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Merck KGaA 2 pentanol
2 Pentanol, supplied by Merck KGaA, used in various techniques. Bioz Stars score: 88/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/2 pentanol/product/Merck KGaA
Average 88 stars, based on 3 article reviews
Price from $9.99 to $1999.99
2 pentanol - by Bioz Stars, 2020-11
88/100 stars

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Article Title: Acylation of Chiral Alcohols: A Simple Procedure for Chiral GC Analysis
Article Snippet: 2-Pentanol (2) was acquired from Merck, Barcelona, Spain.

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  • 88
    Merck KGaA ctsb specific inhibitor iv
    C 2 <t>-ceramide</t> induced activation and release of <t>CTSB.</t> ( a ) Cells were treated with 50 μ M C 2 -ceramide (C 2 -Cer) for 6 h. Ceramide amounts were measured by LC-MS/MS. Values are mean±S.D. from three different experiments. * P
    Ctsb Specific Inhibitor Iv, supplied by Merck KGaA, used in various techniques. Bioz Stars score: 88/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/ctsb specific inhibitor iv/product/Merck KGaA
    Average 88 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    ctsb specific inhibitor iv - by Bioz Stars, 2020-11
    88/100 stars
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    94
    Merck KGaA ca 074 me
    (A) The NLPR3 inhibitors (MCC950 [0.01-10 μM]) and extracellular K+ [5-30 mM]) were added immediately prior to stimulation of PBMCs with ChAdOx1 (MOI=10 3 vp), and CD69 and granzyme B (GzmB) production by MAIT cells (CD161++Vα7.2+ T cells) was assessed after 24 h (N=4). Cathepsin B inhibitor <t>(CA-074-Me</t> [0.01-10 μM]) (B) and Caspase 1 inhibitor (Z-YVAD-FMK [0.1-100 μM]) (C) were added immediately prior to stimulation of PBMCs with ChAdOx1 (MOI=10 3 vp). After 24 h, IFN-γ, CD69, and GzmB production by MAIT cells was assessed (N=4). (D) Concentration of IL-18 in cell culture supernatants of PBMCs treated with the indicated inhibitors 24 h after stimulation with ChAdOx1 MOI=10 3 vp; N=4). (E) Frequency of GFP+ PBMCs (N=4) at 24 h following transduction with ChAdOx1 expressing GFP (MOI=10 3 vp) in the presence of the indicated dose of CA-074 Me, MCC950, extracellular K+ ions, or Z-YVAD-FMK. *, P
    Ca 074 Me, supplied by Merck KGaA, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/ca 074 me/product/Merck KGaA
    Average 94 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    ca 074 me - by Bioz Stars, 2020-11
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    89
    Merck KGaA ca 074
    Concurrent inhibition of calpain-2 and cathepsin B attenuated cell death induced in DMDP-1 treated PC-3 and DMDP-2 treated DU 145 cells MTT cell viability assay carried out to investigate the role of calpain-2 and cathepsin B in CI-PCD induction using their respective inhibitors, calpeptin and <t>CA-074.</t> PC-3 was treated with DMDP-1 and DU 145 with DMDP-2, co-cultured with either calpeptin or CA-074 or both inhibitors combined. Comparison made with uninhibited cells 24 h of treatment presented as mean intensity ± S.D. of three independent experiments and (*) is used to denote p
    Ca 074, supplied by Merck KGaA, used in various techniques. Bioz Stars score: 89/100, based on 5 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/ca 074/product/Merck KGaA
    Average 89 stars, based on 5 article reviews
    Price from $9.99 to $1999.99
    ca 074 - by Bioz Stars, 2020-11
    89/100 stars
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    88
    Merck KGaA 4 methyl 2 pentanol
    Concurrent inhibition of calpain-2 and cathepsin B attenuated cell death induced in DMDP-1 treated PC-3 and DMDP-2 treated DU 145 cells MTT cell viability assay carried out to investigate the role of calpain-2 and cathepsin B in CI-PCD induction using their respective inhibitors, calpeptin and <t>CA-074.</t> PC-3 was treated with DMDP-1 and DU 145 with DMDP-2, co-cultured with either calpeptin or CA-074 or both inhibitors combined. Comparison made with uninhibited cells 24 h of treatment presented as mean intensity ± S.D. of three independent experiments and (*) is used to denote p
    4 Methyl 2 Pentanol, supplied by Merck KGaA, used in various techniques. Bioz Stars score: 88/100, based on 0 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/4 methyl 2 pentanol/product/Merck KGaA
    Average 88 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    4 methyl 2 pentanol - by Bioz Stars, 2020-11
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    C 2 -ceramide induced activation and release of CTSB. ( a ) Cells were treated with 50 μ M C 2 -ceramide (C 2 -Cer) for 6 h. Ceramide amounts were measured by LC-MS/MS. Values are mean±S.D. from three different experiments. * P

