3730xl dna analyzer  (Thermo Fisher)

 
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    Name:
    3730xl DNA Analyzer
    Description:
    The 96 capillary 3730xl DNA Analyzer is the Gold Standard for high throughput genetic analysis Use this for DNA fragment analysis applications such as microsatellites AFLP SNP analysis mutation detection and traditional DNA sequencing Get the highest quality data at a low cost per sample • Higher optical sensitivity and advanced polymers enable you to obtain higher quality sequencing data for less • Multiple automation features decrease costly human errors • Optimized polymers increase your productivity without compromising your results • Perform a wide variety of sequencing and fragment analysis applications including resequencing microsatellite analysis AFLP LOH SSCP SNP screening and SNP validation Large Scale DNA Analysis on a Small Scale BudgetBy combining advances in automation with innovative optics and proprietary reagents to increase throughput yield high quality data and minimize reagent consumption the 3730xl Analyzer provides your laboratory and production facility with faster better cheaper analysis Streamline Your Workflow The 3730xl DNA Analyzer system is engineered for highly reliable unattended operation of up to 48 hours applies to modules with run times longer than 30 minutes To minimize the need for operator intervention and decrease the risk of human error automation features include an integrated plate stacker internal bar code reader and onboard polymer delivery system Increase ProductivityThe high signal to noise ratio ensures you get high quality data even when you use low concentration samples and reagents Labor saving automation features minimize hands on time and enable you to analyze more data more efficiently Get the Highest Quality Sequencing and Genotyping DataThe enhanced optical design provides a higher signal to noise ratio and a more uniform signal profile across the array This design combined with our new advanced polymer enables the longest read lengths of any available system and provides enhanced color balance for streamlined genotyping sample handling In addition exceptional sensitivity enables higher success rates across a wide range of sample template types and concentrations One Instrument Multiple ApplicationsWith the 3730xl DNA Analyzer you get the highest quality data from a wide array of applications In addition to being ideal for high throughput sequencing the analyzer s optimized application assays instrument and analysis software also provide a complete solution for genotyping and resequencing Integrated Data Analysis Tools Reduce Time to ResultsThe 3730xl DNA Analyzer software suite allows you to generate more meaningful data with less work This system s labor saving software suite includes • Data Collection supplied with the instrument Manages your instrument setup controls instrument operations allows real time data visualization and performs diagnostics • Sequencing Analysis Software Designed to base call assign quality values trim display edit and print DNA sequencing data using the KB basecaller • Seqscape Provides everything you need to perform resequencing applications such as VariantSEQr Resequencing System • GeneMapper Enables configurable automated allele calling a plus for high throughput genotyping and includes tools for SNPlex data analysis New features include • Auto analysis with GeneMapper and SeqScape • Flexibility to use any choice in dye set option • Tools to assist with regulatory and compliance requirements In the United States this assists with FDA 21CFR part 11 • Additional optimized run modules covering more applications • Support for fragment analysis applications on the 96 capillary arrayThe instrument comes with a one year limited warranty on parts and labor For Research Use Only Not for use in diagnostics procedures
    Catalog Number:
    3730xl
    Price:
    None
    Applications:
    Amplified Fragment Length Polymorphism-AFLP®|Bacterial Artificial Chromosome (BAC) Fingerprinting|DNA Sequencing|Epigenetic Sequencing|Fragment Analysis|Genotyping & Genomic Profiling|Methylation-Sensitive Mobility Shift Assay|Microsatellite Marker Analysis|Mitochondrial Sequencing|Quantitative Fluorescence PCR (qf-PCR)|RNAi, Epigenetics & Non-Coding RNA Research|Resequencing|SNP Genotyping by Fragment-Analysis|Sanger Sequencing|Sanger Sequencing Technology & Accessories|Methylation Analysis|Gene Expression Analysis & Genotyping|SNP Genotyping|Sequencing|Methylation Analysis by Sequencing|Restriction Fragment Length Polymorphisms (RFLP) Analysis|Single-Strand Conformation Polymorphism (SSCP) Analysis|Genotyping Instruments, Software & Calibration|Chimerism|Microsatellite Instability|Microsatellite STR Analysis|ISSR (Inter-Simple Sequence Repeat) Analysis|Microsatellite Analysis
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    Instruments and Equipment
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    Structured Review

