pan 14 3 3  (ProSci Incorporated)


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    ProSci Incorporated pan 14 3 3
    Pan 14 3 3, supplied by ProSci Incorporated, used in various techniques. Bioz Stars score: 85/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/pan 14 3 3/product/ProSci Incorporated
    Average 85 stars, based on 1 article reviews
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    pan 14 3 3 - by Bioz Stars, 2023-06
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    pro caspase 1  (ProSci Incorporated)


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    ProSci Incorporated pro caspase 1
    Lithium inhibits pyroptosis in the spinal cord of rats with SCI . Sham group: no spinal cord injury or treatment; SCI group: spinal cord injury only; LiCl group: lithium treatment after spinal cord injury. (A) Representative images of immunohistochemistry staining for <t>Caspase-1</t> 7 days after surgery. The number of Caspase-1–positive cells was higher in the LiCl group than in the sham group, but lower than in the SCI group. Black arrows indicate Caspase-1–positive neurons. Scale bars: 50 μm. (B) Quantitation of Caspase-1–positive cells per 1 mm2 7 days after injury. (C) NLRP3, ASC, pro-Caspase-1, Caspase-1, GSDMD, and IL-18 expression in the spinal cord. (D) Quantification of NLRP3, ASC, pro-Caspase-1, Caspase-1, GSDMD, and IL-18 expression in the spinal cord. Data are shown as mean ± SD ( n = 6). * P < 0.05, vs . sham group; # P < 0.05, vs . SCI group (one-way analysis of variance followed by the least significant difference test). ASC: Apoptosi-associated speck-like protein; GSDMD: gasdermin-d; IL-18: interleukin-18; LiCl: lithium chloride; NLRP3: NOD-like receptors 3; SCI: spinal cord injury.
    Pro Caspase 1, supplied by ProSci Incorporated, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    1) Product Images from "Lithium promotes recovery after spinal cord injury"

    Article Title: Lithium promotes recovery after spinal cord injury

    Journal: Neural Regeneration Research

    doi: 10.4103/1673-5374.327348

    Lithium inhibits pyroptosis in the spinal cord of rats with SCI . Sham group: no spinal cord injury or treatment; SCI group: spinal cord injury only; LiCl group: lithium treatment after spinal cord injury. (A) Representative images of immunohistochemistry staining for Caspase-1 7 days after surgery. The number of Caspase-1–positive cells was higher in the LiCl group than in the sham group, but lower than in the SCI group. Black arrows indicate Caspase-1–positive neurons. Scale bars: 50 μm. (B) Quantitation of Caspase-1–positive cells per 1 mm2 7 days after injury. (C) NLRP3, ASC, pro-Caspase-1, Caspase-1, GSDMD, and IL-18 expression in the spinal cord. (D) Quantification of NLRP3, ASC, pro-Caspase-1, Caspase-1, GSDMD, and IL-18 expression in the spinal cord. Data are shown as mean ± SD ( n = 6). * P < 0.05, vs . sham group; # P < 0.05, vs . SCI group (one-way analysis of variance followed by the least significant difference test). ASC: Apoptosi-associated speck-like protein; GSDMD: gasdermin-d; IL-18: interleukin-18; LiCl: lithium chloride; NLRP3: NOD-like receptors 3; SCI: spinal cord injury.
    Figure Legend Snippet: Lithium inhibits pyroptosis in the spinal cord of rats with SCI . Sham group: no spinal cord injury or treatment; SCI group: spinal cord injury only; LiCl group: lithium treatment after spinal cord injury. (A) Representative images of immunohistochemistry staining for Caspase-1 7 days after surgery. The number of Caspase-1–positive cells was higher in the LiCl group than in the sham group, but lower than in the SCI group. Black arrows indicate Caspase-1–positive neurons. Scale bars: 50 μm. (B) Quantitation of Caspase-1–positive cells per 1 mm2 7 days after injury. (C) NLRP3, ASC, pro-Caspase-1, Caspase-1, GSDMD, and IL-18 expression in the spinal cord. (D) Quantification of NLRP3, ASC, pro-Caspase-1, Caspase-1, GSDMD, and IL-18 expression in the spinal cord. Data are shown as mean ± SD ( n = 6). * P < 0.05, vs . sham group; # P < 0.05, vs . SCI group (one-way analysis of variance followed by the least significant difference test). ASC: Apoptosi-associated speck-like protein; GSDMD: gasdermin-d; IL-18: interleukin-18; LiCl: lithium chloride; NLRP3: NOD-like receptors 3; SCI: spinal cord injury.

