Review





Similar Products

mouse anti md2  (Proteintech)
94
Proteintech mouse anti md2
<t>Clec7a–MD2</t> signaling mediates synaptic loss in PS19 mice. ( A – C ) Representative immunoblots of MD2 in ventral hippocampal lysate from WT or PS19 mice at 3 months ( A ), 6 months ( B ), and 9 months ( C ). ( D ) Representative immunoblots of hippocampus samples from AD patients. ( E ) Endogenous Clec7a was co-immunoprecipitated with MD2. ( F ) Quantitation of MD2 levels shown in panel ( A – C ) ( n = 6 mice per group, unpaired Student’s t test). ( G ) Quantitation of MD2 amounts in ( D ) ( n = 3 biologically independent samples per group, unpaired Student’s t test). ( H ) High resolution confocal images and 3D reconstructions show the presence of MD2 (magenta) tagged PSD95 (red) within Iba1 + cells (green) in the DG regions of hippocampal tissue from Laminarin-administered PS19 mice. White arrows indicating PSD95+ MD2+ puncta in Iba1 + cell. Scale bars, 5 μm. ( I ) Quantitation of MD2-PSD95 colocalized puncta ( n = 6 mice per group, one-way ANOVA test). ( J ) Quantitation of MD2-PSD95 colocalized puncta in Iba1 + cell ( n = 6 mice per group, one-way ANOVA test). * p < 0.05; ** p < 0.01; *** p < 0.001. Data are presented as mean ± SD.
Mouse Anti Md2, supplied by Proteintech, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/mouse anti md2/product/Proteintech
Average 94 stars, based on 1 article reviews
mouse anti md2 - by Bioz Stars, 2025-06
94/100 stars
  Buy from Supplier
anti md2  (Proteintech)
94
Proteintech anti md2
<t>Clec7a–MD2</t> signaling mediates synaptic loss in PS19 mice. ( A – C ) Representative immunoblots of MD2 in ventral hippocampal lysate from WT or PS19 mice at 3 months ( A ), 6 months ( B ), and 9 months ( C ). ( D ) Representative immunoblots of hippocampus samples from AD patients. ( E ) Endogenous Clec7a was co-immunoprecipitated with MD2. ( F ) Quantitation of MD2 levels shown in panel ( A – C ) ( n = 6 mice per group, unpaired Student’s t test). ( G ) Quantitation of MD2 amounts in ( D ) ( n = 3 biologically independent samples per group, unpaired Student’s t test). ( H ) High resolution confocal images and 3D reconstructions show the presence of MD2 (magenta) tagged PSD95 (red) within Iba1 + cells (green) in the DG regions of hippocampal tissue from Laminarin-administered PS19 mice. White arrows indicating PSD95+ MD2+ puncta in Iba1 + cell. Scale bars, 5 μm. ( I ) Quantitation of MD2-PSD95 colocalized puncta ( n = 6 mice per group, one-way ANOVA test). ( J ) Quantitation of MD2-PSD95 colocalized puncta in Iba1 + cell ( n = 6 mice per group, one-way ANOVA test). * p < 0.05; ** p < 0.01; *** p < 0.001. Data are presented as mean ± SD.
Anti Md2, supplied by Proteintech, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/anti md2/product/Proteintech
Average 94 stars, based on 1 article reviews
anti md2 - by Bioz Stars, 2025-06
94/100 stars
  Buy from Supplier
mouse anti md2 antibody  (Proteintech)
94
Proteintech mouse anti md2 antibody
<t>Clec7a–MD2</t> signaling mediates synaptic loss in PS19 mice. ( A – C ) Representative immunoblots of MD2 in ventral hippocampal lysate from WT or PS19 mice at 3 months ( A ), 6 months ( B ), and 9 months ( C ). ( D ) Representative immunoblots of hippocampus samples from AD patients. ( E ) Endogenous Clec7a was co-immunoprecipitated with MD2. ( F ) Quantitation of MD2 levels shown in panel ( A – C ) ( n = 6 mice per group, unpaired Student’s t test). ( G ) Quantitation of MD2 amounts in ( D ) ( n = 3 biologically independent samples per group, unpaired Student’s t test). ( H ) High resolution confocal images and 3D reconstructions show the presence of MD2 (magenta) tagged PSD95 (red) within Iba1 + cells (green) in the DG regions of hippocampal tissue from Laminarin-administered PS19 mice. White arrows indicating PSD95+ MD2+ puncta in Iba1 + cell. Scale bars, 5 μm. ( I ) Quantitation of MD2-PSD95 colocalized puncta ( n = 6 mice per group, one-way ANOVA test). ( J ) Quantitation of MD2-PSD95 colocalized puncta in Iba1 + cell ( n = 6 mice per group, one-way ANOVA test). * p < 0.05; ** p < 0.01; *** p < 0.001. Data are presented as mean ± SD.
Mouse Anti Md2 Antibody, supplied by Proteintech, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/mouse anti md2 antibody/product/Proteintech
Average 94 stars, based on 1 article reviews
mouse anti md2 antibody - by Bioz Stars, 2025-06
94/100 stars
  Buy from Supplier
md2 rabbit  (Proteintech)
93
Proteintech md2 rabbit
<t>Clec7a–MD2</t> signaling mediates synaptic loss in PS19 mice. ( A – C ) Representative immunoblots of MD2 in ventral hippocampal lysate from WT or PS19 mice at 3 months ( A ), 6 months ( B ), and 9 months ( C ). ( D ) Representative immunoblots of hippocampus samples from AD patients. ( E ) Endogenous Clec7a was co-immunoprecipitated with MD2. ( F ) Quantitation of MD2 levels shown in panel ( A – C ) ( n = 6 mice per group, unpaired Student’s t test). ( G ) Quantitation of MD2 amounts in ( D ) ( n = 3 biologically independent samples per group, unpaired Student’s t test). ( H ) High resolution confocal images and 3D reconstructions show the presence of MD2 (magenta) tagged PSD95 (red) within Iba1 + cells (green) in the DG regions of hippocampal tissue from Laminarin-administered PS19 mice. White arrows indicating PSD95+ MD2+ puncta in Iba1 + cell. Scale bars, 5 μm. ( I ) Quantitation of MD2-PSD95 colocalized puncta ( n = 6 mice per group, one-way ANOVA test). ( J ) Quantitation of MD2-PSD95 colocalized puncta in Iba1 + cell ( n = 6 mice per group, one-way ANOVA test). * p < 0.05; ** p < 0.01; *** p < 0.001. Data are presented as mean ± SD.
Md2 Rabbit, supplied by Proteintech, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/md2 rabbit/product/Proteintech
Average 93 stars, based on 1 article reviews
md2 rabbit - by Bioz Stars, 2025-06
93/100 stars
  Buy from Supplier

