intellicage  (TSE systems)


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    TSE systems intellicage
    Behavioral phenotyping of TS2‐neo mice in the <t>IntelliCage.</t> (A) Schematic illustration of the IntelliCage apparatus. (B) Daily timeline. (C) Schematic illustrations of a behavioral sequencing task composed of acquisition and reversal blocks to assess flexibility. Acquisition and each reversal block include 20 sessions and 9 sessions, respectively. (D) Learning performance and behavioral flexibility were not affected in TS2‐neo mice. The discrimination error rate was based on the total number of visits to the never‐rewarded corner in the first 100 visits in each session. (E) Cumulative error visits in the first 100 visits in the first and last session of acquisition and reversal blocks. n = 8 mice in WT and n = 5 in TS2‐neo mice. Data are mean ± SEM.
    Intellicage, supplied by TSE systems, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/intellicage/product/TSE systems
    Average 97 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    intellicage - by Bioz Stars, 2022-05
    97/100 stars

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    1) Product Images from "A mouse model of Timothy syndrome exhibits altered social competitive dominance and inhibitory neuron development"

    Article Title: A mouse model of Timothy syndrome exhibits altered social competitive dominance and inhibitory neuron development

    Journal: FEBS Open Bio

    doi: 10.1002/2211-5463.12924

    Behavioral phenotyping of TS2‐neo mice in the IntelliCage. (A) Schematic illustration of the IntelliCage apparatus. (B) Daily timeline. (C) Schematic illustrations of a behavioral sequencing task composed of acquisition and reversal blocks to assess flexibility. Acquisition and each reversal block include 20 sessions and 9 sessions, respectively. (D) Learning performance and behavioral flexibility were not affected in TS2‐neo mice. The discrimination error rate was based on the total number of visits to the never‐rewarded corner in the first 100 visits in each session. (E) Cumulative error visits in the first 100 visits in the first and last session of acquisition and reversal blocks. n = 8 mice in WT and n = 5 in TS2‐neo mice. Data are mean ± SEM.
    Figure Legend Snippet: Behavioral phenotyping of TS2‐neo mice in the IntelliCage. (A) Schematic illustration of the IntelliCage apparatus. (B) Daily timeline. (C) Schematic illustrations of a behavioral sequencing task composed of acquisition and reversal blocks to assess flexibility. Acquisition and each reversal block include 20 sessions and 9 sessions, respectively. (D) Learning performance and behavioral flexibility were not affected in TS2‐neo mice. The discrimination error rate was based on the total number of visits to the never‐rewarded corner in the first 100 visits in each session. (E) Cumulative error visits in the first 100 visits in the first and last session of acquisition and reversal blocks. n = 8 mice in WT and n = 5 in TS2‐neo mice. Data are mean ± SEM.

    Techniques Used: Mouse Assay, Sequencing, Blocking Assay

    TS2‐neo mice showed highly competitive dominance in the IntelliCage. (A) Average visit duration per minute at the active rewarded corners throughout each 3‐h session from day 1 to day 20 during the acquisition block. (B) Averaged visit duration at the water available corner in the first 10 min after the start of water availability from day 16 to day 20 during acquisition. (C) Average total visit duration throughout the 3‐h session from day 16 to day 20 during acquisition. n = 8 mice in WT and n = 5 in TS2‐neo mice. Data are mean ± SEM, * P
    Figure Legend Snippet: TS2‐neo mice showed highly competitive dominance in the IntelliCage. (A) Average visit duration per minute at the active rewarded corners throughout each 3‐h session from day 1 to day 20 during the acquisition block. (B) Averaged visit duration at the water available corner in the first 10 min after the start of water availability from day 16 to day 20 during acquisition. (C) Average total visit duration throughout the 3‐h session from day 16 to day 20 during acquisition. n = 8 mice in WT and n = 5 in TS2‐neo mice. Data are mean ± SEM, * P

    Techniques Used: Mouse Assay, Blocking Assay

    2) Product Images from "Automated dissection of permanent effects of hippocampal or prefrontal lesions on performance at spatial, working memory and circadian timing tasks of C57BL/6 mice in IntelliCage"

    Article Title: Automated dissection of permanent effects of hippocampal or prefrontal lesions on performance at spatial, working memory and circadian timing tasks of C57BL/6 mice in IntelliCage

