proband is indicated by an arrow. (b) DNA sequence electropherograms demonstrating c.296G > A (p.Arg99His) and c.2749T > G (p.Trp917Gly) mutations in the proband. (c) Burns on the buttock caused by a pressure cooker. (d and e) Injured foot due to bike accident. (f and g) Conservation of residues Arg99 and Trp917 among different species (from G. gallus to H. sapiens ) and sodium channel subtypes (Nav1.1 to Nav1.9 and Nax) in human.
    Figure Legend Snippet: Novel compound heterozygous SCN9A mutations identified and the images of damaged tissues in the proband with CIP and anosmia. (a) Family pedigree. The proband is indicated by an arrow. (b) DNA sequence electropherograms demonstrating c.296G > A (p.Arg99His) and c.2749T > G (p.Trp917Gly) mutations in the proband. (c) Burns on the buttock caused by a pressure cooker. (d and e) Injured foot due to bike accident. (f and g) Conservation of residues Arg99 and Trp917 among different species (from G. gallus to H. sapiens ) and sodium channel subtypes (Nav1.1 to Nav1.9 and Nax) in human.

    Techniques Used: Sequencing

    The expression and subcellular location of WT and mutant Nav1.7 channels in HEK293 cells. (a) Expression of WT and mutant Nav1.7 channels in HEK293 cells analyzed by Western blotting. (b) Quantitative analysis based on three independent experiments, data are presented as the mean ± SEM (*** P
    Figure Legend Snippet: The expression and subcellular location of WT and mutant Nav1.7 channels in HEK293 cells. (a) Expression of WT and mutant Nav1.7 channels in HEK293 cells analyzed by Western blotting. (b) Quantitative analysis based on three independent experiments, data are presented as the mean ± SEM (*** P

    Techniques Used: Expressing, Mutagenesis, Western Blot

    Biophysical characterization of WT and mutant Nav1.7 channels in HEK293 cells. (a–c) Representative inward current traces recorded from HEK293 cells expressing WT, mutant p.Arg99His, and p.Trp917Gly Nav1.7 channels, respectively. (d) Current–voltage relationship of WT and mutant p.Arg99His and p.Trp917Gly channels. Peak current density normalized to membrane capacitance is presented as the mean ± SEM. (e) The scatter plot of peak Nav1.7 current density. (f) Time-to-peak calculated from pulse onset to maximum peak inward current for WT and p.Arg99His mutant channels in the interval between −60 mV to 20 mV. (g) Relative conductance–voltage relationship for WTand p.Arg99His channels. (h) Steady-state fast inactivation for the WT channel and the p.Arg99His mutant channel.
    Figure Legend Snippet: Biophysical characterization of WT and mutant Nav1.7 channels in HEK293 cells. (a–c) Representative inward current traces recorded from HEK293 cells expressing WT, mutant p.Arg99His, and p.Trp917Gly Nav1.7 channels, respectively. (d) Current–voltage relationship of WT and mutant p.Arg99His and p.Trp917Gly channels. Peak current density normalized to membrane capacitance is presented as the mean ± SEM. (e) The scatter plot of peak Nav1.7 current density. (f) Time-to-peak calculated from pulse onset to maximum peak inward current for WT and p.Arg99His mutant channels in the interval between −60 mV to 20 mV. (g) Relative conductance–voltage relationship for WTand p.Arg99His channels. (h) Steady-state fast inactivation for the WT channel and the p.Arg99His mutant channel.

    Techniques Used: Mutagenesis, Expressing

    10) Product Images from "Efficacy of Anti-NaV1.7 Antibody on the Sensory Nervous System in a Rat Model of Lumbar Intervertebral Disc Injury"

    Article Title: Efficacy of Anti-NaV1.7 Antibody on the Sensory Nervous System in a Rat Model of Lumbar Intervertebral Disc Injury

    Journal: Yonsei Medical Journal

    doi: 10.3349/ymj.2016.57.3.748

    Ratio of FG-labeled/CGRP-IR DRG neurons to FG-labeled DRG neurons in the non-puncture, puncture+saline, and puncture+anti-NaV1.7 antibody groups on day 14. The ratio at levels L1 to L6 in the puncture+saline group was significantly greater than in the non-puncture and the puncture+NaV1.7 antibody groups ( * p
    Figure Legend Snippet: Ratio of FG-labeled/CGRP-IR DRG neurons to FG-labeled DRG neurons in the non-puncture, puncture+saline, and puncture+anti-NaV1.7 antibody groups on day 14. The ratio at levels L1 to L6 in the puncture+saline group was significantly greater than in the non-puncture and the puncture+NaV1.7 antibody groups ( * p

