2 chloro n 6 cyclopentyladenosine  (Tocris)

 
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  • 94
    Name:
    2 Chloro N6 cyclopentyladenosine
    Description:
    Potent selective A1 agonist
    Catalog Number:
    1705
    Product Aliases:
    CCPA
    Price:
    None
    Purity:
    ≥98% (HPLC)
    Category:
    Adenosine A1 Receptor Agonists Adenosine A1 Receptors Adenosine Receptors 7 TM Receptors Pharmacology
    Formula:
    2-Chloro-N-cyclopentyladenosine
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    Structured Review

    Tocris 2 chloro n 6 cyclopentyladenosine
    2 Chloro N6 cyclopentyladenosine
    Potent selective A1 agonist
    https://www.bioz.com/result/2 chloro n 6 cyclopentyladenosine/product/Tocris
    Average 94 stars, based on 2 article reviews
    Price from $9.99 to $1999.99
    2 chloro n 6 cyclopentyladenosine - by Bioz Stars, 2020-09
    94/100 stars

    Images

    1) Product Images from "A1 adenosine receptor allosteric enhancer PD-81723 protects against renal ischemia-reperfusion injury"

    Article Title: A1 adenosine receptor allosteric enhancer PD-81723 protects against renal ischemia-reperfusion injury

    Journal: American Journal of Physiology - Renal Physiology

    doi: 10.1152/ajprenal.00157.2012

    Differential cardiovascular effects of PD-81723 and CCPA. We compared the effects of a selective A 1 AR allosteric enhancer (PD-81723) and a selective A 1 AR agonist [2-chloro- N 6 -cyclopentyladenosine (CCPA)] on mouse heart rate ( A ) and systolic blood pressure ( B ). We measured systolic blood pressure as well as heart rate via an indwelling carotid artery catheter. PD-81723 (3 and 6 mg/kg ip) did not significantly change heart or systolic blood pressure in mice ( n = 4). In contrast, CCPA (0.1 and 0.5mg/kg ip, n = 4) caused dose-dependent decreases in heart rate and systolic blood pressure in mice. Arrows indicate the time of drug injection. * P
    Figure Legend Snippet: Differential cardiovascular effects of PD-81723 and CCPA. We compared the effects of a selective A 1 AR allosteric enhancer (PD-81723) and a selective A 1 AR agonist [2-chloro- N 6 -cyclopentyladenosine (CCPA)] on mouse heart rate ( A ) and systolic blood pressure ( B ). We measured systolic blood pressure as well as heart rate via an indwelling carotid artery catheter. PD-81723 (3 and 6 mg/kg ip) did not significantly change heart or systolic blood pressure in mice ( n = 4). In contrast, CCPA (0.1 and 0.5mg/kg ip, n = 4) caused dose-dependent decreases in heart rate and systolic blood pressure in mice. Arrows indicate the time of drug injection. * P

    Techniques Used: Mouse Assay, Injection

    Related Articles

    other:

    Article Title: A1 adenosine receptor–stimulated exocytosis in bladder umbrella cells requires phosphorylation of ADAM17 Ser-811 and EGF receptor transactivation
    Article Snippet: The following stock solutions were prepared in dimethyl sulfoxide: AG1478 (10 mM), calphostin C (250 μM), CCPA (10 mM), GM6001 (15 mM), SB203580 (1 mM), Tapi-2 (15 mM; Tocris, Bristol, United Kingdom), and U0126 (10 mM).

    Article Title: Enhanced A1 adenosine receptor-induced vascular contractions in mesenteric artery and aorta of in L-NAME mouse model of hypertension.
    Article Snippet: 5’-(N-ethylcarboxamido) adenosine (NECA) and 2-chloro-N cyclopentyladenosine (CCPA) were purchased from Tocris Biosciences (Minneapolis, MN).

    Article Title: A1 adenosine receptor allosteric enhancer PD-81723 protects against renal ischemia-reperfusion injury
    Article Snippet: 2-Amino-4,5-dimethyl-3-thienyl-[3-(trifluoromethyl)phenyl] methanone (PD-81723; a selective allosteric enhancer for the A1 AR; ), 2-chloro- N 6 -cyclopentyladenosine (CCPA; a selective A1 AR agonist), 8-cyclopentyl-1,3-dipropylxanthine (DPCPX; a selective antagonist for the A1 AR) and 4-{[4-(4-chlorophenyl)-2-thiazolyl]amino}phenol [SKI-II, a selective nonlipid inhibitor of sphingosine kinase (SK)] were purchased from Tocris (Minneapolis, MN).

    Article Title: Adenosine-induced activation of esophageal nociceptors
    Article Snippet: CCPA (Tocris) and CGS-21680 (Tocris) were dissolved in DMSO (stock solutions 10 mM).

