nrcam  (Alomone Labs)


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    Alomone Labs nrcam
    Targeting of β IV spectrin, Na v 1.6, <t>NrCAM,</t> and neurofascin to Purkinje neuron initial segments is disrupted in <t>ankyrin-G</t> cerebellum- specific knockout mice. Cerebellar sections from wild-type (A, D, G, J, and M) or cerebellar ankyrin-G knockout mice (B, C, E, F, H, I, K, L, N, and O) were double labeled with antibodies against calbindin (red in A–F; green in G–L) and either ankyrin-G (green in A–C), βIV spectrin (green in D–F), Na v 1.6 (red in G–I), NrCAM (red in J–L), or neurofascin (M–O). All images except M–O are composites. Bars: (A, B, and E) 5 μm; (C, D, F, G, I, and J–O) 10 μm; and (H) 25 μm.
    Nrcam, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 80/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/nrcam/product/Alomone Labs
    Average 80 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    nrcam - by Bioz Stars, 2022-08
    80/100 stars

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    1) Product Images from "Ankyrin-G coordinates assembly of the spectrin-based membrane skeleton, voltage-gated sodium channels, and L1 CAMs at Purkinje neuron initial segments"

    Article Title: Ankyrin-G coordinates assembly of the spectrin-based membrane skeleton, voltage-gated sodium channels, and L1 CAMs at Purkinje neuron initial segments

    Journal: The Journal of Cell Biology

    doi: 10.1083/jcb.200109026

    Targeting of β IV spectrin, Na v 1.6, NrCAM, and neurofascin to Purkinje neuron initial segments is disrupted in ankyrin-G cerebellum- specific knockout mice. Cerebellar sections from wild-type (A, D, G, J, and M) or cerebellar ankyrin-G knockout mice (B, C, E, F, H, I, K, L, N, and O) were double labeled with antibodies against calbindin (red in A–F; green in G–L) and either ankyrin-G (green in A–C), βIV spectrin (green in D–F), Na v 1.6 (red in G–I), NrCAM (red in J–L), or neurofascin (M–O). All images except M–O are composites. Bars: (A, B, and E) 5 μm; (C, D, F, G, I, and J–O) 10 μm; and (H) 25 μm.
    Figure Legend Snippet: Targeting of β IV spectrin, Na v 1.6, NrCAM, and neurofascin to Purkinje neuron initial segments is disrupted in ankyrin-G cerebellum- specific knockout mice. Cerebellar sections from wild-type (A, D, G, J, and M) or cerebellar ankyrin-G knockout mice (B, C, E, F, H, I, K, L, N, and O) were double labeled with antibodies against calbindin (red in A–F; green in G–L) and either ankyrin-G (green in A–C), βIV spectrin (green in D–F), Na v 1.6 (red in G–I), NrCAM (red in J–L), or neurofascin (M–O). All images except M–O are composites. Bars: (A, B, and E) 5 μm; (C, D, F, G, I, and J–O) 10 μm; and (H) 25 μm.

    Techniques Used: Knock-Out, Mouse Assay, Labeling

    Na v 1.6, ankyrin-G, β IV spectrin, neurofascin, and NrCAM are targeted to axon initial segments of cerebellar Purkinje neurons. Sections of adult rat cerebellum were triple labeled with antibodies against calbindin (blue), ankyrin-G (green), and either Na v 1.6 (B), βIV spectrin (E), neurofascin (H), or NrCAM (K) (red). Composite images are shown in C, F, I, and L. Arrowheads indicate Purkinje cell initial segments. Bars, 10 μm.
    Figure Legend Snippet: Na v 1.6, ankyrin-G, β IV spectrin, neurofascin, and NrCAM are targeted to axon initial segments of cerebellar Purkinje neurons. Sections of adult rat cerebellum were triple labeled with antibodies against calbindin (blue), ankyrin-G (green), and either Na v 1.6 (B), βIV spectrin (E), neurofascin (H), or NrCAM (K) (red). Composite images are shown in C, F, I, and L. Arrowheads indicate Purkinje cell initial segments. Bars, 10 μm.

