Review



il 1β  (Chondrex Inc)


Bioz Verified Symbol Chondrex Inc is a verified supplier
Bioz Manufacturer Symbol Chondrex Inc manufactures this product  
  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
  • 92

    Structured Review

    Chondrex Inc il 1β
    ELVN-34 reduce the expression of pro-inflammatory cytokines, chemokines and cell adhesion molecule in HNEpC challenged with LPS or poly(I:C). HNEpC challenged with LPS or poly(I:C) (30 μg/mL) display enhanced production of pro-inflammatory cytokines and chemokines <t>IL-6,</t> <t>IL-1β,</t> IL-8/CXCL8, CCL2/MCP-1, CXCL1/KC/GRO, VEGF, and cell adhesion molecule ICAM1(CD54) compared to non-treated cells. This increase in the production of pro-inflammatory molecules is abrogated by the addition of ELVN-34 (500 nM) 30 min post-challenge. LPS and poly(I:C) induce a reduction of anti-inflammatory IL-10 expression in HNEpC that is restored to normal levels after treatment with ELVN-34 (500 nM). The results showed the averages of three independent experiments. (**** p < 0.0001, NS—not significant).
    Il 1β, supplied by Chondrex Inc, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/il 1β/product/Chondrex Inc
    Average 92 stars, based on 1 article reviews
    il 1β - by Bioz Stars, 2025-02
    92/100 stars

    Images

    1) Product Images from "Elovanoids Counteract Inflammatory Signaling, Autophagy, Endoplasmic Reticulum Stress, and Senescence Gene Programming in Human Nasal Epithelial Cells Exposed to Allergens"

    Article Title: Elovanoids Counteract Inflammatory Signaling, Autophagy, Endoplasmic Reticulum Stress, and Senescence Gene Programming in Human Nasal Epithelial Cells Exposed to Allergens

    Journal: Pharmaceutics

    doi: 10.3390/pharmaceutics14010113

    ELVN-34 reduce the expression of pro-inflammatory cytokines, chemokines and cell adhesion molecule in HNEpC challenged with LPS or poly(I:C). HNEpC challenged with LPS or poly(I:C) (30 μg/mL) display enhanced production of pro-inflammatory cytokines and chemokines IL-6, IL-1β, IL-8/CXCL8, CCL2/MCP-1, CXCL1/KC/GRO, VEGF, and cell adhesion molecule ICAM1(CD54) compared to non-treated cells. This increase in the production of pro-inflammatory molecules is abrogated by the addition of ELVN-34 (500 nM) 30 min post-challenge. LPS and poly(I:C) induce a reduction of anti-inflammatory IL-10 expression in HNEpC that is restored to normal levels after treatment with ELVN-34 (500 nM). The results showed the averages of three independent experiments. (**** p < 0.0001, NS—not significant).
    Figure Legend Snippet: ELVN-34 reduce the expression of pro-inflammatory cytokines, chemokines and cell adhesion molecule in HNEpC challenged with LPS or poly(I:C). HNEpC challenged with LPS or poly(I:C) (30 μg/mL) display enhanced production of pro-inflammatory cytokines and chemokines IL-6, IL-1β, IL-8/CXCL8, CCL2/MCP-1, CXCL1/KC/GRO, VEGF, and cell adhesion molecule ICAM1(CD54) compared to non-treated cells. This increase in the production of pro-inflammatory molecules is abrogated by the addition of ELVN-34 (500 nM) 30 min post-challenge. LPS and poly(I:C) induce a reduction of anti-inflammatory IL-10 expression in HNEpC that is restored to normal levels after treatment with ELVN-34 (500 nM). The results showed the averages of three independent experiments. (**** p < 0.0001, NS—not significant).