    Thermo Fisher 3730xl dna analyzer
    Variant validation by Sanger sequencing and fragment analysis. Sanger sequence of a wildtype and homozygous affected cat for the 7 bp GDF7 variant (boxed region). (B) Fluorescence-based fragment analysis using an ABI <t>3730XL</t> for the GDF7 variant. Left – homozygous wildtype with 294 bp fragment, middle – heterozygous with 287 and 294 bp fragments, and right – affected with 287 bp fragment. LIZ standard (Applied Biosystems, Foster City, CA, USA).
    The 96 capillary 3730xl DNA Analyzer is the Gold Standard for high throughput genetic analysis Use this for DNA fragment analysis applications such as microsatellites AFLP SNP analysis mutation detection and traditional DNA sequencing Get the highest quality data at a low cost per sample • Higher optical sensitivity and advanced polymers enable you to obtain higher quality sequencing data for less • Multiple automation features decrease costly human errors • Optimized polymers increase your productivity without compromising your results • Perform a wide variety of sequencing and fragment analysis applications including resequencing microsatellite analysis AFLP LOH SSCP SNP screening and SNP validation Large Scale DNA Analysis on a Small Scale BudgetBy combining advances in automation with innovative optics and proprietary reagents to increase throughput yield high quality data and minimize reagent consumption the 3730xl Analyzer provides your laboratory and production facility with faster better cheaper analysis Streamline Your Workflow The 3730xl DNA Analyzer system is engineered for highly reliable unattended operation of up to 48 hours applies to modules with run times longer than 30 minutes To minimize the need for operator intervention and decrease the risk of human error automation features include an integrated plate stacker internal bar code reader and onboard polymer delivery system Increase ProductivityThe high signal to noise ratio ensures you get high quality data even when you use low concentration samples and reagents Labor saving automation features minimize hands on time and enable you to analyze more data more efficiently Get the Highest Quality Sequencing and Genotyping DataThe enhanced optical design provides a higher signal to noise ratio and a more uniform signal profile across the array This design combined with our new advanced polymer enables the longest read lengths of any available system and provides enhanced color balance for streamlined genotyping sample handling In addition exceptional sensitivity enables higher success rates across a wide range of sample template types and concentrations One Instrument Multiple ApplicationsWith the 3730xl DNA Analyzer you get the highest quality data from a wide array of applications In addition to being ideal for high throughput sequencing the analyzer s optimized application assays instrument and analysis software also provide a complete solution for genotyping and resequencing Integrated Data Analysis Tools Reduce Time to ResultsThe 3730xl DNA Analyzer software suite allows you to generate more meaningful data with less work This system s labor saving software suite includes • Data Collection supplied with the instrument Manages your instrument setup controls instrument operations allows real time data visualization and performs diagnostics • Sequencing Analysis Software Designed to base call assign quality values trim display edit and print DNA sequencing data using the KB basecaller • Seqscape Provides everything you need to perform resequencing applications such as VariantSEQr Resequencing System • GeneMapper Enables configurable automated allele calling a plus for high throughput genotyping and includes tools for SNPlex data analysis New features include • Auto analysis with GeneMapper and SeqScape • Flexibility to use any choice in dye set option • Tools to assist with regulatory and compliance requirements In the United States this assists with FDA 21CFR part 11 • Additional optimized run modules covering more applications • Support for fragment analysis applications on the 96 capillary arrayThe instrument comes with a one year limited warranty on parts and labor For Research Use Only Not for use in diagnostics procedures
    https://www.bioz.com/result/3730xl dna analyzer/product/Thermo Fisher
    Average 99 stars, based on 6868 article reviews
    Price from $9.99 to $1999.99
    3730xl dna analyzer - by Bioz Stars, 2021-02
    99/100 stars

    Images

    1) Product Images from "A deletion in GDF7 is associated with a heritable forebrain commissural malformation concurrent with ventriculomegaly and interhemispheric cysts in cats"