    Techniques Used: Labeling

    Ratio of FG-labeled/CGRP-IR DRG neurons to FG-labeled DRG neurons in the non-puncture, puncture+saline, and puncture+anti-NaV1.7 antibody groups on day 7. The ratio at levels L1 to L6 in the puncture+saline group was significantly greater than the non-puncture and the puncture+NaV1.7 antibody groups ( * p
    Figure Legend Snippet: Ratio of FG-labeled/CGRP-IR DRG neurons to FG-labeled DRG neurons in the non-puncture, puncture+saline, and puncture+anti-NaV1.7 antibody groups on day 7. The ratio at levels L1 to L6 in the puncture+saline group was significantly greater than the non-puncture and the puncture+NaV1.7 antibody groups ( * p

    Techniques Used: Labeling

    FG-labeled (A, B, and C) and CGRP-IR (D, E, and F) DRG neurons among 3 group. FG-labeled (A) and CGRP-IR (D) DRG neurons in the non-puncture group. FG-labeled (B) and CGRP-IR (E) DRG neurons in the puncture+saline group. FG-labeled (C) and CGRP-IR (F) DRG neurons in the puncture+anti-NaV1.7 antibody group. Arrowheads indicate FG-labeled/CGRP-IR DRG neurons. Magnification rate is ×400. FG, Fluoro-Gold; CGRP-IR, calcitonin gene-related peptide-immunoreactive; DRG, dorsal root ganglion; NaV, voltage-gated sodium.
    Figure Legend Snippet: FG-labeled (A, B, and C) and CGRP-IR (D, E, and F) DRG neurons among 3 group. FG-labeled (A) and CGRP-IR (D) DRG neurons in the non-puncture group. FG-labeled (B) and CGRP-IR (E) DRG neurons in the puncture+saline group. FG-labeled (C) and CGRP-IR (F) DRG neurons in the puncture+anti-NaV1.7 antibody group. Arrowheads indicate FG-labeled/CGRP-IR DRG neurons. Magnification rate is ×400. FG, Fluoro-Gold; CGRP-IR, calcitonin gene-related peptide-immunoreactive; DRG, dorsal root ganglion; NaV, voltage-gated sodium.

    Techniques Used: Labeling

    11) Product Images from "Pharmacological Targeting of the Mammalian Clock Reveals a Novel Analgesic for Osteoarthritis-Induced Pain"

    Article Title: Pharmacological Targeting of the Mammalian Clock Reveals a Novel Analgesic for Osteoarthritis-Induced Pain

    Journal: Gene

    doi: 10.1016/j.gene.2018.02.048

    Loss of the clock gene Bmal1 in Nav1.8+ sensory neurons leads to reduced pain-related protein in DRG. Expression of pain-related targets in the dorsal root ganglia (DRG) following OA surgery in bmal1f/f Nav1.8CreERT(−) bmal1f/f Nav1.8CreERT(+) groups. Double immunofluorescence staining of substance P (red; 5A-5B), NGF (red; 5C-5D), CGRP (red; 5E-5F), TrkA (red; 5G-5H) and Nav1.7 (red; 5I-5J) and NeuN (green) in DRG of bmal1f/f Nav1.8CreERT(−) bmal1f/f Nav1.8CreERT(+) groups mice. Co-localization of the two stains appear yellow. A scale bar was 20μm and is shown in white in color for all images. Quantitative analyses of substance P, NGF, CGRP, TrkA and Nav1.7 expression in DRGs shows lower expression in the bmal1f/f Nav1.8CreERT(+) group (Fig. 5K-4O). Values are mean±SEM.
    Figure Legend Snippet: Loss of the clock gene Bmal1 in Nav1.8+ sensory neurons leads to reduced pain-related protein in DRG. Expression of pain-related targets in the dorsal root ganglia (DRG) following OA surgery in bmal1f/f Nav1.8CreERT(−) bmal1f/f Nav1.8CreERT(+) groups. Double immunofluorescence staining of substance P (red; 5A-5B), NGF (red; 5C-5D), CGRP (red; 5E-5F), TrkA (red; 5G-5H) and Nav1.7 (red; 5I-5J) and NeuN (green) in DRG of bmal1f/f Nav1.8CreERT(−) bmal1f/f Nav1.8CreERT(+) groups mice. Co-localization of the two stains appear yellow. A scale bar was 20μm and is shown in white in color for all images. Quantitative analyses of substance P, NGF, CGRP, TrkA and Nav1.7 expression in DRGs shows lower expression in the bmal1f/f Nav1.8CreERT(+) group (Fig. 5K-4O). Values are mean±SEM.

