5 amino 1 pentanol  (Millipore)


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  • 95
    Name:
    5 Amino 1 pentanol solution
    Description:
    5 Aminopentan 1 ol is a colorless to faint yellow liquid
    Catalog Number:
    11318
    Price:
    None
    Applications:
    5-amino-1-pentanol is used in the preparation of fibres from random copolypeptides consisting of N-hydroxyalkyl L-glutamine and gamma-methyl L-glutamate with different monomer ratios. 5-amino-1-pentanol (5-Aminopentan-1-ol) was also used in the preparation of 5-phthalimidopentanal and tetracyclic core of the natural compound (+/-)-dibromoagelaspongin.
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    Structured Review

    Millipore 5 amino 1 pentanol
    5 Amino 1 pentanol solution
    5 Aminopentan 1 ol is a colorless to faint yellow liquid
    https://www.bioz.com/result/5 amino 1 pentanol/product/Millipore
    Average 95 stars, based on 2 article reviews
    Price from $9.99 to $1999.99
    5 amino 1 pentanol - by Bioz Stars, 2020-11
    95/100 stars

    Images

    1) Product Images from "Layer-by-layer DNA films incorporating highly transfecting bioreducible poly(amido amine) and polyethylenimine for sequential gene delivery"

    Article Title: Layer-by-layer DNA films incorporating highly transfecting bioreducible poly(amido amine) and polyethylenimine for sequential gene delivery

    Journal: International Journal of Nanomedicine

    doi: 10.2147/IJN.S162353

    The molecular structure of the random copolymer PAA containing APOL (left) and synthesis of dPEI (right). The R group is either R 1 (non-reducible monomer) or R 2 (reducible monomer). Abbreviations: PEI, polyethylenimine; dPEI, degradable polyethylenimine; PAA, poly(amido amine); APOL, 5-amino-1-pentanol.
    Figure Legend Snippet: The molecular structure of the random copolymer PAA containing APOL (left) and synthesis of dPEI (right). The R group is either R 1 (non-reducible monomer) or R 2 (reducible monomer). Abbreviations: PEI, polyethylenimine; dPEI, degradable polyethylenimine; PAA, poly(amido amine); APOL, 5-amino-1-pentanol.

    Techniques Used:

    2) Product Images from "Poly (β-amino esters): Procedures for Synthesis and Gene Delivery"

    Article Title: Poly (β-amino esters): Procedures for Synthesis and Gene Delivery

    Journal: Methods in molecular biology (Clifton, N.J.)

    doi: 10.1007/978-1-59745-429-2_4

    Polymerization of 1,4-butanediol diacrylate and 5-amino-1-pentanol to form gene delivery polymer C32.
    Figure Legend Snippet: Polymerization of 1,4-butanediol diacrylate and 5-amino-1-pentanol to form gene delivery polymer C32.

    Techniques Used:

    3) Product Images from "Layer-by-layer DNA films incorporating highly transfecting bioreducible poly(amido amine) and polyethylenimine for sequential gene delivery"

    Article Title: Layer-by-layer DNA films incorporating highly transfecting bioreducible poly(amido amine) and polyethylenimine for sequential gene delivery

    Journal: International Journal of Nanomedicine

    doi: 10.2147/IJN.S162353

    The molecular structure of the random copolymer PAA containing APOL (left) and synthesis of dPEI (right). The R group is either R 1 (non-reducible monomer) or R 2 (reducible monomer). Abbreviations: PEI, polyethylenimine; dPEI, degradable polyethylenimine; PAA, poly(amido amine); APOL, 5-amino-1-pentanol.
    Figure Legend Snippet: The molecular structure of the random copolymer PAA containing APOL (left) and synthesis of dPEI (right). The R group is either R 1 (non-reducible monomer) or R 2 (reducible monomer). Abbreviations: PEI, polyethylenimine; dPEI, degradable polyethylenimine; PAA, poly(amido amine); APOL, 5-amino-1-pentanol.