Image Search Results


Clec7a–MD2 signaling mediates synaptic loss in PS19 mice. ( A – C ) Representative immunoblots of MD2 in ventral hippocampal lysate from WT or PS19 mice at 3 months ( A ), 6 months ( B ), and 9 months ( C ). ( D ) Representative immunoblots of hippocampus samples from AD patients. ( E ) Endogenous Clec7a was co-immunoprecipitated with MD2. ( F ) Quantitation of MD2 levels shown in panel ( A – C ) ( n = 6 mice per group, unpaired Student’s t test). ( G ) Quantitation of MD2 amounts in ( D ) ( n = 3 biologically independent samples per group, unpaired Student’s t test). ( H ) High resolution confocal images and 3D reconstructions show the presence of MD2 (magenta) tagged PSD95 (red) within Iba1 + cells (green) in the DG regions of hippocampal tissue from Laminarin-administered PS19 mice. White arrows indicating PSD95+ MD2+ puncta in Iba1 + cell. Scale bars, 5 μm. ( I ) Quantitation of MD2-PSD95 colocalized puncta ( n = 6 mice per group, one-way ANOVA test). ( J ) Quantitation of MD2-PSD95 colocalized puncta in Iba1 + cell ( n = 6 mice per group, one-way ANOVA test). * p < 0.05; ** p < 0.01; *** p < 0.001. Data are presented as mean ± SD.

Journal: International Journal of Molecular Sciences

Article Title: Clec7a Signaling in Microglia Promotes Synapse Loss Associated with Tauopathy

doi: 10.3390/ijms26072888

Figure Lengend Snippet: Clec7a–MD2 signaling mediates synaptic loss in PS19 mice. ( A – C ) Representative immunoblots of MD2 in ventral hippocampal lysate from WT or PS19 mice at 3 months ( A ), 6 months ( B ), and 9 months ( C ). ( D ) Representative immunoblots of hippocampus samples from AD patients. ( E ) Endogenous Clec7a was co-immunoprecipitated with MD2. ( F ) Quantitation of MD2 levels shown in panel ( A – C ) ( n = 6 mice per group, unpaired Student’s t test). ( G ) Quantitation of MD2 amounts in ( D ) ( n = 3 biologically independent samples per group, unpaired Student’s t test). ( H ) High resolution confocal images and 3D reconstructions show the presence of MD2 (magenta) tagged PSD95 (red) within Iba1 + cells (green) in the DG regions of hippocampal tissue from Laminarin-administered PS19 mice. White arrows indicating PSD95+ MD2+ puncta in Iba1 + cell. Scale bars, 5 μm. ( I ) Quantitation of MD2-PSD95 colocalized puncta ( n = 6 mice per group, one-way ANOVA test). ( J ) Quantitation of MD2-PSD95 colocalized puncta in Iba1 + cell ( n = 6 mice per group, one-way ANOVA test). * p < 0.05; ** p < 0.01; *** p < 0.001. Data are presented as mean ± SD.