    Techniques Used: Immunohistochemistry, Staining, Quantitation Assay, Expressing

    Lithium attenuates pyroptotic injury by activating the Nrf2/HO-1 signaling pathway in PC12 cells subjected to OGD . Con group: untreated PC12 cells; OGD group: PC12 cells subjected to OGD; OGD + LiCl group: PC12 cells subjected to OGD and treated with LiCl; OGD + LiCl + ATRA group: PC12 cells subjected to OGD and treated with LiCl treatment and the Nrf2 inhibitor ATRA. (A, B) NLRP3, ASC, pro-Caspase-1, Caspase-1, GSDMD, and IL-18 expression. (C, D) Nrf2 and HO-1 expression. (E) The expression levels of pyroptosis-related proteins were significantly higher in the OGD group than in the Con group, and this effect was largely reversed by treatment with LiCl. The expression levels of these proteins were significantly higher in the ATRA group than in the LiCl group, with the exception of pro-Caspase-1. Nrf2 and HO-1 expression levels were significantly increased by LiCl treatment, and this effect was largely reversed by treatment with the Nrf2 inhibitor ATRA. Data are shown as mean ± SD ( n = 6). * P < 0.05, vs . control group; # P < 0.05, vs . OGD group; & P < 0.05, vs . OGD + LiCl group (one-way analysis of variance followed by least significant difference test). (F) Representative images of Nrf2 and HO-1 immunofluorescence. White arrows indicate neurons that were positive for Nrf2 staining (red, Alexa Fluor 647), HO-1 staining (green, Alexa Fluor 488), and cell nucleus staining (blue, DAPI). Scale bar: 50 μm. ASC: Apoptosis-associated speck-like protein; ATRA: all-trans retinoic acid; Con: control; DAPI: 4’,6-diamidino-2-phenylindole; GSDMD: gasdermin-d; HO-1: heme oxygenase-1; IL-18: interleukin-18; LiCl: lithium chloride; NLRP3: NOD-like receptors 3; Nrf2: nuclear factor E2-related factor 2; OGD: oxygen glucose deprivation.
    Figure Legend Snippet: Lithium attenuates pyroptotic injury by activating the Nrf2/HO-1 signaling pathway in PC12 cells subjected to OGD . Con group: untreated PC12 cells; OGD group: PC12 cells subjected to OGD; OGD + LiCl group: PC12 cells subjected to OGD and treated with LiCl; OGD + LiCl + ATRA group: PC12 cells subjected to OGD and treated with LiCl treatment and the Nrf2 inhibitor ATRA. (A, B) NLRP3, ASC, pro-Caspase-1, Caspase-1, GSDMD, and IL-18 expression. (C, D) Nrf2 and HO-1 expression. (E) The expression levels of pyroptosis-related proteins were significantly higher in the OGD group than in the Con group, and this effect was largely reversed by treatment with LiCl. The expression levels of these proteins were significantly higher in the ATRA group than in the LiCl group, with the exception of pro-Caspase-1. Nrf2 and HO-1 expression levels were significantly increased by LiCl treatment, and this effect was largely reversed by treatment with the Nrf2 inhibitor ATRA. Data are shown as mean ± SD ( n = 6). * P < 0.05, vs . control group; # P < 0.05, vs . OGD group; & P < 0.05, vs . OGD + LiCl group (one-way analysis of variance followed by least significant difference test). (F) Representative images of Nrf2 and HO-1 immunofluorescence. White arrows indicate neurons that were positive for Nrf2 staining (red, Alexa Fluor 647), HO-1 staining (green, Alexa Fluor 488), and cell nucleus staining (blue, DAPI). Scale bar: 50 μm. ASC: Apoptosis-associated speck-like protein; ATRA: all-trans retinoic acid; Con: control; DAPI: 4’,6-diamidino-2-phenylindole; GSDMD: gasdermin-d; HO-1: heme oxygenase-1; IL-18: interleukin-18; LiCl: lithium chloride; NLRP3: NOD-like receptors 3; Nrf2: nuclear factor E2-related factor 2; OGD: oxygen glucose deprivation.

    Techniques Used: Expressing, Immunofluorescence, Staining

    pan 14 3 3  (ProSci Incorporated)


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    ProSci Incorporated pan 14 3 3
    Pan 14 3 3, supplied by ProSci Incorporated, used in various techniques. Bioz Stars score: 85/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 85 stars, based on 1 article reviews
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    pan 14 3 3 - by Bioz Stars, 2023-06
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