    Techniques Used: Expressing

    HDM triggered multiple signaling in HNEpC. HNEpC challenged with HDM ( D. farinae + D. pteronyssinus ) (30 μg/mL) induces the expression of several genes related with autophagy (ATG3, ATG5, ATG7, BECLIN-1, and P62), unfolded protein response (UPR) (ATF6, CHOP, and IRE1), and matrix metalloproteinases (MMPs) (MMP8, MMP2, MMP9, MMP3, MMP12, TIMP1, and TIMP2). HDM stressors also induce the expression of senescence (P21, P16, P27, and P53) and inflammation genes (IL-1α, IL-6, and IL-1β) on HNEpC. The treatment with ELVN-34 Na (500 nM) reduces the expression of autophagy, UPR, MMP, senescence (except P53), and inflammation genes induced by HDM extracts. The results showed the averages of three independent experiments. (**** p < 0.0001, NS—not significant).
    Figure Legend Snippet: HDM triggered multiple signaling in HNEpC. HNEpC challenged with HDM ( D. farinae + D. pteronyssinus ) (30 μg/mL) induces the expression of several genes related with autophagy (ATG3, ATG5, ATG7, BECLIN-1, and P62), unfolded protein response (UPR) (ATF6, CHOP, and IRE1), and matrix metalloproteinases (MMPs) (MMP8, MMP2, MMP9, MMP3, MMP12, TIMP1, and TIMP2). HDM stressors also induce the expression of senescence (P21, P16, P27, and P53) and inflammation genes (IL-1α, IL-6, and IL-1β) on HNEpC. The treatment with ELVN-34 Na (500 nM) reduces the expression of autophagy, UPR, MMP, senescence (except P53), and inflammation genes induced by HDM extracts. The results showed the averages of three independent experiments. (**** p < 0.0001, NS—not significant).

    Techniques Used: Expressing



    Similar Products

    92
    Chondrex Inc il 1β
    ELVN-34 reduce the expression of pro-inflammatory cytokines, chemokines and cell adhesion molecule in HNEpC challenged with LPS or poly(I:C). HNEpC challenged with LPS or poly(I:C) (30 μg/mL) display enhanced production of pro-inflammatory cytokines and chemokines <t>IL-6,</t> <t>IL-1β,</t> IL-8/CXCL8, CCL2/MCP-1, CXCL1/KC/GRO, VEGF, and cell adhesion molecule ICAM1(CD54) compared to non-treated cells. This increase in the production of pro-inflammatory molecules is abrogated by the addition of ELVN-34 (500 nM) 30 min post-challenge. LPS and poly(I:C) induce a reduction of anti-inflammatory IL-10 expression in HNEpC that is restored to normal levels after treatment with ELVN-34 (500 nM). The results showed the averages of three independent experiments. (**** p < 0.0001, NS—not significant).
    Il 1β, supplied by Chondrex Inc, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/il 1β/product/Chondrex Inc
    Average 92 stars, based on 1 article reviews
    il 1β - by Bioz Stars, 2025-02
    92/100 stars
      Buy from Supplier

    86
    Millipore te buffer omnipur millipore 6805
    ELVN-34 reduce the expression of pro-inflammatory cytokines, chemokines and cell adhesion molecule in HNEpC challenged with LPS or poly(I:C). HNEpC challenged with LPS or poly(I:C) (30 μg/mL) display enhanced production of pro-inflammatory cytokines and chemokines <t>IL-6,</t> <t>IL-1β,</t> IL-8/CXCL8, CCL2/MCP-1, CXCL1/KC/GRO, VEGF, and cell adhesion molecule ICAM1(CD54) compared to non-treated cells. This increase in the production of pro-inflammatory molecules is abrogated by the addition of ELVN-34 (500 nM) 30 min post-challenge. LPS and poly(I:C) induce a reduction of anti-inflammatory IL-10 expression in HNEpC that is restored to normal levels after treatment with ELVN-34 (500 nM). The results showed the averages of three independent experiments. (**** p < 0.0001, NS—not significant).
    Te Buffer Omnipur Millipore 6805, supplied by Millipore, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/te buffer omnipur millipore 6805/product/Millipore
    Average 86 stars, based on 1 article reviews
    te buffer omnipur millipore 6805 - by Bioz Stars, 2025-02
    86/100 stars
      Buy from Supplier

    86
    BioMimetic Therapeutics mezzovico vira 6805
    ELVN-34 reduce the expression of pro-inflammatory cytokines, chemokines and cell adhesion molecule in HNEpC challenged with LPS or poly(I:C). HNEpC challenged with LPS or poly(I:C) (30 μg/mL) display enhanced production of pro-inflammatory cytokines and chemokines <t>IL-6,</t> <t>IL-1β,</t> IL-8/CXCL8, CCL2/MCP-1, CXCL1/KC/GRO, VEGF, and cell adhesion molecule ICAM1(CD54) compared to non-treated cells. This increase in the production of pro-inflammatory molecules is abrogated by the addition of ELVN-34 (500 nM) 30 min post-challenge. LPS and poly(I:C) induce a reduction of anti-inflammatory IL-10 expression in HNEpC that is restored to normal levels after treatment with ELVN-34 (500 nM). The results showed the averages of three independent experiments. (**** p < 0.0001, NS—not significant).
    Mezzovico Vira 6805, supplied by BioMimetic Therapeutics, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/mezzovico vira 6805/product/BioMimetic Therapeutics
    Average 86 stars, based on 1 article reviews
    mezzovico vira 6805 - by Bioz Stars, 2025-02
    86/100 stars
      Buy from Supplier

