caco 2  (CLS Cell Lines Service GmbH)


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    CLS Cell Lines Service GmbH caco 2
    Caco 2, supplied by CLS Cell Lines Service GmbH, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    caco 2  (CLS Cell Lines Service GmbH)


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    CLS Cell Lines Service GmbH caco 2
    Caco 2, supplied by CLS Cell Lines Service GmbH, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    caco 2 cells  (CLS Cell Lines Service GmbH)


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    CLS Cell Lines Service GmbH caco 2 cells
    Caco 2 Cells, supplied by CLS Cell Lines Service GmbH, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    caco 2  (CLS Cell Lines Service GmbH)


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    CLS Cell Lines Service GmbH caco 2
    rMYL1 is transported intact through a monolayer of <t>Caco‐2</t> cells. Anti‐rMYL1 immunoblot of the medium applied to the apical (AP) side and collected from the basolateral side (BL) of a Caco‐2 cell monolayer cultured on permeable supports. Cells were incubated with undigested rMYL1, with rMYL1 digested by pepsin for 60 min (G60) or with medium (CT) only. Molecular weights (kDa) are indicated in the left margin.
    Caco 2, supplied by CLS Cell Lines Service GmbH, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    1) Product Images from "Bos d 13, A Novel Heat‐Stable Beef Allergen"

    Article Title: Bos d 13, A Novel Heat‐Stable Beef Allergen

    Journal: Molecular Nutrition & Food Research

    doi: 10.1002/mnfr.202200601

    rMYL1 is transported intact through a monolayer of Caco‐2 cells. Anti‐rMYL1 immunoblot of the medium applied to the apical (AP) side and collected from the basolateral side (BL) of a Caco‐2 cell monolayer cultured on permeable supports. Cells were incubated with undigested rMYL1, with rMYL1 digested by pepsin for 60 min (G60) or with medium (CT) only. Molecular weights (kDa) are indicated in the left margin.
    Figure Legend Snippet: rMYL1 is transported intact through a monolayer of Caco‐2 cells. Anti‐rMYL1 immunoblot of the medium applied to the apical (AP) side and collected from the basolateral side (BL) of a Caco‐2 cell monolayer cultured on permeable supports. Cells were incubated with undigested rMYL1, with rMYL1 digested by pepsin for 60 min (G60) or with medium (CT) only. Molecular weights (kDa) are indicated in the left margin.

    Techniques Used: Western Blot, Cell Culture, Incubation

    caco 2 cells  (CLS Cell Lines Service GmbH)


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    CLS Cell Lines Service GmbH caco 2 cells
    Caco 2 Cells, supplied by CLS Cell Lines Service GmbH, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    caco 2 cells  (CLS Cell Lines Service GmbH)


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    CLS Cell Lines Service GmbH caco 2 cells
    Caco 2 Cells, supplied by CLS Cell Lines Service GmbH, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    caco 2 cells  (CLS Cell Lines Service GmbH)


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    CLS Cell Lines Service GmbH caco 2 cells
    Caco 2 Cells, supplied by CLS Cell Lines Service GmbH, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    caco 2 cells  (CLS Cell Lines Service GmbH)


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    CLS Cell Lines Service GmbH caco 2 cells
    Caco 2 Cells, supplied by CLS Cell Lines Service GmbH, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    caco 2 cells  (CLS Cell Lines Service GmbH)


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    CLS Cell Lines Service GmbH caco 2 cells
    Caco 2 Cells, supplied by CLS Cell Lines Service GmbH, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    caco 2 cells  (CLS Cell Lines Service GmbH)


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    CLS Cell Lines Service GmbH caco 2 cells
    Selection and characterization of antibody-resistant SARS-CoV-2. (A) Cultivation of the SARS-CoV-2 input strain (GenBank accession no. ON715117) in Vero cells for 12 weeks, using increasing concentrations (c) of neutralizing monoclonal antibody (mAB) S309 or non-neutralizing mAB CR3022 (see <xref ref-type= Supplementary Figure 1 ). Data show mean viral loads in cell culture supernatants of each passage at 5d post infection, transferred weekly in duplicates to fresh cells containing fourfold increased antibody concentrations. A virus control without antibodies was included in each passage and continuously propagated during the entire selection period. (B) Neutralization of input strain (CA) and resistant (7S1) virus by increasing S309 and CR3022 concentrations. (C–E) Neutralizing activity (inhibitory concentration 50%, IC50) of (C) REGN10933, (D) REGN10987 and (E) a combination of both Regeneron antibodies on Vero and CaCo-2 cells. Viral loads were determined in cell culture supernatants using RT-qPCR 2d post infection and plotted as percent neutralization in a non-linear fit. Data show mean and standard error of three independent experiments. Statistics is based on repeated measures (RM) one-way ANOVA, adjusted for multiple testing using Tukey’s correction. *p<0.05; **p<0.01; ***p<0.001. " width="250" height="auto" />
    Caco 2 Cells, supplied by CLS Cell Lines Service GmbH, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    1) Product Images from "Targeted escape of SARS-CoV-2 in vitro from monoclonal antibody S309, the precursor of sotrovimab"

