phenylethanol  (Millipore)

 
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  • 93
    Name:
    1 Phenylethanol
    Description:

    Catalog Number:
    P13800
    Price:
    None
    Applications:
    . 1-Phenylethanol can be used in the acid catalyzed Ritter reaction to synthesize various N-benzylacetamides.. It is one of the key precursors for the synthesis of [60] fullerene-fused isochroman derivatives via palladium-catalyzed hydroxyl-directed cyclization.. It is used in Friedlander synthesis of quinolines where 1-phenylethanol reacts with 2-aminobenzylic alcohol derivatives to yield corresponding quinones.. It can also be used in the regioselective, iridium-catalyzed multicomponent synthesis of pyrimidines.
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    Structured Review

    Millipore phenylethanol
    1 Phenylethanol

    https://www.bioz.com/result/phenylethanol/product/Millipore
    Average 93 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    phenylethanol - by Bioz Stars, 2021-05
    93/100 stars

    Images

    1) Product Images from "Enzyme-Modified Particles for Selective Biocatalytic Hydrogenation by Hydrogen-Driven NADH Recycling"

    Article Title: Enzyme-Modified Particles for Selective Biocatalytic Hydrogenation by Hydrogen-Driven NADH Recycling

    Journal: Chemcatchem

    doi: 10.1002/cctc.201500766

    Schematic representation of the H 2 -driven particle system for NADH-dependent biocatalysis. Oxidation of H 2 by a hydrogenase (green) transfers electrons (e − ) into an electronically conducting particle and these are then used by an NAD + reductase (blue) for selective NAD + reduction. A co-immobilised NADH-dependent AHD (red) is supplied with NADH that is used for catalytic reduction of a ketone (here, acetophenone). Both hydrogen atoms of H 2 are incorporated into the product (here phenylethanol) to allow a 100 % atom-efficient chemical synthesis.
    Figure Legend Snippet: Schematic representation of the H 2 -driven particle system for NADH-dependent biocatalysis. Oxidation of H 2 by a hydrogenase (green) transfers electrons (e − ) into an electronically conducting particle and these are then used by an NAD + reductase (blue) for selective NAD + reduction. A co-immobilised NADH-dependent AHD (red) is supplied with NADH that is used for catalytic reduction of a ketone (here, acetophenone). Both hydrogen atoms of H 2 are incorporated into the product (here phenylethanol) to allow a 100 % atom-efficient chemical synthesis.

    Techniques Used:

    HPLC confirms the purity of the reaction product, phenylethanol, after H 2 -driven acetophenone reduction by particles with co-immobilised hydrogenase, NAD + reductase and ADH; traces correspond to 1.5 (grey) and 21.5 h (black), reaction conditions: 10 m m acetophenone, Tris-HCl buffer, pH 8, 25 °C, 1 m m NAD + , 2 % DMSO.
    Figure Legend Snippet: HPLC confirms the purity of the reaction product, phenylethanol, after H 2 -driven acetophenone reduction by particles with co-immobilised hydrogenase, NAD + reductase and ADH; traces correspond to 1.5 (grey) and 21.5 h (black), reaction conditions: 10 m m acetophenone, Tris-HCl buffer, pH 8, 25 °C, 1 m m NAD + , 2 % DMSO.

    Techniques Used: High Performance Liquid Chromatography

    Comparison of the rate of phenylethanol generation using particles modified with hydrogenase, NAD + reductase and ADH (▪) or hydrogenase and NAD + reductase supplying ADH in solution (○). Each experiment was performed in H 2 -saturated buffer solution (50 m m Tris-HCl, pH 8, 2 % DMSO, 22 °C) that contained NAD + (1 m m ) and acetophenone (10 m m ). The samples were left in a shaker vessel (500 rpm) with H 2 flowing through the headspace. At specific time points aliquots were removed and analysed by HPLC.
    Figure Legend Snippet: Comparison of the rate of phenylethanol generation using particles modified with hydrogenase, NAD + reductase and ADH (▪) or hydrogenase and NAD + reductase supplying ADH in solution (○). Each experiment was performed in H 2 -saturated buffer solution (50 m m Tris-HCl, pH 8, 2 % DMSO, 22 °C) that contained NAD + (1 m m ) and acetophenone (10 m m ). The samples were left in a shaker vessel (500 rpm) with H 2 flowing through the headspace. At specific time points aliquots were removed and analysed by HPLC.

