aminopyridine  (Alomone Labs)


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    Alomone Labs aminopyridine
    Aminopyridine, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 94/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/aminopyridine/product/Alomone Labs
    Average 94 stars, based on 2 article reviews
    Price from $9.99 to $1999.99
    aminopyridine - by Bioz Stars, 2022-12
    94/100 stars

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    Alomone Labs 4 aminopyridine
    4 Aminopyridine, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/4 aminopyridine/product/Alomone Labs
    Average 94 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    4 aminopyridine - by Bioz Stars, 2022-12
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    93
    Alomone Labs ns1643
    <t>NS1643</t> inhibits expression of N-cadherin while augmenting E-cadherin ( A ) Relative expression level of mRNA encoding for N-Cadherin or ( B ) E-cadherin by RT-PCR in HT29, SW480, and FET cells treated with or without NS1643 (50 µM) for 48 h. Data = mean ± SEM; n = 3; * p
    Ns1643, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/ns1643/product/Alomone Labs
    Average 93 stars, based on 1 article reviews
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    NS1643 inhibits expression of N-cadherin while augmenting E-cadherin ( A ) Relative expression level of mRNA encoding for N-Cadherin or ( B ) E-cadherin by RT-PCR in HT29, SW480, and FET cells treated with or without NS1643 (50 µM) for 48 h. Data = mean ± SEM; n = 3; * p

    Journal: Cancers

    Article Title: Molecular Activation of the Kv11.1 Channel Reprograms EMT in Colon Cancer by Inhibiting TGFβ Signaling via Activation of Calcineurin

    doi: 10.3390/cancers13236025

    Figure Lengend Snippet: NS1643 inhibits expression of N-cadherin while augmenting E-cadherin ( A ) Relative expression level of mRNA encoding for N-Cadherin or ( B ) E-cadherin by RT-PCR in HT29, SW480, and FET cells treated with or without NS1643 (50 µM) for 48 h. Data = mean ± SEM; n = 3; * p

    Article Snippet: E4031 and NS1643 were purchased from Alomone Labs (Jerusalem, Israel).

    Techniques: Expressing, Reverse Transcription Polymerase Chain Reaction

    NS1643 inhibits migration. ( A ) Western blot analysis showing expression of Kv11.1 in HT29, SW480, and FET colon cancer cell lines. For the original Western blots, see Supplementary Figure S1 . ( B ) Representative Kv11.1 current in control HT29 cells in the presence of DMSO (control), NS1643 (activator; 50 µM) alone, or NS1643 + E4031 (blocker; 5 µM), with the voltage protocol shown. ( C ) Representative diary plot depicting the Kv11.1 peak currents (at −100 mV) as a function of time in HT29 cells before and after application of NS1643 alone or in combination with E4031. ( D ) Wound-healing assay with HT29, SW480, or FET cells treated with DMSO or 50 µM NS1643 for 16 h. ( E ) Quantification of the experiments in ( D ). Error bars indicate the standard error of the mean ( n = 3; * p

    Journal: Cancers

    Article Title: Molecular Activation of the Kv11.1 Channel Reprograms EMT in Colon Cancer by Inhibiting TGFβ Signaling via Activation of Calcineurin

    doi: 10.3390/cancers13236025

    Figure Lengend Snippet: NS1643 inhibits migration. ( A ) Western blot analysis showing expression of Kv11.1 in HT29, SW480, and FET colon cancer cell lines. For the original Western blots, see Supplementary Figure S1 . ( B ) Representative Kv11.1 current in control HT29 cells in the presence of DMSO (control), NS1643 (activator; 50 µM) alone, or NS1643 + E4031 (blocker; 5 µM), with the voltage protocol shown. ( C ) Representative diary plot depicting the Kv11.1 peak currents (at −100 mV) as a function of time in HT29 cells before and after application of NS1643 alone or in combination with E4031. ( D ) Wound-healing assay with HT29, SW480, or FET cells treated with DMSO or 50 µM NS1643 for 16 h. ( E ) Quantification of the experiments in ( D ). Error bars indicate the standard error of the mean ( n = 3; * p

    Article Snippet: E4031 and NS1643 were purchased from Alomone Labs (Jerusalem, Israel).

    Techniques: Migration, Western Blot, Expressing, Wound Healing Assay

    NS1643 inhibits TGFβ signaling via activation of calcineurin. ( A ) Western blots showing the expression level of phosphorylated smad2/3 and total smad2/3 in HT29 cells treated with DMSO, NS1643 (50 µM) alone, EDTA (10 mM) alone, or NS1643 + EDTA for 2 h. Bar graphs indicate quantification of the experiments in ( A ). Data = mean ± SEM; n = 3; ** p

    Journal: Cancers

    Article Title: Molecular Activation of the Kv11.1 Channel Reprograms EMT in Colon Cancer by Inhibiting TGFβ Signaling via Activation of Calcineurin

    doi: 10.3390/cancers13236025

    Figure Lengend Snippet: NS1643 inhibits TGFβ signaling via activation of calcineurin. ( A ) Western blots showing the expression level of phosphorylated smad2/3 and total smad2/3 in HT29 cells treated with DMSO, NS1643 (50 µM) alone, EDTA (10 mM) alone, or NS1643 + EDTA for 2 h. Bar graphs indicate quantification of the experiments in ( A ). Data = mean ± SEM; n = 3; ** p

    Article Snippet: E4031 and NS1643 were purchased from Alomone Labs (Jerusalem, Israel).