    Article Title: Targeted escape of SARS-CoV-2 in vitro from monoclonal antibody S309, the precursor of sotrovimab

    Journal: Frontiers in Immunology

    doi: 10.3389/fimmu.2022.966236

    Selection and characterization of antibody-resistant SARS-CoV-2. (A) Cultivation of the SARS-CoV-2 input strain (GenBank accession no. ON715117) in Vero cells for 12 weeks, using increasing concentrations (c) of neutralizing monoclonal antibody (mAB) S309 or non-neutralizing mAB CR3022 (see <xref ref-type= Supplementary Figure 1 ). Data show mean viral loads in cell culture supernatants of each passage at 5d post infection, transferred weekly in duplicates to fresh cells containing fourfold increased antibody concentrations. A virus control without antibodies was included in each passage and continuously propagated during the entire selection period. (B) Neutralization of input strain (CA) and resistant (7S1) virus by increasing S309 and CR3022 concentrations. (C–E) Neutralizing activity (inhibitory concentration 50%, IC50) of (C) REGN10933, (D) REGN10987 and (E) a combination of both Regeneron antibodies on Vero and CaCo-2 cells. Viral loads were determined in cell culture supernatants using RT-qPCR 2d post infection and plotted as percent neutralization in a non-linear fit. Data show mean and standard error of three independent experiments. Statistics is based on repeated measures (RM) one-way ANOVA, adjusted for multiple testing using Tukey’s correction. *p<0.05; **p<0.01; ***p<0.001. " title="... combination of both Regeneron antibodies on Vero and CaCo-2 cells. Viral loads were determined in cell culture ..." property="contentUrl" width="100%" height="100%"/>
    Figure Legend Snippet: Selection and characterization of antibody-resistant SARS-CoV-2. (A) Cultivation of the SARS-CoV-2 input strain (GenBank accession no. ON715117) in Vero cells for 12 weeks, using increasing concentrations (c) of neutralizing monoclonal antibody (mAB) S309 or non-neutralizing mAB CR3022 (see Supplementary Figure 1 ). Data show mean viral loads in cell culture supernatants of each passage at 5d post infection, transferred weekly in duplicates to fresh cells containing fourfold increased antibody concentrations. A virus control without antibodies was included in each passage and continuously propagated during the entire selection period. (B) Neutralization of input strain (CA) and resistant (7S1) virus by increasing S309 and CR3022 concentrations. (C–E) Neutralizing activity (inhibitory concentration 50%, IC50) of (C) REGN10933, (D) REGN10987 and (E) a combination of both Regeneron antibodies on Vero and CaCo-2 cells. Viral loads were determined in cell culture supernatants using RT-qPCR 2d post infection and plotted as percent neutralization in a non-linear fit. Data show mean and standard error of three independent experiments. Statistics is based on repeated measures (RM) one-way ANOVA, adjusted for multiple testing using Tukey’s correction. *p<0.05; **p<0.01; ***p<0.001.

    Techniques Used: Selection, Cell Culture, Infection, Neutralization, Activity Assay, Concentration Assay, Quantitative RT-PCR

    Replication kinetics of SARS-CoV-2 strains before and after selection with S309. (A, B) Vero and (C, D) CaCo-2 cells were infected with input (CA) and resistant (7S1) SARS-CoV-2 viruses using a multiplicity of infection of 0.05. Viruses were cultivated with CR3022 (squares) and S309 (circles) at a concentration of 5 µg/ml in the absence and presence of FcR-blocking reagent. Viral supernatants were harvested at 6h, 12h, 24h, and 48h post infection and analyzed using RT-qPCR. A control with paraformaldehyde-fixed cells was included to quantify background viral load. Virus control (triangles) shows viral loads in the absence of antibodies with background subtracted. Mean and standard error of three independent experiments on Vero cells and four independent experiments on CaCo-2 cells are shown. The asterisk in <xref ref-type= Figure 4A indicates a mean viral load in the virus control below the background level at 6h p.i. " title="... with S309. (A, B) Vero and (C, D) CaCo-2 cells were infected with input (CA) and resistant ..." property="contentUrl" width="100%" height="100%"/>
    Figure Legend Snippet: Replication kinetics of SARS-CoV-2 strains before and after selection with S309. (A, B) Vero and (C, D) CaCo-2 cells were infected with input (CA) and resistant (7S1) SARS-CoV-2 viruses using a multiplicity of infection of 0.05. Viruses were cultivated with CR3022 (squares) and S309 (circles) at a concentration of 5 µg/ml in the absence and presence of FcR-blocking reagent. Viral supernatants were harvested at 6h, 12h, 24h, and 48h post infection and analyzed using RT-qPCR. A control with paraformaldehyde-fixed cells was included to quantify background viral load. Virus control (triangles) shows viral loads in the absence of antibodies with background subtracted. Mean and standard error of three independent experiments on Vero cells and four independent experiments on CaCo-2 cells are shown. The asterisk in Figure 4A indicates a mean viral load in the virus control below the background level at 6h p.i.

