Structured Review

steraloids inc 4 cholesten 3 one
<t>7α,12α-Dihydroxy-4-cholesten-3-one</t> and 7α,12α-dihydroxy-5β-cholestan-3-one present in plasma from untreated CTX patient
4 Cholesten 3 One, supplied by steraloids inc, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 92 stars, based on 1 article reviews
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4 cholesten 3 one - by Bioz Stars, 2020-04
92/100 stars

Images

1) Product Images from "\u201cProfiling Sterols in Cerebrotendinous Xanthomatosis: Utility of Girard Derivatization and High Resolution Exact Mass LC-ESI-MSn Analysis\u201d"

Article Title: \u201cProfiling Sterols in Cerebrotendinous Xanthomatosis: Utility of Girard Derivatization and High Resolution Exact Mass LC-ESI-MSn Analysis\u201d

Journal: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences

doi: 10.1016/j.jchromb.2010.11.019

7α,12α-Dihydroxy-4-cholesten-3-one and 7α,12α-dihydroxy-5β-cholestan-3-one present in plasma from untreated CTX patient
Figure Legend Snippet: 7α,12α-Dihydroxy-4-cholesten-3-one and 7α,12α-dihydroxy-5β-cholestan-3-one present in plasma from untreated CTX patient

Techniques Used:

7α-Hydroxy-4-cholesten-3-one and 4-cholesten-3-one present in plasma from untreated CTX patient and cyp27A1 −/− mice
Figure Legend Snippet: 7α-Hydroxy-4-cholesten-3-one and 4-cholesten-3-one present in plasma from untreated CTX patient and cyp27A1 −/− mice

Techniques Used: Mouse Assay

Fragmentation routes for GP-tagged 3-oxo-4-ene sterols illustrated by 4-cholesten-3-one
Figure Legend Snippet: Fragmentation routes for GP-tagged 3-oxo-4-ene sterols illustrated by 4-cholesten-3-one

Techniques Used:

2) Product Images from "Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor"

Article Title: Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor

Journal: Proceedings of the National Academy of Sciences of the United States of America

doi: 10.1073/pnas.0237082100

Hepatic mRNA expression levels of several enzymes involved in bile acid biosynthesis are altered in the Cyp27a1 −/− mouse. Relative hepatic RNA levels were determined by Northern analysis from male, mixed-strain, wild-type and Cyp27a1 −/− mice fed a standard rodent diet. The values shown in boxes represent the mean ± SEM of the fold change in mRNA levels ( n = 6 mice per genotype). Bile acid intermediates that would be predicted to accumulate upstream of CYP3A11 because of these changes in enzyme levels include the following: 1 , 7α-hydroxycholesterol (5-cholesten-3β,7α-diol); 2 , 7α-hydroxy-4-cholesten-3-one (4-cholesten-7α-ol-3-one); 3 , 5β-cholestan-3α,7α,12α-triol; 4 , 4-cholesten-3-one; and 5 , cholestanol (5α-cholestan-3β-ol).
Figure Legend Snippet: Hepatic mRNA expression levels of several enzymes involved in bile acid biosynthesis are altered in the Cyp27a1 −/− mouse. Relative hepatic RNA levels were determined by Northern analysis from male, mixed-strain, wild-type and Cyp27a1 −/− mice fed a standard rodent diet. The values shown in boxes represent the mean ± SEM of the fold change in mRNA levels ( n = 6 mice per genotype). Bile acid intermediates that would be predicted to accumulate upstream of CYP3A11 because of these changes in enzyme levels include the following: 1 , 7α-hydroxycholesterol (5-cholesten-3β,7α-diol); 2 , 7α-hydroxy-4-cholesten-3-one (4-cholesten-7α-ol-3-one); 3 , 5β-cholestan-3α,7α,12α-triol; 4 , 4-cholesten-3-one; and 5 , cholestanol (5α-cholestan-3β-ol).

