p2x3 antagonist  (Alomone Labs)


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    Structured Review

    Alomone Labs p2x3 antagonist
    Expression of EYFP in the rNST and taste buds of a GAD65-ChR2/EYFP mouse. A , 20× confocal photomicrograph (single 2-μm Z level) demonstrates EYFP expression throughout the nucleus. B , At higher magnification (60×, digital zoom = 3, single 1-μm z level), EYFP expression is evident in somal membranes (arrows) and the neuropil. Scale bars: 100 μm ( A ) and 10 μm ( B ). White dotted line indicates the approximate border of the nucleus. st, solitary tract; dor, dorsal; med, medial. C , Low-power photomicrographs of native EYFP expression in different taste bud groups: soft palate (SP), nasoincisor ducts (NID), circumvallate (CV), foliate (FOL), and fungiform papillae (FUNGI). These are surface views of the whole tongue from above and the peeled palatal epithelium, viewed from below. In each panel, anterior (ant) is to the right and posterior (post) to the left. Scale bars: 1 mm. Extended Data Figure 1-1 provides functional characterization of these taste bud cells. Immunohistochemistry shows that EYFP/ChR2 taste bud cells in this mouse are mostly Type I cells. Activating them with blue light elicits NST responses dependent on oral <t>P2X3-containing</t> receptors, similar to responses to taste stimuli.
    P2x3 Antagonist, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    p2x3 antagonist - by Bioz Stars, 2022-12
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    Images

    1) Product Images from "Characteristics and Impact of the rNST GABA Network on Neural and Behavioral Taste Responses"

    Article Title: Characteristics and Impact of the rNST GABA Network on Neural and Behavioral Taste Responses

    Journal: eNeuro

    doi: 10.1523/ENEURO.0262-22.2022

    Expression of EYFP in the rNST and taste buds of a GAD65-ChR2/EYFP mouse. A , 20× confocal photomicrograph (single 2-μm Z level) demonstrates EYFP expression throughout the nucleus. B , At higher magnification (60×, digital zoom = 3, single 1-μm z level), EYFP expression is evident in somal membranes (arrows) and the neuropil. Scale bars: 100 μm ( A ) and 10 μm ( B ). White dotted line indicates the approximate border of the nucleus. st, solitary tract; dor, dorsal; med, medial. C , Low-power photomicrographs of native EYFP expression in different taste bud groups: soft palate (SP), nasoincisor ducts (NID), circumvallate (CV), foliate (FOL), and fungiform papillae (FUNGI). These are surface views of the whole tongue from above and the peeled palatal epithelium, viewed from below. In each panel, anterior (ant) is to the right and posterior (post) to the left. Scale bars: 1 mm. Extended Data Figure 1-1 provides functional characterization of these taste bud cells. Immunohistochemistry shows that EYFP/ChR2 taste bud cells in this mouse are mostly Type I cells. Activating them with blue light elicits NST responses dependent on oral P2X3-containing receptors, similar to responses to taste stimuli.
    Figure Legend Snippet: Expression of EYFP in the rNST and taste buds of a GAD65-ChR2/EYFP mouse. A , 20× confocal photomicrograph (single 2-μm Z level) demonstrates EYFP expression throughout the nucleus. B , At higher magnification (60×, digital zoom = 3, single 1-μm z level), EYFP expression is evident in somal membranes (arrows) and the neuropil. Scale bars: 100 μm ( A ) and 10 μm ( B ). White dotted line indicates the approximate border of the nucleus. st, solitary tract; dor, dorsal; med, medial. C , Low-power photomicrographs of native EYFP expression in different taste bud groups: soft palate (SP), nasoincisor ducts (NID), circumvallate (CV), foliate (FOL), and fungiform papillae (FUNGI). These are surface views of the whole tongue from above and the peeled palatal epithelium, viewed from below. In each panel, anterior (ant) is to the right and posterior (post) to the left. Scale bars: 1 mm. Extended Data Figure 1-1 provides functional characterization of these taste bud cells. Immunohistochemistry shows that EYFP/ChR2 taste bud cells in this mouse are mostly Type I cells. Activating them with blue light elicits NST responses dependent on oral P2X3-containing receptors, similar to responses to taste stimuli.