    Article Title: A deletion in GDF7 is associated with a heritable forebrain commissural malformation concurrent with ventriculomegaly and interhemispheric cysts in cats

    Journal: bioRxiv

    doi: 10.1101/2020.05.12.091686

    Variant validation by Sanger sequencing and fragment analysis. Sanger sequence of a wildtype and homozygous affected cat for the 7 bp GDF7 variant (boxed region). (B) Fluorescence-based fragment analysis using an ABI 3730XL for the GDF7 variant. Left – homozygous wildtype with 294 bp fragment, middle – heterozygous with 287 and 294 bp fragments, and right – affected with 287 bp fragment. LIZ standard (Applied Biosystems, Foster City, CA, USA).
    Figure Legend Snippet: Variant validation by Sanger sequencing and fragment analysis. Sanger sequence of a wildtype and homozygous affected cat for the 7 bp GDF7 variant (boxed region). (B) Fluorescence-based fragment analysis using an ABI 3730XL for the GDF7 variant. Left – homozygous wildtype with 294 bp fragment, middle – heterozygous with 287 and 294 bp fragments, and right – affected with 287 bp fragment. LIZ standard (Applied Biosystems, Foster City, CA, USA).

    Techniques Used: Variant Assay, Sequencing, Fluorescence

    2) Product Images from "A deletion in GDF7 is associated with a heritable forebrain commissural malformation concurrent with ventriculomegaly and interhemispheric cysts in cats"

    Article Title: A deletion in GDF7 is associated with a heritable forebrain commissural malformation concurrent with ventriculomegaly and interhemispheric cysts in cats

    Journal: bioRxiv

    doi: 10.1101/2020.05.12.091686

    Variant validation by Sanger sequencing and fragment analysis. Sanger sequence of a wildtype and homozygous affected cat for the 7 bp GDF7 variant (boxed region). (B) Fluorescence-based fragment analysis using an ABI 3730XL for the GDF7 variant. Left – homozygous wildtype with 294 bp fragment, middle – heterozygous with 287 and 294 bp fragments, and right – affected with 287 bp fragment. LIZ standard (Applied Biosystems, Foster City, CA, USA).
    Figure Legend Snippet: Variant validation by Sanger sequencing and fragment analysis. Sanger sequence of a wildtype and homozygous affected cat for the 7 bp GDF7 variant (boxed region). (B) Fluorescence-based fragment analysis using an ABI 3730XL for the GDF7 variant. Left – homozygous wildtype with 294 bp fragment, middle – heterozygous with 287 and 294 bp fragments, and right – affected with 287 bp fragment. LIZ standard (Applied Biosystems, Foster City, CA, USA).

    Techniques Used: Variant Assay, Sequencing, Fluorescence

    Related Articles

    Clone Assay:

    Article Title: Diversity of Bacteria and Archaea in hypersaline sediment from Death Valley National Park, California
    Article Snippet: .. Sequencing and phylogenetic analysis The 16S rRNA genes from the bacterial clones and isolates were sequenced using an Applied BioSystems (Foster City, CA) model 3730xl automated DNA sequencing system. ..

    Agarose Gel Electrophoresis:

    Article Title: Atlas of tissue- and developmental stage specific gene expression for the bovine insulin-like growth factor (IGF) system
    Article Snippet: .. Target specificity and integrity was confirmed via sequencing of selected amplicons on a 3730xl DNA Analyzer (Applied Biosystems, Inc., Foster City, CA, USA), plots of the melting curve derived by Mastercycler® ep Realplex software (Eppendorf, Inc., Hamburg, Germany), and by electrophoresis of PCR products on a 2% agarose gel (Agarose low EEO, AppliChem GmbH, Darmstadt, Germany) and visual inspection under UV with Gel DocTM 1000 Single Wavelength Mini-Transilluminator, using Quantity One image analyzing software (Bio-Rad Laboratories, Inc., Hercules, CA, USA) after staining with GelRed™ Nucleic Acid Stain (Biotium, Inc., Hayward, CA, USA). .. Melt-curve dissociation analyses were performed to ensure that amplifications were free of primer dimers; amplification efficiencies were ≧ 0.9.

