Structured Review

Millipore ω conotoxin mviia
Effects of columbianadin (CBN) or osthole (OST) on the I–V currents of total Ica in the presence of L-, P/Q, and N-type calcium channel blockers in small dorsal root ganglion (DRG) neurons. (A) Representative whole-cell total Ica recorded from a small DRG neuron in the presence of 2 μM nimodipine, 0.2 μM ω-Agatoxin IVA, and 1 μM <t>ω-Conotoxin</t> <t>MVIIA.</t> (B , C) Representative Ica in the presence of calcium channel blockers and 100 μM CBN or 100 μM OST. Recordings are all from independent cells and each cell is only used for a single treatment. (D) Current-voltage relationships of the Ica in control (black line), OST (blue line), and CBN (red line) groups. Data points are mean ± SEM. *p
ω Conotoxin Mviia, supplied by Millipore, used in various techniques. Bioz Stars score: 93/100, based on 5 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/ω conotoxin mviia/product/Millipore
Average 93 stars, based on 5 article reviews
Price from $9.99 to $1999.99
ω conotoxin mviia - by Bioz Stars, 2022-11
93/100 stars

Images

1) Product Images from "Inhibitory Effects of Columbianadin on Nociceptive Behaviors in a Neuropathic Pain Model, and on Voltage-Gated Calcium Currents in Dorsal Root Ganglion Neurons in Mice"

Article Title: Inhibitory Effects of Columbianadin on Nociceptive Behaviors in a Neuropathic Pain Model, and on Voltage-Gated Calcium Currents in Dorsal Root Ganglion Neurons in Mice

Journal: Frontiers in Pharmacology

doi: 10.3389/fphar.2019.01522

Effects of columbianadin (CBN) or osthole (OST) on the I–V currents of total Ica in the presence of L-, P/Q, and N-type calcium channel blockers in small dorsal root ganglion (DRG) neurons. (A) Representative whole-cell total Ica recorded from a small DRG neuron in the presence of 2 μM nimodipine, 0.2 μM ω-Agatoxin IVA, and 1 μM ω-Conotoxin MVIIA. (B , C) Representative Ica in the presence of calcium channel blockers and 100 μM CBN or 100 μM OST. Recordings are all from independent cells and each cell is only used for a single treatment. (D) Current-voltage relationships of the Ica in control (black line), OST (blue line), and CBN (red line) groups. Data points are mean ± SEM. *p
Figure Legend Snippet: Effects of columbianadin (CBN) or osthole (OST) on the I–V currents of total Ica in the presence of L-, P/Q, and N-type calcium channel blockers in small dorsal root ganglion (DRG) neurons. (A) Representative whole-cell total Ica recorded from a small DRG neuron in the presence of 2 μM nimodipine, 0.2 μM ω-Agatoxin IVA, and 1 μM ω-Conotoxin MVIIA. (B , C) Representative Ica in the presence of calcium channel blockers and 100 μM CBN or 100 μM OST. Recordings are all from independent cells and each cell is only used for a single treatment. (D) Current-voltage relationships of the Ica in control (black line), OST (blue line), and CBN (red line) groups. Data points are mean ± SEM. *p

Techniques Used:

Effect of columbianadin (CBN) or osthole (OST) on the I–V current of Ica in the presence of N-type Ica blocker ω-Conotoxin MVIIA in small dorsal root ganglion (DRG) neurons. (A) Representative whole-cell Ica in the presence of 1 μM ω-Conotoxin MVIIA (ω-CNTX) recorded from a small DRG neuron in the absence of any compound. (B) Representative Ica in the presence of 1 μM ω-Conotoxin MVIIA and 100 μM CBN. (C) Representative Ica in the presence of 1 μM ω-Conotoxin MVIIA and 100 μM OST. Recordings are all from independent cells and each cell is only used for a single treatment. (D) Current-voltage relationships of the Ica in ω-Conotoxin MVIIA (black line), during exposure 100 μM OST (blue line) and 100 μM CBN (red line). Data points are mean ± SEM. *p
Figure Legend Snippet: Effect of columbianadin (CBN) or osthole (OST) on the I–V current of Ica in the presence of N-type Ica blocker ω-Conotoxin MVIIA in small dorsal root ganglion (DRG) neurons. (A) Representative whole-cell Ica in the presence of 1 μM ω-Conotoxin MVIIA (ω-CNTX) recorded from a small DRG neuron in the absence of any compound. (B) Representative Ica in the presence of 1 μM ω-Conotoxin MVIIA and 100 μM CBN. (C) Representative Ica in the presence of 1 μM ω-Conotoxin MVIIA and 100 μM OST. Recordings are all from independent cells and each cell is only used for a single treatment. (D) Current-voltage relationships of the Ica in ω-Conotoxin MVIIA (black line), during exposure 100 μM OST (blue line) and 100 μM CBN (red line). Data points are mean ± SEM. *p

Techniques Used:

2) Product Images from "Impact of gabapentin on neuronal high voltage-activated Ca2+ channel properties of injured-side axotomized and adjacent uninjured dorsal root ganglions in a rat model of spinal nerve ligation"

Article Title: Impact of gabapentin on neuronal high voltage-activated Ca2+ channel properties of injured-side axotomized and adjacent uninjured dorsal root ganglions in a rat model of spinal nerve ligation

Journal: Experimental and Therapeutic Medicine

doi: 10.3892/etm.2017.4071

Sub-types of HVA-Ca 2+ currents identified by application of specific channel blockers. (A) To individually assess various types of calcium channels present in the same cell, 20 µmol/l nifedipine (L-type Ca 2+ -specific channel blocker), 2 µmol/l ω-conotoxin MVIIC (P/Q-type Ca 2+ channel-specific blocker) and 2 µmol/l ω-conotoxin MVIIA (N-type Ca 2+ channel-specific blocker) were applied to the bath in sequence when stable currents were reached. (B) Fraction changes of each sub-type (L, N, P/Q) Ca 2+ channel current over the total HVA-Ca 2+ peak currents in control, adjacent and axotomized neurons. Values are expressed as the mean ± standard deviation (n=10). *P
Figure Legend Snippet: Sub-types of HVA-Ca 2+ currents identified by application of specific channel blockers. (A) To individually assess various types of calcium channels present in the same cell, 20 µmol/l nifedipine (L-type Ca 2+ -specific channel blocker), 2 µmol/l ω-conotoxin MVIIC (P/Q-type Ca 2+ channel-specific blocker) and 2 µmol/l ω-conotoxin MVIIA (N-type Ca 2+ channel-specific blocker) were applied to the bath in sequence when stable currents were reached. (B) Fraction changes of each sub-type (L, N, P/Q) Ca 2+ channel current over the total HVA-Ca 2+ peak currents in control, adjacent and axotomized neurons. Values are expressed as the mean ± standard deviation (n=10). *P

Techniques Used: Sequencing, Standard Deviation

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    Millipore ω conotoxin mviia
    Effects of columbianadin (CBN) or osthole (OST) on the I–V currents of total Ica in the presence of L-, P/Q, and N-type calcium channel blockers in small dorsal root ganglion (DRG) neurons. (A) Representative whole-cell total Ica recorded from a small DRG neuron in the presence of 2 μM nimodipine, 0.2 μM ω-Agatoxin IVA, and 1 μM <t>ω-Conotoxin</t> <t>MVIIA.</t> (B , C) Representative Ica in the presence of calcium channel blockers and 100 μM CBN or 100 μM OST. Recordings are all from independent cells and each cell is only used for a single treatment. (D) Current-voltage relationships of the Ica in control (black line), OST (blue line), and CBN (red line) groups. Data points are mean ± SEM. *p
    ω Conotoxin Mviia, supplied by Millipore, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/ω conotoxin mviia/product/Millipore
    Average 93 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    ω conotoxin mviia - by Bioz Stars, 2022-11
    93/100 stars
      Buy from Supplier