    Techniques Used:

    Related Articles

    Luciferase:

    Article Title: Highly Branched Poly(5-amino-1-pentanol-co-1,4-butanediol diacrylate) for High Performance Gene Transfection
    Article Snippet: .. Materials Chemicals 1,4-butanediol diacrylate (C, VWR, Dublin, Ireland, 98%), 5-amino-1-pentanol (32, Sigma, Dublin, 99%), 1,3-diaminopropane (103, Sigma, Dublin, Ireland, 99%), trimethylolpropane triacrylate (Sigma, Dublin, 99%), lithium bromide (LiBr, Sigma, Dublin, Ireland, 99%), solvents dimethyl sulfoxide (DMSO, Sigma, Dublin, Ireland, 99%), dimethylformamide (DMF, Fisher Scientific, Dublin, Ireland, 99%), diethyl ether (Sigma, Dublin, Ireland, 99%), deuterated chloroform (CDCl3 , Sigma, Dublin, Ireland, 99.9%), Hank’s balanced salt solution (HBSS, Sigma, Dublin, Ireland), branched polyethyleneimine (PEI, M w = 25 kDa, Sigma, Dublin, Ireland), SuperFect (Qiagen, Dublin, Ireland), BioLuxTM Gaussia Luciferase Assay Kit (New England Biolabs, Dublin, Ireland) and Alamarblue Assay Kit (Invitrogen, Dublin, Ireland) were used as received. .. Sodium acetate (Sigma, Dublin, Ireland, pH 5.2 ± 0.1, 3 M) was diluted to 0.025 M prior to use.

    Synthesized:

    Article Title: Lipopolyplex potentiates anti-tumor immunity of mRNA-based vaccination
    Article Snippet: .. In the first step, the base polymer was synthesized by mixing 1,4-butanediol diacrylate (Sigma-Aldrich) with 5-amino-1-pentanol (Sigma-Aldrich) at a molar ratio of 1.2:1. ..

    Article Title: Tissue-Specific Gene Delivery via Nanoparticle Coating
    Article Snippet: .. Briefly, acrylate-terminated poly(5-amino-1-pentanol-co-1,4-butanediol diacrylate) (C32), was synthesized by the addition of 5-amino-1-pentanol (Sigma-Aldrich, St. Louis, MO, USA) to 1,4-butanediol diacrylate (Scientific Polymer Products Inc., Ontario, NY, USA) at a 1.2:1 molar ratio of diacrylate monomer to amine monomer. ..

    Alamar Blue Assay:

    Article Title: Highly Branched Poly(5-amino-1-pentanol-co-1,4-butanediol diacrylate) for High Performance Gene Transfection
    Article Snippet: .. Materials Chemicals 1,4-butanediol diacrylate (C, VWR, Dublin, Ireland, 98%), 5-amino-1-pentanol (32, Sigma, Dublin, 99%), 1,3-diaminopropane (103, Sigma, Dublin, Ireland, 99%), trimethylolpropane triacrylate (Sigma, Dublin, 99%), lithium bromide (LiBr, Sigma, Dublin, Ireland, 99%), solvents dimethyl sulfoxide (DMSO, Sigma, Dublin, Ireland, 99%), dimethylformamide (DMF, Fisher Scientific, Dublin, Ireland, 99%), diethyl ether (Sigma, Dublin, Ireland, 99%), deuterated chloroform (CDCl3 , Sigma, Dublin, Ireland, 99.9%), Hank’s balanced salt solution (HBSS, Sigma, Dublin, Ireland), branched polyethyleneimine (PEI, M w = 25 kDa, Sigma, Dublin, Ireland), SuperFect (Qiagen, Dublin, Ireland), BioLuxTM Gaussia Luciferase Assay Kit (New England Biolabs, Dublin, Ireland) and Alamarblue Assay Kit (Invitrogen, Dublin, Ireland) were used as received. .. Sodium acetate (Sigma, Dublin, Ireland, pH 5.2 ± 0.1, 3 M) was diluted to 0.025 M prior to use.

    other:

    Article Title: Highly Integrated Elastic Island-Structured Printed Circuit Board with Controlled Young’s Modulus for Stretchable Electronics
    Article Snippet: First, a solution for the aqueous core of the RMI was prepared by stirring 1.0 mL of ethanol (95%, Samchun Chemical) and 0.1 g of 5-amino-1-pentanol (95%, Sigma-Aldrich, St. Louis, MO, USA) [ ].

    Article Title: Poly (β-amino esters): Procedures for Synthesis and Gene Delivery
    Article Snippet: For synthesis of one lead polymer, poly(5-amino-1-pentanol- co -1,4-butanediol diacrylate) (referred to as C32), 5-amino-1-pentanol (Aldrich) and 1,4-butanediol diacrylate (Scientific Polymer Products, Inc.) are required.