    Isolation:

    Article Title: Impact of next-generation sequencing error on analysis of barcoded plasmid libraries of known complexity and sequence
    Article Snippet: .. Production of defined barcode librariesFrom the Illumina-compatible and SOLiD-compatible plasmid libraries, individual plasmids containing 119 and 100 unique barcodes, respectively, were isolated, quantified using a NanoDrop 1000 spectrophotometer (Thermo Fisher Scientific), and Sanger-sequenced using an AB 3730xl instrument (Australian Genome Research Facility). .. Barcode libraries of defined complexity comprising known sequence identities were produced by mixing the plasmids containing these sequenced barcodes in equimolar proportions.

    Derivative Assay:

    Article Title: Atlas of tissue- and developmental stage specific gene expression for the bovine insulin-like growth factor (IGF) system
    Article Snippet: .. Target specificity and integrity was confirmed via sequencing of selected amplicons on a 3730xl DNA Analyzer (Applied Biosystems, Inc., Foster City, CA, USA), plots of the melting curve derived by Mastercycler® ep Realplex software (Eppendorf, Inc., Hamburg, Germany), and by electrophoresis of PCR products on a 2% agarose gel (Agarose low EEO, AppliChem GmbH, Darmstadt, Germany) and visual inspection under UV with Gel DocTM 1000 Single Wavelength Mini-Transilluminator, using Quantity One image analyzing software (Bio-Rad Laboratories, Inc., Hercules, CA, USA) after staining with GelRed™ Nucleic Acid Stain (Biotium, Inc., Hayward, CA, USA). .. Melt-curve dissociation analyses were performed to ensure that amplifications were free of primer dimers; amplification efficiencies were ≧ 0.9.

    Spectrophotometry:

    Article Title: Impact of next-generation sequencing error on analysis of barcoded plasmid libraries of known complexity and sequence
    Article Snippet: .. Production of defined barcode librariesFrom the Illumina-compatible and SOLiD-compatible plasmid libraries, individual plasmids containing 119 and 100 unique barcodes, respectively, were isolated, quantified using a NanoDrop 1000 spectrophotometer (Thermo Fisher Scientific), and Sanger-sequenced using an AB 3730xl instrument (Australian Genome Research Facility). .. Barcode libraries of defined complexity comprising known sequence identities were produced by mixing the plasmids containing these sequenced barcodes in equimolar proportions.

    Electrophoresis:

    Article Title: Atlas of tissue- and developmental stage specific gene expression for the bovine insulin-like growth factor (IGF) system
    Article Snippet: .. Target specificity and integrity was confirmed via sequencing of selected amplicons on a 3730xl DNA Analyzer (Applied Biosystems, Inc., Foster City, CA, USA), plots of the melting curve derived by Mastercycler® ep Realplex software (Eppendorf, Inc., Hamburg, Germany), and by electrophoresis of PCR products on a 2% agarose gel (Agarose low EEO, AppliChem GmbH, Darmstadt, Germany) and visual inspection under UV with Gel DocTM 1000 Single Wavelength Mini-Transilluminator, using Quantity One image analyzing software (Bio-Rad Laboratories, Inc., Hercules, CA, USA) after staining with GelRed™ Nucleic Acid Stain (Biotium, Inc., Hayward, CA, USA). .. Melt-curve dissociation analyses were performed to ensure that amplifications were free of primer dimers; amplification efficiencies were ≧ 0.9.

    Sequencing:

    Article Title: Diversity of Bacteria and Archaea in hypersaline sediment from Death Valley National Park, California
    Article Snippet: .. Sequencing and phylogenetic analysis The 16S rRNA genes from the bacterial clones and isolates were sequenced using an Applied BioSystems (Foster City, CA) model 3730xl automated DNA sequencing system. ..

