Journal: The Journal of Biological Chemistry
Article Title: Exploring the Structure of the Voltage-gated Na+ Channel by an Engineered Drug Access Pathway to the Receptor Site for Local Anesthetics *
Figure Lengend Snippet: The binding site for external QX-222 is in the internal vestibule. Modulation of the EAP by an additional mutation in the selectivity filter and by mutations of Trp-1531 is shown. The stimulation protocol and depiction are the same as in B. A , residue
Article Snippet: In some experiments, QX-222 (Alomone Labs, Jerusalem, Israel) and/or tetrodotoxin (TTX; Latoxan, Valance, France) was dissolved in the intracellular or extracellular solution.
Techniques: Binding Assay, Mutagenesis