    Molecular Weight:

    Article Title: Layer-by-layer DNA films incorporating highly transfecting bioreducible poly(amido amine) and polyethylenimine for sequential gene delivery
    Article Snippet: .. Materials N,N′-Methylenebisacrylamide (MBA, 99%), dithiothreitol (DTT, 99%), high molecular weight bPEI (weight-average molecular weight [Mw ] ~25,000 Da, ≤1% water), low molecular weight bPEI (Mw ~800 Da), poly(2-hydroxyethyl methacrylate) (poly-HEMA, BioReagent grade), 1,6-hexanediol diacrylate (80%), 5-amino-1-pentanol (APOL, 95%), bovine serum albumin (BSA, heat shock fraction, pH 7, ≥98%), and fibronectin from human plasmid (0.1%) were purchased from Sigma-Aldrich Co. (St Louis, MO, USA). .. N,N′-Cystaminebisacrylamide (CBA, Electro Pure™) was purchased from PolySciences, Inc. (Warrington, PA, USA).

    Article Title: Layer-by-layer DNA films incorporating highly transfecting bioreducible poly(amido amine) and polyethylenimine for sequential gene delivery
    Article Snippet: .. N,N′-Methylenebisacrylamide (MBA, 99%), dithiothreitol (DTT, 99%), high molecular weight bPEI (weight-average molecular weight [Mw ] ~25,000 Da, ≤1% water), low molecular weight bPEI (Mw ~800 Da), poly(2-hydroxyethyl methacrylate) (poly-HEMA, BioReagent grade), 1,6-hexanediol diacrylate (80%), 5-amino-1-pentanol (APOL, 95%), bovine serum albumin (BSA, heat shock fraction, pH 7, ≥98%), and fibronectin from human plasmid (0.1%) were purchased from Sigma-Aldrich Co. (St Louis, MO, USA). .. N,N′-Cystaminebisacrylamide (CBA, Electro Pure™) was purchased from PolySciences, Inc. (Warrington, PA, USA).

    Plasmid Preparation:

    Article Title: Layer-by-layer DNA films incorporating highly transfecting bioreducible poly(amido amine) and polyethylenimine for sequential gene delivery
    Article Snippet: .. Materials N,N′-Methylenebisacrylamide (MBA, 99%), dithiothreitol (DTT, 99%), high molecular weight bPEI (weight-average molecular weight [Mw ] ~25,000 Da, ≤1% water), low molecular weight bPEI (Mw ~800 Da), poly(2-hydroxyethyl methacrylate) (poly-HEMA, BioReagent grade), 1,6-hexanediol diacrylate (80%), 5-amino-1-pentanol (APOL, 95%), bovine serum albumin (BSA, heat shock fraction, pH 7, ≥98%), and fibronectin from human plasmid (0.1%) were purchased from Sigma-Aldrich Co. (St Louis, MO, USA). .. N,N′-Cystaminebisacrylamide (CBA, Electro Pure™) was purchased from PolySciences, Inc. (Warrington, PA, USA).

    Article Title: Layer-by-layer DNA films incorporating highly transfecting bioreducible poly(amido amine) and polyethylenimine for sequential gene delivery
    Article Snippet: .. N,N′-Methylenebisacrylamide (MBA, 99%), dithiothreitol (DTT, 99%), high molecular weight bPEI (weight-average molecular weight [Mw ] ~25,000 Da, ≤1% water), low molecular weight bPEI (Mw ~800 Da), poly(2-hydroxyethyl methacrylate) (poly-HEMA, BioReagent grade), 1,6-hexanediol diacrylate (80%), 5-amino-1-pentanol (APOL, 95%), bovine serum albumin (BSA, heat shock fraction, pH 7, ≥98%), and fibronectin from human plasmid (0.1%) were purchased from Sigma-Aldrich Co. (St Louis, MO, USA). .. N,N′-Cystaminebisacrylamide (CBA, Electro Pure™) was purchased from PolySciences, Inc. (Warrington, PA, USA).