    Journal: Behavioural Brain Research

    doi: 10.1016/j.bbr.2017.08.048

    Place avoidance learning is impaired in HIPP mice and probe trial analysis reveals retention problems, in Avoid paradigm tested 3 times in Les2 (see Fig. 2 ). A ) Visits to criterion when any nosepoke in one corner caused an airpuff, while the three other corners gave access to water upon nosepoking. Framed symbols refer to censored observations (i.e., preference criterion not reached). HIPP mice expressed avoidance more slowly. B) Proportion of first 250 visits with nosepoke to previously punished corner during probe trials after a 24 h period outside IntelliCage (all corners now without punishment). Chance levels at 0.25 is indicated by dotted lines. HIPP mice had visiting rates closer to chance level during probe trials. C) Smoothed lines for visiting rates of subject over the initial 250 visits of the probe trials reveal little evidence of avoidance in HIPP mice (see text for closer examination).
    Figure Legend Snippet: Place avoidance learning is impaired in HIPP mice and probe trial analysis reveals retention problems, in Avoid paradigm tested 3 times in Les2 (see Fig. 2 ). A ) Visits to criterion when any nosepoke in one corner caused an airpuff, while the three other corners gave access to water upon nosepoking. Framed symbols refer to censored observations (i.e., preference criterion not reached). HIPP mice expressed avoidance more slowly. B) Proportion of first 250 visits with nosepoke to previously punished corner during probe trials after a 24 h period outside IntelliCage (all corners now without punishment). Chance levels at 0.25 is indicated by dotted lines. HIPP mice had visiting rates closer to chance level during probe trials. C) Smoothed lines for visiting rates of subject over the initial 250 visits of the probe trials reveal little evidence of avoidance in HIPP mice (see text for closer examination).

    Techniques Used: Mouse Assay

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    TSE systems intellicage apparatus
    Effects of developmental ACE exposure on behavioral flexibility . The comparison of the discrimination error rates (the number of discrimination errors in the first 100 corner visits in the session) in (A) male and (B) female mice. The numbers of animals used are indicated in parentheses. The data are presented as the mean ± SEM. The data for session 38–41 (6th reversal phase) and session 46–53 (8th and 9th reversal phases) in male were omitted due to the technical issues with the <t>IntelliCage</t> apparatus. Thus, the session 42 to 45 is denoted as Rev 6 and the session 54–57 is denoted as Rev 7 on (A) .
    Intellicage Apparatus, supplied by TSE systems, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/intellicage apparatus/product/TSE systems
    Average 97 stars, based on 1 article reviews
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    intellicage apparatus - by Bioz Stars, 2022-05
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    Effects of developmental ACE exposure on behavioral flexibility . The comparison of the discrimination error rates (the number of discrimination errors in the first 100 corner visits in the session) in (A) male and (B) female mice. The numbers of animals used are indicated in parentheses. The data are presented as the mean ± SEM. The data for session 38–41 (6th reversal phase) and session 46–53 (8th and 9th reversal phases) in male were omitted due to the technical issues with the IntelliCage apparatus. Thus, the session 42 to 45 is denoted as Rev 6 and the session 54–57 is denoted as Rev 7 on (A) .

    Journal: Frontiers in Neuroscience

    Article Title: In utero and Lactational Exposure to Acetamiprid Induces Abnormalities in Socio-Sexual and Anxiety-Related Behaviors of Male Mice

    doi: 10.3389/fnins.2016.00228

    Figure Lengend Snippet: Effects of developmental ACE exposure on behavioral flexibility . The comparison of the discrimination error rates (the number of discrimination errors in the first 100 corner visits in the session) in (A) male and (B) female mice. The numbers of animals used are indicated in parentheses. The data are presented as the mean ± SEM. The data for session 38–41 (6th reversal phase) and session 46–53 (8th and 9th reversal phases) in male were omitted due to the technical issues with the IntelliCage apparatus. Thus, the session 42 to 45 is denoted as Rev 6 and the session 54–57 is denoted as Rev 7 on (A) .

    Article Snippet: Another 1–2 mice of both sexes from each litter (males: 13–20 weeks of age; females: 23–32 weeks of age) were assigned to the behavioral flexibility test using the IntelliCage apparatus (NewBehavior AG, Zurich, Switzerland).