    Techniques Used: Expressing, Double Immunofluorescence Staining, Mouse Assay

    Analgesic activity of the i.a. REV-ERB agonist SR9009 in a model of OA (osteoarthritis) induced pain. Expression of pain-related targets in the dorsal root ganglia (DRG) following groups of mice including naïve, PMM and SR9009 treated mice. Double immunofluorescence staining of TrkA (red; 7A-7C), NGF (red; 7D-7F), Nav1.7 (red; 7G-7I), Nav1.8 (red; 7J-7L) and TRPV1 (red; 7M-7O) and NeuN (green) in DRGs of Naïve, PMM and SR9009 treated groups mice. Co-localization of the two stains appears yellow. A scale bar was 20μm and is shown in white in color for all images. Quantitative analyses of TrkA, NGF, Nav1.7, Nav1.8 and TRPV1expression in DRGs (Fig. 7P-7T) showed that they were increased in OA mice, but that was reduced with i.a. SR9009. Values are mean±SEM.
    Figure Legend Snippet: Analgesic activity of the i.a. REV-ERB agonist SR9009 in a model of OA (osteoarthritis) induced pain. Expression of pain-related targets in the dorsal root ganglia (DRG) following groups of mice including naïve, PMM and SR9009 treated mice. Double immunofluorescence staining of TrkA (red; 7A-7C), NGF (red; 7D-7F), Nav1.7 (red; 7G-7I), Nav1.8 (red; 7J-7L) and TRPV1 (red; 7M-7O) and NeuN (green) in DRGs of Naïve, PMM and SR9009 treated groups mice. Co-localization of the two stains appears yellow. A scale bar was 20μm and is shown in white in color for all images. Quantitative analyses of TrkA, NGF, Nav1.7, Nav1.8 and TRPV1expression in DRGs (Fig. 7P-7T) showed that they were increased in OA mice, but that was reduced with i.a. SR9009. Values are mean±SEM.

    Techniques Used: Activity Assay, Expressing, Mouse Assay, Double Immunofluorescence Staining

    Related Articles

    Electrophoresis:

    Article Title: Novel SCN9A missense mutations contribute to congenital insensitivity to pain: Unexpected correlation between electrophysiological characterization and clinical phenotype
    Article Snippet: .. Proteins were separated by electrophoresis on 10% sodium dodecyl sulfate polyacrylamide gels, transferred to a 0.45 µm nitrocellulose membrane (Merck Millipore) and blotted with Nav1.7 rabbit polyclonal antibodies (1:200, Alomone Labs). ..

    Immunohistochemistry:

    Article Title: The alarmins S100A8 and S100A9 mediate acute pain in experimental synovitis
    Article Snippet: .. On DRG, IHC staining was performed for F4/80, to detect monocytes/macrophages, and for NAV1.7 (Alomone Labs, asc-008). ..

    Staining:

    Article Title: The alarmins S100A8 and S100A9 mediate acute pain in experimental synovitis
    Article Snippet: .. On DRG, IHC staining was performed for F4/80, to detect monocytes/macrophages, and for NAV1.7 (Alomone Labs, asc-008). ..

    Blocking Assay:

    Article Title: NGF-Induced Nav1.7 Upregulation Contributes to Chronic Post-surgical Pain by Activating SGK1-Dependent Nedd4-2 Phosphorylation.
    Article Snippet: .. At present, chronic post-surgical pain (CPSP) is difficult to prevent and cure clinically because of our lack of understanding of its mechanisms.. Surgical injury induces the upregulation of voltage-gated sodium channel Nav1.7 in dorsal root ganglion (DRG) neurons, suggesting that Nav1.7 is involved in the development of CPSP. ..

