p2x7r  (Alomone Labs)


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    Structured Review

    Alomone Labs p2x7r
    Increased expression of <t>P2X7R</t> in experimental and human epilepsy. A , Photomicrograph showing EGFP immunofluorescence in the hippocampus of a control P2rx7-EGFP mouse. Scale bar, 125 μm. Panels below show higher-power images of CA1 (i) and DG (ii) hippocampal subfields from the P2rx7-EGFP control animal. Scale bar, 50 μm. Note that the constitutive EGFP appears mainly in cells of the DG. B , Photomicrograph showing EGFP immunofluorescence in the hippocampus of an epileptic P2rx7-EGFP mouse 14 d after status epilepticus. Scale bar, 125 μm. Panels below show higher-power images of CA1 (i) and DG (ii) hippocampal subfields from the P2rx7-EGFP epileptic animal. Scale bar, 50 μm. C , Double-stained confocal immunofluorescence images showing EGFP (green, GFP) and neuronal marker NeuN (red), in the CA1 and DG subfields from epileptic P2rx7-EGFP mice. Scale bar, 50 μm. D , Immunofluorescence staining showing EGFP (green, GFP) and microglia marker Iba1 (red) in the CA3 subfield of a P2rx7-EGFP epileptic mouse. Scale bar, 20 μm. Images are representative of data from n = 5 animals per group. E , Graph showing P2rx7 mRNA levels in the CA1, CA3, and DG subfields of control (Con) and epileptic (Epi) mice ( n = 9/group; ANOVA with Bonferroni test, * p
    P2x7r, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/p2x7r/product/Alomone Labs
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    p2x7r - by Bioz Stars, 2022-05
    86/100 stars

    Images

    1) Product Images from "Transient P2X7 Receptor Antagonism Produces Lasting Reductions in Spontaneous Seizures and Gliosis in Experimental Temporal Lobe Epilepsy"

    Article Title: Transient P2X7 Receptor Antagonism Produces Lasting Reductions in Spontaneous Seizures and Gliosis in Experimental Temporal Lobe Epilepsy

    Journal: The Journal of Neuroscience

    doi: 10.1523/JNEUROSCI.4009-15.2016

    Increased expression of P2X7R in experimental and human epilepsy. A , Photomicrograph showing EGFP immunofluorescence in the hippocampus of a control P2rx7-EGFP mouse. Scale bar, 125 μm. Panels below show higher-power images of CA1 (i) and DG (ii) hippocampal subfields from the P2rx7-EGFP control animal. Scale bar, 50 μm. Note that the constitutive EGFP appears mainly in cells of the DG. B , Photomicrograph showing EGFP immunofluorescence in the hippocampus of an epileptic P2rx7-EGFP mouse 14 d after status epilepticus. Scale bar, 125 μm. Panels below show higher-power images of CA1 (i) and DG (ii) hippocampal subfields from the P2rx7-EGFP epileptic animal. Scale bar, 50 μm. C , Double-stained confocal immunofluorescence images showing EGFP (green, GFP) and neuronal marker NeuN (red), in the CA1 and DG subfields from epileptic P2rx7-EGFP mice. Scale bar, 50 μm. D , Immunofluorescence staining showing EGFP (green, GFP) and microglia marker Iba1 (red) in the CA3 subfield of a P2rx7-EGFP epileptic mouse. Scale bar, 20 μm. Images are representative of data from n = 5 animals per group. E , Graph showing P2rx7 mRNA levels in the CA1, CA3, and DG subfields of control (Con) and epileptic (Epi) mice ( n = 9/group; ANOVA with Bonferroni test, * p
    Figure Legend Snippet: Increased expression of P2X7R in experimental and human epilepsy. A , Photomicrograph showing EGFP immunofluorescence in the hippocampus of a control P2rx7-EGFP mouse. Scale bar, 125 μm. Panels below show higher-power images of CA1 (i) and DG (ii) hippocampal subfields from the P2rx7-EGFP control animal. Scale bar, 50 μm. Note that the constitutive EGFP appears mainly in cells of the DG. B , Photomicrograph showing EGFP immunofluorescence in the hippocampus of an epileptic P2rx7-EGFP mouse 14 d after status epilepticus. Scale bar, 125 μm. Panels below show higher-power images of CA1 (i) and DG (ii) hippocampal subfields from the P2rx7-EGFP epileptic animal. Scale bar, 50 μm. C , Double-stained confocal immunofluorescence images showing EGFP (green, GFP) and neuronal marker NeuN (red), in the CA1 and DG subfields from epileptic P2rx7-EGFP mice. Scale bar, 50 μm. D , Immunofluorescence staining showing EGFP (green, GFP) and microglia marker Iba1 (red) in the CA3 subfield of a P2rx7-EGFP epileptic mouse. Scale bar, 20 μm. Images are representative of data from n = 5 animals per group. E , Graph showing P2rx7 mRNA levels in the CA1, CA3, and DG subfields of control (Con) and epileptic (Epi) mice ( n = 9/group; ANOVA with Bonferroni test, * p

