P2x3 Antagonist, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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1) Product Images from "Characteristics and Impact of the rNST GABA Network on Neural and Behavioral Taste Responses"
Article Title: Characteristics and Impact of the rNST GABA Network on Neural and Behavioral Taste Responses
Figure Legend Snippet: Expression of EYFP in the rNST and taste buds of a GAD65-ChR2/EYFP mouse. A , 20× confocal photomicrograph (single 2-μm Z level) demonstrates EYFP expression throughout the nucleus. B , At higher magnification (60×, digital zoom = 3, single 1-μm z level), EYFP expression is evident in somal membranes (arrows) and the neuropil. Scale bars: 100 μm ( A ) and 10 μm ( B ). White dotted line indicates the approximate border of the nucleus. st, solitary tract; dor, dorsal; med, medial. C , Low-power photomicrographs of native EYFP expression in different taste bud groups: soft palate (SP), nasoincisor ducts (NID), circumvallate (CV), foliate (FOL), and fungiform papillae (FUNGI). These are surface views of the whole tongue from above and the peeled palatal epithelium, viewed from below. In each panel, anterior (ant) is to the right and posterior (post) to the left. Scale bars: 1 mm. Extended Data Figure 1-1 provides functional characterization of these taste bud cells. Immunohistochemistry shows that EYFP/ChR2 taste bud cells in this mouse are mostly Type I cells. Activating them with blue light elicits NST responses dependent on oral P2X3-containing receptors, similar to responses to taste stimuli.
Techniques Used: Expressing, Functional Assay, Immunohistochemistry