streptozotocin  (Valiant)


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    Name:
    Streptozotocin
    Description:
    Streptozotocin
    Catalog Number:
    02100557-cf
    Price:
    10.0
    Applications:
    Treatment of pancreatic (islet-cell) tumors
    Category:
    Life Sciences Biochemicals Antibiotics
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    Structured Review

    Valiant streptozotocin
    Streptozotocin
    Streptozotocin
    https://www.bioz.com/result/streptozotocin/product/Valiant
    Average 93 stars, based on 29 article reviews
    Price from $9.99 to $1999.99
    streptozotocin - by Bioz Stars, 2021-02
    93/100 stars

    Images

    1) Product Images from "Glial and neuronal dysfunction in streptozotocin-induced diabetic rats"

    Article Title: Glial and neuronal dysfunction in streptozotocin-induced diabetic rats

    Journal: Journal of Ocular Biology, Diseases, and Informatics

    doi: 10.1007/s12177-011-9069-3

    Comparisons of retinal function between control and diabetic rats. a Averaged dark-adapted, full-field electroretinogram waveforms and b scotopic threshold responses over a range of luminous energies (−6.79 to 2.07 log cd.s.m −2 ) for control ( dark grey trace , n = 8) and diabetic ( black trace , n = 9) eyes after 4 weeks of streptozotocin (STZ) injection. All waveforms are normalised to each eye’s a-wave minimum at 2.07 log cd.s.m −2 . Light grey areas denote the 95% confidence limits for the control group. c Averaged (± SEM) saturated amplitude of phototransduction (Rm P3 , μV) and d sensitivity (log( S ), m 2 .cd −1 .s −3 ) for control ( unfilled bars ) and diabetic ( filled bars ). e P2 amplitude (ON-bipolar cell function), f P2 peak time, g oscillatory potential amplitude and h scotopic threshold response (amplitude at a fixed time of 110 ms) for control ( unfilled symbols ) and diabetic ( filled symbols ) animals. Asterisks denotes significant difference (* P
    Figure Legend Snippet: Comparisons of retinal function between control and diabetic rats. a Averaged dark-adapted, full-field electroretinogram waveforms and b scotopic threshold responses over a range of luminous energies (−6.79 to 2.07 log cd.s.m −2 ) for control ( dark grey trace , n = 8) and diabetic ( black trace , n = 9) eyes after 4 weeks of streptozotocin (STZ) injection. All waveforms are normalised to each eye’s a-wave minimum at 2.07 log cd.s.m −2 . Light grey areas denote the 95% confidence limits for the control group. c Averaged (± SEM) saturated amplitude of phototransduction (Rm P3 , μV) and d sensitivity (log( S ), m 2 .cd −1 .s −3 ) for control ( unfilled bars ) and diabetic ( filled bars ). e P2 amplitude (ON-bipolar cell function), f P2 peak time, g oscillatory potential amplitude and h scotopic threshold response (amplitude at a fixed time of 110 ms) for control ( unfilled symbols ) and diabetic ( filled symbols ) animals. Asterisks denotes significant difference (* P

    Techniques Used: Injection, Cell Function Assay, Mass Spectrometry

    2) Product Images from "Progressive Loss of Corneal Nerve Fibers and Sensitivity in Rats Modeling Obesity and Type 2 Diabetes Is Reversible with Omega-3 Fatty Acid Intervention: Supporting Cornea Analyses as a Marker for Peripheral Neuropathy and Treatment"

    Article Title: Progressive Loss of Corneal Nerve Fibers and Sensitivity in Rats Modeling Obesity and Type 2 Diabetes Is Reversible with Omega-3 Fatty Acid Intervention: Supporting Cornea Analyses as a Marker for Peripheral Neuropathy and Treatment