    Cycling Probe Technology:

    Article Title: Modulation of Ca2+-currents by sequential and simultaneous activation of adenosine A1 and A2A receptors in striatal projection neurons
    Article Snippet: .. The A1 -type receptor agonist—2-chloro-N6 -cyclopentyladenosine ( CCPA ), the A2A -type receptor agonist: 4-(2-((6-amino-9-( N -ethyl-β- d -ribofuranuron-amidosyl)-9H-purin-2-yl)amino)ethyl)benzene propanoic acid hydrochloride ( CGS 21680 ), the A2A -type receptor antagonist—2-(2-furanyl)-7-(2-phenylethyl)-7H-pyrazolo(4,3-e)(1,2,4)triazolo(1,5-c)pyrimidin-5-amine ( SCH 58261 ) and the A1 -type receptor antagonist—8-cyclopentyl-1,3-dimethylxanthine ( CPT ; Tocris Cookson, Ellisville, MO). ..

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  • ccpa  (Tocris)
    94
    Tocris ccpa
    Saturation binding assays at ARs stably expressed in recombinant CHO cells: a mA 1 AR using [ 3 <t>H]CCPA;</t> b mA 1 AR using [ 3 H]DPCPX; c mA 2A AR using [ 3 <t>H]CGS-21680;</t> d mA 2A AR using [ 3 H]MSX-2. Data are means of three independent saturation assays each performed in
    Ccpa, supplied by Tocris, used in various techniques. Bioz Stars score: 94/100, based on 15 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/ccpa/product/Tocris
    Average 94 stars, based on 15 article reviews
    Price from $9.99 to $1999.99
    ccpa - by Bioz Stars, 2020-09
    94/100 stars
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    Saturation binding assays at ARs stably expressed in recombinant CHO cells: a mA 1 AR using [ 3 H]CCPA; b mA 1 AR using [ 3 H]DPCPX; c mA 2A AR using [ 3 H]CGS-21680; d mA 2A AR using [ 3 H]MSX-2. Data are means of three independent saturation assays each performed in

    Journal: Purinergic Signalling

    Article Title: Selectivity is species-dependent: Characterization of standard agonists and antagonists at human, rat, and mouse adenosine receptors

    doi: 10.1007/s11302-015-9460-9

    Figure Lengend Snippet: Saturation binding assays at ARs stably expressed in recombinant CHO cells: a mA 1 AR using [ 3 H]CCPA; b mA 1 AR using [ 3 H]DPCPX; c mA 2A AR using [ 3 H]CGS-21680; d mA 2A AR using [ 3 H]MSX-2. Data are means of three independent saturation assays each performed in

    Article Snippet: CCPA, CGS-21680, Cl-IB-MECA, IB-MECA, DPCPX, ZM-241835, and MRS-1745 were commercially available from TOCRIS.

    Techniques: Binding Assay, Stable Transfection, Recombinant

    Stimulation of adenosine receptors sensitizes the mechanical response of esophageal nociceptors. Nodose nociceptive fibers are sensitized via the adenosine A 1 receptor and/or A 2A receptor, whereas jugular nociceptive fibers are sensitized only via the adenosine A 1 receptor. The response to esophageal distention with intraluminal pressure 60 mmHg (20 s) was quantified in the absence and in the presence of the indicated agonist. Control response (100%) averaged 45 and 29 action potentials/20 s in nodose and jugular nociceptors, respectively. The effect on mechanical response was tested with CCPA (0.1 μM) and CGS-21680 (0.1 μM,) in nodose nociceptors and CCPA (0.3 μM) and CGS-21680 (0.3 μM) in jugular nociceptors. * P

    Journal: American Journal of Physiology - Gastrointestinal and Liver Physiology

    Article Title: Adenosine-induced activation of esophageal nociceptors

    doi: 10.1152/ajpgi.00361.2010

    Figure Lengend Snippet: Stimulation of adenosine receptors sensitizes the mechanical response of esophageal nociceptors. Nodose nociceptive fibers are sensitized via the adenosine A 1 receptor and/or A 2A receptor, whereas jugular nociceptive fibers are sensitized only via the adenosine A 1 receptor. The response to esophageal distention with intraluminal pressure 60 mmHg (20 s) was quantified in the absence and in the presence of the indicated agonist. Control response (100%) averaged 45 and 29 action potentials/20 s in nodose and jugular nociceptors, respectively. The effect on mechanical response was tested with CCPA (0.1 μM) and CGS-21680 (0.1 μM,) in nodose nociceptors and CCPA (0.3 μM) and CGS-21680 (0.3 μM) in jugular nociceptors. * P

    Article Snippet: CCPA (Tocris) and CGS-21680 (Tocris) were dissolved in DMSO (stock solutions 10 mM).