Techniques Used: Expressing, Northern Blot, Mouse Assay

Related Articles

High Performance Liquid Chromatography:

Article Title: Cholesterol Modulates Cellular TGF-β Responsiveness by Altering TGF-β Binding to TGF-β Receptors
Article Snippet: 25-Hydroxycholesterol, 7-dehydrocholesterol (7-DHC), 7-ketocholestanol, 7-ketocholesterol 5-cholesten-7-one and 4-cholesten-3-one were obtained from Steraloids (Newport, RI). .. Reverse-phase HPLC revealed a mixture of polar products, but no remaining 7-DHC.

other:

Article Title: A novel alkyne cholesterol to trace cellular cholesterol metabolism and localization [S]
Article Snippet: Deuterated d6-cholesterol, cholesterol-26,26,26,27,27,27-2 H6 , and 4-cholesten-3-one were from C/D/N Isotopes and Steraloids, respectively.

Synthesized:

Article Title: \u201cProfiling Sterols in Cerebrotendinous Xanthomatosis: Utility of Girard Derivatization and High Resolution Exact Mass LC-ESI-MSn Analysis\u201d
Article Snippet: 4,6-Cholestadiene-3-one, 5α-cholestan-3β-ol (5α-cholestanol), 5α-cholestan-3-one, 4-cholesten-3-one (C4-3-one), cholesterol (5-cholesten-3β-ol), 7α-hydroxy-4-cholesten-3-one (C4-7α-ol-3-one) and 3α,7α,12α-trihydroxy-5β-cholestane were from Steraloids (Newport, RI). .. 7α,12α-dihydroxy-5β-cholestan-3-one was synthesized from 3α,7α,12α-trihydroxy-5β-cholestane using 3α-hydroxysteroid dehydrogenase from Sigma-Aldrich in the presence of β-NAD [ ].

Article Title: Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor
Article Snippet: 5-Cholesten-3β 7α-diol (7α-OH-cholesterol), 4-cholesten-7α-ol-3-one (7α-OH-4-cholesten-3-one), and 4-cholesten-3-one were purchased from Steraloids (Newport, RI). .. 5β-cholestan-3α,7α,12α-triol ( ) was custom synthesized by Steraloids.

Mass Spectrometry:

Article Title: Microbial Functional Responses to Cholesterol Catabolism in Denitrifying Sludge
Article Snippet: The MS counts of each metabolite were visualized as a heat map using the Web-based tool MetaboAnalyst ( ). .. Cholest-4-en-3-one, cholesta-1,4-diene-3-one, and pregn-4-en-3-one-20-carboxylic acid were purchased from Steraloids (Newport, RI, USA).

Software:

Article Title: Microbial Functional Responses to Cholesterol Catabolism in Denitrifying Sludge
Article Snippet: The predicted elemental composition of individual steroid metabolites was calculated using Xcalibur mass spectrometry software (Thermo Fisher Scientific). .. Cholest-4-en-3-one, cholesta-1,4-diene-3-one, and pregn-4-en-3-one-20-carboxylic acid were purchased from Steraloids (Newport, RI, USA).