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    Millipore sr 95531
    Suppression following luminance steps. a. Population modulation index (mean ± s.e.m.) of ON (light gray, N = 259) and OFF (dark gray, N = 107) RGCs for probe flashes following luminance steps (blue line). Modulation index for each RGC was based on its average response to 56 or 156 luminance step sequences (Fig. S1b) spanning a contrast range of −0.5 to +0.5 Michelson contrast (Methods). Probe flashes were presented at 17 ms, 33, 50, 100, 250, 500, 1000 and 2000 (baseline) after luminance steps. Probe flash responses were suppressed in both ON and OFF RGCs, with similar time course and recovery as in the saccade paradigm with textures ( Fig. 1e ). Error bars are not visible due to small s.e.m. b. Same as in a , except that the modulation index for each RGC was separately based on average responses to probe flashes after positive-contrast luminance steps (left panel; +0.03 to +0.5 Michelson contrast), and after negative-contrast luminance steps (right panel; −0.03 to −0.5 Michelson contrast). Underlying population data is shown in Fig. S8. c. Same as in b , for a subset of ON RGCs (N = 115) in control conditions (light gray lines) and with GABA A,C and glycine receptors blocked (green lines; cocktail of 5μM <t>SR-95531,</t> 100 μM Picrotoxin and 1μM Strychnine). Hash symbol: significant difference between modulation of ON and OFF RGCs in a or between ON RGCs without and with pharmacological blockers in c (p
    Sr 95531, supplied by Millipore, used in various techniques. Bioz Stars score: 94/100, based on 12 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/sr 95531/product/Millipore
    Average 94 stars, based on 12 article reviews
    Price from $9.99 to $1999.99
    sr 95531 - by Bioz Stars, 2020-11
    94/100 stars
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    94
    Millipore catb inhibitor ca 074
    Suppression following luminance steps. a. Population modulation index (mean ± s.e.m.) of ON (light gray, N = 259) and OFF (dark gray, N = 107) RGCs for probe flashes following luminance steps (blue line). Modulation index for each RGC was based on its average response to 56 or 156 luminance step sequences (Fig. S1b) spanning a contrast range of −0.5 to +0.5 Michelson contrast (Methods). Probe flashes were presented at 17 ms, 33, 50, 100, 250, 500, 1000 and 2000 (baseline) after luminance steps. Probe flash responses were suppressed in both ON and OFF RGCs, with similar time course and recovery as in the saccade paradigm with textures ( Fig. 1e ). Error bars are not visible due to small s.e.m. b. Same as in a , except that the modulation index for each RGC was separately based on average responses to probe flashes after positive-contrast luminance steps (left panel; +0.03 to +0.5 Michelson contrast), and after negative-contrast luminance steps (right panel; −0.03 to −0.5 Michelson contrast). Underlying population data is shown in Fig. S8. c. Same as in b , for a subset of ON RGCs (N = 115) in control conditions (light gray lines) and with GABA A,C and glycine receptors blocked (green lines; cocktail of 5μM <t>SR-95531,</t> 100 μM Picrotoxin and 1μM Strychnine). Hash symbol: significant difference between modulation of ON and OFF RGCs in a or between ON RGCs without and with pharmacological blockers in c (p
    Catb Inhibitor Ca 074, supplied by Millipore, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/catb inhibitor ca 074/product/Millipore
    Average 94 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    catb inhibitor ca 074 - by Bioz Stars, 2020-11
    94/100 stars
      Buy from Supplier

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    Suppression following luminance steps. a. Population modulation index (mean ± s.e.m.) of ON (light gray, N = 259) and OFF (dark gray, N = 107) RGCs for probe flashes following luminance steps (blue line). Modulation index for each RGC was based on its average response to 56 or 156 luminance step sequences (Fig. S1b) spanning a contrast range of −0.5 to +0.5 Michelson contrast (Methods). Probe flashes were presented at 17 ms, 33, 50, 100, 250, 500, 1000 and 2000 (baseline) after luminance steps. Probe flash responses were suppressed in both ON and OFF RGCs, with similar time course and recovery as in the saccade paradigm with textures ( Fig. 1e ). Error bars are not visible due to small s.e.m. b. Same as in a , except that the modulation index for each RGC was separately based on average responses to probe flashes after positive-contrast luminance steps (left panel; +0.03 to +0.5 Michelson contrast), and after negative-contrast luminance steps (right panel; −0.03 to −0.5 Michelson contrast). Underlying population data is shown in Fig. S8. c. Same as in b , for a subset of ON RGCs (N = 115) in control conditions (light gray lines) and with GABA A,C and glycine receptors blocked (green lines; cocktail of 5μM SR-95531, 100 μM Picrotoxin and 1μM Strychnine). Hash symbol: significant difference between modulation of ON and OFF RGCs in a or between ON RGCs without and with pharmacological blockers in c (p