    Techniques Used: Expressing, Immunofluorescence, Staining, Marker, Mouse Assay

    Decreased astrogliosis and microgliosis in JNJ-47965567-treated epileptic mice. A–D , Photomicrographs of representative Iba1 staining of the hippocampus from vehicle- (Veh) and JNJ-47965567 (JNJ)-treated epileptic mice showing field views ( A ) and 20× lens magnifications ( B–D ) of individual subfields from the same animal. Note, the decrease in the number of Iba1 + cells and the immunoreactivity in mice treated with the specific P2X7R inhibitor JNJ-47965567. E , Graph showing the quantification of Iba1 + microglia found in each hippocampal subfield of vehicle- and JNJ-47965567-treated mice killed 6 d after drug washout at the end of recordings ( n = 9/group; ANOVA with Bonferroni test, ** p
    Figure Legend Snippet: Decreased astrogliosis and microgliosis in JNJ-47965567-treated epileptic mice. A–D , Photomicrographs of representative Iba1 staining of the hippocampus from vehicle- (Veh) and JNJ-47965567 (JNJ)-treated epileptic mice showing field views ( A ) and 20× lens magnifications ( B–D ) of individual subfields from the same animal. Note, the decrease in the number of Iba1 + cells and the immunoreactivity in mice treated with the specific P2X7R inhibitor JNJ-47965567. E , Graph showing the quantification of Iba1 + microglia found in each hippocampal subfield of vehicle- and JNJ-47965567-treated mice killed 6 d after drug washout at the end of recordings ( n = 9/group; ANOVA with Bonferroni test, ** p

    Techniques Used: Mouse Assay, Staining

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    Alomone Labs p2x7r
    Increased expression of <t>P2X7R</t> in experimental and human epilepsy. A , Photomicrograph showing EGFP immunofluorescence in the hippocampus of a control P2rx7-EGFP mouse. Scale bar, 125 μm. Panels below show higher-power images of CA1 (i) and DG (ii) hippocampal subfields from the P2rx7-EGFP control animal. Scale bar, 50 μm. Note that the constitutive EGFP appears mainly in cells of the DG. B , Photomicrograph showing EGFP immunofluorescence in the hippocampus of an epileptic P2rx7-EGFP mouse 14 d after status epilepticus. Scale bar, 125 μm. Panels below show higher-power images of CA1 (i) and DG (ii) hippocampal subfields from the P2rx7-EGFP epileptic animal. Scale bar, 50 μm. C , Double-stained confocal immunofluorescence images showing EGFP (green, GFP) and neuronal marker NeuN (red), in the CA1 and DG subfields from epileptic P2rx7-EGFP mice. Scale bar, 50 μm. D , Immunofluorescence staining showing EGFP (green, GFP) and microglia marker Iba1 (red) in the CA3 subfield of a P2rx7-EGFP epileptic mouse. Scale bar, 20 μm. Images are representative of data from n = 5 animals per group. E , Graph showing P2rx7 mRNA levels in the CA1, CA3, and DG subfields of control (Con) and epileptic (Epi) mice ( n = 9/group; ANOVA with Bonferroni test, * p
    P2x7r, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/p2x7r/product/Alomone Labs
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    p2x7r - by Bioz Stars, 2022-05
    86/100 stars
      Buy from Supplier

    86
    Alomone Labs p2x7 primary antibody
    Increased expression of <t>P2X7R</t> in experimental and human epilepsy. A , Photomicrograph showing EGFP immunofluorescence in the hippocampus of a control P2rx7-EGFP mouse. Scale bar, 125 μm. Panels below show higher-power images of CA1 (i) and DG (ii) hippocampal subfields from the P2rx7-EGFP control animal. Scale bar, 50 μm. Note that the constitutive EGFP appears mainly in cells of the DG. B , Photomicrograph showing EGFP immunofluorescence in the hippocampus of an epileptic P2rx7-EGFP mouse 14 d after status epilepticus. Scale bar, 125 μm. Panels below show higher-power images of CA1 (i) and DG (ii) hippocampal subfields from the P2rx7-EGFP epileptic animal. Scale bar, 50 μm. C , Double-stained confocal immunofluorescence images showing EGFP (green, GFP) and neuronal marker NeuN (red), in the CA1 and DG subfields from epileptic P2rx7-EGFP mice. Scale bar, 50 μm. D , Immunofluorescence staining showing EGFP (green, GFP) and microglia marker Iba1 (red) in the CA3 subfield of a P2rx7-EGFP epileptic mouse. Scale bar, 20 μm. Images are representative of data from n = 5 animals per group. E , Graph showing P2rx7 mRNA levels in the CA1, CA3, and DG subfields of control (Con) and epileptic (Epi) mice ( n = 9/group; ANOVA with Bonferroni test, * p
    P2x7 Primary Antibody, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/p2x7 primary antibody/product/Alomone Labs
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    p2x7 primary antibody - by Bioz Stars, 2022-05
    86/100 stars
      Buy from Supplier

    Image Search Results


    Increased expression of P2X7R in experimental and human epilepsy. A , Photomicrograph showing EGFP immunofluorescence in the hippocampus of a control P2rx7-EGFP mouse. Scale bar, 125 μm. Panels below show higher-power images of CA1 (i) and DG (ii) hippocampal subfields from the P2rx7-EGFP control animal. Scale bar, 50 μm. Note that the constitutive EGFP appears mainly in cells of the DG. B , Photomicrograph showing EGFP immunofluorescence in the hippocampus of an epileptic P2rx7-EGFP mouse 14 d after status epilepticus. Scale bar, 125 μm. Panels below show higher-power images of CA1 (i) and DG (ii) hippocampal subfields from the P2rx7-EGFP epileptic animal. Scale bar, 50 μm. C , Double-stained confocal immunofluorescence images showing EGFP (green, GFP) and neuronal marker NeuN (red), in the CA1 and DG subfields from epileptic P2rx7-EGFP mice. Scale bar, 50 μm. D , Immunofluorescence staining showing EGFP (green, GFP) and microglia marker Iba1 (red) in the CA3 subfield of a P2rx7-EGFP epileptic mouse. Scale bar, 20 μm. Images are representative of data from n = 5 animals per group. E , Graph showing P2rx7 mRNA levels in the CA1, CA3, and DG subfields of control (Con) and epileptic (Epi) mice ( n = 9/group; ANOVA with Bonferroni test, * p