    Incubation:

    Article Title: NGF-Induced Nav1.7 Upregulation Contributes to Chronic Post-surgical Pain by Activating SGK1-Dependent Nedd4-2 Phosphorylation.
    Article Snippet: .. At present, chronic post-surgical pain (CPSP) is difficult to prevent and cure clinically because of our lack of understanding of its mechanisms.. Surgical injury induces the upregulation of voltage-gated sodium channel Nav1.7 in dorsal root ganglion (DRG) neurons, suggesting that Nav1.7 is involved in the development of CPSP. ..

    Article Title: Modulation of Voltage-Gated Sodium Channel Activity in Human Dorsal Root Ganglion Neurons by Herpesvirus Quiescent Infection
    Article Snippet: .. After overnight incubation with a Nav1.7 antibody (catalog no. ASC-008; Alomone Labs, Jerusalem, Israel) diluted 1:250 in antibody dilution buffer (1× PBS, 1% BSA, 0.1% Tween 20) at 4°C, the cells were washed with PBS three times, for 5 min each time. ..

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    Alomone Labs rabbit anti nav1 7
    ALA downregulated <t>NaV1.7</t> and NaV1.8 expression. Notes: (A) Western blots for NaV1.7 of T13-L2 DRGs from NS- and ALA-treatment rats. Bar graph showed mean density relative to GAPHD for NaV1.7. ALA treatment greatly reduced expressions of NaV1.7 (n=4 for each group, ** p
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    ALA downregulated NaV1.7 and NaV1.8 expression. Notes: (A) Western blots for NaV1.7 of T13-L2 DRGs from NS- and ALA-treatment rats. Bar graph showed mean density relative to GAPHD for NaV1.7. ALA treatment greatly reduced expressions of NaV1.7 (n=4 for each group, ** p

    Journal: Journal of Pain Research

    Article Title: α-lipoic acid suppresses neuronal excitability and attenuates colonic hypersensitivity to colorectal distention in diabetic rats

    doi: 10.2147/JPR.S135017

    Figure Lengend Snippet: ALA downregulated NaV1.7 and NaV1.8 expression. Notes: (A) Western blots for NaV1.7 of T13-L2 DRGs from NS- and ALA-treatment rats. Bar graph showed mean density relative to GAPHD for NaV1.7. ALA treatment greatly reduced expressions of NaV1.7 (n=4 for each group, ** p

    Article Snippet: The primary antibodies used to probe the target proteins included rabbit anti-NaV1.7 or anti-NaV1.8 (1:200, Alomone Labs, Jerusalem, Israel), rabbit anti-GAPDH (1:1000, Biotechnology Co., CHN), and mouse anti-actin (1:1000; Chemicon, Temecula, CA, USA).

    Techniques: Expressing, Western Blot

    Expression of Nav1.7 in HD10.6 cells. (A and B) The expression of Nav1.7 protein and mRNA was assessed by Western blotting (A) and qRT-PCR (B), respectively. (A) Lane 1, control; lane 2, latent cells; lane 3, control plus TSA; lane 4, latent cells plus TSA. (B) The asterisk (*) indicates a statistically significant difference ( P

    Journal: Journal of Virology

    Article Title: Modulation of Voltage-Gated Sodium Channel Activity in Human Dorsal Root Ganglion Neurons by Herpesvirus Quiescent Infection

    doi: 10.1128/JVI.01823-19

    Figure Lengend Snippet: Expression of Nav1.7 in HD10.6 cells. (A and B) The expression of Nav1.7 protein and mRNA was assessed by Western blotting (A) and qRT-PCR (B), respectively. (A) Lane 1, control; lane 2, latent cells; lane 3, control plus TSA; lane 4, latent cells plus TSA. (B) The asterisk (*) indicates a statistically significant difference ( P

    Article Snippet: After overnight incubation with a Nav1.7 antibody (catalog no. ASC-008; Alomone Labs, Jerusalem, Israel) diluted 1:250 in antibody dilution buffer (1× PBS, 1% BSA, 0.1% Tween 20) at 4°C, the cells were washed with PBS three times, for 5 min each time.