    86
    BYK Gardner gardner 6805 photoelectric colorimeter
    ELVN-34 reduce the expression of pro-inflammatory cytokines, chemokines and cell adhesion molecule in HNEpC challenged with LPS or poly(I:C). HNEpC challenged with LPS or poly(I:C) (30 μg/mL) display enhanced production of pro-inflammatory cytokines and chemokines <t>IL-6,</t> <t>IL-1β,</t> IL-8/CXCL8, CCL2/MCP-1, CXCL1/KC/GRO, VEGF, and cell adhesion molecule ICAM1(CD54) compared to non-treated cells. This increase in the production of pro-inflammatory molecules is abrogated by the addition of ELVN-34 (500 nM) 30 min post-challenge. LPS and poly(I:C) induce a reduction of anti-inflammatory IL-10 expression in HNEpC that is restored to normal levels after treatment with ELVN-34 (500 nM). The results showed the averages of three independent experiments. (**** p < 0.0001, NS—not significant).
    Gardner 6805 Photoelectric Colorimeter, supplied by BYK Gardner, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/gardner 6805 photoelectric colorimeter/product/BYK Gardner
    Average 86 stars, based on 1 article reviews
    gardner 6805 photoelectric colorimeter - by Bioz Stars, 2025-02
    86/100 stars
      Buy from Supplier

    86
    Thermo Fisher iec 6805
    Conjugation experiments using M. avium 88.3 as the donor strain.
    Iec 6805, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/iec 6805/product/Thermo Fisher
    Average 86 stars, based on 1 article reviews
    iec 6805 - by Bioz Stars, 2025-02
    86/100 stars
      Buy from Supplier

    86
    Shanghai Huayi Company Ltd g 6805 electroacupuncture device
    Conjugation experiments using M. avium 88.3 as the donor strain.
    G 6805 Electroacupuncture Device, supplied by Shanghai Huayi Company Ltd, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/g 6805 electroacupuncture device/product/Shanghai Huayi Company Ltd
    Average 86 stars, based on 1 article reviews
    g 6805 electroacupuncture device - by Bioz Stars, 2025-02
    86/100 stars
      Buy from Supplier

    86
    Millipore 6805 41 0 mecamylamine sigma
    Conjugation experiments using M. avium 88.3 as the donor strain.
    6805 41 0 Mecamylamine Sigma, supplied by Millipore, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/6805 41 0 mecamylamine sigma/product/Millipore
    Average 86 stars, based on 1 article reviews
    6805 41 0 mecamylamine sigma - by Bioz Stars, 2025-02
    86/100 stars
      Buy from Supplier

    86
    Qingdao Xinsheng Heat Energy Equipment Co Ltd g 6805 electric acupuncture apparatus
    Conjugation experiments using M. avium 88.3 as the donor strain.
    G 6805 Electric Acupuncture Apparatus, supplied by Qingdao Xinsheng Heat Energy Equipment Co Ltd, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/g 6805 electric acupuncture apparatus/product/Qingdao Xinsheng Heat Energy Equipment Co Ltd
    Average 86 stars, based on 1 article reviews
    g 6805 electric acupuncture apparatus - by Bioz Stars, 2025-02
    86/100 stars
      Buy from Supplier

    Image Search Results


    ELVN-34 reduce the expression of pro-inflammatory cytokines, chemokines and cell adhesion molecule in HNEpC challenged with LPS or poly(I:C). HNEpC challenged with LPS or poly(I:C) (30 μg/mL) display enhanced production of pro-inflammatory cytokines and chemokines IL-6, IL-1β, IL-8/CXCL8, CCL2/MCP-1, CXCL1/KC/GRO, VEGF, and cell adhesion molecule ICAM1(CD54) compared to non-treated cells. This increase in the production of pro-inflammatory molecules is abrogated by the addition of ELVN-34 (500 nM) 30 min post-challenge. LPS and poly(I:C) induce a reduction of anti-inflammatory IL-10 expression in HNEpC that is restored to normal levels after treatment with ELVN-34 (500 nM). The results showed the averages of three independent experiments. (**** p < 0.0001, NS—not significant).

