β pompilidotoxin pomp  (Alomone Labs)


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    Alomone Labs β pompilidotoxin pomp
    Effect of tefluthin, β-pompilidoxin, tefluthrin plus sparsentan, <t>β-pompilidotoxin</t> plus sparsentan on I Na in GH 3 cells. The voltage-clamp experiments were undertaken, as cells were voltage-clamped at −80 mV and the depolarizing pulse to −10 mV was imposed to them. ( A ) Representative current traces obtained in the control period (a, sparsentan was not present), and during exposure to 3 μM sparsentan (b) or to 3 μM sparsentan plus 3 μM tefluthrin (c). The top panel indicates the voltage-clamp protocol applied. Of note, the deactivating I Na was additionally detected as membrane potential was returned to −50 mV with a duration of 40 ms. ( B ) Summary bar graph demonstrating effect of 3 μM tefluthrin, 3 μM β-pompilidotoxn, 3 μM tefluthrin plus 3 μM sparsentan and 3 μM β-pompilidotoxin plus 3 μM sparsentan on the peak amplitude of I Na (mean ± SEM; n = 8 for each bar). The peak amplitude was measured at the start of 40 ms depolarizing command voltage from −80 to −10 mV. Tef: tefluthrin; Pomp: β-pompilidotoxin; Spar, sparsentan. Statistical analysis was performed by one-way ANOVA ( p < 0.05). * Significantly different from controls ( p < 0.05) and ** significantly different from Tef (3 μM) or Pomp (3 μM) alone group ( p < 0.05).
    β Pompilidotoxin Pomp, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/β pompilidotoxin pomp/product/Alomone Labs
    Average 94 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    β pompilidotoxin pomp - by Bioz Stars, 2023-02
    94/100 stars

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    1) Product Images from "The Evidence for Sparsentan-Mediated Inhibition of I Na and I K(erg) : Possibly Unlinked to Its Antagonism of Angiotensin II or Endothelin Type a Receptor"

    Article Title: The Evidence for Sparsentan-Mediated Inhibition of I Na and I K(erg) : Possibly Unlinked to Its Antagonism of Angiotensin II or Endothelin Type a Receptor

    Journal: Biomedicines

    doi: 10.3390/biomedicines10010086

    Effect of tefluthin, β-pompilidoxin, tefluthrin plus sparsentan, β-pompilidotoxin plus sparsentan on I Na in GH 3 cells. The voltage-clamp experiments were undertaken, as cells were voltage-clamped at −80 mV and the depolarizing pulse to −10 mV was imposed to them. ( A ) Representative current traces obtained in the control period (a, sparsentan was not present), and during exposure to 3 μM sparsentan (b) or to 3 μM sparsentan plus 3 μM tefluthrin (c). The top panel indicates the voltage-clamp protocol applied. Of note, the deactivating I Na was additionally detected as membrane potential was returned to −50 mV with a duration of 40 ms. ( B ) Summary bar graph demonstrating effect of 3 μM tefluthrin, 3 μM β-pompilidotoxn, 3 μM tefluthrin plus 3 μM sparsentan and 3 μM β-pompilidotoxin plus 3 μM sparsentan on the peak amplitude of I Na (mean ± SEM; n = 8 for each bar). The peak amplitude was measured at the start of 40 ms depolarizing command voltage from −80 to −10 mV. Tef: tefluthrin; Pomp: β-pompilidotoxin; Spar, sparsentan. Statistical analysis was performed by one-way ANOVA ( p < 0.05). * Significantly different from controls ( p < 0.05) and ** significantly different from Tef (3 μM) or Pomp (3 μM) alone group ( p < 0.05).
    Figure Legend Snippet: Effect of tefluthin, β-pompilidoxin, tefluthrin plus sparsentan, β-pompilidotoxin plus sparsentan on I Na in GH 3 cells. The voltage-clamp experiments were undertaken, as cells were voltage-clamped at −80 mV and the depolarizing pulse to −10 mV was imposed to them. ( A ) Representative current traces obtained in the control period (a, sparsentan was not present), and during exposure to 3 μM sparsentan (b) or to 3 μM sparsentan plus 3 μM tefluthrin (c). The top panel indicates the voltage-clamp protocol applied. Of note, the deactivating I Na was additionally detected as membrane potential was returned to −50 mV with a duration of 40 ms. ( B ) Summary bar graph demonstrating effect of 3 μM tefluthrin, 3 μM β-pompilidotoxn, 3 μM tefluthrin plus 3 μM sparsentan and 3 μM β-pompilidotoxin plus 3 μM sparsentan on the peak amplitude of I Na (mean ± SEM; n = 8 for each bar). The peak amplitude was measured at the start of 40 ms depolarizing command voltage from −80 to −10 mV. Tef: tefluthrin; Pomp: β-pompilidotoxin; Spar, sparsentan. Statistical analysis was performed by one-way ANOVA ( p < 0.05). * Significantly different from controls ( p < 0.05) and ** significantly different from Tef (3 μM) or Pomp (3 μM) alone group ( p < 0.05).