    Techniques: Expressing, Western Blot, Quantitative RT-PCR

    Ratio of FG-labeled/CGRP-IR DRG neurons to FG-labeled DRG neurons in the non-puncture, puncture+saline, and puncture+anti-NaV1.7 antibody groups on day 14. The ratio at levels L1 to L6 in the puncture+saline group was significantly greater than in the non-puncture and the puncture+NaV1.7 antibody groups ( * p

    Journal: Yonsei Medical Journal

    Article Title: Efficacy of Anti-NaV1.7 Antibody on the Sensory Nervous System in a Rat Model of Lumbar Intervertebral Disc Injury

    doi: 10.3349/ymj.2016.57.3.748

    Figure Lengend Snippet: Ratio of FG-labeled/CGRP-IR DRG neurons to FG-labeled DRG neurons in the non-puncture, puncture+saline, and puncture+anti-NaV1.7 antibody groups on day 14. The ratio at levels L1 to L6 in the puncture+saline group was significantly greater than in the non-puncture and the puncture+NaV1.7 antibody groups ( * p

    Article Snippet: The hole was immediately sealed with cyanoacrylate adhesive to prevent leakage of anti-NaV1.7 antibody or saline, and the skin was closed.

    Techniques: Labeling

    Ratio of FG-labeled/CGRP-IR DRG neurons to FG-labeled DRG neurons in the non-puncture, puncture+saline, and puncture+anti-NaV1.7 antibody groups on day 7. The ratio at levels L1 to L6 in the puncture+saline group was significantly greater than the non-puncture and the puncture+NaV1.7 antibody groups ( * p

    Journal: Yonsei Medical Journal

    Article Title: Efficacy of Anti-NaV1.7 Antibody on the Sensory Nervous System in a Rat Model of Lumbar Intervertebral Disc Injury

    doi: 10.3349/ymj.2016.57.3.748

    Figure Lengend Snippet: Ratio of FG-labeled/CGRP-IR DRG neurons to FG-labeled DRG neurons in the non-puncture, puncture+saline, and puncture+anti-NaV1.7 antibody groups on day 7. The ratio at levels L1 to L6 in the puncture+saline group was significantly greater than the non-puncture and the puncture+NaV1.7 antibody groups ( * p

    Article Snippet: The hole was immediately sealed with cyanoacrylate adhesive to prevent leakage of anti-NaV1.7 antibody or saline, and the skin was closed.

    Techniques: Labeling

    FG-labeled (A, B, and C) and CGRP-IR (D, E, and F) DRG neurons among 3 group. FG-labeled (A) and CGRP-IR (D) DRG neurons in the non-puncture group. FG-labeled (B) and CGRP-IR (E) DRG neurons in the puncture+saline group. FG-labeled (C) and CGRP-IR (F) DRG neurons in the puncture+anti-NaV1.7 antibody group. Arrowheads indicate FG-labeled/CGRP-IR DRG neurons. Magnification rate is ×400. FG, Fluoro-Gold; CGRP-IR, calcitonin gene-related peptide-immunoreactive; DRG, dorsal root ganglion; NaV, voltage-gated sodium.

    Journal: Yonsei Medical Journal

    Article Title: Efficacy of Anti-NaV1.7 Antibody on the Sensory Nervous System in a Rat Model of Lumbar Intervertebral Disc Injury

    doi: 10.3349/ymj.2016.57.3.748

    Figure Lengend Snippet: FG-labeled (A, B, and C) and CGRP-IR (D, E, and F) DRG neurons among 3 group. FG-labeled (A) and CGRP-IR (D) DRG neurons in the non-puncture group. FG-labeled (B) and CGRP-IR (E) DRG neurons in the puncture+saline group. FG-labeled (C) and CGRP-IR (F) DRG neurons in the puncture+anti-NaV1.7 antibody group. Arrowheads indicate FG-labeled/CGRP-IR DRG neurons. Magnification rate is ×400. FG, Fluoro-Gold; CGRP-IR, calcitonin gene-related peptide-immunoreactive; DRG, dorsal root ganglion; NaV, voltage-gated sodium.

    Article Snippet: The hole was immediately sealed with cyanoacrylate adhesive to prevent leakage of anti-NaV1.7 antibody or saline, and the skin was closed.

    Techniques: Labeling