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Journal: Neuropsychopharmacology

Article Title: Comparing affective bias modification by first- and second-generation antidepressants in male rats using a translational behavioural task

doi: 10.1038/s41386-026-02376-4

Figure Lengend Snippet: Rats were administered amitriptyline (0.3, 1, and 3 mg/kg; n = 16) or venlafaxine (3 mg/kg; n = 16), moclobemide (3 and 10 mg/kg; n = 12), or sertraline (1, 3, and 10 mg/kg; n = 12) before substrate-reward pairing sessions. Choice bias was assessed 24 h after the final pairing session. Amitriptyline (0.3 and 1 mg/kg) induced a significant positive bias, comparable to venlafaxine (3 mg/kg), F ₄,₆₀ = 10.82, p < 0.0001). Moclobemide ( F ₂,₂₂ = 11.84, p = 0.0029) and sertraline ( F ₃,₃₃ = 9.259, p = 0.0016) both showed significant effects, with 3 mg/kg inducing a positive bias and 10 mg/kg inducing a negative bias, though only the highest dose of sertraline significantly differed from vehicle ( p = 0.0069). Data are shown as mean % choice bias ± SEM and were analysed using a one-sample t -test ( * p < 0.05, ** p < 0.01, *** p < 0.001) and Dunnett’s test following main effect with RM-ANOVA ( # p < 0.05, ## p < 0.01, #### p < 0.0001).

Article Snippet: Moclobemide (reversible MAO-A inhibitor; Tocris Bioscience, UK) , s.c. , 3, 10 , t = −30 min , New learning: both doses tested. Retrieval: doses producing a positive affective bias (3, 10 mg/kg) administered 30 min and/or 24 h prior to the choice test following FG7142-induced negative bias..

Techniques:

Journal: Neuropsychopharmacology

Article Title: Comparing affective bias modification by first- and second-generation antidepressants in male rats using a translational behavioural task

doi: 10.1038/s41386-026-02376-4

Figure Lengend Snippet: FG7142 (3 mg/kg) was administered before substrate-reward pairing sessions to induce a negative affective bias, and rats were then treated with amitriptyline (0.3 and 1 mg/kg, n = 16), moclobemide (3 mg/kg, n = 12) or sertraline (3 and 10 mg/kg, n = 12) prior to choice testing. Amitriptyline attenuated the FG7142-induced negative affective bias ( F (2,30) = 23.43, p < 0.0001), with no bias observed at both 0.3 mg/kg ( t (15) = 1.464, p = 0.1639) and 1 mg/kg ( t (15) = 0.2997, p = 0.7685). Sertraline showed a similar attenuation during choice testing ( F (2,22) = 6.652, p = 0.0055) but only at the lowest dose ( p = 0.0028), and animals given 10 mg/kg continued show a negative affective bias ( t (11) = 2.609, p = 0.0243). Moclobemide had no attenuating effect ( t (11) = 1.000, p = 0.3388), with negative bias persisting at 3 mg/kg, t (11) = 7.416, p < 0.0001). Data are shown as mean % choice bias ± SEM and were analysed using a one-sample t -test ( * p < 0.05, **** p < 0.0001) and Dunnett’s test following main effect with RM-ANOVA or two-tailed paired t -test ( ## p < 0.01, #### p < 0.0001).

Article Snippet: Moclobemide (reversible MAO-A inhibitor; Tocris Bioscience, UK) , s.c. , 3, 10 , t = −30 min , New learning: both doses tested. Retrieval: doses producing a positive affective bias (3, 10 mg/kg) administered 30 min and/or 24 h prior to the choice test following FG7142-induced negative bias..

Techniques: Two Tailed Test

Journal: Neuropsychopharmacology

Article Title: Comparing affective bias modification by first- and second-generation antidepressants in male rats using a translational behavioural task

doi: 10.1038/s41386-026-02376-4

Figure Lengend Snippet: FG7142 (3 mg/kg) was administered before substrate-reward pairing sessions to induce a negative affective bias, and rats were then treated with amitriptyline (0.3 and 1 mg/kg, n = 16), moclobemide (3 mg/kg, n = 12) or sertraline (3 and 10 mg/kg, n = 12) 24 h before the choice test. Amitriptyline produced sustained attenuation of FG7142-induced negative bias 24 h after treatment ( F (2,30) = 7.081, p = 0.0030), with no bias observed at both 0.3 mg/kg ( t (15) = 0.5222, p = 0.6091) and 1 mg/kg ( t (11) = 1.820, p = 0.0960). A main effect of treatment was also observed for sertraline ( F (2,22) = 4.188, p = 0.0288) but only animals given 3 mg/kg differed from vehicle controls ( p = 0.0215), while negative affective bias persisted at 1 mg/kg ( t (11) = 0.5180, p = 0.6147). Moclobemide failed to attenuate FG7142-induced negative bias when tested 24 h post-treatment ( t (11) = 0.5180, p = 0.6147), with 3 mg/kg treated animals exhibiting a negative bias similar to vehicle. Data are shown as mean % choice bias ± SEM and were analysed using a one-sample t -test ( *** p < 0.001, **** p < 0.0001) and Dunnett’s test following main effect with RM-ANOVA or two-tailed paired t -test ( # p < 0.05, ## p < 0.01).

Article Snippet: Moclobemide (reversible MAO-A inhibitor; Tocris Bioscience, UK) , s.c. , 3, 10 , t = −30 min , New learning: both doses tested. Retrieval: doses producing a positive affective bias (3, 10 mg/kg) administered 30 min and/or 24 h prior to the choice test following FG7142-induced negative bias..

Techniques: Produced, Two Tailed Test