    Techniques Used: Selection, Infection, Concentration Assay, Blocking Assay, Quantitative RT-PCR

    Susceptibility of SARS-CoV-2 variants to inhibition of endocytosis and fusion by aloxistatin and camostat, respectively. CaCo-2 and HEK293T cells were infected with (A, B) a SARS-CoV-2 Delta strain , (C, D) wild-type virus (CA) used as input for selection of S309-resistant strains, and mutant strains with (E, F) R346S and (G, H) R346S+P337L (7S1), using a multiplicity of infection of 0.05. Cells were propagated in the presence of the endocytosis inhibitor aloxistatin, the fusion inhibitor camostat or both in a 1:1 ratio (mix) at concentrations of the individual inhibitors between 0.024-100 µM. At 2d post infection, SARS-CoV-2 concentrations were determined in cell culture supernatants and plotted as log viral load in a non-linear fit, using cells infected in the absence of inhibitors (virus control) and cells fixed with 4% paraformaldehyde (background control) as constraints. Data show mean and standard error of three independent experiments. Statistics was calculated using one-way ANOVA with Dunnett’s correction, comparing each inhibitor concentration with the respective uninhibited control (*p<0.05, **p<0.01, ***p<0.001). Macromolecular electrostatics of the SARS-CoV-2 receptor-binding domain (RBD) upon evolution of amino acid exchange R346S is shown in <xref ref-type= Supplementary Figure 3 . " title="... endocytosis and fusion by aloxistatin and camostat, respectively. CaCo-2 and HEK293T cells were infected with (A, B) ..." property="contentUrl" width="100%" height="100%"/>
    Figure Legend Snippet: Susceptibility of SARS-CoV-2 variants to inhibition of endocytosis and fusion by aloxistatin and camostat, respectively. CaCo-2 and HEK293T cells were infected with (A, B) a SARS-CoV-2 Delta strain , (C, D) wild-type virus (CA) used as input for selection of S309-resistant strains, and mutant strains with (E, F) R346S and (G, H) R346S+P337L (7S1), using a multiplicity of infection of 0.05. Cells were propagated in the presence of the endocytosis inhibitor aloxistatin, the fusion inhibitor camostat or both in a 1:1 ratio (mix) at concentrations of the individual inhibitors between 0.024-100 µM. At 2d post infection, SARS-CoV-2 concentrations were determined in cell culture supernatants and plotted as log viral load in a non-linear fit, using cells infected in the absence of inhibitors (virus control) and cells fixed with 4% paraformaldehyde (background control) as constraints. Data show mean and standard error of three independent experiments. Statistics was calculated using one-way ANOVA with Dunnett’s correction, comparing each inhibitor concentration with the respective uninhibited control (*p<0.05, **p<0.01, ***p<0.001). Macromolecular electrostatics of the SARS-CoV-2 receptor-binding domain (RBD) upon evolution of amino acid exchange R346S is shown in Supplementary Figure 3 .

    Techniques Used: Inhibition, Infection, Selection, Mutagenesis, Cell Culture, Concentration Assay, Binding Assay

    caco2 cells  (CLS Cell Lines Service GmbH)


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    CLS Cell Lines Service GmbH caco2 cells
    : Toxicity and virostatic effect of different endocytosis inhibitors. Toxicity (shown as cell viability (%), grey) was tested using the <t>CaCo2</t> cell line and virostatic activity (green) was analyzed using the Omicron SARS-CoV-2 lentiviral pseudovirus. All compounds were tested at 10 µM. Five different proteins of the endocytosis pathway were analyzed. PI3K using Copanlisib, Pictilisib and YM201636; Dynamin using Mdivi1; PDE using PDE10-IN-1 and Sildenafil; ß-arrestin using Pirenzepine and Levetimidine; Calmodulin using A-7, Zaldaride, Dexniguldipine (also a p-gp efflux pump inhibitor). Data shown is based on the average and standard deviation of three independent experiments.
    Caco2 Cells, supplied by CLS Cell Lines Service GmbH, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    1) Product Images from "High-throughput drug screening allowed identification of entry inhibitors specifically targeting different routes of SARS-CoV-2 Delta and Omicron/BA.1"