    Journal: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy

    doi: 10.2147/DMSO.S247571

    Effect of duration of obesity or type 2 diabetes on vascular reactivity to acetylcholine by epineurial arterioles of the sciatic nerve. Vascular reactivity was determined as described in the 'Methods' section after 22 (black circles), 28 (red circles) or 36 (green circles) weeks of age in Sprague Dawley rats fed a normal diet or in rats fed a high-fat diet at 12 weeks of age for 10 (black triangles), 16 (red triangles) or 24 (green triangles) weeks or in type 2 diabetic rats that were treated with a low dose of streptozotocin after 8 weeks of a high-fat diet and 2 (black diamonds), 8 (red diamonds) or 16 (green diamonds) weeks of hyperglycemia. Data are presented as the mean ± SEM. in % relaxation. The number of rats in each group was 12. *p
    Figure Legend Snippet: Effect of duration of obesity or type 2 diabetes on vascular reactivity to acetylcholine by epineurial arterioles of the sciatic nerve. Vascular reactivity was determined as described in the 'Methods' section after 22 (black circles), 28 (red circles) or 36 (green circles) weeks of age in Sprague Dawley rats fed a normal diet or in rats fed a high-fat diet at 12 weeks of age for 10 (black triangles), 16 (red triangles) or 24 (green triangles) weeks or in type 2 diabetic rats that were treated with a low dose of streptozotocin after 8 weeks of a high-fat diet and 2 (black diamonds), 8 (red diamonds) or 16 (green diamonds) weeks of hyperglycemia. Data are presented as the mean ± SEM. in % relaxation. The number of rats in each group was 12. *p

    Techniques Used:

    Effect of duration of obesity or type 2 diabetes on motor and sensory nerve conduction velocity. Motor (top) and sensory (bottom) nerve conduction velocity was examined as described in the 'Methods' section after 22 (open bars), 28 (left hatch bars) or 36 (right hatch bars) weeks of age in Sprague Dawley rats fed a normal diet or in rats fed a high-fat diet at 12 weeks of age for 10 (open bars), 16 (left hatch bars) or 24 (right hatch bars) weeks or in type 2 diabetic rats that were treated with a low dose of streptozotocin after 8 weeks of a high-fat diet and 2 (open bars), 8 (left hatch bars) or 16 (right hatch bars) weeks of hyperglycemia. Data are presented as the mean ± SEM. in m/s. The number of rats in each group was 12. *p
    Figure Legend Snippet: Effect of duration of obesity or type 2 diabetes on motor and sensory nerve conduction velocity. Motor (top) and sensory (bottom) nerve conduction velocity was examined as described in the 'Methods' section after 22 (open bars), 28 (left hatch bars) or 36 (right hatch bars) weeks of age in Sprague Dawley rats fed a normal diet or in rats fed a high-fat diet at 12 weeks of age for 10 (open bars), 16 (left hatch bars) or 24 (right hatch bars) weeks or in type 2 diabetic rats that were treated with a low dose of streptozotocin after 8 weeks of a high-fat diet and 2 (open bars), 8 (left hatch bars) or 16 (right hatch bars) weeks of hyperglycemia. Data are presented as the mean ± SEM. in m/s. The number of rats in each group was 12. *p

    Techniques Used:

    Effect of duration of obesity or type 2 diabetes on cornea sensitivity. Cornea sensitivity was determined using a Cochet–Bonnet filament esthesiometer (top) or by response to a hyperosmolar solution (bottom) as described in the 'Methods' section after 22 (open bars), 28 (left hatch bars) or 36 (right hatch bars) weeks of age in Sprague Dawley rats fed a normal diet or in rats fed a high-fat diet at 12 weeks of age for 10 (open bars), 16 (left hatch bars) or 24 (right hatch bars) weeks or in type 2 diabetic rats that were treated with a low dose of streptozotocin after 8 weeks of a high-fat diet and 2 (open bars), 8 (left hatch bars) or 16 (right hatch bars) weeks of hyperglycemia. Data are presented as the mean ± SEM. in cm for determination of cornea sensitivity by the filament esthesiometer and area under the curve (AUC) for cornea sensitivity by the hyperosmolar solution approach. The number of rats in each group was 12. *p
    Figure Legend Snippet: Effect of duration of obesity or type 2 diabetes on cornea sensitivity. Cornea sensitivity was determined using a Cochet–Bonnet filament esthesiometer (top) or by response to a hyperosmolar solution (bottom) as described in the 'Methods' section after 22 (open bars), 28 (left hatch bars) or 36 (right hatch bars) weeks of age in Sprague Dawley rats fed a normal diet or in rats fed a high-fat diet at 12 weeks of age for 10 (open bars), 16 (left hatch bars) or 24 (right hatch bars) weeks or in type 2 diabetic rats that were treated with a low dose of streptozotocin after 8 weeks of a high-fat diet and 2 (open bars), 8 (left hatch bars) or 16 (right hatch bars) weeks of hyperglycemia. Data are presented as the mean ± SEM. in cm for determination of cornea sensitivity by the filament esthesiometer and area under the curve (AUC) for cornea sensitivity by the hyperosmolar solution approach. The number of rats in each group was 12. *p

    Techniques Used:

    Effect of duration of obesity or type 2 diabetes on thermal nociception. Thermal nociception was examined as described in the 'Methods' section after 22 (open bars), 28 (left hatch bars) or 36 (right hatch bars) weeks of age in Sprague Dawley rats fed a normal diet or in rats fed a high-fat diet at 12 weeks of age for 10 (open bars), 16 (left hatch bars) or 24 (right hatch bars) weeks or in type 2 diabetic rats that were treated with a low dose of streptozotocin after 8 weeks of a high-fat diet and 2 (open bars), 8 (left hatch bars) or 16 (right hatch bars) weeks of hyperglycemia. Data are presented as the mean ± SEM. in sec. The number of rats in each group was 12. *p
    Figure Legend Snippet: Effect of duration of obesity or type 2 diabetes on thermal nociception. Thermal nociception was examined as described in the 'Methods' section after 22 (open bars), 28 (left hatch bars) or 36 (right hatch bars) weeks of age in Sprague Dawley rats fed a normal diet or in rats fed a high-fat diet at 12 weeks of age for 10 (open bars), 16 (left hatch bars) or 24 (right hatch bars) weeks or in type 2 diabetic rats that were treated with a low dose of streptozotocin after 8 weeks of a high-fat diet and 2 (open bars), 8 (left hatch bars) or 16 (right hatch bars) weeks of hyperglycemia. Data are presented as the mean ± SEM. in sec. The number of rats in each group was 12. *p

    Techniques Used:

    Effect of duration of obesity or type 2 diabetes on intraepidermal nerve fiber density and corneal nerve fiber length. Intraepidermal nerve fiber density (top) and corneal nerve fiber length (bottom) were examined as described in the 'Methods' section after 22 (open bars), 28 (left hatch bars) or 36 (right hatch bars) weeks of age in Sprague Dawley rats fed a normal diet or in rats fed a high-fat diet at 12 weeks of age for 10 (open bars), 16 (left hatch bars) or 24 (right hatch bars) weeks or in type 2 diabetic rats that were treated with a low dose of streptozotocin after 8 weeks of a high-fat diet and 2 (open bars), 8 (left hatch bars) or 16 (right hatch bars) weeks of hyperglycemia. Data are presented as the mean ± SEM. in fibers/mm for intraepidermal nerve fibers and mm/mm 2 for corneal nerve fiber length. The number of rats in each group was 12. *p
    Figure Legend Snippet: Effect of duration of obesity or type 2 diabetes on intraepidermal nerve fiber density and corneal nerve fiber length. Intraepidermal nerve fiber density (top) and corneal nerve fiber length (bottom) were examined as described in the 'Methods' section after 22 (open bars), 28 (left hatch bars) or 36 (right hatch bars) weeks of age in Sprague Dawley rats fed a normal diet or in rats fed a high-fat diet at 12 weeks of age for 10 (open bars), 16 (left hatch bars) or 24 (right hatch bars) weeks or in type 2 diabetic rats that were treated with a low dose of streptozotocin after 8 weeks of a high-fat diet and 2 (open bars), 8 (left hatch bars) or 16 (right hatch bars) weeks of hyperglycemia. Data are presented as the mean ± SEM. in fibers/mm for intraepidermal nerve fibers and mm/mm 2 for corneal nerve fiber length. The number of rats in each group was 12. *p

    Techniques Used:

