Girk1, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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1) Product Images from "GIRK2 splice variants and neuronal G protein-gated K+ channels: implications for channel function and behavior"
Article Title: GIRK2 splice variants and neuronal G protein-gated K+ channels: implications for channel function and behavior
Journal: Scientific Reports
Figure Legend Snippet: Functional comparison of GIRK2a and GIRK2c in HEK cells. ( A ) Whole-cell currents (V hold = −70 mV) evoked by baclofen (100 μM) in HEK cells expressing GABA B R, GIRK1, and either GIRK2a (red) or GIRK2c (blue). No current was evoked by baclofen in cells expressing only GABA B R (control, black). Scale: 500 pA/10 s. ( B ) Summary of baclofen-induced, steady-state current densities (I baclofen , pA/pF) in HEK cells expressing GIRK1/GIRK2a or GIRK1/GIRK2c ( t 19 = 1.1, P = 0.29; n = 10–11/group). Individual data points are represented as small squares overlapping the relevant bar in the plot. ( C,D ) Activation ( t 19 = 1.5, P = 0.16) and deactivation ( t 16 = 0.4, P = 0.72) kinetics for baclofen-induced currents in HEK cells expressing GIRK1/GIRK2a or GIRK1/GIRK2c (n = 9–11/group). ( E ) Representative concentration-response experiment for a HEK cell expressing GABA B R and GIRK1/GIRK2c. Scale: 500 pA/10 s. ( F,G ) Summary of concentration-response experiments for baclofen-induced currents in HEK cells expressing GIRK1/GIRK2a or GIRK1/GIRK2c ( t 17 = 1.0, P = 0.32; n = 9–10/group). Currents were normalized to the response evoked by 100 μM baclofen in each experiment.
Techniques Used: Functional Assay, Expressing, Activation Assay, Concentration Assay