    Techniques Used: Modification, High Performance Liquid Chromatography

    2) Product Images from "Effect of Crown Ethers on Structure, Stability, Activity, and Enantioselectivity of Subtilisin Carlsberg in Organic Solvents"

    Article Title: Effect of Crown Ethers on Structure, Stability, Activity, and Enantioselectivity of Subtilisin Carlsberg in Organic Solvents

    Journal: Biotechnology and bioengineering

    doi:

    Initial rates for the formation of S- enantiomer (A) and enantioselectivity [ k cat / K M ] R /[ k cat / K M ] S (B) for the transesterification of (±)-1-phenylethanol with vinylbutyrate in THF at various temperatures catalyzed by subtilisin Carlsberg lyophilized with crown ethers. Reaction conditions: 70 m M (±)-1-phenylethanol; 100 m M vinylbutyrate; enzyme concentration 1 mg/mL; 45°C, 300 rpm on an orbital shaker.
    Figure Legend Snippet: Initial rates for the formation of S- enantiomer (A) and enantioselectivity [ k cat / K M ] R /[ k cat / K M ] S (B) for the transesterification of (±)-1-phenylethanol with vinylbutyrate in THF at various temperatures catalyzed by subtilisin Carlsberg lyophilized with crown ethers. Reaction conditions: 70 m M (±)-1-phenylethanol; 100 m M vinylbutyrate; enzyme concentration 1 mg/mL; 45°C, 300 rpm on an orbital shaker.

    Techniques Used: Concentration Assay

    Related Articles

    Purification:

    Article Title: 1-(2-Hy-droxy-2-phenyl-eth-yl)-3-(4-meth-oxy-phen-yl)urea
    Article Snippet: .. Experimental 2-Amino-1-phenylethanol and 4-methoxyphenyl isocyanate were purchased from Sigma Chemical Co. All other chemicals and solvents were of analytical grade and were used without further purification. ..

    Article Title: Enzyme-Modified Particles for Selective Biocatalytic Hydrogenation by Hydrogen-Driven NADH Recycling
    Article Snippet: .. Chemicals Acetophenone (Sigma), phenylethanol (Sigma), NAD+ (Prozomix), acetonitrile (Sigma), carbon black particles (Black Pearls 2000, BP2000, Cabot Corporation) and buffer salts (Sigma) were used as received without further purification. .. All solutions were prepared with MilliQ water (Millipore, 18 MΩ cm).

    other:

    Article Title: A comparison of semi-quantitative methods suitable for establishing volatile profiles
    Article Snippet: Normalization of peak areas of each compound was done by using 1-phenylethanol (RT 7.096, Sigma-Aldrich, ) as an internal standard by adding 10 µL (0.1%) to the sucrose solution during the flower scent analysis.

    Article Title: Tailoring the Spacer Arm for Covalent Immobilization of Candida antarctica Lipase B—Thermal Stabilization by Bisepoxide-Activated Aminoalkyl Resins in Continuous-Flow Reactors
    Article Snippet: Racemic 1-phenylethanol (rac -1), vinyl acetate, glutaraldehyde (GA) solution (25% w/v in H2 O); hydrochloric acid, glycerol diglycidyl ether (GDGE) and Triton™ X-100 [4-(1,1,3,3-tetramethylbutyl)phenyl-polyethylene glycol] were purchased from Sigma-Aldrich (Milwaukee, WI, USA).

    Article Title: Effect of Crown Ethers on Structure, Stability, Activity, and Enantioselectivity of Subtilisin Carlsberg in Organic Solvents
    Article Snippet: The substrates for the enzymatic assays were from the following sources: (±)-1-phenylethanol and 1-propanol were from Aldrich; vinylbutyrate was from TCI; and N -acetyl-L-phenylalanine ethylester was from Sigma.