    Techniques: Mouse Assay

    Significant behavioral alterations in Macf1 mutant mice determined by IntelliCage analyses. ( A ) Schematic diagram of the attention test. Mice can drink water if they perform a nose poke in the gate on which an LED light was turned on. ( B ) Correct rate of male Macf1 mutant mice in the attention test. Macf1 mutant mice showed a significantly lower correct rate. Stim 0.3 s/0.5 s/1.0 s means the duration (0.3, 0.5 or 1.0 s) turning on the LED light on the door. Data shown are the mean ± standard error of the mean (SEM). Two-way analysis of variance (ANOVA) was used for multiple comparisons. n = 7 for each group. Interaction; P = 0.43, stimulation; P = 0.0001. Genotype; P = 0.016. Effect size, interaction; η 2 = 0.025, stimulation; η 2 = 0.095, genotype; η 2 = 0.35. ( C ) Schematic diagram of the delay discounting test. The opening of the gate of saccharin water is delayed compared with the gate with water. The delay time between activation and opening increased by 1 s each day. ( D ) Rate of saccharin water selection by female Macf1 mutant mice in the delay discounting test. Female Macf1 mutant mice showed a significantly higher rate of choice of saccharin water even in long delay times. We measured the rate of choice of saccharin water at 0 s after all of the sessions to verify whether the preference of saccharin water remains or not. The data shown are the mean ± SEM. Two-way ANOVA was used for multiple comparisons. n = 7 for each group. Interaction; P = 0.14, Time; P = 0.0001, Genotype; P = 0.014. Effect size, Interaction; η 2 = 0.035, Time; η 2 = 0.30, Genotype; η 2 = 0.16. The post-hoc test was performed by Bonferroni’s multiple comparison test. * P

    Journal: Human Molecular Genetics

    Article Title: Functional and behavioral effects of de novo mutations in calcium-related genes in patients with bipolar disorder

    doi: 10.1093/hmg/ddab152

    Figure Lengend Snippet: Significant behavioral alterations in Macf1 mutant mice determined by IntelliCage analyses. ( A ) Schematic diagram of the attention test. Mice can drink water if they perform a nose poke in the gate on which an LED light was turned on. ( B ) Correct rate of male Macf1 mutant mice in the attention test. Macf1 mutant mice showed a significantly lower correct rate. Stim 0.3 s/0.5 s/1.0 s means the duration (0.3, 0.5 or 1.0 s) turning on the LED light on the door. Data shown are the mean ± standard error of the mean (SEM). Two-way analysis of variance (ANOVA) was used for multiple comparisons. n = 7 for each group. Interaction; P = 0.43, stimulation; P = 0.0001. Genotype; P = 0.016. Effect size, interaction; η 2 = 0.025, stimulation; η 2 = 0.095, genotype; η 2 = 0.35. ( C ) Schematic diagram of the delay discounting test. The opening of the gate of saccharin water is delayed compared with the gate with water. The delay time between activation and opening increased by 1 s each day. ( D ) Rate of saccharin water selection by female Macf1 mutant mice in the delay discounting test. Female Macf1 mutant mice showed a significantly higher rate of choice of saccharin water even in long delay times. We measured the rate of choice of saccharin water at 0 s after all of the sessions to verify whether the preference of saccharin water remains or not. The data shown are the mean ± SEM. Two-way ANOVA was used for multiple comparisons. n = 7 for each group. Interaction; P = 0.14, Time; P = 0.0001, Genotype; P = 0.014. Effect size, Interaction; η 2 = 0.035, Time; η 2 = 0.30, Genotype; η 2 = 0.16. The post-hoc test was performed by Bonferroni’s multiple comparison test. * P

    Article Snippet: Seven wild-type and seven mutant mice of the same sex of each mouse line were kept and analyzed in each IntelliCage to avoid overcrowded breeding although at most 16 mice can be kept in one IntelliCage apparatus.