    Effect of duration of obesity or type 2 diabetes on vascular reactivity to calcitonin gene-related peptide by epineurial arterioles of the sciatic nerve. Vascular reactivity was determined as described in the 'Methods' section after 22 (black circles), 28 (red circles) or 36 (green circles) weeks of age in Sprague Dawley rats fed a normal diet or in rats fed a high-fat diet at 12 weeks of age for 10 (black triangles), 16 (red triangles) or 24 (green triangles) weeks or in type 2 diabetic rats that were treated with a low dose of streptozotocin after 8 weeks of a high-fat diet and 2 (black diamonds), 8 (red diamonds) or 16 (green diamonds) weeks of hyperglycemia. Data are presented as the mean ± SEM. in % relaxation. The number of rats in each group was 12. *p
    Figure Legend Snippet: Effect of duration of obesity or type 2 diabetes on vascular reactivity to calcitonin gene-related peptide by epineurial arterioles of the sciatic nerve. Vascular reactivity was determined as described in the 'Methods' section after 22 (black circles), 28 (red circles) or 36 (green circles) weeks of age in Sprague Dawley rats fed a normal diet or in rats fed a high-fat diet at 12 weeks of age for 10 (black triangles), 16 (red triangles) or 24 (green triangles) weeks or in type 2 diabetic rats that were treated with a low dose of streptozotocin after 8 weeks of a high-fat diet and 2 (black diamonds), 8 (red diamonds) or 16 (green diamonds) weeks of hyperglycemia. Data are presented as the mean ± SEM. in % relaxation. The number of rats in each group was 12. *p

    Techniques Used:

    Related Articles

    Injection:

    Article Title: Early Growth Response 1 (Egr1) Is a Transcriptional Activator of NOX4 in Oxidative Stress of Diabetic Kidney Disease
    Article Snippet: .. Male C57BL/6J mice (Animal Center of Guangdong province, 3-4 w) weighing 15-16 g received a high-fat diet (protein 26.2%, fat 34.9%, and carbohydrate 26.3%) for four weeks and then received a single injection of streptozotocin (STZ) (120 mg/kg, i.p., in citrate buffer, pH = 4.5, MP Biomedicals). ..

    Article Title: Glial and neuronal dysfunction in streptozotocin-induced diabetic rats
    Article Snippet: .. Animals were fasted overnight (~12 h) prior to diabetes induction via a tail vein injection of 65-mg/kg streptozotocin (MP Biomedicals, Seven Hills, NSW, Australia) dissolved in 0.1-M sodium citrate buffer (pH 4.5, Sigma-Aldrich, Castle Hill, NSW, Australia). ..

    other:

    Article Title: Hydrogen sulfide ameliorates cognitive dysfunction in streptozotocin-induced diabetic rats: involving suppression in hippocampal endoplasmic reticulum stress
    Article Snippet: Streptozotocin (STZ) was purchased from MP Biomedicals, LLc (Santa Ana, California, USA).

    Article Title: Progressive Loss of Corneal Nerve Fibers and Sensitivity in Rats Modeling Obesity and Type 2 Diabetes Is Reversible with Omega-3 Fatty Acid Intervention: Supporting Cornea Analyses as a Marker for Peripheral Neuropathy and Treatment
    Article Snippet: After 8 weeks, one group of the high-fat-fed rats was treated with a low dose of streptozotocin (30 mg/kg, i.p.) (MP Biomedicals, Solon, OH) to induce hyperglycemia.

    Mouse Assay:

    Article Title: Early Growth Response 1 (Egr1) Is a Transcriptional Activator of NOX4 in Oxidative Stress of Diabetic Kidney Disease
    Article Snippet: .. Male C57BL/6J mice (Animal Center of Guangdong province, 3-4 w) weighing 15-16 g received a high-fat diet (protein 26.2%, fat 34.9%, and carbohydrate 26.3%) for four weeks and then received a single injection of streptozotocin (STZ) (120 mg/kg, i.p., in citrate buffer, pH = 4.5, MP Biomedicals). ..

    Article Title: Hyperglycemia Impairs Proteasome Function by Methylglyoxal
    Article Snippet: .. In brief, 7-week-old mice were rendered diabetic via intraperitoneal injections of 50 mg · kg−1 · day−1 STZ (MP Biomedicals, Eschwege, Germany). .. Mice developed hyperglycemia after 10–12 weeks, with reduced insulin levels and increased glucose levels.

    Article Title: Ligation of CD40 in Human Müller Cells Induces P2X7 Receptor–Dependent Death of Retinal Endothelial Cells
    Article Snippet: .. Fasted mice of 20 to 25 g body weight received five daily intraperitoneal injections of STZ (55 mg/kg; MP Biomedicals, Solon, OH, USA). ..

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