    Plasmid Purification:

    Article Title: Conversion of Phenylalanine to Benzaldehyde Initiated by an Aminotransferase in Lactobacillus plantarum
    Article Snippet: .. Phenylalanine, phenylpyruvic acid, α-ketoglutaric acid, pyridoxal 5′-phosphate (PLP), lysozyme, benzaldehyde, phenylglyoxylic acid, and phenylethanol were obtained from Sigma Chemical Co. (St. Louis, Mo.). .. Phenylacetic acid, trans -cinnamic acid, and mandelic acid were purchased from Acros Chimica (Geel, Belgium), and benzoic acid was obtained from Merck (Darmstadt, Germany).

    Article Title: Engineered baker’s yeast as whole-cell biocatalyst for one-pot stereo-selective conversion of amines to alcohols
    Article Snippet: .. Chemicals All chemicals were bought from VWR (Leuven, Belgium) except acetophenone (ACP), racemic 1-phenylethylamine (1-PEA), (R )-1-PEA, (S )-1-PEA and sodium pyruvate from Merck (Hohenbrunn, Germany), (R )-1-phenylethanol (PE) and (S )-1-PE from Sigma-Aldrich (Steinheim, Germany) and pyridoxal-5’-phosphate (PLP) from AppliChem (Darmstadt, Germany). .. Strains, media, and cell growth S. cerevisiae strain TMB4150 (MAT a, ura3-52 MAL2-8 C SUC2 ) was kindly provided by Jan Knudsen, Applied Microbiology, Lund University, Sweden.

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  • 93
    Millipore salbutamol
    Effects of <t>salbutamol</t> and roflumilast on macrophages. Macrophages were pre‐incubated (30 min) with indomethacin (1 μM) and then with or without either (A) salbutamol, (B) roflumilast or (C) PGE 2 in the absence (control) or presence of a single concentration of roflumilast (30 nM) for 30 min before challenge with LPS (1 ng·mL −1 ) for 22 h after which TNF‐α was measured in the supernatants. The horizontal grid line in (C) shows the inhibition seen with roflumilast alone (22 ± 5% inhibition). Results are expressed as the % inhibition of the unblocked control TNF‐α releases, which ranged from 2363 ± 835 to 2208 ± 969 pg·mL −1 . Data shown are means ± SEM for five (A, B and C) experiments.
    Salbutamol, supplied by Millipore, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/salbutamol/product/Millipore
    Average 93 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    salbutamol - by Bioz Stars, 2021-05
    93/100 stars
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    N/A
    This product is provided as delivered and specified by the issuing Pharmacopoeia All information provided in support of this product including SDS and any product information leaflets have been developed
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    Image Search Results


    Effects of salbutamol and roflumilast on macrophages. Macrophages were pre‐incubated (30 min) with indomethacin (1 μM) and then with or without either (A) salbutamol, (B) roflumilast or (C) PGE 2 in the absence (control) or presence of a single concentration of roflumilast (30 nM) for 30 min before challenge with LPS (1 ng·mL −1 ) for 22 h after which TNF‐α was measured in the supernatants. The horizontal grid line in (C) shows the inhibition seen with roflumilast alone (22 ± 5% inhibition). Results are expressed as the % inhibition of the unblocked control TNF‐α releases, which ranged from 2363 ± 835 to 2208 ± 969 pg·mL −1 . Data shown are means ± SEM for five (A, B and C) experiments.

    Journal: British Journal of Pharmacology

    Article Title: The anti‐inflammatory effects of PGE2 on human lung macrophages are mediated by the EP4 receptor) The anti‐inflammatory effects of PGE2 on human lung macrophages are mediated by the EP4 receptor

    doi: 10.1111/bph.13565

    Figure Lengend Snippet: Effects of salbutamol and roflumilast on macrophages. Macrophages were pre‐incubated (30 min) with indomethacin (1 μM) and then with or without either (A) salbutamol, (B) roflumilast or (C) PGE 2 in the absence (control) or presence of a single concentration of roflumilast (30 nM) for 30 min before challenge with LPS (1 ng·mL −1 ) for 22 h after which TNF‐α was measured in the supernatants. The horizontal grid line in (C) shows the inhibition seen with roflumilast alone (22 ± 5% inhibition). Results are expressed as the % inhibition of the unblocked control TNF‐α releases, which ranged from 2363 ± 835 to 2208 ± 969 pg·mL −1 . Data shown are means ± SEM for five (A, B and C) experiments.