    Image Search Results


    Effects of columbianadin (CBN) or osthole (OST) on the I–V currents of total Ica in the presence of L-, P/Q, and N-type calcium channel blockers in small dorsal root ganglion (DRG) neurons. (A) Representative whole-cell total Ica recorded from a small DRG neuron in the presence of 2 μM nimodipine, 0.2 μM ω-Agatoxin IVA, and 1 μM ω-Conotoxin MVIIA. (B , C) Representative Ica in the presence of calcium channel blockers and 100 μM CBN or 100 μM OST. Recordings are all from independent cells and each cell is only used for a single treatment. (D) Current-voltage relationships of the Ica in control (black line), OST (blue line), and CBN (red line) groups. Data points are mean ± SEM. *p

    Journal: Frontiers in Pharmacology

    Article Title: Inhibitory Effects of Columbianadin on Nociceptive Behaviors in a Neuropathic Pain Model, and on Voltage-Gated Calcium Currents in Dorsal Root Ganglion Neurons in Mice

    doi: 10.3389/fphar.2019.01522

    Figure Lengend Snippet: Effects of columbianadin (CBN) or osthole (OST) on the I–V currents of total Ica in the presence of L-, P/Q, and N-type calcium channel blockers in small dorsal root ganglion (DRG) neurons. (A) Representative whole-cell total Ica recorded from a small DRG neuron in the presence of 2 μM nimodipine, 0.2 μM ω-Agatoxin IVA, and 1 μM ω-Conotoxin MVIIA. (B , C) Representative Ica in the presence of calcium channel blockers and 100 μM CBN or 100 μM OST. Recordings are all from independent cells and each cell is only used for a single treatment. (D) Current-voltage relationships of the Ica in control (black line), OST (blue line), and CBN (red line) groups. Data points are mean ± SEM. *p

    Article Snippet: Drugs and Their Administration Oxaliplatin, nimodipine, ω-Conotoxin MVIIA, niflumic acid, and gabapentin were purchased from Sigma-Aldrich (St. Louis, MO, USA). ω-Agatoxin IVA were from Tocris, Bio-Techne Corporation (Minneapolis, MN, USA).

    Techniques:

    Effect of columbianadin (CBN) or osthole (OST) on the I–V current of Ica in the presence of N-type Ica blocker ω-Conotoxin MVIIA in small dorsal root ganglion (DRG) neurons. (A) Representative whole-cell Ica in the presence of 1 μM ω-Conotoxin MVIIA (ω-CNTX) recorded from a small DRG neuron in the absence of any compound. (B) Representative Ica in the presence of 1 μM ω-Conotoxin MVIIA and 100 μM CBN. (C) Representative Ica in the presence of 1 μM ω-Conotoxin MVIIA and 100 μM OST. Recordings are all from independent cells and each cell is only used for a single treatment. (D) Current-voltage relationships of the Ica in ω-Conotoxin MVIIA (black line), during exposure 100 μM OST (blue line) and 100 μM CBN (red line). Data points are mean ± SEM. *p

    Journal: Frontiers in Pharmacology

    Article Title: Inhibitory Effects of Columbianadin on Nociceptive Behaviors in a Neuropathic Pain Model, and on Voltage-Gated Calcium Currents in Dorsal Root Ganglion Neurons in Mice

    doi: 10.3389/fphar.2019.01522

    Figure Lengend Snippet: Effect of columbianadin (CBN) or osthole (OST) on the I–V current of Ica in the presence of N-type Ica blocker ω-Conotoxin MVIIA in small dorsal root ganglion (DRG) neurons. (A) Representative whole-cell Ica in the presence of 1 μM ω-Conotoxin MVIIA (ω-CNTX) recorded from a small DRG neuron in the absence of any compound. (B) Representative Ica in the presence of 1 μM ω-Conotoxin MVIIA and 100 μM CBN. (C) Representative Ica in the presence of 1 μM ω-Conotoxin MVIIA and 100 μM OST. Recordings are all from independent cells and each cell is only used for a single treatment. (D) Current-voltage relationships of the Ica in ω-Conotoxin MVIIA (black line), during exposure 100 μM OST (blue line) and 100 μM CBN (red line). Data points are mean ± SEM. *p

