trpc1  (Alomone Labs)


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  • 94
    Name:
    TRPC1 Blocking Peptide
    Description:
    A Blocking Peptide for Anti TRPC1 Antibody
    Catalog Number:
    BLP-CC010
    Price:
    245.0
    Category:
    Control reagent Negative Control
    Source:
    Synthetic peptide
    Applications:
    Blocking
    Purity:
    >70% (amino acid analysis and mass spectrometry).
    Size:
    40 mcg
    Format:
    Lyophilized powder
    Buy from Supplier


    Structured Review

    Alomone Labs trpc1
    TRPC1 Blocking Peptide
    A Blocking Peptide for Anti TRPC1 Antibody
    https://www.bioz.com/result/trpc1/product/Alomone Labs
    Average 94 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    trpc1 - by Bioz Stars, 2021-10
    94/100 stars

    Images

    1) Product Images from "Crucial Role of TRPC1 and TRPC4 in Cystitis-Induced Neuronal Sprouting and Bladder Overactivity"

    Article Title: Crucial Role of TRPC1 and TRPC4 in Cystitis-Induced Neuronal Sprouting and Bladder Overactivity

    Journal: PLoS ONE

    doi: 10.1371/journal.pone.0069550

    CYP-induced bladder overactivity is decreased in Trpc1/c4 −/− mice. A, Typical urodynamic traces of WT and Trpc1/c4 −/− mice in vehicle or following CYP treatment. B,C, Analysis of intercontractile interval in vehicle ( B ) and CYP-treatment mice ( C ) in WT and Trpc1/c4 −/− mice shows that double knock-out mice are functionally less affected by CYP treatment. D, Typical muscle strip contractility traces of WT mice in control and in CYP c rats activated by 10 nM of carbachol. The statistical analysis of carbachol-induced contraction of muscle strips did not show difference between the two genotypes in CYP c mice. E, Typical traces of muscle strip contractility of WT mice stimulated with high KCl concentration (122 mM). There is no difference between WT and Trpc1/c4 −/− in control and CYP c conditions.
    Figure Legend Snippet: CYP-induced bladder overactivity is decreased in Trpc1/c4 −/− mice. A, Typical urodynamic traces of WT and Trpc1/c4 −/− mice in vehicle or following CYP treatment. B,C, Analysis of intercontractile interval in vehicle ( B ) and CYP-treatment mice ( C ) in WT and Trpc1/c4 −/− mice shows that double knock-out mice are functionally less affected by CYP treatment. D, Typical muscle strip contractility traces of WT mice in control and in CYP c rats activated by 10 nM of carbachol. The statistical analysis of carbachol-induced contraction of muscle strips did not show difference between the two genotypes in CYP c mice. E, Typical traces of muscle strip contractility of WT mice stimulated with high KCl concentration (122 mM). There is no difference between WT and Trpc1/c4 −/− in control and CYP c conditions.

    Techniques Used: Mouse Assay, Knock-Out, Stripping Membranes, Concentration Assay

    TRP expression screening in DRG of CYPc rats. A–D, qRT-PCR analysis of Trpc ( A ), Trpm ( B ), Trpv ( C ), and Trpa1 and Trpml ( D ) mRNA shows an up-regulation of Trpc1 and Trpc4 transcripts and a decreased expression of Trpc5 and Trpc6 transcripts in L6-S1 DRG of CYP-treated rats.
    Figure Legend Snippet: TRP expression screening in DRG of CYPc rats. A–D, qRT-PCR analysis of Trpc ( A ), Trpm ( B ), Trpv ( C ), and Trpa1 and Trpml ( D ) mRNA shows an up-regulation of Trpc1 and Trpc4 transcripts and a decreased expression of Trpc5 and Trpc6 transcripts in L6-S1 DRG of CYP-treated rats.

    Techniques Used: Expressing, Quantitative RT-PCR

    TRPC1 is upregulated in bladder-innervating neurons in CYP c rats. A, B Immunocytochemistry of TRPC1 in DRG of control and CYP c rats, retrolabelled with DiI - scales bar: 50 µm. C, Quantitative analysis of colocalization of DiI and TRPC1. D, Immunohistochemistry showing that a majority of GAP-43 positive neurons are TRPC1 positive in CYP c rats – scale bar: 20 µm.
    Figure Legend Snippet: TRPC1 is upregulated in bladder-innervating neurons in CYP c rats. A, B Immunocytochemistry of TRPC1 in DRG of control and CYP c rats, retrolabelled with DiI - scales bar: 50 µm. C, Quantitative analysis of colocalization of DiI and TRPC1. D, Immunohistochemistry showing that a majority of GAP-43 positive neurons are TRPC1 positive in CYP c rats – scale bar: 20 µm.