Article Snippet: The blots were probed with rabbit anti-Clec7a (1:500, mabg-mdct, Invivogen, San Diego, CA, USA) and mouse anti-MD2 (1:500, 11784-1-AP, Proteintech, Wuhan, China) antibodies.

Techniques: Western Blot, Immunoprecipitation, Quantitation Assay

Clec7a–MD2 signaling mediates synaptic loss in PS19 mice. ( A – C ) Representative immunoblots of MD2 in ventral hippocampal lysate from WT or PS19 mice at 3 months ( A ), 6 months ( B ), and 9 months ( C ). ( D ) Representative immunoblots of hippocampus samples from AD patients. ( E ) Endogenous Clec7a was co-immunoprecipitated with MD2. ( F ) Quantitation of MD2 levels shown in panel ( A – C ) ( n = 6 mice per group, unpaired Student’s t test). ( G ) Quantitation of MD2 amounts in ( D ) ( n = 3 biologically independent samples per group, unpaired Student’s t test). ( H ) High resolution confocal images and 3D reconstructions show the presence of MD2 (magenta) tagged PSD95 (red) within Iba1 + cells (green) in the DG regions of hippocampal tissue from Laminarin-administered PS19 mice. White arrows indicating PSD95+ MD2+ puncta in Iba1 + cell. Scale bars, 5 μm. ( I ) Quantitation of MD2-PSD95 colocalized puncta ( n = 6 mice per group, one-way ANOVA test). ( J ) Quantitation of MD2-PSD95 colocalized puncta in Iba1 + cell ( n = 6 mice per group, one-way ANOVA test). * p < 0.05; ** p < 0.01; *** p < 0.001. Data are presented as mean ± SD.

Journal: International Journal of Molecular Sciences

Article Title: Clec7a Signaling in Microglia Promotes Synapse Loss Associated with Tauopathy

doi: 10.3390/ijms26072888

Figure Lengend Snippet: Clec7a–MD2 signaling mediates synaptic loss in PS19 mice. ( A – C ) Representative immunoblots of MD2 in ventral hippocampal lysate from WT or PS19 mice at 3 months ( A ), 6 months ( B ), and 9 months ( C ). ( D ) Representative immunoblots of hippocampus samples from AD patients. ( E ) Endogenous Clec7a was co-immunoprecipitated with MD2. ( F ) Quantitation of MD2 levels shown in panel ( A – C ) ( n = 6 mice per group, unpaired Student’s t test). ( G ) Quantitation of MD2 amounts in ( D ) ( n = 3 biologically independent samples per group, unpaired Student’s t test). ( H ) High resolution confocal images and 3D reconstructions show the presence of MD2 (magenta) tagged PSD95 (red) within Iba1 + cells (green) in the DG regions of hippocampal tissue from Laminarin-administered PS19 mice. White arrows indicating PSD95+ MD2+ puncta in Iba1 + cell. Scale bars, 5 μm. ( I ) Quantitation of MD2-PSD95 colocalized puncta ( n = 6 mice per group, one-way ANOVA test). ( J ) Quantitation of MD2-PSD95 colocalized puncta in Iba1 + cell ( n = 6 mice per group, one-way ANOVA test). * p < 0.05; ** p < 0.01; *** p < 0.001. Data are presented as mean ± SD.

Article Snippet: The following antibodies were used: anti-β-actin (GB15001-100, Servicebio, Wuhan, China); anti-Clec7a (AF1756-SP, R&D, Minneapolis, MN, USA); anti-Clec7a (YN2088, Immunoway, Wuhan China); anti-MD2 (11784-1-AP, Proteintech, Wuhan, China); anti-mouse IL-1β (AF-401-NA, R&D); anti-mouse Caspase-1 (24232, Proteintech); anti-NLRP3 (15101, Proteintech); anti-Mouse IgG(H + L) (A00001, Zenbio, Chengdu, China); anti-PSD95 (A0131, ABclonal, Wuhan, China); and anti-Synaptophysin (A19122, ABclonal)

Techniques: Western Blot, Immunoprecipitation, Quantitation Assay