    Article Snippet: The materials used were supplied as follows: indomethacin, PGE2 , Percoll, salbutamol, Tri‐Reagent (all Sigma); gentamicin, penicillin/streptomycin, fungizone, RPMI 1640, (Invitrogen, Paisley, UK); butaprost, misoprostol, L‐902,688 (Cayman Chemical Company); L‐161,982 (Tocris Bioscience, Bristol, UK); roflumilast (Santa Cruz Biotechnology, Heidelberg, Germany); Quick‐Diff (Reagena, Toivala, Finland); FCS (Promocell, Heidelberg, Germany); and LPS (Enzo Life Sciences, Exeter, UK).

    Techniques: Incubation, Concentration Assay, Inhibition

    The effect of NS309, salbutamol and GEA3175 in (A–C) human pulmonary arteries with or without endothelium, (D–F) human bronchioles with or without epithelium. Data points represent means ± SEM, with n = 4–7 per data point.

    Journal: British Journal of Pharmacology

    Article Title: Activation of endothelial and epithelial KCa2.3 calcium-activated potassium channels by NS309 relaxes human small pulmonary arteries and bronchioles

    doi: 10.1111/j.1476-5381.2012.01986.x

    Figure Lengend Snippet: The effect of NS309, salbutamol and GEA3175 in (A–C) human pulmonary arteries with or without endothelium, (D–F) human bronchioles with or without epithelium. Data points represent means ± SEM, with n = 4–7 per data point.

    Article Snippet: Concentration–response curves (0.001–10 µM) were constructed for the KCa 2.3 and KCa 3.1 channel opener NS309 (Neurosearch A/S, Ballerup, Denmark), the ‘classical’ KCa 2.3 and KCa 3.1 channel opener 1-ethyl-benzimidazolinone (1-EBIO; Sigma Aldrich, St. Louis, MO); a selective activator of KCa 2 channels, cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine (CyPPA); a NO donor, 3-(2-chloro-3-methylphenyl)-5-[[(4-methylphenyl)sulphonyl] amino]-hydroxide (GEA 3175; GEA A/S, Copenhagen, Denmark) and the β2 -adrenoceptor agonist, salbutamol (Sigma Aldrich).

    Techniques:

    The effect of vehicle, NS309, 1-EBIO, levcromakalim, salbutamol and GEA 3175 in (A, B) human pulmonary arteries and (C, D) human bronchioles. Data points represent means ± SEM, with n = 4–12 per data point.

    Journal: British Journal of Pharmacology

    Article Title: Activation of endothelial and epithelial KCa2.3 calcium-activated potassium channels by NS309 relaxes human small pulmonary arteries and bronchioles

    doi: 10.1111/j.1476-5381.2012.01986.x

    Figure Lengend Snippet: The effect of vehicle, NS309, 1-EBIO, levcromakalim, salbutamol and GEA 3175 in (A, B) human pulmonary arteries and (C, D) human bronchioles. Data points represent means ± SEM, with n = 4–12 per data point.

    Article Snippet: Concentration–response curves (0.001–10 µM) were constructed for the KCa 2.3 and KCa 3.1 channel opener NS309 (Neurosearch A/S, Ballerup, Denmark), the ‘classical’ KCa 2.3 and KCa 3.1 channel opener 1-ethyl-benzimidazolinone (1-EBIO; Sigma Aldrich, St. Louis, MO); a selective activator of KCa 2 channels, cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine (CyPPA); a NO donor, 3-(2-chloro-3-methylphenyl)-5-[[(4-methylphenyl)sulphonyl] amino]-hydroxide (GEA 3175; GEA A/S, Copenhagen, Denmark) and the β2 -adrenoceptor agonist, salbutamol (Sigma Aldrich).

