R N4 Hydroxy N1 S 2 1H indol 3 yl 1 methylcarbamoyl ethyl 2 isobutyl succinamide
(R)-N4-Hydroxy-N1-[(S)-2-(1H-indol-3-yl)-1-methylcarbamoyl-ethyl]-2-isobutyl-succinamide has been used:. To study its effect on the profiling of active aggrecanases and their specific aggrecan degradation fragments. . To study the involvement of autocrine EGF (epidermal growth factor) receptor activation in the regulation of the morphogenetic process, using human umbilical vein endothelial cells.. To study the effect of GM6001 blockade on the expression of angiotensin II, the interstitial collagenases and soluble elastin fragments in explant culture supernatants.
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Article Title: The Effect of Protease Inhibitors on the Induction of Osteoarthritis-Related Biomarkers in Bovine Full-Depth Cartilage Explants
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Article Title: Inhibition of Pseudomonas aeruginosa secreted virulence factors reduces lung inflammation in CF mice
Article Snippet: .. Briefly, 350 µl reaction mixture containing 0.1 M Tris-HCl pH 8.0 and 1% azocasein (Sigma-Aldrich, cat. n. A2765) resuspended in 0.5% NaHCO3 was added to 150 µl supernatant with/without MMPIs Ilomastat, Marimastat,