    Journal: Pharmaceutics

    Article Title: Elovanoids Counteract Inflammatory Signaling, Autophagy, Endoplasmic Reticulum Stress, and Senescence Gene Programming in Human Nasal Epithelial Cells Exposed to Allergens

    doi: 10.3390/pharmaceutics14010113

    Figure Lengend Snippet: ELVN-34 reduce the expression of pro-inflammatory cytokines, chemokines and cell adhesion molecule in HNEpC challenged with LPS or poly(I:C). HNEpC challenged with LPS or poly(I:C) (30 μg/mL) display enhanced production of pro-inflammatory cytokines and chemokines IL-6, IL-1β, IL-8/CXCL8, CCL2/MCP-1, CXCL1/KC/GRO, VEGF, and cell adhesion molecule ICAM1(CD54) compared to non-treated cells. This increase in the production of pro-inflammatory molecules is abrogated by the addition of ELVN-34 (500 nM) 30 min post-challenge. LPS and poly(I:C) induce a reduction of anti-inflammatory IL-10 expression in HNEpC that is restored to normal levels after treatment with ELVN-34 (500 nM). The results showed the averages of three independent experiments. (**** p < 0.0001, NS—not significant).

    Article Snippet: In addition, the expression of the following cytokines was analyzed in the supernatant of HNEpC exposed to different allergic inductors: IL-6 (Catalog# 6802, Chondrex) range of detection: (9–600 pg/mL), IL-1β (Catalog# 6805, Chondrex) range of detection: (4–250 pg/mL) IL-8/CXCL8 (Quantikine ELISA Kit, Catalog# D8000C, R&D Systems) range of detection: (31–2000 pg/mL), vascular endothelial growth factor (VEGF) (Catalog# 6810, Chondrex) range of detection: (31–2000 pg/mL), ICAM1(CD54) (ELISA Kit, Catalog# ab100640, Abcam) range of detection: (16–1000 pg/mL), CXCL1/KC/GRO (Catalog# 6825, Chondrex) range of detection: CCL2/MCP-1 (Catalog# 6821, Chondrex) range of detection: (16–1000 pg/mL), and IL-10 (Catalog# 6806, Chondrex) range of detection: (8–500 pg/mL).

    Techniques: Expressing

    HDM triggered multiple signaling in HNEpC. HNEpC challenged with HDM ( D. farinae + D. pteronyssinus ) (30 μg/mL) induces the expression of several genes related with autophagy (ATG3, ATG5, ATG7, BECLIN-1, and P62), unfolded protein response (UPR) (ATF6, CHOP, and IRE1), and matrix metalloproteinases (MMPs) (MMP8, MMP2, MMP9, MMP3, MMP12, TIMP1, and TIMP2). HDM stressors also induce the expression of senescence (P21, P16, P27, and P53) and inflammation genes (IL-1α, IL-6, and IL-1β) on HNEpC. The treatment with ELVN-34 Na (500 nM) reduces the expression of autophagy, UPR, MMP, senescence (except P53), and inflammation genes induced by HDM extracts. The results showed the averages of three independent experiments. (**** p < 0.0001, NS—not significant).

    Journal: Pharmaceutics

    Article Title: Elovanoids Counteract Inflammatory Signaling, Autophagy, Endoplasmic Reticulum Stress, and Senescence Gene Programming in Human Nasal Epithelial Cells Exposed to Allergens

    doi: 10.3390/pharmaceutics14010113

    Figure Lengend Snippet: HDM triggered multiple signaling in HNEpC. HNEpC challenged with HDM ( D. farinae + D. pteronyssinus ) (30 μg/mL) induces the expression of several genes related with autophagy (ATG3, ATG5, ATG7, BECLIN-1, and P62), unfolded protein response (UPR) (ATF6, CHOP, and IRE1), and matrix metalloproteinases (MMPs) (MMP8, MMP2, MMP9, MMP3, MMP12, TIMP1, and TIMP2). HDM stressors also induce the expression of senescence (P21, P16, P27, and P53) and inflammation genes (IL-1α, IL-6, and IL-1β) on HNEpC. The treatment with ELVN-34 Na (500 nM) reduces the expression of autophagy, UPR, MMP, senescence (except P53), and inflammation genes induced by HDM extracts. The results showed the averages of three independent experiments. (**** p < 0.0001, NS—not significant).

