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MICs of tigecycline, omadacycline, and eravacycline against Mycobacterium abscessus ATCC 19977 and 28 drug-resistant M. abscessus complex clinical isolates in CAMHB

Journal: Antimicrobial Agents and Chemotherapy

Article Title: In Vitro Activity of New Tetracycline Analogs Omadacycline and Eravacycline against Drug-Resistant Clinical Isolates of Mycobacterium abscessus

doi: 10.1128/AAC.00470-19

Figure Lengend Snippet: MICs of tigecycline, omadacycline, and eravacycline against Mycobacterium abscessus ATCC 19977 and 28 drug-resistant M. abscessus complex clinical isolates in CAMHB

Article Snippet: Interestingly, while the present study was under review, a newly published study reported similar MICs for tigecycline and omadacycline against M. abscessus complex clinical isolates ( 19 ). table ft1 table-wrap mode="anchored" t5 TABLE 1 caption a7 Isolate or MIC M. abscessus subspecies MIC (μg/ml) Tigecycline Omadacycline Eravacycline Isolates Strain ATCC 19977 a abscessus 1 1 0.5 1N abscessus 1 1 0.5 2N massiliense-bolletii b 1 1 0.25 3N abscessus 2 2 1 4N massiliense 1 1 0.25 5N massiliense 1 0.5 0.25 6N abscessus 2 4 1 11N abscessus 1 2 2 12N abscessus 1 0.5 0.25 13N massiliense-bolletii 1 2 0.5 14N massiliense-bolletii 2 2 1 19N abscessus 1 0.5 0.25 201 abscessus 1 0.5 0.25 202 abscessus 1 2 0.5 203 massiliense-bolletii 1 2 0.5 204 massiliense 1 1 0.5 206 massiliense 0.5 0.5 0.125 208 massiliense 2 2 0.5 210 abscessus 2 2 0.5 211 abscessus 2 2 0.5 212 massiliense-bolletii 1 1 0.25 214 massiliense 1 1 0.5 215 abscessus 1 1 0.25 216 massiliense 1 1 0.25 218 abscessus 4 4 2 JHH2 abscessus 1 1 0.25 JHH4 abscessus 1 1 0.25 JHH9 abscessus 2 2 0.5 JHHKB abscessus 2 2 0.5 MIC data MIC range 0.5–4 0.5–4 0.125–2 MIC 50 1 1 0.5 MIC 90 2 2 1 Open in a separate window a M. abscessus strain ATCC 19977 is included as a reference strain, and the MIC values for this strain were not included when determining the MIC range, MIC 50 , and MIC 90 . b Five isolates had truncated erm (41) genes, indicating subsp. massiliense , but had rpoB sequences matching subsp. bolletii .

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