    Article Title: High-throughput drug screening allowed identification of entry inhibitors specifically targeting different routes of SARS-CoV-2 Delta and Omicron/BA.1

    Journal: Biomedicine & Pharmacotherapy

    doi: 10.1016/j.biopha.2022.113104

    : Toxicity and virostatic effect of different endocytosis inhibitors. Toxicity (shown as cell viability (%), grey) was tested using the CaCo2 cell line and virostatic activity (green) was analyzed using the Omicron SARS-CoV-2 lentiviral pseudovirus. All compounds were tested at 10 µM. Five different proteins of the endocytosis pathway were analyzed. PI3K using Copanlisib, Pictilisib and YM201636; Dynamin using Mdivi1; PDE using PDE10-IN-1 and Sildenafil; ß-arrestin using Pirenzepine and Levetimidine; Calmodulin using A-7, Zaldaride, Dexniguldipine (also a p-gp efflux pump inhibitor). Data shown is based on the average and standard deviation of three independent experiments.
    Figure Legend Snippet: : Toxicity and virostatic effect of different endocytosis inhibitors. Toxicity (shown as cell viability (%), grey) was tested using the CaCo2 cell line and virostatic activity (green) was analyzed using the Omicron SARS-CoV-2 lentiviral pseudovirus. All compounds were tested at 10 µM. Five different proteins of the endocytosis pathway were analyzed. PI3K using Copanlisib, Pictilisib and YM201636; Dynamin using Mdivi1; PDE using PDE10-IN-1 and Sildenafil; ß-arrestin using Pirenzepine and Levetimidine; Calmodulin using A-7, Zaldaride, Dexniguldipine (also a p-gp efflux pump inhibitor). Data shown is based on the average and standard deviation of three independent experiments.

    Techniques Used: Activity Assay, Standard Deviation

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    CLS Cell Lines Service GmbH caco 2
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    CLS Cell Lines Service GmbH caco 2 cells
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    CLS Cell Lines Service GmbH caco2 cells
    : Toxicity and virostatic effect of different endocytosis inhibitors. Toxicity (shown as cell viability (%), grey) was tested using the <t>CaCo2</t> cell line and virostatic activity (green) was analyzed using the Omicron SARS-CoV-2 lentiviral pseudovirus. All compounds were tested at 10 µM. Five different proteins of the endocytosis pathway were analyzed. PI3K using Copanlisib, Pictilisib and YM201636; Dynamin using Mdivi1; PDE using PDE10-IN-1 and Sildenafil; ß-arrestin using Pirenzepine and Levetimidine; Calmodulin using A-7, Zaldaride, Dexniguldipine (also a p-gp efflux pump inhibitor). Data shown is based on the average and standard deviation of three independent experiments.
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    : Toxicity and virostatic effect of different endocytosis inhibitors. Toxicity (shown as cell viability (%), grey) was tested using the CaCo2 cell line and virostatic activity (green) was analyzed using the Omicron SARS-CoV-2 lentiviral pseudovirus. All compounds were tested at 10 µM. Five different proteins of the endocytosis pathway were analyzed. PI3K using Copanlisib, Pictilisib and YM201636; Dynamin using Mdivi1; PDE using PDE10-IN-1 and Sildenafil; ß-arrestin using Pirenzepine and Levetimidine; Calmodulin using A-7, Zaldaride, Dexniguldipine (also a p-gp efflux pump inhibitor). Data shown is based on the average and standard deviation of three independent experiments.

    Journal: Biomedicine & Pharmacotherapy

    Article Title: High-throughput drug screening allowed identification of entry inhibitors specifically targeting different routes of SARS-CoV-2 Delta and Omicron/BA.1

    doi: 10.1016/j.biopha.2022.113104

    Figure Lengend Snippet: : Toxicity and virostatic effect of different endocytosis inhibitors. Toxicity (shown as cell viability (%), grey) was tested using the CaCo2 cell line and virostatic activity (green) was analyzed using the Omicron SARS-CoV-2 lentiviral pseudovirus. All compounds were tested at 10 µM. Five different proteins of the endocytosis pathway were analyzed. PI3K using Copanlisib, Pictilisib and YM201636; Dynamin using Mdivi1; PDE using PDE10-IN-1 and Sildenafil; ß-arrestin using Pirenzepine and Levetimidine; Calmodulin using A-7, Zaldaride, Dexniguldipine (also a p-gp efflux pump inhibitor). Data shown is based on the average and standard deviation of three independent experiments.

    Article Snippet: CaCo2 cells, were obtained from Cell Lines Service (CLS, #300137) and used between passage 5 and 25.

    Techniques: Activity Assay, Standard Deviation