    Techniques: Mutagenesis, Mouse Assay, Activation Assay, Selection

    Motor functions and general well-being in TBI versus sham mice in a controlled cortical impact model. ( A ) Box/scatter plots showing running times in rotarod trials with accelerating speed or constant speed in experiment-1 with TBI/sham cohort-1 (blue) and experiment-2 with TBI/sham cohort-2 (red). Initial tests were done 10–14 days after TBI before tests of nociception and cognition. Final rotarod runs were done after completion of IntelliCage experiments 3 months (Exp1) or 6 months (Exp2) after surgery. The right panel shows the distance traveled in the red/blue box. The box shows the interquartile range, the line is the median; the whiskers show minimum to maximum, each scatter is a mouse. In 'Final-Exp1’ each mouse is represented with 2 trials. ( B ) Time courses of the body weights (means ± SD) in TBI and sham mice up to 35 days after surgery in Exp1 (blue, n = 10 sham, n = 21 TBI) and up to 170 in Exp2 (red; n = 15 both groups). Asterisks indicate significant differences between groups (2-way ANOVA for time courses, factor

    Journal: Scientific Reports

    Article Title: Low brain endocannabinoids associated with persistent non-goal directed nighttime hyperactivity after traumatic brain injury in mice

    doi: 10.1038/s41598-020-71879-x

    Figure Lengend Snippet: Motor functions and general well-being in TBI versus sham mice in a controlled cortical impact model. ( A ) Box/scatter plots showing running times in rotarod trials with accelerating speed or constant speed in experiment-1 with TBI/sham cohort-1 (blue) and experiment-2 with TBI/sham cohort-2 (red). Initial tests were done 10–14 days after TBI before tests of nociception and cognition. Final rotarod runs were done after completion of IntelliCage experiments 3 months (Exp1) or 6 months (Exp2) after surgery. The right panel shows the distance traveled in the red/blue box. The box shows the interquartile range, the line is the median; the whiskers show minimum to maximum, each scatter is a mouse. In 'Final-Exp1’ each mouse is represented with 2 trials. ( B ) Time courses of the body weights (means ± SD) in TBI and sham mice up to 35 days after surgery in Exp1 (blue, n = 10 sham, n = 21 TBI) and up to 170 in Exp2 (red; n = 15 both groups). Asterisks indicate significant differences between groups (2-way ANOVA for time courses, factor "group", 2-sided independent T test for comparison of final body weights, ***

    Article Snippet: The IntelliCage is controlled by the IntelliCage Plus software, which executes pre-programmed experimental tasks and schedules.

    Techniques: Mouse Assay

    Canonical discriminant analyses of IntelliCage parameters, activity readouts in different tasks and behavioral z scores during place preference learning and reversal learning. ( A ) Canonical discriminant analysis score plot and structure. DA factor 1 explained 100% of the variance. The box shows the interquartile range, the line is the median, and the whiskers show minimum to maximum, each scatter is a mouse, the circle shows the mean. ( B ) Box/scatter plots of visits in different tasks normalized to periods of 10 days for each task. Each scatter is a mouse. n = 10 sham, n = 21 TBI; each two mice with incomplete data were excluded from the analysis. Data were compared with 2-way ANOVA for

    Journal: Scientific Reports

    Article Title: Low brain endocannabinoids associated with persistent non-goal directed nighttime hyperactivity after traumatic brain injury in mice

    doi: 10.1038/s41598-020-71879-x

    Figure Lengend Snippet: Canonical discriminant analyses of IntelliCage parameters, activity readouts in different tasks and behavioral z scores during place preference learning and reversal learning. ( A ) Canonical discriminant analysis score plot and structure. DA factor 1 explained 100% of the variance. The box shows the interquartile range, the line is the median, and the whiskers show minimum to maximum, each scatter is a mouse, the circle shows the mean. ( B ) Box/scatter plots of visits in different tasks normalized to periods of 10 days for each task. Each scatter is a mouse. n = 10 sham, n = 21 TBI; each two mice with incomplete data were excluded from the analysis. Data were compared with 2-way ANOVA for "group" × "task" and subsequent t test for group. *P

    Article Snippet: The IntelliCage is controlled by the IntelliCage Plus software, which executes pre-programmed experimental tasks and schedules.