    Journal: Cell Death & Disease

    Article Title: Lysosomal ceramide generated by acid sphingomyelinase triggers cytosolic cathepsin B-mediated degradation of X-linked inhibitor of apoptosis protein in natural killer/T lymphoma cell apoptosis

    doi: 10.1038/cddis.2015.82

    Figure Lengend Snippet: C 2 -ceramide induced activation and release of CTSB. ( a ) Cells were treated with 50 μ M C 2 -ceramide (C 2 -Cer) for 6 h. Ceramide amounts were measured by LC-MS/MS. Values are mean±S.D. from three different experiments. * P

    Article Snippet: Materials Materials were purchased as follows: human recombinant IL-2 (Imunase 35) (Shionogi Pharmaceutical, Osaka, Japan); C6 -NBD ceramide, C6 -NBD sphingomyelin, and C2 -ceramide (Matreya, Pleasant Gap, PA, USA); CTSB specific inhibitor IV (CA-074 Me) (Merck Millipore, Darmstadt, Germany); pepstatin A and desipramine (Sigma-Aldrich, St. Louis, MO, USA); anti-caspase-8, anti-caspase-9, anti-PARP, antilysosomal-associated membrane protein 1 (Lamp1), anti-Lamp2, anti-ASM, anti-CTSB, anti-CTSD, and anti-β -actin antibodies (Santa Cruz Biotechnology Inc., Santa Cruz, CA, USA); Annexin V-conjugated FITC and monoclonal antibody against XIAP (BD Biosciences, Beverly, MA, USA); antiactive caspase-3 (p17) antibody and horseradish peroxidase–conjugated secondary antibodies (Promega, Madison, WI, USA); anti-caspase-3, anti-pan-cadherin, and anti-glyceraldehyde 3-phosphate dehydrogenase (GAPDH) antibodies (Cell signaling, Danvers, MA, USA); and anti-ceramide monoclonal IgM Ab clone (NHCER-2) was produced previously in our lab.

    Techniques: Activation Assay, Liquid Chromatography with Mass Spectroscopy, Mass Spectrometry

    (A) The NLPR3 inhibitors (MCC950 [0.01-10 μM]) and extracellular K+ [5-30 mM]) were added immediately prior to stimulation of PBMCs with ChAdOx1 (MOI=10 3 vp), and CD69 and granzyme B (GzmB) production by MAIT cells (CD161++Vα7.2+ T cells) was assessed after 24 h (N=4). Cathepsin B inhibitor (CA-074-Me [0.01-10 μM]) (B) and Caspase 1 inhibitor (Z-YVAD-FMK [0.1-100 μM]) (C) were added immediately prior to stimulation of PBMCs with ChAdOx1 (MOI=10 3 vp). After 24 h, IFN-γ, CD69, and GzmB production by MAIT cells was assessed (N=4). (D) Concentration of IL-18 in cell culture supernatants of PBMCs treated with the indicated inhibitors 24 h after stimulation with ChAdOx1 MOI=10 3 vp; N=4). (E) Frequency of GFP+ PBMCs (N=4) at 24 h following transduction with ChAdOx1 expressing GFP (MOI=10 3 vp) in the presence of the indicated dose of CA-074 Me, MCC950, extracellular K+ ions, or Z-YVAD-FMK. *, P