    Article Snippet: In addition, the expression of the following cytokines was analyzed in the supernatant of HNEpC exposed to different allergic inductors: IL-6 (Catalog# 6802, Chondrex) range of detection: (9–600 pg/mL), IL-1β (Catalog# 6805, Chondrex) range of detection: (4–250 pg/mL) IL-8/CXCL8 (Quantikine ELISA Kit, Catalog# D8000C, R&D Systems) range of detection: (31–2000 pg/mL), vascular endothelial growth factor (VEGF) (Catalog# 6810, Chondrex) range of detection: (31–2000 pg/mL), ICAM1(CD54) (ELISA Kit, Catalog# ab100640, Abcam) range of detection: (16–1000 pg/mL), CXCL1/KC/GRO (Catalog# 6825, Chondrex) range of detection: CCL2/MCP-1 (Catalog# 6821, Chondrex) range of detection: (16–1000 pg/mL), and IL-10 (Catalog# 6806, Chondrex) range of detection: (8–500 pg/mL).

    Techniques: Expressing

    Conjugation experiments using M. avium 88.3 as the donor strain.

    Journal: PLoS ONE

    Article Title: First Description of Natural and Experimental Conjugation between Mycobacteria Mediated by a Linear Plasmid

    doi: 10.1371/journal.pone.0029884

    Figure Lengend Snippet: Conjugation experiments using M. avium 88.3 as the donor strain.

    Article Snippet: Two M. kansasii clinical isolates, IAL 413 and IEC 6805, Mycobacterium smegmatis mc 2 155, Mycobacterium bovis BCG Moreau and Escherichia coli DH5α (Life Technologies Co., Carlsbad, CA) were used in this study ( ).

    Techniques: Conjugation Assay

    (A) PFGE with undigested DNA; (B) Southern blot of PFGE gels with undigested DNA and hybridization with IS 1245 -derived probe; (C) PFGE-DraI; (D) Southern blot of PFGE-DraI gels and hybridization with pMA100-derived probe. Open arrows indicate the linear plasmid pMA100. 1: M. avium 88.3; 2: M. kansasii 88.6; 3: M. kansasii IAL 413; 4: M. kansasii IEC 6805; 5: M. bovis BCG Moreau; W: wild-type colony; T: transconjugant colony.

    Journal: PLoS ONE

    Article Title: First Description of Natural and Experimental Conjugation between Mycobacteria Mediated by a Linear Plasmid

    doi: 10.1371/journal.pone.0029884

    Figure Lengend Snippet: (A) PFGE with undigested DNA; (B) Southern blot of PFGE gels with undigested DNA and hybridization with IS 1245 -derived probe; (C) PFGE-DraI; (D) Southern blot of PFGE-DraI gels and hybridization with pMA100-derived probe. Open arrows indicate the linear plasmid pMA100. 1: M. avium 88.3; 2: M. kansasii 88.6; 3: M. kansasii IAL 413; 4: M. kansasii IEC 6805; 5: M. bovis BCG Moreau; W: wild-type colony; T: transconjugant colony.

    Article Snippet: Two M. kansasii clinical isolates, IAL 413 and IEC 6805, Mycobacterium smegmatis mc 2 155, Mycobacterium bovis BCG Moreau and Escherichia coli DH5α (Life Technologies Co., Carlsbad, CA) were used in this study ( ).

    Techniques: Southern Blot, Hybridization, Derivative Assay, Plasmid Preparation

    Clinical isolates and strains used in this study.

    Journal: PLoS ONE

    Article Title: First Description of Natural and Experimental Conjugation between Mycobacteria Mediated by a Linear Plasmid

    doi: 10.1371/journal.pone.0029884

    Figure Lengend Snippet: Clinical isolates and strains used in this study.

    Article Snippet: Two M. kansasii clinical isolates, IAL 413 and IEC 6805, Mycobacterium smegmatis mc 2 155, Mycobacterium bovis BCG Moreau and Escherichia coli DH5α (Life Technologies Co., Carlsbad, CA) were used in this study ( ).

    Techniques: