tei 9647 medchemexpress  (MedChemExpress)


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    MedChemExpress tei 9647 medchemexpress
    Tei 9647 Medchemexpress, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Teijin Pharma tei 9647
    Tei 9647, supplied by Teijin Pharma, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Springer Science+Business Media LLC s10459 015 9648 3
    S10459 015 9648 3, supplied by Springer Science+Business Media LLC, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    GlpBio Technology Inc vdr inhibitor tei 9647
    Inhibition of VDR regulates inflammation and apoptosis through the MEK1/2-ERK1/2 pathway in BEAS-2B cells exposed to hyperoxia. ( A ) The RT-qPCR detected repression of IL-6, IFN-γ, and TNF-α mRNA levels in the BPD+VitD group in relation to the BPD group, which were further repressed with the addition of the VDR inhibitor <t>TEI-9647.</t> ( B and C ) Proportions of living and apoptotic cells were detected by flow cytometry analysis. The percentage of surviving cells is shown in the lower left quadrant (K3), early apoptotic cells are shown in the lower right quadrant (K4), and late apoptotic cells are shown in the upper right quadrant (K2). The apoptotic cell rate (K2+K4) decreased in the BPD+VitD group and increased with the addition of the inhibitor TEI-9647. Ten thousand cells were analyzed in each sample. ( D – F ) Western blot detected MEK1/2 and ERK1/2 phosphorylation inhibition in the BPD+VitD group, which were reversed by TEI-9647 treatment. Graphs show the quantitative analysis of the protein expression levels in the five groups. Western blot densitometric values were normalized to GAPDH. Results shown were observed in at least three independent experiments. N (Number of samples per group) = 10. *p < 0.05; **p < 0.01, ***p < 0.001, ****p < 0.0001.
    Vdr Inhibitor Tei 9647, supplied by GlpBio Technology Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    1) Product Images from "Vitamin D Ameliorates Apoptosis and Inflammation by Targeting the Mitochondrial and MEK1/2-ERK1/2 Pathways in Hyperoxia-Induced Bronchopulmonary Dysplasia"

    Article Title: Vitamin D Ameliorates Apoptosis and Inflammation by Targeting the Mitochondrial and MEK1/2-ERK1/2 Pathways in Hyperoxia-Induced Bronchopulmonary Dysplasia

    Journal: Journal of Inflammation Research

    doi: 10.2147/JIR.S371906

    Inhibition of VDR regulates inflammation and apoptosis through the MEK1/2-ERK1/2 pathway in BEAS-2B cells exposed to hyperoxia. ( A ) The RT-qPCR detected repression of IL-6, IFN-γ, and TNF-α mRNA levels in the BPD+VitD group in relation to the BPD group, which were further repressed with the addition of the VDR inhibitor TEI-9647. ( B and C ) Proportions of living and apoptotic cells were detected by flow cytometry analysis. The percentage of surviving cells is shown in the lower left quadrant (K3), early apoptotic cells are shown in the lower right quadrant (K4), and late apoptotic cells are shown in the upper right quadrant (K2). The apoptotic cell rate (K2+K4) decreased in the BPD+VitD group and increased with the addition of the inhibitor TEI-9647. Ten thousand cells were analyzed in each sample. ( D – F ) Western blot detected MEK1/2 and ERK1/2 phosphorylation inhibition in the BPD+VitD group, which were reversed by TEI-9647 treatment. Graphs show the quantitative analysis of the protein expression levels in the five groups. Western blot densitometric values were normalized to GAPDH. Results shown were observed in at least three independent experiments. N (Number of samples per group) = 10. *p < 0.05; **p < 0.01, ***p < 0.001, ****p < 0.0001.
    Figure Legend Snippet: Inhibition of VDR regulates inflammation and apoptosis through the MEK1/2-ERK1/2 pathway in BEAS-2B cells exposed to hyperoxia. ( A ) The RT-qPCR detected repression of IL-6, IFN-γ, and TNF-α mRNA levels in the BPD+VitD group in relation to the BPD group, which were further repressed with the addition of the VDR inhibitor TEI-9647. ( B and C ) Proportions of living and apoptotic cells were detected by flow cytometry analysis. The percentage of surviving cells is shown in the lower left quadrant (K3), early apoptotic cells are shown in the lower right quadrant (K4), and late apoptotic cells are shown in the upper right quadrant (K2). The apoptotic cell rate (K2+K4) decreased in the BPD+VitD group and increased with the addition of the inhibitor TEI-9647. Ten thousand cells were analyzed in each sample. ( D – F ) Western blot detected MEK1/2 and ERK1/2 phosphorylation inhibition in the BPD+VitD group, which were reversed by TEI-9647 treatment. Graphs show the quantitative analysis of the protein expression levels in the five groups. Western blot densitometric values were normalized to GAPDH. Results shown were observed in at least three independent experiments. N (Number of samples per group) = 10. *p < 0.05; **p < 0.01, ***p < 0.001, ****p < 0.0001.

    Techniques Used: Inhibition, Quantitative RT-PCR, Flow Cytometry, Western Blot, Expressing


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    Teijin Pharma tei 9647
    Tei 9647, supplied by Teijin Pharma, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Tei 9647, supplied by Amgen, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Amgen tei 9647
    Tei 9647, supplied by Amgen, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 86 stars, based on 1 article reviews
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    Amgen tei 9647
    Tei 9647, supplied by Amgen, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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