    Techniques Used: Immunocytochemistry, Immunohistochemistry

    CYP-induced peripheral sprouting is abolished in Trpc1/c4 −/− mice. A, PGP9.5 staining in whole mount bladder mucosa in control and CYP-treated wild type, TRPC1, TRPC4 and TRPC1/C4 deficient mice - scale bar : 50 µm. B–D, Quantitative analysis of neurite segments ( B ), neurite length ( C ) and neurite density ( D ) shows a normal innervation in treated Trpc1/c4 −/− mice.
    Figure Legend Snippet: CYP-induced peripheral sprouting is abolished in Trpc1/c4 −/− mice. A, PGP9.5 staining in whole mount bladder mucosa in control and CYP-treated wild type, TRPC1, TRPC4 and TRPC1/C4 deficient mice - scale bar : 50 µm. B–D, Quantitative analysis of neurite segments ( B ), neurite length ( C ) and neurite density ( D ) shows a normal innervation in treated Trpc1/c4 −/− mice.

    Techniques Used: Mouse Assay, Staining

    Related Articles

    Isolation:

    Article Title: Activation of the hexosamine biosynthesis pathway and protein O-GlcNAcylation modulate hypertrophic and cell signaling pathways in cardiomyocytes from diabetic mice
    Article Snippet: .. Protein levels in isolated cardiomyocytes or whole heart lysates were determined using standard immunoblot techniques as previously described ( ) using antibodies to calsequestrin (Abcam), α-sarcomeric actin (Abcam), atrial natriuretic peptide (ANP, Santa Cruz) and TRPC1 (Alomone Labs), Bcl-2 (Cell Signaling), Bax (Santa Cruz), p53 (Santa Cruz), phosphorylated and total p38 (Santa Cruz), phosphorylated and total ERK (Cell Signaling), phosphorylated Akt (Ser473) and total Akt (Cell Signaling). ..

    Aqueous Normal-phase Chromatography:

    Article Title: Activation of the hexosamine biosynthesis pathway and protein O-GlcNAcylation modulate hypertrophic and cell signaling pathways in cardiomyocytes from diabetic mice
    Article Snippet: .. Protein levels in isolated cardiomyocytes or whole heart lysates were determined using standard immunoblot techniques as previously described ( ) using antibodies to calsequestrin (Abcam), α-sarcomeric actin (Abcam), atrial natriuretic peptide (ANP, Santa Cruz) and TRPC1 (Alomone Labs), Bcl-2 (Cell Signaling), Bax (Santa Cruz), p53 (Santa Cruz), phosphorylated and total p38 (Santa Cruz), phosphorylated and total ERK (Cell Signaling), phosphorylated Akt (Ser473) and total Akt (Cell Signaling). ..

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  • 94
    Alomone Labs trpc1
    CYP-induced bladder overactivity is decreased in <t>Trpc1/c4</t> −/− mice. A, Typical urodynamic traces of WT and Trpc1/c4 −/− mice in vehicle or following CYP treatment. B,C, Analysis of intercontractile interval in vehicle ( B ) and CYP-treatment mice ( C ) in WT and Trpc1/c4 −/− mice shows that double knock-out mice are functionally less affected by CYP treatment. D, Typical muscle strip contractility traces of WT mice in control and in CYP c rats activated by 10 nM of carbachol. The statistical analysis of carbachol-induced contraction of muscle strips did not show difference between the two genotypes in CYP c mice. E, Typical traces of muscle strip contractility of WT mice stimulated with high KCl concentration (122 mM). There is no difference between WT and Trpc1/c4 −/− in control and CYP c conditions.
    Trpc1, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/trpc1/product/Alomone Labs
    Average 94 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    trpc1 - by Bioz Stars, 2021-10
    94/100 stars
      Buy from Supplier

    Image Search Results


    CYP-induced bladder overactivity is decreased in Trpc1/c4 −/− mice. A, Typical urodynamic traces of WT and Trpc1/c4 −/− mice in vehicle or following CYP treatment. B,C, Analysis of intercontractile interval in vehicle ( B ) and CYP-treatment mice ( C ) in WT and Trpc1/c4 −/− mice shows that double knock-out mice are functionally less affected by CYP treatment. D, Typical muscle strip contractility traces of WT mice in control and in CYP c rats activated by 10 nM of carbachol. The statistical analysis of carbachol-induced contraction of muscle strips did not show difference between the two genotypes in CYP c mice. E, Typical traces of muscle strip contractility of WT mice stimulated with high KCl concentration (122 mM). There is no difference between WT and Trpc1/c4 −/− in control and CYP c conditions.