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  • 93
    steraloids inc cholest 4 en 3 one
    The 2,3- seco pathway of anaerobic cholesterol metabolism in Stl. denitrificans . Enzymes functionally characterized in previous studies are bolded. AcmA, cholesterol dehydrogenase/isomerase; AcmB, <t>cholest-4-en-3-one-Δ1-dehydrogenase;</t> C25DH, cholesterol C25 dehydrogenase; ACS, acyl-CoA synthetase; ACAD, acyl-CoA dehydrogenase; ECH, enoyl-CoA hydratase; ALD, aldolase; ALDH, aldehyde dehydrogenase; Δ4R, ketosteroid-Δ4-reductase; DH, dehydrogenase; AtcABC, 1-testosterone dehydrogenase/hydratase.
    Cholest 4 En 3 One, supplied by steraloids inc, used in various techniques. Bioz Stars score: 93/100, based on 4 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 93 stars, based on 4 article reviews
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    cholest 4 en 3 one - by Bioz Stars, 2020-04
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    93
    steraloids inc cholestenone
    Transition temperatures ( top ) and vesicle micrographs ( bottom ) for vesicles of 1:1:(1 − x ): x <t>DOPC/DPPC/cholesterol/cholestenone</t> with 0.8 mol % TR-DPPE. Coexisting liquid phases are observed below the miscibility transition temperature in membranes with more cholesterol (▴), and solid and liquid phases are observed below the melting transition in membranes with more cholestenone (▪). In membranes with an equal ratio of cholesterol and cholestenone (•), fluctuations at domains boundaries relax slowly (∼1–10 s) and dark domains may contain a solid phase. Vesicles contain x = 0%, 25%, 50%, 75%, and 100% cholestenone (from left to right ) and are imaged at 16°C. All scale bars are 20 μ m.
    Cholestenone, supplied by steraloids inc, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 93 stars, based on 1 article reviews
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    85
    steraloids inc 7α hydroxy 4 cholesten 3 one
    Levels of cholestanol and <t>7α-hydroxy-4-cholesten-3-one</t> (C4) in female wild-type (WT) and CYP27KO mice (A) in plasma. B: Cerebrum cholestanol levels and plasma 7α-hydroxy-4-cholesten-3-one levels shown in the same diagrams. Number of mice, used to measure 7α-hydroxy-4-cholesten-3-one levels in plasma, per group were: WT and KO; ctrl n4 (pool) and n3, cholestyramine n4 (pool) and n3, cholic acid n5 and n5). Number of mice, used to measure cholestanol levels in plasma and cerebrum, per group were: WT and KO; ctrl n4 and n5, cholestyramine n4 and n3, cholic acid n5 and n5.
    7α Hydroxy 4 Cholesten 3 One, supplied by steraloids inc, used in various techniques. Bioz Stars score: 85/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Image Search Results


    The 2,3- seco pathway of anaerobic cholesterol metabolism in Stl. denitrificans . Enzymes functionally characterized in previous studies are bolded. AcmA, cholesterol dehydrogenase/isomerase; AcmB, cholest-4-en-3-one-Δ1-dehydrogenase; C25DH, cholesterol C25 dehydrogenase; ACS, acyl-CoA synthetase; ACAD, acyl-CoA dehydrogenase; ECH, enoyl-CoA hydratase; ALD, aldolase; ALDH, aldehyde dehydrogenase; Δ4R, ketosteroid-Δ4-reductase; DH, dehydrogenase; AtcABC, 1-testosterone dehydrogenase/hydratase.

    Journal: mSystems

    Article Title: Microbial Functional Responses to Cholesterol Catabolism in Denitrifying Sludge

    doi: 10.1128/mSystems.00113-18

    Figure Lengend Snippet: The 2,3- seco pathway of anaerobic cholesterol metabolism in Stl. denitrificans . Enzymes functionally characterized in previous studies are bolded. AcmA, cholesterol dehydrogenase/isomerase; AcmB, cholest-4-en-3-one-Δ1-dehydrogenase; C25DH, cholesterol C25 dehydrogenase; ACS, acyl-CoA synthetase; ACAD, acyl-CoA dehydrogenase; ECH, enoyl-CoA hydratase; ALD, aldolase; ALDH, aldehyde dehydrogenase; Δ4R, ketosteroid-Δ4-reductase; DH, dehydrogenase; AtcABC, 1-testosterone dehydrogenase/hydratase.

    Article Snippet: Cholest-4-en-3-one, cholesta-1,4-diene-3-one, and pregn-4-en-3-one-20-carboxylic acid were purchased from Steraloids (Newport, RI, USA).

    Techniques:

    7α,12α-Dihydroxy-4-cholesten-3-one and 7α,12α-dihydroxy-5β-cholestan-3-one present in plasma from untreated CTX patient

    Journal: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences

    Article Title: \u201cProfiling Sterols in Cerebrotendinous Xanthomatosis: Utility of Girard Derivatization and High Resolution Exact Mass LC-ESI-MSn Analysis\u201d

    doi: 10.1016/j.jchromb.2010.11.019

    Figure Lengend Snippet: 7α,12α-Dihydroxy-4-cholesten-3-one and 7α,12α-dihydroxy-5β-cholestan-3-one present in plasma from untreated CTX patient

    Article Snippet: 4,6-Cholestadiene-3-one, 5α-cholestan-3β-ol (5α-cholestanol), 5α-cholestan-3-one, 4-cholesten-3-one (C4-3-one), cholesterol (5-cholesten-3β-ol), 7α-hydroxy-4-cholesten-3-one (C4-7α-ol-3-one) and 3α,7α,12α-trihydroxy-5β-cholestane were from Steraloids (Newport, RI).