    Techniques: Activity Assay, Mouse Assay

    EGFL7 deficiency improved spatial learning and memory in MWM and IntelliCage in young adult mice ( a ) In the Morris water maze (MWM), the latency to reach the visible platform, the proportion of time spent in the platform quarter and the swimming velocity were similar in both genotypes. ( b ) Body weights were similar throughout experiments. Exemplary cohort is shown as mean ± SD. ( c ) EGFL7 -/- mice reached the hidden platform faster. Escape latency was reduced considering the full-time course (AUCs) and late trials. ( d ) The proportion of time spent in the platform quarter after its removal was increased. For MWM sample sizes were n = 19 for EGFL7 -/- mice and n = 33 for wild-type littermate controls (WT). Data were compared by paired (visible platform) and unpaired two-sided Student’s t-tests, or 2-way ANOVA for time courses. ( e ) In the IntelliCage, EGFL7 -/- mice maintained longer avoidance of a previously punished corner (air puff), as revealed by a reduced proportion of nosepoke errors (n = 16 per genotype). ( f ) During preference learning in active module times (11-13:00 and 16-18:00 h each day), EGFL7 -/- mice showed faster relearning to prefer a specified corner upon switching to the opposite side (reversal learning), indicated by a higher accuracy of nosepokes (n = 16 per genotype). Overall activity is shown in ( Supplementary Fig. 8_2 ). ( g,h ) During periods in which the learning modules were inactive (doors remain closed, “default-times”), EGFL7 -/- mice retained higher preference of rewarding corners and the proportion of “memorizers” was higher, the latter defined as 35% accuracy of corner visits (random = 25%). Time course data are represented as mean ± SEM, summarizing data as mean ± SD. The boxes show the interquartile range, the line is the median, and whiskers are plotted minimum to maximum. Scatters represent individual mice. Time courses were compared by 2-way ANOVA and subsequent posthoc t-tests to assess genotype differences at specific time points without multiplicity adjustment for between group comparisons, AUCs were compared with 2-sided unpaired t-tests; * p

    Journal: bioRxiv

    Article Title: Less is more - loss of EGFL7 improves memory by upregulation of VEGF-D

    doi: 10.1101/2022.04.07.487327

    Figure Lengend Snippet: EGFL7 deficiency improved spatial learning and memory in MWM and IntelliCage in young adult mice ( a ) In the Morris water maze (MWM), the latency to reach the visible platform, the proportion of time spent in the platform quarter and the swimming velocity were similar in both genotypes. ( b ) Body weights were similar throughout experiments. Exemplary cohort is shown as mean ± SD. ( c ) EGFL7 -/- mice reached the hidden platform faster. Escape latency was reduced considering the full-time course (AUCs) and late trials. ( d ) The proportion of time spent in the platform quarter after its removal was increased. For MWM sample sizes were n = 19 for EGFL7 -/- mice and n = 33 for wild-type littermate controls (WT). Data were compared by paired (visible platform) and unpaired two-sided Student’s t-tests, or 2-way ANOVA for time courses. ( e ) In the IntelliCage, EGFL7 -/- mice maintained longer avoidance of a previously punished corner (air puff), as revealed by a reduced proportion of nosepoke errors (n = 16 per genotype). ( f ) During preference learning in active module times (11-13:00 and 16-18:00 h each day), EGFL7 -/- mice showed faster relearning to prefer a specified corner upon switching to the opposite side (reversal learning), indicated by a higher accuracy of nosepokes (n = 16 per genotype). Overall activity is shown in ( Supplementary Fig. 8_2 ). ( g,h ) During periods in which the learning modules were inactive (doors remain closed, “default-times”), EGFL7 -/- mice retained higher preference of rewarding corners and the proportion of “memorizers” was higher, the latter defined as 35% accuracy of corner visits (random = 25%). Time course data are represented as mean ± SEM, summarizing data as mean ± SD. The boxes show the interquartile range, the line is the median, and whiskers are plotted minimum to maximum. Scatters represent individual mice. Time courses were compared by 2-way ANOVA and subsequent posthoc t-tests to assess genotype differences at specific time points without multiplicity adjustment for between group comparisons, AUCs were compared with 2-sided unpaired t-tests; * p

    Article Snippet: IntelliCage The IntelliCage experiments were performed with 16 female mice per genotype (EGFL7-/- or WT), which were 11-16 weeks old at the onset of the experiments; eight mice were housed per cage.

    Techniques: Mouse Assay, Activity Assay