    Journal: PLoS ONE

    Article Title: Crucial Role of TRPC1 and TRPC4 in Cystitis-Induced Neuronal Sprouting and Bladder Overactivity

    doi: 10.1371/journal.pone.0069550

    Figure Lengend Snippet: CYP-induced bladder overactivity is decreased in Trpc1/c4 −/− mice. A, Typical urodynamic traces of WT and Trpc1/c4 −/− mice in vehicle or following CYP treatment. B,C, Analysis of intercontractile interval in vehicle ( B ) and CYP-treatment mice ( C ) in WT and Trpc1/c4 −/− mice shows that double knock-out mice are functionally less affected by CYP treatment. D, Typical muscle strip contractility traces of WT mice in control and in CYP c rats activated by 10 nM of carbachol. The statistical analysis of carbachol-induced contraction of muscle strips did not show difference between the two genotypes in CYP c mice. E, Typical traces of muscle strip contractility of WT mice stimulated with high KCl concentration (122 mM). There is no difference between WT and Trpc1/c4 −/− in control and CYP c conditions.

    Article Snippet: The vast majority of the growing, GAP-43 positive neurons was also positive to TRPC1 ( )(84/103; 81.5%).

    Techniques: Mouse Assay, Knock-Out, Stripping Membranes, Concentration Assay

    TRP expression screening in DRG of CYPc rats. A–D, qRT-PCR analysis of Trpc ( A ), Trpm ( B ), Trpv ( C ), and Trpa1 and Trpml ( D ) mRNA shows an up-regulation of Trpc1 and Trpc4 transcripts and a decreased expression of Trpc5 and Trpc6 transcripts in L6-S1 DRG of CYP-treated rats.

    Journal: PLoS ONE

    Article Title: Crucial Role of TRPC1 and TRPC4 in Cystitis-Induced Neuronal Sprouting and Bladder Overactivity

    doi: 10.1371/journal.pone.0069550

    Figure Lengend Snippet: TRP expression screening in DRG of CYPc rats. A–D, qRT-PCR analysis of Trpc ( A ), Trpm ( B ), Trpv ( C ), and Trpa1 and Trpml ( D ) mRNA shows an up-regulation of Trpc1 and Trpc4 transcripts and a decreased expression of Trpc5 and Trpc6 transcripts in L6-S1 DRG of CYP-treated rats.

    Article Snippet: The vast majority of the growing, GAP-43 positive neurons was also positive to TRPC1 ( )(84/103; 81.5%).

    Techniques: Expressing, Quantitative RT-PCR

    TRPC1 is upregulated in bladder-innervating neurons in CYP c rats. A, B Immunocytochemistry of TRPC1 in DRG of control and CYP c rats, retrolabelled with DiI - scales bar: 50 µm. C, Quantitative analysis of colocalization of DiI and TRPC1. D, Immunohistochemistry showing that a majority of GAP-43 positive neurons are TRPC1 positive in CYP c rats – scale bar: 20 µm.

    Journal: PLoS ONE

    Article Title: Crucial Role of TRPC1 and TRPC4 in Cystitis-Induced Neuronal Sprouting and Bladder Overactivity

    doi: 10.1371/journal.pone.0069550

    Figure Lengend Snippet: TRPC1 is upregulated in bladder-innervating neurons in CYP c rats. A, B Immunocytochemistry of TRPC1 in DRG of control and CYP c rats, retrolabelled with DiI - scales bar: 50 µm. C, Quantitative analysis of colocalization of DiI and TRPC1. D, Immunohistochemistry showing that a majority of GAP-43 positive neurons are TRPC1 positive in CYP c rats – scale bar: 20 µm.

    Article Snippet: The vast majority of the growing, GAP-43 positive neurons was also positive to TRPC1 ( )(84/103; 81.5%).

    Techniques: Immunocytochemistry, Immunohistochemistry

    CYP-induced peripheral sprouting is abolished in Trpc1/c4 −/− mice. A, PGP9.5 staining in whole mount bladder mucosa in control and CYP-treated wild type, TRPC1, TRPC4 and TRPC1/C4 deficient mice - scale bar : 50 µm. B–D, Quantitative analysis of neurite segments ( B ), neurite length ( C ) and neurite density ( D ) shows a normal innervation in treated Trpc1/c4 −/− mice.

    Journal: PLoS ONE

    Article Title: Crucial Role of TRPC1 and TRPC4 in Cystitis-Induced Neuronal Sprouting and Bladder Overactivity

    doi: 10.1371/journal.pone.0069550

    Figure Lengend Snippet: CYP-induced peripheral sprouting is abolished in Trpc1/c4 −/− mice. A, PGP9.5 staining in whole mount bladder mucosa in control and CYP-treated wild type, TRPC1, TRPC4 and TRPC1/C4 deficient mice - scale bar : 50 µm. B–D, Quantitative analysis of neurite segments ( B ), neurite length ( C ) and neurite density ( D ) shows a normal innervation in treated Trpc1/c4 −/− mice.

    Article Snippet: The vast majority of the growing, GAP-43 positive neurons was also positive to TRPC1 ( )(84/103; 81.5%).

    Techniques: Mouse Assay, Staining