    Techniques:

    7α-Hydroxy-4-cholesten-3-one and 4-cholesten-3-one present in plasma from untreated CTX patient and cyp27A1 −/− mice

    Journal: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences

    Article Title: \u201cProfiling Sterols in Cerebrotendinous Xanthomatosis: Utility of Girard Derivatization and High Resolution Exact Mass LC-ESI-MSn Analysis\u201d

    doi: 10.1016/j.jchromb.2010.11.019

    Figure Lengend Snippet: 7α-Hydroxy-4-cholesten-3-one and 4-cholesten-3-one present in plasma from untreated CTX patient and cyp27A1 −/− mice

    Article Snippet: 4,6-Cholestadiene-3-one, 5α-cholestan-3β-ol (5α-cholestanol), 5α-cholestan-3-one, 4-cholesten-3-one (C4-3-one), cholesterol (5-cholesten-3β-ol), 7α-hydroxy-4-cholesten-3-one (C4-7α-ol-3-one) and 3α,7α,12α-trihydroxy-5β-cholestane were from Steraloids (Newport, RI).

    Techniques: Mouse Assay

    Fragmentation routes for GP-tagged 3-oxo-4-ene sterols illustrated by 4-cholesten-3-one

    Journal: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences

    Article Title: \u201cProfiling Sterols in Cerebrotendinous Xanthomatosis: Utility of Girard Derivatization and High Resolution Exact Mass LC-ESI-MSn Analysis\u201d

    doi: 10.1016/j.jchromb.2010.11.019

    Figure Lengend Snippet: Fragmentation routes for GP-tagged 3-oxo-4-ene sterols illustrated by 4-cholesten-3-one

    Article Snippet: 4,6-Cholestadiene-3-one, 5α-cholestan-3β-ol (5α-cholestanol), 5α-cholestan-3-one, 4-cholesten-3-one (C4-3-one), cholesterol (5-cholesten-3β-ol), 7α-hydroxy-4-cholesten-3-one (C4-7α-ol-3-one) and 3α,7α,12α-trihydroxy-5β-cholestane were from Steraloids (Newport, RI).

    Techniques:

    Transition temperatures ( top ) and vesicle micrographs ( bottom ) for vesicles of 1:1:(1 − x ): x DOPC/DPPC/cholesterol/cholestenone with 0.8 mol % TR-DPPE. Coexisting liquid phases are observed below the miscibility transition temperature in membranes with more cholesterol (▴), and solid and liquid phases are observed below the melting transition in membranes with more cholestenone (▪). In membranes with an equal ratio of cholesterol and cholestenone (•), fluctuations at domains boundaries relax slowly (∼1–10 s) and dark domains may contain a solid phase. Vesicles contain x = 0%, 25%, 50%, 75%, and 100% cholestenone (from left to right ) and are imaged at 16°C. All scale bars are 20 μ m.

    Journal: Biophysical Journal

    Article Title: Sterol Structure Determines Miscibility versus Melting Transitions in Lipid Vesicles

    doi: 10.1529/biophysj.104.049635

    Figure Lengend Snippet: Transition temperatures ( top ) and vesicle micrographs ( bottom ) for vesicles of 1:1:(1 − x ): x DOPC/DPPC/cholesterol/cholestenone with 0.8 mol % TR-DPPE. Coexisting liquid phases are observed below the miscibility transition temperature in membranes with more cholesterol (▴), and solid and liquid phases are observed below the melting transition in membranes with more cholestenone (▪). In membranes with an equal ratio of cholesterol and cholestenone (•), fluctuations at domains boundaries relax slowly (∼1–10 s) and dark domains may contain a solid phase. Vesicles contain x = 0%, 25%, 50%, 75%, and 100% cholestenone (from left to right ) and are imaged at 16°C. All scale bars are 20 μ m.

