s pneumoniae (ATCC)
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S Pneumoniae, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 99 stars, based on 1 article reviews
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1) Product Images from "Nebulized antithrombin limits bacterial outgrowth and lung injury in Streptococcus pneumoniae pneumonia in rats"
Article Title: Nebulized antithrombin limits bacterial outgrowth and lung injury in Streptococcus pneumoniae pneumonia in rats
Journal: Critical Care
doi: 10.1186/cc8040
Figure Legend Snippet: Pulmonary coagulation and fibrinolysis. The effects of anticoagulants nebulized into the lungs of rats on levels of (a) thrombin-antithrombin complexes (TATc), (b) antithrombin activity (AT), (c) fibrin degradation products (FDP), (d) plasminogen activator activity (PAA%), and (e) plasminogen activator inhibitor-1 (PAI-1) in bronchoalveolar lavage fluid (BALF), 40 hours after intra-tracheal bacterial challenge ( Streptococcus pneumoniae , serotype 3, ATCC 6303). Dotted lines stipulate the normal values in healthy animals and untreated animals with pneumonia. Data represent mean ± standard deviation. * P < 0.01 vs. placebo. APC = recombinant-human activated protein C; AT = plasma = derived human antithrombin; Hep = heparin; Dan = danaparoid.
Techniques Used: Coagulation, Activity Assay, Standard Deviation, Recombinant, Derivative Assay
Figure Legend Snippet: The effects of anticoagulants on numbers of Streptococcus pneumoniae colony forming units in (a) lung homogenate and (b) bronchoalveolar lavage fluid (BALF), 40 hours after intra-tracheal bacterial challenge. Data represent median ± interquartile range. * P < 0.05 vs. placebo. APC = recombinant-human activated protein C; AT = plasma = derived human antithrombin; CFU = colony-forming units; Hep = heparin; Dan = danaparoid.
Techniques Used: Recombinant, Derivative Assay
Figure Legend Snippet: Total cell and neutrophil counts in bronchoalveolar lavage fluid
Techniques Used:
Figure Legend Snippet: Histopathological changes in Streptococcus pneumoniae pneumonia. Shown are representative hematoxylin and eosin-stained photomicrographs (magnification, ×100) of lung tissue from rats treated with (a) saline, (b) recombinant human activated protein C (APC), (c) plasma-derived antithrombin (AT), (d) heparin (Hep), (e) danaparoid (Dan), at 40 hours after bacterial challenge. (f) Total histopathologic scores are presented as median with interquartile range. * P < 0.05 vs. placebo.
Techniques Used: Staining, Recombinant, Derivative Assay
Figure Legend Snippet: The effects of BALF from placebo treated rats (BALF-none) and BALF from rats treated with plasma-derived AT (BALF-AT) on survival of Streptococcus pneumoniae in vitro . (a) After five hours outgrowth of S. pneumoniae in bronchoalveolar lavage fluid from rats treated with plasma-derived antithrombin (BALF-AT) was reduced (closed symbols), compared with the outgrowth in BALF-none samples (open symbols). * P < 0.0001 vs. BALF-AT. (b) In vitro added plasma-derived AT did not affect the number of colony-forming units (CFU; for clarity only the highest concentrations are shown: 1.1 mg/mL, open symbols; 4.4 mg/mL, closed symbols). (c) Sodium polyanetholsulphonate (SPS) blocked the inhibitory effect of BALF-AT on outgrowth of S. pneumoniae (BALF-AT without SPS, closed symbols; BALF-AT with SPS, open symbols). Data represent mean ± standard deviation. * P < 0.0001 vs. BALF-AT without SPS.
Techniques Used: Derivative Assay, In Vitro, Standard Deviation