P2x4r Fitc, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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1) Product Images from "Neuroprotective and Neuro-rehabilitative Effects of Acute Purinergic Receptor P2X4 (P2X4R) Blockade after Ischemic Stroke"
Article Title: Neuroprotective and Neuro-rehabilitative Effects of Acute Purinergic Receptor P2X4 (P2X4R) Blockade after Ischemic Stroke
Journal: Experimental neurology
Figure Legend Snippet: Determining IC50 of 5-BDBD. Plot indicates the effect of 5-BDBD at various concentrations (10 nM to 30 μM; log10 [nM] = −4.52 to −8) after P2X4R agonist ATP (1 μM) induced [Ca 2+ ]i response. Calculated IC50 was 3.8 × 10 −6 M.
Figure Legend Snippet: P2X4R-expressing IBA1+ myeloid cells are significantly reduced near the core/penumbra junction after 5-BDBD treatment. Images (top) and quantification (bottom) of P2X4R expression (green) in lba-1 positive cells (red) from immunostaining of brain sections 3 days after stroke. 20x magnification. DAPI (blue) = 4′,6-diamidino-2-phenylindole (nuclear stain). Scale bar 20 μm. Data are Mean ± SD (n=3 mice/group). *p
Techniques Used: Expressing, Immunostaining, Staining, Mouse Assay
Figure Legend Snippet: 5-BDBD treatment show differential response on BDNF levels at 3 days and at 30 days after stroke. Representative western blots are shown in the top panel. Effects of vehicle or 5-BDBD on pro and mature BDNF at (A) 3 days and (B) 30 days after stroke. C) Effects of vehicle and 5-BDBD treatment on pro/mature BDNF ratio 3 and 30 days after stroke. (D) P2X4R expression at 3 and 30 days after stroke were not different; Data are Mean ± SD (n=4–8 mice/group/time point). *p
Techniques Used: Western Blot, Expressing, Mouse Assay