    Techniques:

    Nodose nociceptive nerve terminals are activated via the adenosine A 1 receptor and/or A 2A receptor, whereas jugular nociceptive nerve terminals are activated via the adenosine A 1 receptor. A : example of a nodose fiber responsive to both the selective adenosine A 1 receptor agonist CCPA and the selective adenosine A 2A receptor agonist CGS-21680. B : example of a jugular fiber responsive to CCPA but not CGS-21680. In jugular traces, several units were simultaneously recorded, but only the unit with indicated large-amplitude action potential waveform had a mechanosensitive nerve terminal in the esophagus. The trivial activity seen in the presence of CGS-21680 in the jugular fiber was similar to the control activity before the drug (

    Journal: American Journal of Physiology - Gastrointestinal and Liver Physiology

    Article Title: Adenosine-induced activation of esophageal nociceptors

    doi: 10.1152/ajpgi.00361.2010

    Figure Lengend Snippet: Nodose nociceptive nerve terminals are activated via the adenosine A 1 receptor and/or A 2A receptor, whereas jugular nociceptive nerve terminals are activated via the adenosine A 1 receptor. A : example of a nodose fiber responsive to both the selective adenosine A 1 receptor agonist CCPA and the selective adenosine A 2A receptor agonist CGS-21680. B : example of a jugular fiber responsive to CCPA but not CGS-21680. In jugular traces, several units were simultaneously recorded, but only the unit with indicated large-amplitude action potential waveform had a mechanosensitive nerve terminal in the esophagus. The trivial activity seen in the presence of CGS-21680 in the jugular fiber was similar to the control activity before the drug (

    Article Snippet: CCPA (Tocris) and CGS-21680 (Tocris) were dissolved in DMSO (stock solutions 10 mM).

    Techniques: Activity Assay

    Effects of NECA, a non-selective adenosine receptor agonist; CCPA, an A 1 receptor agonist; and AB-MECA, an A 3 receptor agonist, on the production of TNF-α by LPS-stimulated human lung macrophages. Values are means ± SEM of five experiments. * P

    Journal: British Journal of Pharmacology

    Article Title: The role of adenosine receptors in regulating production of tumour necrosis factor-? and chemokines by human lung macrophages

    doi: 10.1111/j.1476-5381.2009.00614.x

    Figure Lengend Snippet: Effects of NECA, a non-selective adenosine receptor agonist; CCPA, an A 1 receptor agonist; and AB-MECA, an A 3 receptor agonist, on the production of TNF-α by LPS-stimulated human lung macrophages. Values are means ± SEM of five experiments. * P

    Article Snippet: NECA (5′- N -ethyl-carboxamidoadenosine), CCPA (2-chloro- N 6 -cyclopentyladenosine), ZM 241385 (4-(2-[7-amino-2-(2-furyl)[1,2,4]triazolo-[2,3- a ][1,3,5]triazin-5-yl-amino]ethyl)phenol), MRS 1754 ( N -(4-cyano-phenyl)-2-[4-(2,6-dioxo-1,3-dipropyl-2,3,4,5,6,7-hexahydro-1 H -purin-8-yl)-phenoxy]acetamide) and MRS 1220 (9-chloro-2-(2-furanyl)-5-[(phenylacetyl)amino][1,2,4]-triazolo[1,5- c ]quinazoline) were purchased from Tocris Bioscience (Bristol, UK).

    Techniques:

    Differential cardiovascular effects of PD-81723 and CCPA. We compared the effects of a selective A 1 AR allosteric enhancer (PD-81723) and a selective A 1 AR agonist [2-chloro- N 6 -cyclopentyladenosine (CCPA)] on mouse heart rate ( A ) and systolic blood pressure ( B ). We measured systolic blood pressure as well as heart rate via an indwelling carotid artery catheter. PD-81723 (3 and 6 mg/kg ip) did not significantly change heart or systolic blood pressure in mice ( n = 4). In contrast, CCPA (0.1 and 0.5mg/kg ip, n = 4) caused dose-dependent decreases in heart rate and systolic blood pressure in mice. Arrows indicate the time of drug injection. * P

    Journal: American Journal of Physiology - Renal Physiology

    Article Title: A1 adenosine receptor allosteric enhancer PD-81723 protects against renal ischemia-reperfusion injury

    doi: 10.1152/ajprenal.00157.2012

    Figure Lengend Snippet: Differential cardiovascular effects of PD-81723 and CCPA. We compared the effects of a selective A 1 AR allosteric enhancer (PD-81723) and a selective A 1 AR agonist [2-chloro- N 6 -cyclopentyladenosine (CCPA)] on mouse heart rate ( A ) and systolic blood pressure ( B ). We measured systolic blood pressure as well as heart rate via an indwelling carotid artery catheter. PD-81723 (3 and 6 mg/kg ip) did not significantly change heart or systolic blood pressure in mice ( n = 4). In contrast, CCPA (0.1 and 0.5mg/kg ip, n = 4) caused dose-dependent decreases in heart rate and systolic blood pressure in mice. Arrows indicate the time of drug injection. * P

    Article Snippet: 2-Amino-4,5-dimethyl-3-thienyl-[3-(trifluoromethyl)phenyl] methanone (PD-81723; a selective allosteric enhancer for the A1 AR; ), 2-chloro- N 6 -cyclopentyladenosine (CCPA; a selective A1 AR agonist), 8-cyclopentyl-1,3-dipropylxanthine (DPCPX; a selective antagonist for the A1 AR) and 4-{[4-(4-chlorophenyl)-2-thiazolyl]amino}phenol [SKI-II, a selective nonlipid inhibitor of sphingosine kinase (SK)] were purchased from Tocris (Minneapolis, MN).

    Techniques: Mouse Assay, Injection