    Techniques: Activation Assay, Western Blot, Expressing

    NS1643 abolishes the TGFβ1 effects on R-SMADs phosphorylation and EMT markers ( A ) Western blot showing expression of phosphorylated smad2/3 (P-Smad2/3) in HT29 cells treated for different times as indicated with NS1643 (50 µM) alone, TGFβ1 (2 ng/mL), or NS1643 and TGFβ1. Cells were in a serum-deprived medium for 16 h before application of drugs. Bar graphs indicate quantification of the experiments in ( A ) at the time point of 2 h. Data = mean ± SEM; n = 3; * p

    Journal: Cancers

    Article Title: Molecular Activation of the Kv11.1 Channel Reprograms EMT in Colon Cancer by Inhibiting TGFβ Signaling via Activation of Calcineurin

    doi: 10.3390/cancers13236025

    Figure Lengend Snippet: NS1643 abolishes the TGFβ1 effects on R-SMADs phosphorylation and EMT markers ( A ) Western blot showing expression of phosphorylated smad2/3 (P-Smad2/3) in HT29 cells treated for different times as indicated with NS1643 (50 µM) alone, TGFβ1 (2 ng/mL), or NS1643 and TGFβ1. Cells were in a serum-deprived medium for 16 h before application of drugs. Bar graphs indicate quantification of the experiments in ( A ) at the time point of 2 h. Data = mean ± SEM; n = 3; * p

    Article Snippet: E4031 and NS1643 were purchased from Alomone Labs (Jerusalem, Israel).

    Techniques: Western Blot, Expressing

    PP2B-γ Mediates the Inhibitory Effect of NS1643 on TGFβ Signaling. ( A ) Kaplan–Meier plots of overall survival in colon cancer patients with high (pink) and low (blue) expression of PPP3CA, ( B ) PPP3CB, or ( C ) PPP3CC. Side panel indicate the fragments per kilobase of transcript per million (FPKM) mapped reads. ( D ) Survival analysis of PPP3CA, PPP3CB, or PPP3CC gene expression in colorectal cancer patients. ( E ) Western blot showing the expression level of PP2B and E-cadherin at different time after that cells were transfected with si-RNA targeting PPP3CC. For the original Western blots, see Supplementary Figure S1 .

    Journal: Cancers

    Article Title: Molecular Activation of the Kv11.1 Channel Reprograms EMT in Colon Cancer by Inhibiting TGFβ Signaling via Activation of Calcineurin

    doi: 10.3390/cancers13236025

    Figure Lengend Snippet: PP2B-γ Mediates the Inhibitory Effect of NS1643 on TGFβ Signaling. ( A ) Kaplan–Meier plots of overall survival in colon cancer patients with high (pink) and low (blue) expression of PPP3CA, ( B ) PPP3CB, or ( C ) PPP3CC. Side panel indicate the fragments per kilobase of transcript per million (FPKM) mapped reads. ( D ) Survival analysis of PPP3CA, PPP3CB, or PPP3CC gene expression in colorectal cancer patients. ( E ) Western blot showing the expression level of PP2B and E-cadherin at different time after that cells were transfected with si-RNA targeting PPP3CC. For the original Western blots, see Supplementary Figure S1 .

    Article Snippet: E4031 and NS1643 were purchased from Alomone Labs (Jerusalem, Israel).

    Techniques: Expressing, Western Blot, Transfection

    NS1643 inhibits expression of EMT markers. ( A ) Relative expression level of mRNA encoding for the EMT markers (SNAIL, SLUG, TWIST, and ZEB1) by RT-PCR in HT29, SW480, and FET cells treated with or without NS1643 (50 µM) for 48 h. Data = mean ± SEM; n = 3; * p

    Journal: Cancers

    Article Title: Molecular Activation of the Kv11.1 Channel Reprograms EMT in Colon Cancer by Inhibiting TGFβ Signaling via Activation of Calcineurin

    doi: 10.3390/cancers13236025

    Figure Lengend Snippet: NS1643 inhibits expression of EMT markers. ( A ) Relative expression level of mRNA encoding for the EMT markers (SNAIL, SLUG, TWIST, and ZEB1) by RT-PCR in HT29, SW480, and FET cells treated with or without NS1643 (50 µM) for 48 h. Data = mean ± SEM; n = 3; * p

    Article Snippet: E4031 and NS1643 were purchased from Alomone Labs (Jerusalem, Israel).

    Techniques: Expressing, Reverse Transcription Polymerase Chain Reaction

    NS1643 inhibits R-SMADs phosphorylation ( A ) Western blot showing expression of phosphorylated SMAD2 (P-Smad2) in HT29, ( B ) SW480, or ( C ) FET colon cancer cell lines treated for different times, as indicated with NS1643 (50 µM). Cells were kept in full medium. Bar graph indicates quantification. Data = mean ± SEM; n = 3; * p

    Journal: Cancers

    Article Title: Molecular Activation of the Kv11.1 Channel Reprograms EMT in Colon Cancer by Inhibiting TGFβ Signaling via Activation of Calcineurin

    doi: 10.3390/cancers13236025

    Figure Lengend Snippet: NS1643 inhibits R-SMADs phosphorylation ( A ) Western blot showing expression of phosphorylated SMAD2 (P-Smad2) in HT29, ( B ) SW480, or ( C ) FET colon cancer cell lines treated for different times, as indicated with NS1643 (50 µM). Cells were kept in full medium. Bar graph indicates quantification. Data = mean ± SEM; n = 3; * p

    Article Snippet: E4031 and NS1643 were purchased from Alomone Labs (Jerusalem, Israel).

    Techniques: Western Blot, Expressing