    Journal: bioRxiv

    Article Title: Retinal mechanisms of saccadic suppression and their role in processing sequential stimuli

    doi: 10.1101/2020.08.21.261198

    Figure Lengend Snippet: Suppression following luminance steps. a. Population modulation index (mean ± s.e.m.) of ON (light gray, N = 259) and OFF (dark gray, N = 107) RGCs for probe flashes following luminance steps (blue line). Modulation index for each RGC was based on its average response to 56 or 156 luminance step sequences (Fig. S1b) spanning a contrast range of −0.5 to +0.5 Michelson contrast (Methods). Probe flashes were presented at 17 ms, 33, 50, 100, 250, 500, 1000 and 2000 (baseline) after luminance steps. Probe flash responses were suppressed in both ON and OFF RGCs, with similar time course and recovery as in the saccade paradigm with textures ( Fig. 1e ). Error bars are not visible due to small s.e.m. b. Same as in a , except that the modulation index for each RGC was separately based on average responses to probe flashes after positive-contrast luminance steps (left panel; +0.03 to +0.5 Michelson contrast), and after negative-contrast luminance steps (right panel; −0.03 to −0.5 Michelson contrast). Underlying population data is shown in Fig. S8. c. Same as in b , for a subset of ON RGCs (N = 115) in control conditions (light gray lines) and with GABA A,C and glycine receptors blocked (green lines; cocktail of 5μM SR-95531, 100 μM Picrotoxin and 1μM Strychnine). Hash symbol: significant difference between modulation of ON and OFF RGCs in a or between ON RGCs without and with pharmacological blockers in c (p

    Article Snippet: We first prepared a 1000x stock solution of these pharmacological blockers as follows: SR-95531 was dissolved in water at a concentration of 5 mM; picrotoxin was dissolved in DMSO at a concentration of 100 mM; Strychnine was dissolved in Chloroform at a concentration of 1mM.

    Techniques:

    Spatial origins of retinal saccadic suppression. a. Spatial layout of the visual stimulation paradigm used in experiments to probe the global component of suppression. Saccades were presented either full-field (left; same as in Fig. 1 ) or in the periphery (right), where a 1000 x1000 μm 2 mask (intensity: mean luminance of texture) covered at least 2- σ of the 2D Gaussian fit to the RGC receptive fields (Fig. S5b). b. Population modulation index (mean ± s.e.m.) of ON (top) and OFF (bottom) RGCs for full-field saccades condition (thick gray lines, same as Fig. 1e rightmost panel; N = 68 to 574 RGCs (see Fig. S3 for exact numbers)); periphery saccades condition (thin gray lines; N = 91 ON RGCs, N = 56 OFF RGCs); and periphery saccades condition in the presence of GABA A receptor blocker (5μM SR-95531; green lines; N = 62 ON RGCs, N = 35 OFF RGCs). Blue window shows the timing of the saccade. In these experiments, we used a coarse background texture (300 μm spatial scale). Timing of probe flashes: 50 and 150 (only for full-field saccade), 117, 200, 350, 600 and 2100 ms (baseline) after saccade onset. c.d. Population modulation index (mean ± s.e.m.) of ON (top) and OFF (bottom) RGCs for full-field saccades without any pharmacological agents (gray lines; N = 82 ON RGCs, N = 30 OFF RGCs) and with GABA A,C receptor blockers 5 μM SR-95531 + 100 μM Picrotoxin ( c ; green lines), and for a subset of RGCs where we additionally blocked glycine receptors using 1 μM Strychnine ( d ; green lines; N = 51 ON RGCs, N = 13 OFF RGCs). In these experiments, we used a coarse background texture (150 μm spatial scale). Probe flashes were presented at 117 ms, 150, 200, 350, 600, 1100 and 2100 (baseline) after saccade onset. e . Spatial layout of the visual stimulation paradigm used in experiments to probe local components of suppression. Saccades and flashes were presented in 100 x 100 μm 2 square regions, separated by 100 μm gaps with mean overall luminance. Left: Saccades and flashes were presented in all regions. Right: Saccades and flashes were presented in alternate regions; only cells with receptive fields (RFs) in the non-saccade regions (orange) were analyzed (black ellipse: 1-σ of the 2D Gaussian fit to an example RGC receptive field). Consequently, saccades were excluded from at most ~300 x 300 μm 2 of a cell’s RF center. In these experiments, we used a coarse background texture (150 μm spatial scale). f. Population modulation index (mean ± s.e.m.) of ON (top; N = 32) and OFF (bottom; N = 38) RGCs for saccades and flashes in all regions (thick lines) or saccades excluded from RGC RF center (thin lines). Red arrow indicates significant loss in suppression in ON RGCs for early flashes at 117 and 150 ms upon excluding saccades from RF center (p = 0.0016 and p = 0.002 respectively; two-tailed Wilcoxon rank-sum test). In all panels, hash symbols indicate statistically significant difference between groups (p