    Techniques:

    Effects of isoprenaline, salbutamol and SR 59104A on pulmonary reactivity; influence of K+ channel, EDRF and cyclo-oxygenase inhibitors

    Journal: British Journal of Pharmacology

    Article Title: Role of potassium channels and nitric oxide in the relaxant effects elicited by ?-adrenoceptor agonists on hypoxic vasoconstriction in the isolated perfused lung of the rat

    doi: 10.1038/sj.bjp.0702575

    Figure Lengend Snippet: Effects of isoprenaline, salbutamol and SR 59104A on pulmonary reactivity; influence of K+ channel, EDRF and cyclo-oxygenase inhibitors

    Article Snippet: The drugs used were: SR 59104A (N- [6 hydroxy-1,2,3,4-tetrahydronaphtalen-(2 R )-2yl) methyl]-(2 R )-2hydroxy-2-(3-chlorophenyl) ethanamine hydrochloride (Sanofi-Midy, Research Centre, Milan, Italy), glibenclamide (Laboratoire Hoechst, Paris la Défense, France), isoprenaline, salbutamol, angiotensin II, NG -nitro- L -arginine methyl ester, indomethacin (Sigma Chimie, La Verpillère, France) and charybdotoxin and apamin (Latoxan, Rosans, France).

    Techniques:

    Effects of isoprenaline, salbutamol and SR 59104A on pulmonary reactivity; influence of K+ channel, EDRF and cyclo-oxygenase inhibitors

    Journal: British Journal of Pharmacology

    Article Title: Role of potassium channels and nitric oxide in the relaxant effects elicited by ?-adrenoceptor agonists on hypoxic vasoconstriction in the isolated perfused lung of the rat

    doi: 10.1038/sj.bjp.0702575

    Figure Lengend Snippet: Effects of isoprenaline, salbutamol and SR 59104A on pulmonary reactivity; influence of K+ channel, EDRF and cyclo-oxygenase inhibitors

    Article Snippet: The drugs used were: SR 59104A (N- [6 hydroxy-1,2,3,4-tetrahydronaphtalen-(2 R )-2yl) methyl]-(2 R )-2hydroxy-2-(3-chlorophenyl) ethanamine hydrochloride (Sanofi-Midy, Research Centre, Milan, Italy), glibenclamide (Laboratoire Hoechst, Paris la Défense, France), isoprenaline, salbutamol, angiotensin II, NG -nitro- L -arginine methyl ester, indomethacin (Sigma Chimie, La Verpillère, France) and charybdotoxin and apamin (Latoxan, Rosans, France).

    Techniques:

    Brown adipose tissue (BAT) blood flow estimated by contrast-ultrasound before and during β2-adrenoreceptor stimulation. Individual data of Aβ product at baseline and 10 min after the onset of salbutamol infusion at 0.2 μg·kg

    Journal: Journal of Applied Physiology

    Article Title: Relationship of brown adipose tissue perfusion and function: a study through β2-adrenoreceptor stimulation

    doi: 10.1152/japplphysiol.00634.2015

    Figure Lengend Snippet: Brown adipose tissue (BAT) blood flow estimated by contrast-ultrasound before and during β2-adrenoreceptor stimulation. Individual data of Aβ product at baseline and 10 min after the onset of salbutamol infusion at 0.2 μg·kg

    Article Snippet: Salbutamol was obtained from Sigma Aldrich (S8260) and diluted in sterile 0.9% saline before injection.

    Techniques: Flow Cytometry

    BAT ( A ) and visceral ( B ) and subcutaneous white adipose tissue (WAT; C ) glucose uptake after β2-adrenoreceptor stimulation. Mice were treated with 10 μg/g mouse body wt of salbutamol intraperitoneally ( n = 10), and their glucose uptake

    Journal: Journal of Applied Physiology

    Article Title: Relationship of brown adipose tissue perfusion and function: a study through β2-adrenoreceptor stimulation

    doi: 10.1152/japplphysiol.00634.2015

    Figure Lengend Snippet: BAT ( A ) and visceral ( B ) and subcutaneous white adipose tissue (WAT; C ) glucose uptake after β2-adrenoreceptor stimulation. Mice were treated with 10 μg/g mouse body wt of salbutamol intraperitoneally ( n = 10), and their glucose uptake

    Article Snippet: Salbutamol was obtained from Sigma Aldrich (S8260) and diluted in sterile 0.9% saline before injection.

    Techniques: Mouse Assay