Guinea Pig Anti Hcn4 Antibody, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 94/100, based on 4 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 94 stars, based on 4 article reviews
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1) Product Images from "L-Type Cav1.3 Calcium Channels Are Required for Beta-Adrenergic Triggered Automaticity in Dormant Mouse Sinoatrial Pacemaker Cells"
Article Title: L-Type Cav1.3 Calcium Channels Are Required for Beta-Adrenergic Triggered Automaticity in Dormant Mouse Sinoatrial Pacemaker Cells
Figure Legend Snippet: Co-labeling of Ca v 1.3 and HCN4 in mouse SAN. ( A ) Immunolabeling of Ca v 1.3 (red) and HCN4 (green) in the isolated cranial SAN-RA preparation. ( B ) Left panels: close-up views of the area circled in ( A ); right panels: enlargement with cells expressing Ca v 1.3 or HCN4, from boxed region in left panel. ( C ) Immunolabeling of regions co-expressing Ca v 1.3 and HCN4. The left panel shows the region in accordance with the posterior nodal extension (PNL). The yellow rectangle identifies the region considered for close-up views shown in the left panels. Left panels, from top to bottom, indicate corresponding Ca v 1.3 and HCN4 immunostaining. Yellow arrows indicate SANC co-expressing Ca v 1.3 and HCN4.
Techniques Used: Labeling, Immunolabeling, Isolation, Expressing, Immunostaining
Figure Legend Snippet: Expression of Ca v 1.3 and HCN4 in mouse SAN. ( A ) Immunolabeling of Ca v 1.3 (green) and HCN4 (red) in n = 64 isolated SANC with distribution of SANC based on Ca v 1.3 or HCN4 fluorescence intensity. Low fluorescence intensity is related to a lower expression of the channels while high density is related to a higher expression. ( B ) Bright-field image of a SAN-RA (N = 3) preparation used for immunolabeling of Ca v 1.3. ( C ) Immunolabeling of Ca v 1.3 (red) of the preparation in ( B ). ( D ) Immunolabeling of Ca v 1.3 in the enlarged region corresponding to the white circle in ( C ). ( E ) Close-up view of Ca v 1.3-expressing cells (red), together with nuclear labeling of DNA (blue), in the field corresponding to the central square in panel ( D ). The yellow arrow indicates Ca v 1.3 immunoreactive cells with punctate staining. Abbreviations: RA, right atrium; SVC, superior vena cava ; IVC, inferior vena cava ; IAS, inter-atrial septum; CS, coronary sinus (cut-open view); CT, crista terminalis . The white dashed line roughly indicates the CT boundary.
Techniques Used: Expressing, Immunolabeling, Isolation, Fluorescence, Labeling, Staining