    Journal: bioRxiv

    Article Title: Activation of MAIT cells plays a critical role in viral vector vaccine immunogenicity

    doi: 10.1101/661397

    Figure Lengend Snippet: (A) The NLPR3 inhibitors (MCC950 [0.01-10 μM]) and extracellular K+ [5-30 mM]) were added immediately prior to stimulation of PBMCs with ChAdOx1 (MOI=10 3 vp), and CD69 and granzyme B (GzmB) production by MAIT cells (CD161++Vα7.2+ T cells) was assessed after 24 h (N=4). Cathepsin B inhibitor (CA-074-Me [0.01-10 μM]) (B) and Caspase 1 inhibitor (Z-YVAD-FMK [0.1-100 μM]) (C) were added immediately prior to stimulation of PBMCs with ChAdOx1 (MOI=10 3 vp). After 24 h, IFN-γ, CD69, and GzmB production by MAIT cells was assessed (N=4). (D) Concentration of IL-18 in cell culture supernatants of PBMCs treated with the indicated inhibitors 24 h after stimulation with ChAdOx1 MOI=10 3 vp; N=4). (E) Frequency of GFP+ PBMCs (N=4) at 24 h following transduction with ChAdOx1 expressing GFP (MOI=10 3 vp) in the presence of the indicated dose of CA-074 Me, MCC950, extracellular K+ ions, or Z-YVAD-FMK. *, P

    Article Snippet: Blocking and inhibitory reagents The following reagents were used in the above-described in vitro stimulation assays: mouse IgG1 isotype control antibody (Clone: MOPC-21, BioLegend), mouse IgG2a isotype control antibody (clone: MOPC-173, BioLegend), anti-MR1 antibody (clone: 26.5, BioLegend), anti-IL-12p70 antibody (clone: 24910, R & D Systems), anti-IL-15 antibody (clone: 34559, R & D Systems), anti-IL-18 antibody (clone: 125-2H, R & D Systems), anti-IL-18Ra antibody (clone: 70625, R & D Systems), anti-IFNAR2 (clone: MMHAR-2, Merck Chemicals), B18R (eBioscience), mevastatin (Merck Chemicals), CA-074-Me( ) (Merck Chemicals), MCC950( ) (Sigma-Aldrich), elevated extracellular K+ ion concentration( ) (KCl, Sigma-Aldrich), Z-YVAD-FMK( ) (R & D Systems), vedolizumab (anti-α4β7 integrin antibody; Takeda Pharmaceuticals), adalimumab (anti-TNF-α antibody; AbbVie Inc), etanercept (TNFR2-Fc fusion protein; Pfizer; A kind gift of Dr. Hussein Al-Mossawi, University of Oxford).

    Techniques: Concentration Assay, Cell Culture, Transduction, Expressing

    Concurrent inhibition of calpain-2 and cathepsin B attenuated cell death induced in DMDP-1 treated PC-3 and DMDP-2 treated DU 145 cells MTT cell viability assay carried out to investigate the role of calpain-2 and cathepsin B in CI-PCD induction using their respective inhibitors, calpeptin and CA-074. PC-3 was treated with DMDP-1 and DU 145 with DMDP-2, co-cultured with either calpeptin or CA-074 or both inhibitors combined. Comparison made with uninhibited cells 24 h of treatment presented as mean intensity ± S.D. of three independent experiments and (*) is used to denote p

    Journal: Scientific Reports

    Article Title: Geranylated 4-phenylcoumarins extracted from Mesua elegans induced caspase-independent cell death in prostate cancer cell lines through calpain-2 and cathepsin B

    doi: 10.1038/s41598-020-57781-6

    Figure Lengend Snippet: Concurrent inhibition of calpain-2 and cathepsin B attenuated cell death induced in DMDP-1 treated PC-3 and DMDP-2 treated DU 145 cells MTT cell viability assay carried out to investigate the role of calpain-2 and cathepsin B in CI-PCD induction using their respective inhibitors, calpeptin and CA-074. PC-3 was treated with DMDP-1 and DU 145 with DMDP-2, co-cultured with either calpeptin or CA-074 or both inhibitors combined. Comparison made with uninhibited cells 24 h of treatment presented as mean intensity ± S.D. of three independent experiments and (*) is used to denote p

    Article Snippet: Pharmacological inhibitors Calpain-2 inhibitor, calpeptin and cathepsin B activity inhibitor ≥99%, CA-074 were purchased from Merck (Germany).

    Techniques: Inhibition, MTT Assay, Viability Assay, Cell Culture