    Article Snippet: Androstenolone (5-androsten-3 β -ol-17-one), coprostanol (5 β -cholestan-3 β -ol), cholestenone (4-cholesten-3-one), cholestane (5 α -cholestane), and epicholesterol (5-cholesten-3 α -ol) were obtained from Steraloids (Newport, RI).

    Techniques:

    Fluorescence micrographs of vesicles produced from 1:1:1 DOPC/DPPC/sterol with 0.8 mol % TR-DPPE at 23°C. Vesicles contain ( a ) 25-hydroxycholesterol, ( b ) cholesterol, ( c ) dihydrocholesterol, ( d ) epicholesterol, ( e ) ergosterol, ( f ) no sterol (control), ( g ) androstenolone, ( h ) cholestane, ( i ) cholestenone, and ( j ) coprostanol. As temperature is lowered, phase coexistence is observed between either ( top row ) two liquid phases or ( bottom row ) a solid and liquid phase. With time, liquid phases coalesce to form one bright domain and one dark domain. Scale bars are 10 μ m.

    Journal: Biophysical Journal

    Article Title: Sterol Structure Determines Miscibility versus Melting Transitions in Lipid Vesicles

    doi: 10.1529/biophysj.104.049635

    Figure Lengend Snippet: Fluorescence micrographs of vesicles produced from 1:1:1 DOPC/DPPC/sterol with 0.8 mol % TR-DPPE at 23°C. Vesicles contain ( a ) 25-hydroxycholesterol, ( b ) cholesterol, ( c ) dihydrocholesterol, ( d ) epicholesterol, ( e ) ergosterol, ( f ) no sterol (control), ( g ) androstenolone, ( h ) cholestane, ( i ) cholestenone, and ( j ) coprostanol. As temperature is lowered, phase coexistence is observed between either ( top row ) two liquid phases or ( bottom row ) a solid and liquid phase. With time, liquid phases coalesce to form one bright domain and one dark domain. Scale bars are 10 μ m.

    Article Snippet: Androstenolone (5-androsten-3 β -ol-17-one), coprostanol (5 β -cholestan-3 β -ol), cholestenone (4-cholesten-3-one), cholestane (5 α -cholestane), and epicholesterol (5-cholesten-3 α -ol) were obtained from Steraloids (Newport, RI).

    Techniques: Fluorescence, Produced

    Levels of cholestanol and 7α-hydroxy-4-cholesten-3-one (C4) in female wild-type (WT) and CYP27KO mice (A) in plasma. B: Cerebrum cholestanol levels and plasma 7α-hydroxy-4-cholesten-3-one levels shown in the same diagrams. Number of mice, used to measure 7α-hydroxy-4-cholesten-3-one levels in plasma, per group were: WT and KO; ctrl n4 (pool) and n3, cholestyramine n4 (pool) and n3, cholic acid n5 and n5). Number of mice, used to measure cholestanol levels in plasma and cerebrum, per group were: WT and KO; ctrl n4 and n5, cholestyramine n4 and n3, cholic acid n5 and n5.

    Journal: Journal of Lipid Research

    Article Title: On the mechanism of accumulation of cholestanol in the brain of mice with a disruption of sterol 27-hydroxylase

    doi: 10.1194/jlr.M008326

    Figure Lengend Snippet: Levels of cholestanol and 7α-hydroxy-4-cholesten-3-one (C4) in female wild-type (WT) and CYP27KO mice (A) in plasma. B: Cerebrum cholestanol levels and plasma 7α-hydroxy-4-cholesten-3-one levels shown in the same diagrams. Number of mice, used to measure 7α-hydroxy-4-cholesten-3-one levels in plasma, per group were: WT and KO; ctrl n4 (pool) and n3, cholestyramine n4 (pool) and n3, cholic acid n5 and n5). Number of mice, used to measure cholestanol levels in plasma and cerebrum, per group were: WT and KO; ctrl n4 and n5, cholestyramine n4 and n3, cholic acid n5 and n5.

    Article Snippet: 7α-Hydroxy-4-cholesten-3-one was obtained from Steraloids.

    Techniques: Mouse Assay