    Techniques Used: Expressing, Functional Assay, Immunohistochemistry

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    Alomone Labs p2x3 antagonist
    Expression of EYFP in the rNST and taste buds of a GAD65-ChR2/EYFP mouse. A , 20× confocal photomicrograph (single 2-μm Z level) demonstrates EYFP expression throughout the nucleus. B , At higher magnification (60×, digital zoom = 3, single 1-μm z level), EYFP expression is evident in somal membranes (arrows) and the neuropil. Scale bars: 100 μm ( A ) and 10 μm ( B ). White dotted line indicates the approximate border of the nucleus. st, solitary tract; dor, dorsal; med, medial. C , Low-power photomicrographs of native EYFP expression in different taste bud groups: soft palate (SP), nasoincisor ducts (NID), circumvallate (CV), foliate (FOL), and fungiform papillae (FUNGI). These are surface views of the whole tongue from above and the peeled palatal epithelium, viewed from below. In each panel, anterior (ant) is to the right and posterior (post) to the left. Scale bars: 1 mm. Extended Data Figure 1-1 provides functional characterization of these taste bud cells. Immunohistochemistry shows that EYFP/ChR2 taste bud cells in this mouse are mostly Type I cells. Activating them with blue light elicits NST responses dependent on oral <t>P2X3-containing</t> receptors, similar to responses to taste stimuli.
    P2x3 Antagonist, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/p2x3 antagonist/product/Alomone Labs
    Average 94 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    p2x3 antagonist - by Bioz Stars, 2022-12
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    90
    Alomone Labs anti kir4 1 kcnj10 antibody
    Expression of EYFP in the rNST and taste buds of a GAD65-ChR2/EYFP mouse. A , 20× confocal photomicrograph (single 2-μm Z level) demonstrates EYFP expression throughout the nucleus. B , At higher magnification (60×, digital zoom = 3, single 1-μm z level), EYFP expression is evident in somal membranes (arrows) and the neuropil. Scale bars: 100 μm ( A ) and 10 μm ( B ). White dotted line indicates the approximate border of the nucleus. st, solitary tract; dor, dorsal; med, medial. C , Low-power photomicrographs of native EYFP expression in different taste bud groups: soft palate (SP), nasoincisor ducts (NID), circumvallate (CV), foliate (FOL), and fungiform papillae (FUNGI). These are surface views of the whole tongue from above and the peeled palatal epithelium, viewed from below. In each panel, anterior (ant) is to the right and posterior (post) to the left. Scale bars: 1 mm. Extended Data Figure 1-1 provides functional characterization of these taste bud cells. Immunohistochemistry shows that EYFP/ChR2 taste bud cells in this mouse are mostly Type I cells. Activating them with blue light elicits NST responses dependent on oral <t>P2X3-containing</t> receptors, similar to responses to taste stimuli.
    Anti Kir4 1 Kcnj10 Antibody, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    91
    Alomone Labs kir6 1
    Detection of <t>Kir6.1</t> Immunoreactivity in Mitochondrial Membranes
    Kir6 1, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 91 stars, based on 1 article reviews
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    Image Search Results


    Expression of EYFP in the rNST and taste buds of a GAD65-ChR2/EYFP mouse. A , 20× confocal photomicrograph (single 2-μm Z level) demonstrates EYFP expression throughout the nucleus. B , At higher magnification (60×, digital zoom = 3, single 1-μm z level), EYFP expression is evident in somal membranes (arrows) and the neuropil. Scale bars: 100 μm ( A ) and 10 μm ( B ). White dotted line indicates the approximate border of the nucleus. st, solitary tract; dor, dorsal; med, medial. C , Low-power photomicrographs of native EYFP expression in different taste bud groups: soft palate (SP), nasoincisor ducts (NID), circumvallate (CV), foliate (FOL), and fungiform papillae (FUNGI). These are surface views of the whole tongue from above and the peeled palatal epithelium, viewed from below. In each panel, anterior (ant) is to the right and posterior (post) to the left. Scale bars: 1 mm. Extended Data Figure 1-1 provides functional characterization of these taste bud cells. Immunohistochemistry shows that EYFP/ChR2 taste bud cells in this mouse are mostly Type I cells. Activating them with blue light elicits NST responses dependent on oral P2X3-containing receptors, similar to responses to taste stimuli.

    Journal: eNeuro

    Article Title: Characteristics and Impact of the rNST GABA Network on Neural and Behavioral Taste Responses

    doi: 10.1523/ENEURO.0262-22.2022

    Figure Lengend Snippet: Expression of EYFP in the rNST and taste buds of a GAD65-ChR2/EYFP mouse. A , 20× confocal photomicrograph (single 2-μm Z level) demonstrates EYFP expression throughout the nucleus. B , At higher magnification (60×, digital zoom = 3, single 1-μm z level), EYFP expression is evident in somal membranes (arrows) and the neuropil. Scale bars: 100 μm ( A ) and 10 μm ( B ). White dotted line indicates the approximate border of the nucleus. st, solitary tract; dor, dorsal; med, medial. C , Low-power photomicrographs of native EYFP expression in different taste bud groups: soft palate (SP), nasoincisor ducts (NID), circumvallate (CV), foliate (FOL), and fungiform papillae (FUNGI). These are surface views of the whole tongue from above and the peeled palatal epithelium, viewed from below. In each panel, anterior (ant) is to the right and posterior (post) to the left. Scale bars: 1 mm. Extended Data Figure 1-1 provides functional characterization of these taste bud cells. Immunohistochemistry shows that EYFP/ChR2 taste bud cells in this mouse are mostly Type I cells. Activating them with blue light elicits NST responses dependent on oral P2X3-containing receptors, similar to responses to taste stimuli.

    Article Snippet: Responses are shown prior to (control) and following delivery of a vehicle (polyethylene glycol- PG, 10%) and a P2X3 antagonist (AF353 [Alomone Labs, AF-353], 1 mm dissolved 10% PG, ( ).

    Techniques: Expressing, Functional Assay, Immunohistochemistry

    Detection of Kir6.1 Immunoreactivity in Mitochondrial Membranes

    Journal:

    Article Title: Is Kir6.1 a subunit of mitoKATP?

    doi: 10.1016/j.bbrc.2007.11.154

    Figure Lengend Snippet: Detection of Kir6.1 Immunoreactivity in Mitochondrial Membranes

    Article Snippet: A 51-kDa band was also observed by Suzuki et al. [ ] in rat skeletal muscle and rat liver mitochondria, using a ‘home-grown’ antibody whose antigen corresponds to amino acid residues 375-386 of Kir6.1.

    Techniques:

    Mitochondrial Kir6.1-Immunoreactivity Revealed by a Second Antibody

    Journal:

    Article Title: Is Kir6.1 a subunit of mitoKATP?

    doi: 10.1016/j.bbrc.2007.11.154

    Figure Lengend Snippet: Mitochondrial Kir6.1-Immunoreactivity Revealed by a Second Antibody

    Article Snippet: A 51-kDa band was also observed by Suzuki et al. [ ] in rat skeletal muscle and rat liver mitochondria, using a ‘home-grown’ antibody whose antigen corresponds to amino acid residues 375-386 of Kir6.1.

    Techniques: