Kchip2, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 94/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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1) Product Images from "Transient Outward K+ Current (Ito) Underlies the Right Ventricular Initiation of Polymorphic Ventricular Tachycardia in a Transgenic Rabbit Model of Long QT Type 1"
Article Title: Transient Outward K+ Current (Ito) Underlies the Right Ventricular Initiation of Polymorphic Ventricular Tachycardia in a Transgenic Rabbit Model of Long QT Type 1
Journal: Circulation. Arrhythmia and electrophysiology
Figure Legend Snippet: I to recovery from inactivation. A) The recovery kinetics was tested by a double-pulse protocol with interpulse time varying from 50 ms to 15 sec (n=12 RV and 7 LV cells from n=3 hearts). B) The amplitudes of the slow and fast inactivating components of I to (I to,si and I I to,fi ) as a function of inter-pulse interval were determined by fitting the time course of I to decay during the second pulse to a double exponential function. The x-axis of inter-pulse intervals is in a logarithmic scale. C) The amplitudes of I to,fi and I to,si from RV and LV. Fast and slow-inactivating components (I to,fi and I to,si ) of each I to,f and I to,s were calculated as described in Methods and represented as a stacked column plot. D) Western blots of Kv4.2, Kv1.4, and KChIP2 from LQT1 hearts. E). The accessory unit of I to , KChIP2, known to affect inactivation and recovery kinetics, was twofold higher in RV (ANOVA, p .
Techniques Used: Mass Spectrometry, Size-exclusion Chromatography, Western Blot