trpc1  (Alomone Labs)


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    Structured Review

    Alomone Labs trpc1
    CYP-induced bladder overactivity is decreased in <t>Trpc1/c4</t> −/− mice. A, Typical urodynamic traces of WT and Trpc1/c4 −/− mice in vehicle or following CYP treatment. B,C, Analysis of intercontractile interval in vehicle ( B ) and CYP-treatment mice ( C ) in WT and Trpc1/c4 −/− mice shows that double knock-out mice are functionally less affected by CYP treatment. D, Typical muscle strip contractility traces of WT mice in control and in CYP c rats activated by 10 nM of carbachol. The statistical analysis of carbachol-induced contraction of muscle strips did not show difference between the two genotypes in CYP c mice. E, Typical traces of muscle strip contractility of WT mice stimulated with high KCl concentration (122 mM). There is no difference between WT and Trpc1/c4 −/− in control and CYP c conditions.
    Trpc1, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/trpc1/product/Alomone Labs
    Average 95 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    trpc1 - by Bioz Stars, 2022-12
    95/100 stars

    Images

    1) Product Images from "Crucial Role of TRPC1 and TRPC4 in Cystitis-Induced Neuronal Sprouting and Bladder Overactivity"

    Article Title: Crucial Role of TRPC1 and TRPC4 in Cystitis-Induced Neuronal Sprouting and Bladder Overactivity

    Journal: PLoS ONE

    doi: 10.1371/journal.pone.0069550

    CYP-induced bladder overactivity is decreased in Trpc1/c4 −/− mice. A, Typical urodynamic traces of WT and Trpc1/c4 −/− mice in vehicle or following CYP treatment. B,C, Analysis of intercontractile interval in vehicle ( B ) and CYP-treatment mice ( C ) in WT and Trpc1/c4 −/− mice shows that double knock-out mice are functionally less affected by CYP treatment. D, Typical muscle strip contractility traces of WT mice in control and in CYP c rats activated by 10 nM of carbachol. The statistical analysis of carbachol-induced contraction of muscle strips did not show difference between the two genotypes in CYP c mice. E, Typical traces of muscle strip contractility of WT mice stimulated with high KCl concentration (122 mM). There is no difference between WT and Trpc1/c4 −/− in control and CYP c conditions.
    Figure Legend Snippet: CYP-induced bladder overactivity is decreased in Trpc1/c4 −/− mice. A, Typical urodynamic traces of WT and Trpc1/c4 −/− mice in vehicle or following CYP treatment. B,C, Analysis of intercontractile interval in vehicle ( B ) and CYP-treatment mice ( C ) in WT and Trpc1/c4 −/− mice shows that double knock-out mice are functionally less affected by CYP treatment. D, Typical muscle strip contractility traces of WT mice in control and in CYP c rats activated by 10 nM of carbachol. The statistical analysis of carbachol-induced contraction of muscle strips did not show difference between the two genotypes in CYP c mice. E, Typical traces of muscle strip contractility of WT mice stimulated with high KCl concentration (122 mM). There is no difference between WT and Trpc1/c4 −/− in control and CYP c conditions.

    Techniques Used: Mouse Assay, Knock-Out, Stripping Membranes, Concentration Assay

    TRP expression screening in DRG of CYPc rats. A–D, qRT-PCR analysis of Trpc ( A ), Trpm ( B ), Trpv ( C ), and Trpa1 and Trpml ( D ) mRNA shows an up-regulation of Trpc1 and Trpc4 transcripts and a decreased expression of Trpc5 and Trpc6 transcripts in L6-S1 DRG of CYP-treated rats.
    Figure Legend Snippet: TRP expression screening in DRG of CYPc rats. A–D, qRT-PCR analysis of Trpc ( A ), Trpm ( B ), Trpv ( C ), and Trpa1 and Trpml ( D ) mRNA shows an up-regulation of Trpc1 and Trpc4 transcripts and a decreased expression of Trpc5 and Trpc6 transcripts in L6-S1 DRG of CYP-treated rats.

    Techniques Used: Expressing, Quantitative RT-PCR

    TRPC1 is upregulated in bladder-innervating neurons in CYP c rats. A, B Immunocytochemistry of TRPC1 in DRG of control and CYP c rats, retrolabelled with DiI - scales bar: 50 µm. C, Quantitative analysis of colocalization of DiI and TRPC1. D, Immunohistochemistry showing that a majority of GAP-43 positive neurons are TRPC1 positive in CYP c rats – scale bar: 20 µm.
    Figure Legend Snippet: TRPC1 is upregulated in bladder-innervating neurons in CYP c rats. A, B Immunocytochemistry of TRPC1 in DRG of control and CYP c rats, retrolabelled with DiI - scales bar: 50 µm. C, Quantitative analysis of colocalization of DiI and TRPC1. D, Immunohistochemistry showing that a majority of GAP-43 positive neurons are TRPC1 positive in CYP c rats – scale bar: 20 µm.

    Techniques Used: Immunocytochemistry, Immunohistochemistry

    CYP-induced peripheral sprouting is abolished in Trpc1/c4 −/− mice. A, PGP9.5 staining in whole mount bladder mucosa in control and CYP-treated wild type, TRPC1, TRPC4 and TRPC1/C4 deficient mice - scale bar : 50 µm. B–D, Quantitative analysis of neurite segments ( B ), neurite length ( C ) and neurite density ( D ) shows a normal innervation in treated Trpc1/c4 −/− mice.
    Figure Legend Snippet: CYP-induced peripheral sprouting is abolished in Trpc1/c4 −/− mice. A, PGP9.5 staining in whole mount bladder mucosa in control and CYP-treated wild type, TRPC1, TRPC4 and TRPC1/C4 deficient mice - scale bar : 50 µm. B–D, Quantitative analysis of neurite segments ( B ), neurite length ( C ) and neurite density ( D ) shows a normal innervation in treated Trpc1/c4 −/− mice.

    Techniques Used: Mouse Assay, Staining

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