    Journal: The Journal of Neuroscience

    Article Title: Transient P2X7 Receptor Antagonism Produces Lasting Reductions in Spontaneous Seizures and Gliosis in Experimental Temporal Lobe Epilepsy

    doi: 10.1523/JNEUROSCI.4009-15.2016

    Figure Lengend Snippet: Increased expression of P2X7R in experimental and human epilepsy. A , Photomicrograph showing EGFP immunofluorescence in the hippocampus of a control P2rx7-EGFP mouse. Scale bar, 125 μm. Panels below show higher-power images of CA1 (i) and DG (ii) hippocampal subfields from the P2rx7-EGFP control animal. Scale bar, 50 μm. Note that the constitutive EGFP appears mainly in cells of the DG. B , Photomicrograph showing EGFP immunofluorescence in the hippocampus of an epileptic P2rx7-EGFP mouse 14 d after status epilepticus. Scale bar, 125 μm. Panels below show higher-power images of CA1 (i) and DG (ii) hippocampal subfields from the P2rx7-EGFP epileptic animal. Scale bar, 50 μm. C , Double-stained confocal immunofluorescence images showing EGFP (green, GFP) and neuronal marker NeuN (red), in the CA1 and DG subfields from epileptic P2rx7-EGFP mice. Scale bar, 50 μm. D , Immunofluorescence staining showing EGFP (green, GFP) and microglia marker Iba1 (red) in the CA3 subfield of a P2rx7-EGFP epileptic mouse. Scale bar, 20 μm. Images are representative of data from n = 5 animals per group. E , Graph showing P2rx7 mRNA levels in the CA1, CA3, and DG subfields of control (Con) and epileptic (Epi) mice ( n = 9/group; ANOVA with Bonferroni test, * p

    Article Snippet: Proteins were extracted from human or mouse hippocampus, separated by SDS-PAGE, transferred to nitrocellulose membranes, and then immunoblotted with the following primary antibodies: P2X2R and P2X7R (APR-004, APR-003; 1:500; Alomone Labs), Synaptophysin (1:200; Sigma-Aldrich), GAPDH (1:1000; Cell Signaling Technology), and β-actin and α-tubulin (1:1000; Sigma-Aldrich).

    Techniques: Expressing, Immunofluorescence, Staining, Marker, Mouse Assay

    Decreased astrogliosis and microgliosis in JNJ-47965567-treated epileptic mice. A–D , Photomicrographs of representative Iba1 staining of the hippocampus from vehicle- (Veh) and JNJ-47965567 (JNJ)-treated epileptic mice showing field views ( A ) and 20× lens magnifications ( B–D ) of individual subfields from the same animal. Note, the decrease in the number of Iba1 + cells and the immunoreactivity in mice treated with the specific P2X7R inhibitor JNJ-47965567. E , Graph showing the quantification of Iba1 + microglia found in each hippocampal subfield of vehicle- and JNJ-47965567-treated mice killed 6 d after drug washout at the end of recordings ( n = 9/group; ANOVA with Bonferroni test, ** p

    Journal: The Journal of Neuroscience

    Article Title: Transient P2X7 Receptor Antagonism Produces Lasting Reductions in Spontaneous Seizures and Gliosis in Experimental Temporal Lobe Epilepsy

    doi: 10.1523/JNEUROSCI.4009-15.2016

    Figure Lengend Snippet: Decreased astrogliosis and microgliosis in JNJ-47965567-treated epileptic mice. A–D , Photomicrographs of representative Iba1 staining of the hippocampus from vehicle- (Veh) and JNJ-47965567 (JNJ)-treated epileptic mice showing field views ( A ) and 20× lens magnifications ( B–D ) of individual subfields from the same animal. Note, the decrease in the number of Iba1 + cells and the immunoreactivity in mice treated with the specific P2X7R inhibitor JNJ-47965567. E , Graph showing the quantification of Iba1 + microglia found in each hippocampal subfield of vehicle- and JNJ-47965567-treated mice killed 6 d after drug washout at the end of recordings ( n = 9/group; ANOVA with Bonferroni test, ** p

    Article Snippet: Proteins were extracted from human or mouse hippocampus, separated by SDS-PAGE, transferred to nitrocellulose membranes, and then immunoblotted with the following primary antibodies: P2X2R and P2X7R (APR-004, APR-003; 1:500; Alomone Labs), Synaptophysin (1:200; Sigma-Aldrich), GAPDH (1:1000; Cell Signaling Technology), and β-actin and α-tubulin (1:1000; Sigma-Aldrich).

    Techniques: Mouse Assay, Staining