    Techniques Used: Labeling

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    Alomone Labs nrcam
    Targeting of β IV spectrin, Na v 1.6, <t>NrCAM,</t> and neurofascin to Purkinje neuron initial segments is disrupted in <t>ankyrin-G</t> cerebellum- specific knockout mice. Cerebellar sections from wild-type (A, D, G, J, and M) or cerebellar ankyrin-G knockout mice (B, C, E, F, H, I, K, L, N, and O) were double labeled with antibodies against calbindin (red in A–F; green in G–L) and either ankyrin-G (green in A–C), βIV spectrin (green in D–F), Na v 1.6 (red in G–I), NrCAM (red in J–L), or neurofascin (M–O). All images except M–O are composites. Bars: (A, B, and E) 5 μm; (C, D, F, G, I, and J–O) 10 μm; and (H) 25 μm.
    Nrcam, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 80/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/nrcam/product/Alomone Labs
    Average 80 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    nrcam - by Bioz Stars, 2022-08
    80/100 stars
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    Targeting of β IV spectrin, Na v 1.6, NrCAM, and neurofascin to Purkinje neuron initial segments is disrupted in ankyrin-G cerebellum- specific knockout mice. Cerebellar sections from wild-type (A, D, G, J, and M) or cerebellar ankyrin-G knockout mice (B, C, E, F, H, I, K, L, N, and O) were double labeled with antibodies against calbindin (red in A–F; green in G–L) and either ankyrin-G (green in A–C), βIV spectrin (green in D–F), Na v 1.6 (red in G–I), NrCAM (red in J–L), or neurofascin (M–O). All images except M–O are composites. Bars: (A, B, and E) 5 μm; (C, D, F, G, I, and J–O) 10 μm; and (H) 25 μm.

    Journal: The Journal of Cell Biology

    Article Title: Ankyrin-G coordinates assembly of the spectrin-based membrane skeleton, voltage-gated sodium channels, and L1 CAMs at Purkinje neuron initial segments

    doi: 10.1083/jcb.200109026

    Figure Lengend Snippet: Targeting of β IV spectrin, Na v 1.6, NrCAM, and neurofascin to Purkinje neuron initial segments is disrupted in ankyrin-G cerebellum- specific knockout mice. Cerebellar sections from wild-type (A, D, G, J, and M) or cerebellar ankyrin-G knockout mice (B, C, E, F, H, I, K, L, N, and O) were double labeled with antibodies against calbindin (red in A–F; green in G–L) and either ankyrin-G (green in A–C), βIV spectrin (green in D–F), Na v 1.6 (red in G–I), NrCAM (red in J–L), or neurofascin (M–O). All images except M–O are composites. Bars: (A, B, and E) 5 μm; (C, D, F, G, I, and J–O) 10 μm; and (H) 25 μm.

    Article Snippet: Antibodies used include a mouse monoclonal antibody against the ankyrin-G spectrin–binding domain ( ); affinity-purified rabbit polyclonal antibodies against neurofascin , NrCAM ( ) and the peptide CIANHTGVDIHRNGDFQKNG corresponding to residues 1042–1061 of mouse or rat Nav1.6 (Alomone Labs); a goat polyclonal antibody against calbindin (Santa Cruz Biotech), and a chicken polyclonal antibody against the βIV spectrin unique domain that has been adsorbed against brain lysate from a βIV spectrin knockout mouse (gift of Dr. M. Komada, Tokyo Institute of Technology, Tokyo, Japan).

    Techniques: Knock-Out, Mouse Assay, Labeling

    Na v 1.6, ankyrin-G, β IV spectrin, neurofascin, and NrCAM are targeted to axon initial segments of cerebellar Purkinje neurons. Sections of adult rat cerebellum were triple labeled with antibodies against calbindin (blue), ankyrin-G (green), and either Na v 1.6 (B), βIV spectrin (E), neurofascin (H), or NrCAM (K) (red). Composite images are shown in C, F, I, and L. Arrowheads indicate Purkinje cell initial segments. Bars, 10 μm.

    Journal: The Journal of Cell Biology

    Article Title: Ankyrin-G coordinates assembly of the spectrin-based membrane skeleton, voltage-gated sodium channels, and L1 CAMs at Purkinje neuron initial segments

    doi: 10.1083/jcb.200109026

    Figure Lengend Snippet: Na v 1.6, ankyrin-G, β IV spectrin, neurofascin, and NrCAM are targeted to axon initial segments of cerebellar Purkinje neurons. Sections of adult rat cerebellum were triple labeled with antibodies against calbindin (blue), ankyrin-G (green), and either Na v 1.6 (B), βIV spectrin (E), neurofascin (H), or NrCAM (K) (red). Composite images are shown in C, F, I, and L. Arrowheads indicate Purkinje cell initial segments. Bars, 10 μm.

    Article Snippet: Antibodies used include a mouse monoclonal antibody against the ankyrin-G spectrin–binding domain ( ); affinity-purified rabbit polyclonal antibodies against neurofascin , NrCAM ( ) and the peptide CIANHTGVDIHRNGDFQKNG corresponding to residues 1042–1061 of mouse or rat Nav1.6 (Alomone Labs); a goat polyclonal antibody against calbindin (Santa Cruz Biotech), and a chicken polyclonal antibody against the βIV spectrin unique domain that has been adsorbed against brain lysate from a βIV spectrin knockout mouse (gift of Dr. M. Komada, Tokyo Institute of Technology, Tokyo, Japan).

    Techniques: Labeling