    Article Snippet: Drugs and Their Administration Oxaliplatin, nimodipine, ω-Conotoxin MVIIA, niflumic acid, and gabapentin were purchased from Sigma-Aldrich (St. Louis, MO, USA). ω-Agatoxin IVA were from Tocris, Bio-Techne Corporation (Minneapolis, MN, USA).

    Techniques:

    Sub-types of HVA-Ca 2+ currents identified by application of specific channel blockers. (A) To individually assess various types of calcium channels present in the same cell, 20 µmol/l nifedipine (L-type Ca 2+ -specific channel blocker), 2 µmol/l ω-conotoxin MVIIC (P/Q-type Ca 2+ channel-specific blocker) and 2 µmol/l ω-conotoxin MVIIA (N-type Ca 2+ channel-specific blocker) were applied to the bath in sequence when stable currents were reached. (B) Fraction changes of each sub-type (L, N, P/Q) Ca 2+ channel current over the total HVA-Ca 2+ peak currents in control, adjacent and axotomized neurons. Values are expressed as the mean ± standard deviation (n=10). *P

    Journal: Experimental and Therapeutic Medicine

    Article Title: Impact of gabapentin on neuronal high voltage-activated Ca2+ channel properties of injured-side axotomized and adjacent uninjured dorsal root ganglions in a rat model of spinal nerve ligation

    doi: 10.3892/etm.2017.4071

    Figure Lengend Snippet: Sub-types of HVA-Ca 2+ currents identified by application of specific channel blockers. (A) To individually assess various types of calcium channels present in the same cell, 20 µmol/l nifedipine (L-type Ca 2+ -specific channel blocker), 2 µmol/l ω-conotoxin MVIIC (P/Q-type Ca 2+ channel-specific blocker) and 2 µmol/l ω-conotoxin MVIIA (N-type Ca 2+ channel-specific blocker) were applied to the bath in sequence when stable currents were reached. (B) Fraction changes of each sub-type (L, N, P/Q) Ca 2+ channel current over the total HVA-Ca 2+ peak currents in control, adjacent and axotomized neurons. Values are expressed as the mean ± standard deviation (n=10). *P

    Article Snippet: Stocks of GBP, ω-conotoxin MVIIC, ω-conotoxin MVIIA, CdCl2 and Li-GTP (Sigma-Aldrich; Merck Millipore) were prepared in distilled water and stored at −20°C.

    Techniques: Sequencing, Standard Deviation

    TTX or ziconotide blocked the loss of astrocytic mitochondria after OGD or NMDA injury. Hippocampal slice cultures with astrocytes expressing mitochondrially targeted EGFP and plasma-membrane-targeted mcherry were fixed in 4% paraformaldehyde 24 h after

    Journal: The Journal of Neuroscience

    Article Title: Transient Oxygen/Glucose Deprivation Causes a Delayed Loss of Mitochondria and Increases Spontaneous Calcium Signaling in Astrocytic Processes

    doi: 10.1523/JNEUROSCI.4518-15.2016

    Figure Lengend Snippet: TTX or ziconotide blocked the loss of astrocytic mitochondria after OGD or NMDA injury. Hippocampal slice cultures with astrocytes expressing mitochondrially targeted EGFP and plasma-membrane-targeted mcherry were fixed in 4% paraformaldehyde 24 h after

    Article Snippet: Bafilomycin A1 (BfA) from Streptomyces griseus (catalog #B1793), FK-506 monohydrate (catalog #F4679), ziconotide (ω-conotoxin MVIIA; catalog #C1182), and l -glutamic acid (catalog #G1251) were purchased from Sigma-Aldrich.

    Techniques: Expressing