trpm7 (Alomone Labs)


Structured Review

Trpm7, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/trpm7/product/Alomone Labs
Average 93 stars, based on 1 article reviews
Price from $9.99 to $1999.99
Images
1) Product Images from "The Transient Receptor Potential Melastatin 7 (TRPM7) Inhibitors Suppress Seizure-Induced Neuron Death by Inhibiting Zinc Neurotoxicity"
Article Title: The Transient Receptor Potential Melastatin 7 (TRPM7) Inhibitors Suppress Seizure-Induced Neuron Death by Inhibiting Zinc Neurotoxicity
Journal: International Journal of Molecular Sciences
doi: 10.3390/ijms21217897

Figure Legend Snippet: Possible association of zinc with neuronal death after pilocarpine-induced SE. This schematic drawing represents several chain reactions that may occur after carvacrol and 2-APB treatment in pilocarpine-induced SE. ( A ) These are the possible cellular pathways through which neuronal death occurs after pilocarpine-induced SE. ( B ) Blocking TRPM7 by carvacrol and 2-APB can inhibit several chain reactions that are thought to occur following pilocarpine-induced SE.
Techniques Used: Blocking Assay

Figure Legend Snippet: 2-APB treatment reduces TRPM7 overexpression, zinc accumulation, and neuronal degeneration after seizure. ( A ) Representative images showing TRPM7 immunoreactivity (green) in the CA1 of the hippocampus. Nuclei are counterstained with DAPI (blue). Scale bar = 20 µm. ( B ) The bar graph representing the immunofluorescence intensity of TRPM7 as determined in the same hippocampal region (mean ± SEM; n = 5 from each sham group, n = 5–6 from each seizure group). * p
Techniques Used: Over Expression, Immunofluorescence

Figure Legend Snippet: Carvacrol treatment reduces TRPM7 overexpression, zinc accumulation, and neuronal degeneration after seizure. ( A ) Representative images showing TRPM7 immunoreactivity (green) in the CA1 of the hippocampus. Nuclei are counterstained with DAPI (blue). Scale bar = 20 µm. ( B ) The bar graph representing the immunofluorescence intensity of TRPM7 as determined in the same hippocampal region (mean ± SEM; n = 5 from each sham group, n = 7 from each seizure group). * p
Techniques Used: Over Expression, Immunofluorescence