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    Alomone Labs β pompilidotoxin pomp
    Effect of tefluthin, β-pompilidoxin, tefluthrin plus sparsentan, <t>β-pompilidotoxin</t> plus sparsentan on I Na in GH 3 cells. The voltage-clamp experiments were undertaken, as cells were voltage-clamped at −80 mV and the depolarizing pulse to −10 mV was imposed to them. ( A ) Representative current traces obtained in the control period (a, sparsentan was not present), and during exposure to 3 μM sparsentan (b) or to 3 μM sparsentan plus 3 μM tefluthrin (c). The top panel indicates the voltage-clamp protocol applied. Of note, the deactivating I Na was additionally detected as membrane potential was returned to −50 mV with a duration of 40 ms. ( B ) Summary bar graph demonstrating effect of 3 μM tefluthrin, 3 μM β-pompilidotoxn, 3 μM tefluthrin plus 3 μM sparsentan and 3 μM β-pompilidotoxin plus 3 μM sparsentan on the peak amplitude of I Na (mean ± SEM; n = 8 for each bar). The peak amplitude was measured at the start of 40 ms depolarizing command voltage from −80 to −10 mV. Tef: tefluthrin; Pomp: β-pompilidotoxin; Spar, sparsentan. Statistical analysis was performed by one-way ANOVA ( p < 0.05). * Significantly different from controls ( p < 0.05) and ** significantly different from Tef (3 μM) or Pomp (3 μM) alone group ( p < 0.05).
    β Pompilidotoxin Pomp, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/β pompilidotoxin pomp/product/Alomone Labs
    Average 94 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    β pompilidotoxin pomp - by Bioz Stars, 2023-02
    94/100 stars
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    Effect of tefluthin, β-pompilidoxin, tefluthrin plus sparsentan, β-pompilidotoxin plus sparsentan on I Na in GH 3 cells. The voltage-clamp experiments were undertaken, as cells were voltage-clamped at −80 mV and the depolarizing pulse to −10 mV was imposed to them. ( A ) Representative current traces obtained in the control period (a, sparsentan was not present), and during exposure to 3 μM sparsentan (b) or to 3 μM sparsentan plus 3 μM tefluthrin (c). The top panel indicates the voltage-clamp protocol applied. Of note, the deactivating I Na was additionally detected as membrane potential was returned to −50 mV with a duration of 40 ms. ( B ) Summary bar graph demonstrating effect of 3 μM tefluthrin, 3 μM β-pompilidotoxn, 3 μM tefluthrin plus 3 μM sparsentan and 3 μM β-pompilidotoxin plus 3 μM sparsentan on the peak amplitude of I Na (mean ± SEM; n = 8 for each bar). The peak amplitude was measured at the start of 40 ms depolarizing command voltage from −80 to −10 mV. Tef: tefluthrin; Pomp: β-pompilidotoxin; Spar, sparsentan. Statistical analysis was performed by one-way ANOVA ( p < 0.05). * Significantly different from controls ( p < 0.05) and ** significantly different from Tef (3 μM) or Pomp (3 μM) alone group ( p < 0.05).

    Journal: Biomedicines

    Article Title: The Evidence for Sparsentan-Mediated Inhibition of I Na and I K(erg) : Possibly Unlinked to Its Antagonism of Angiotensin II or Endothelin Type a Receptor

    doi: 10.3390/biomedicines10010086

    Figure Lengend Snippet: Effect of tefluthin, β-pompilidoxin, tefluthrin plus sparsentan, β-pompilidotoxin plus sparsentan on I Na in GH 3 cells. The voltage-clamp experiments were undertaken, as cells were voltage-clamped at −80 mV and the depolarizing pulse to −10 mV was imposed to them. ( A ) Representative current traces obtained in the control period (a, sparsentan was not present), and during exposure to 3 μM sparsentan (b) or to 3 μM sparsentan plus 3 μM tefluthrin (c). The top panel indicates the voltage-clamp protocol applied. Of note, the deactivating I Na was additionally detected as membrane potential was returned to −50 mV with a duration of 40 ms. ( B ) Summary bar graph demonstrating effect of 3 μM tefluthrin, 3 μM β-pompilidotoxn, 3 μM tefluthrin plus 3 μM sparsentan and 3 μM β-pompilidotoxin plus 3 μM sparsentan on the peak amplitude of I Na (mean ± SEM; n = 8 for each bar). The peak amplitude was measured at the start of 40 ms depolarizing command voltage from −80 to −10 mV. Tef: tefluthrin; Pomp: β-pompilidotoxin; Spar, sparsentan. Statistical analysis was performed by one-way ANOVA ( p < 0.05). * Significantly different from controls ( p < 0.05) and ** significantly different from Tef (3 μM) or Pomp (3 μM) alone group ( p < 0.05).

    Article Snippet: Angiotensin II (AngII), endothelin 1, tefluthrin (Tef), tetraethylammonium chloride (TEA) were supplied by Sigma-Aldrich (Merck, Taipei, Taiwan) and β-pompilidotoxin (Pomp) and tetrodotoxin (TTX) were by Alomone (Jerusalem, Israel).

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