    Article Title: Atlas of tissue- and developmental stage specific gene expression for the bovine insulin-like growth factor (IGF) system
    Article Snippet: .. Target specificity and integrity was confirmed via sequencing of selected amplicons on a 3730xl DNA Analyzer (Applied Biosystems, Inc., Foster City, CA, USA), plots of the melting curve derived by Mastercycler® ep Realplex software (Eppendorf, Inc., Hamburg, Germany), and by electrophoresis of PCR products on a 2% agarose gel (Agarose low EEO, AppliChem GmbH, Darmstadt, Germany) and visual inspection under UV with Gel DocTM 1000 Single Wavelength Mini-Transilluminator, using Quantity One image analyzing software (Bio-Rad Laboratories, Inc., Hercules, CA, USA) after staining with GelRed™ Nucleic Acid Stain (Biotium, Inc., Hayward, CA, USA). .. Melt-curve dissociation analyses were performed to ensure that amplifications were free of primer dimers; amplification efficiencies were ≧ 0.9.

    Article Title: QTL‐seq identifies BnaFT.A02 and BnaFLC.A02 as candidates for variation in vernalization requirement and response in winter oilseed rape (Brassica napus)) QTL‐seq identifies BnaFT.A02 and BnaFLC.A02 as candidates for variation in vernalization requirement and response in winter oilseed rape (Brassica napus)
    Article Snippet: .. Sequence analysis of BnaFLC.A02 and BnaFT.A02 To assess for DNA polymorphisms, sequences for BnaFLC.A02 and BnaFT.A02 were extracted from the Cabriolet and Darmor sequence PileUp and aligned against the Darmor‐bzh BnaFLC.A02 and BnaFT.A02 sequences (Chalhoub et al ., ), downloaded from plants.ensembl.org . .. Sequence polymorphisms were identified, and amino acid sequence changes were predicted using AlignX (Vector NTI Advance®, InvitrogenTM , now Thermo Fisher Scientific, https://www.thermofisher.com ).

    Article Title: A Factor I-Like Activity Associated with Chikungunya Virus Contributes to Its Resistance to the Human Complement System
    Article Snippet: .. The viruses used in the study were validated by partial sequencing of the E2 gene of CHIKV and the N, M, and G genes of CHPV in a 3730XL DNA analyzer (Applied Biosystems, CA). .. Viruses were grown and titrated using a plaque assay in Vero cells.

    Article Title: Drug Resistance and Molecular Epidemiology of Carbapenem Resistant Gram-negative Bacilli Isolates
    Article Snippet: .. Sequencing DNA sequencing was performed at TRIYAT SCIENTIFIC CO.(Nagpur, India) using the ABI Prism® Big Dye® Terminator version 3.1 Cycle Sequencing Kit (Applied Biosystems, USA), for forward and reverse primers of NDM-1 gene on 3730xl Genetic Analyzer (Applied Biosystems, USA), separately. .. Phylogenetic analysis Phylogenetic analysis was performed using the software MEGA, version 4, after multiple alignments of data using CLUSTAL X. Pairwise evolutionary distances were estimated by Kimura's two-parameter method, and a phylogenetic tree was constructed by the neighbor-joining method.

    DNA Sequencing:

    Article Title: Diversity of Bacteria and Archaea in hypersaline sediment from Death Valley National Park, California
    Article Snippet: .. Sequencing and phylogenetic analysis The 16S rRNA genes from the bacterial clones and isolates were sequenced using an Applied BioSystems (Foster City, CA) model 3730xl automated DNA sequencing system. ..

    Article Title: Drug Resistance and Molecular Epidemiology of Carbapenem Resistant Gram-negative Bacilli Isolates
    Article Snippet: .. Sequencing DNA sequencing was performed at TRIYAT SCIENTIFIC CO.(Nagpur, India) using the ABI Prism® Big Dye® Terminator version 3.1 Cycle Sequencing Kit (Applied Biosystems, USA), for forward and reverse primers of NDM-1 gene on 3730xl Genetic Analyzer (Applied Biosystems, USA), separately. .. Phylogenetic analysis Phylogenetic analysis was performed using the software MEGA, version 4, after multiple alignments of data using CLUSTAL X. Pairwise evolutionary distances were estimated by Kimura's two-parameter method, and a phylogenetic tree was constructed by the neighbor-joining method.