    Journal: bioRxiv

    Article Title: Retinal mechanisms of saccadic suppression and their role in processing sequential stimuli

    doi: 10.1101/2020.08.21.261198

    Figure Lengend Snippet: Spatial origins of retinal saccadic suppression. a. Spatial layout of the visual stimulation paradigm used in experiments to probe the global component of suppression. Saccades were presented either full-field (left; same as in Fig. 1 ) or in the periphery (right), where a 1000 x1000 μm 2 mask (intensity: mean luminance of texture) covered at least 2- σ of the 2D Gaussian fit to the RGC receptive fields (Fig. S5b). b. Population modulation index (mean ± s.e.m.) of ON (top) and OFF (bottom) RGCs for full-field saccades condition (thick gray lines, same as Fig. 1e rightmost panel; N = 68 to 574 RGCs (see Fig. S3 for exact numbers)); periphery saccades condition (thin gray lines; N = 91 ON RGCs, N = 56 OFF RGCs); and periphery saccades condition in the presence of GABA A receptor blocker (5μM SR-95531; green lines; N = 62 ON RGCs, N = 35 OFF RGCs). Blue window shows the timing of the saccade. In these experiments, we used a coarse background texture (300 μm spatial scale). Timing of probe flashes: 50 and 150 (only for full-field saccade), 117, 200, 350, 600 and 2100 ms (baseline) after saccade onset. c.d. Population modulation index (mean ± s.e.m.) of ON (top) and OFF (bottom) RGCs for full-field saccades without any pharmacological agents (gray lines; N = 82 ON RGCs, N = 30 OFF RGCs) and with GABA A,C receptor blockers 5 μM SR-95531 + 100 μM Picrotoxin ( c ; green lines), and for a subset of RGCs where we additionally blocked glycine receptors using 1 μM Strychnine ( d ; green lines; N = 51 ON RGCs, N = 13 OFF RGCs). In these experiments, we used a coarse background texture (150 μm spatial scale). Probe flashes were presented at 117 ms, 150, 200, 350, 600, 1100 and 2100 (baseline) after saccade onset. e . Spatial layout of the visual stimulation paradigm used in experiments to probe local components of suppression. Saccades and flashes were presented in 100 x 100 μm 2 square regions, separated by 100 μm gaps with mean overall luminance. Left: Saccades and flashes were presented in all regions. Right: Saccades and flashes were presented in alternate regions; only cells with receptive fields (RFs) in the non-saccade regions (orange) were analyzed (black ellipse: 1-σ of the 2D Gaussian fit to an example RGC receptive field). Consequently, saccades were excluded from at most ~300 x 300 μm 2 of a cell’s RF center. In these experiments, we used a coarse background texture (150 μm spatial scale). f. Population modulation index (mean ± s.e.m.) of ON (top; N = 32) and OFF (bottom; N = 38) RGCs for saccades and flashes in all regions (thick lines) or saccades excluded from RGC RF center (thin lines). Red arrow indicates significant loss in suppression in ON RGCs for early flashes at 117 and 150 ms upon excluding saccades from RF center (p = 0.0016 and p = 0.002 respectively; two-tailed Wilcoxon rank-sum test). In all panels, hash symbols indicate statistically significant difference between groups (p

    Article Snippet: We first prepared a 1000x stock solution of these pharmacological blockers as follows: SR-95531 was dissolved in water at a concentration of 5 mM; picrotoxin was dissolved in DMSO at a concentration of 100 mM; Strychnine was dissolved in Chloroform at a concentration of 1mM.

    Techniques: Two Tailed Test