    Polymerase Chain Reaction:

    Article Title: Atlas of tissue- and developmental stage specific gene expression for the bovine insulin-like growth factor (IGF) system
    Article Snippet: .. Target specificity and integrity was confirmed via sequencing of selected amplicons on a 3730xl DNA Analyzer (Applied Biosystems, Inc., Foster City, CA, USA), plots of the melting curve derived by Mastercycler® ep Realplex software (Eppendorf, Inc., Hamburg, Germany), and by electrophoresis of PCR products on a 2% agarose gel (Agarose low EEO, AppliChem GmbH, Darmstadt, Germany) and visual inspection under UV with Gel DocTM 1000 Single Wavelength Mini-Transilluminator, using Quantity One image analyzing software (Bio-Rad Laboratories, Inc., Hercules, CA, USA) after staining with GelRed™ Nucleic Acid Stain (Biotium, Inc., Hayward, CA, USA). .. Melt-curve dissociation analyses were performed to ensure that amplifications were free of primer dimers; amplification efficiencies were ≧ 0.9.

    Staining:

    Article Title: Atlas of tissue- and developmental stage specific gene expression for the bovine insulin-like growth factor (IGF) system
    Article Snippet: .. Target specificity and integrity was confirmed via sequencing of selected amplicons on a 3730xl DNA Analyzer (Applied Biosystems, Inc., Foster City, CA, USA), plots of the melting curve derived by Mastercycler® ep Realplex software (Eppendorf, Inc., Hamburg, Germany), and by electrophoresis of PCR products on a 2% agarose gel (Agarose low EEO, AppliChem GmbH, Darmstadt, Germany) and visual inspection under UV with Gel DocTM 1000 Single Wavelength Mini-Transilluminator, using Quantity One image analyzing software (Bio-Rad Laboratories, Inc., Hercules, CA, USA) after staining with GelRed™ Nucleic Acid Stain (Biotium, Inc., Hayward, CA, USA). .. Melt-curve dissociation analyses were performed to ensure that amplifications were free of primer dimers; amplification efficiencies were ≧ 0.9.

    Plasmid Preparation:

    Article Title: Impact of next-generation sequencing error on analysis of barcoded plasmid libraries of known complexity and sequence
    Article Snippet: .. Production of defined barcode librariesFrom the Illumina-compatible and SOLiD-compatible plasmid libraries, individual plasmids containing 119 and 100 unique barcodes, respectively, were isolated, quantified using a NanoDrop 1000 spectrophotometer (Thermo Fisher Scientific), and Sanger-sequenced using an AB 3730xl instrument (Australian Genome Research Facility). .. Barcode libraries of defined complexity comprising known sequence identities were produced by mixing the plasmids containing these sequenced barcodes in equimolar proportions.

    Software:

    Article Title: Atlas of tissue- and developmental stage specific gene expression for the bovine insulin-like growth factor (IGF) system
    Article Snippet: .. Target specificity and integrity was confirmed via sequencing of selected amplicons on a 3730xl DNA Analyzer (Applied Biosystems, Inc., Foster City, CA, USA), plots of the melting curve derived by Mastercycler® ep Realplex software (Eppendorf, Inc., Hamburg, Germany), and by electrophoresis of PCR products on a 2% agarose gel (Agarose low EEO, AppliChem GmbH, Darmstadt, Germany) and visual inspection under UV with Gel DocTM 1000 Single Wavelength Mini-Transilluminator, using Quantity One image analyzing software (Bio-Rad Laboratories, Inc., Hercules, CA, USA) after staining with GelRed™ Nucleic Acid Stain (Biotium, Inc., Hayward, CA, USA). .. Melt-curve dissociation analyses were performed to ensure that amplifications were free of primer dimers; amplification efficiencies were ≧ 0.9.

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    Thermo Fisher 3730xl dna analyzer
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    https://www.bioz.com/result/3730xl dna analyzer/product/Thermo Fisher
    Average 99 stars, based on 6868 article reviews
    Price from $9.99 to $1999.99
    3730xl dna analyzer - by Bioz Stars, 2021-02
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      Buy from Supplier

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