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Tocris α 7 nachr agonist
α 7 Nachr Agonist, supplied by Tocris, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/α 7 nachr agonist/product/Tocris
Average 94 stars, based on 1 article reviews
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α 7 nachr agonist - by Bioz Stars, 2023-02
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Tocris α7 nachr
α7 Nachr, supplied by Tocris, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/α7 nachr/product/Tocris
Average 94 stars, based on 1 article reviews
Price from $9.99 to $1999.99
α7 nachr - by Bioz Stars, 2023-02
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Tocris α conotoxin imi
Antagonist profile for the nicotine-evoked response at −10 mV. Shown are responses to 10 s of pressured-applied 3 mM nicotine (Nic) in cultured bag cell neurons under whole cell voltage-clamp at a −10 mV holding potential (HP) in nASW with K+-based internal solution. A, top: in control, the response evoked by the first nicotine application was very similar to that produced 10 min later by the second application (bottom). Because there was no desensitization, antagonists were evaluated by delivering drug during the intervening period and measuring any change between the initial and latter response. Scale bars apply to both traces. B: in a separate neuron, bath delivery of 100 μM mecamylamine, a nicotinic receptor blocker, did not alter the second response evoked by pressure-applied nicotine. Scale bars apply to both traces. C: summary data showing the percentage of remaining current between the second and first nicotine applications. None of the classical nicotinic receptor blockers, i.e., mecamylamine (mec), <t>α-conotoxin</t> ImI (ImI), or hexamethonium (hex), significantly altered the magnitude of the nicotine-evoked response (ordinary ANOVA). Numbers in bars indicate number of neurons.
α Conotoxin Imi, supplied by Tocris, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/α conotoxin imi/product/Tocris
Average 86 stars, based on 1 article reviews
Price from $9.99 to $1999.99
α conotoxin imi - by Bioz Stars, 2023-02
86/100 stars

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1) Product Images from "Nicotine inhibits potassium currents in Aplysia bag cell neurons"

Article Title: Nicotine inhibits potassium currents in Aplysia bag cell neurons

Journal: Journal of Neurophysiology

doi: 10.1152/jn.00816.2015

Antagonist profile for the nicotine-evoked response at −10 mV. Shown are responses to 10 s of pressured-applied 3 mM nicotine (Nic) in cultured bag cell neurons under whole cell voltage-clamp at a −10 mV holding potential (HP) in nASW with K+-based internal solution. A, top: in control, the response evoked by the first nicotine application was very similar to that produced 10 min later by the second application (bottom). Because there was no desensitization, antagonists were evaluated by delivering drug during the intervening period and measuring any change between the initial and latter response. Scale bars apply to both traces. B: in a separate neuron, bath delivery of 100 μM mecamylamine, a nicotinic receptor blocker, did not alter the second response evoked by pressure-applied nicotine. Scale bars apply to both traces. C: summary data showing the percentage of remaining current between the second and first nicotine applications. None of the classical nicotinic receptor blockers, i.e., mecamylamine (mec), α-conotoxin ImI (ImI), or hexamethonium (hex), significantly altered the magnitude of the nicotine-evoked response (ordinary ANOVA). Numbers in bars indicate number of neurons.
Figure Legend Snippet: Antagonist profile for the nicotine-evoked response at −10 mV. Shown are responses to 10 s of pressured-applied 3 mM nicotine (Nic) in cultured bag cell neurons under whole cell voltage-clamp at a −10 mV holding potential (HP) in nASW with K+-based internal solution. A, top: in control, the response evoked by the first nicotine application was very similar to that produced 10 min later by the second application (bottom). Because there was no desensitization, antagonists were evaluated by delivering drug during the intervening period and measuring any change between the initial and latter response. Scale bars apply to both traces. B: in a separate neuron, bath delivery of 100 μM mecamylamine, a nicotinic receptor blocker, did not alter the second response evoked by pressure-applied nicotine. Scale bars apply to both traces. C: summary data showing the percentage of remaining current between the second and first nicotine applications. None of the classical nicotinic receptor blockers, i.e., mecamylamine (mec), α-conotoxin ImI (ImI), or hexamethonium (hex), significantly altered the magnitude of the nicotine-evoked response (ordinary ANOVA). Numbers in bars indicate number of neurons.

Techniques Used: Cell Culture, Produced


Structured Review

Tocris α conotoxin imi
Antagonist profile for the nicotine-evoked response at −10 mV. Shown are responses to 10 s of pressured-applied 3 mM nicotine (Nic) in cultured bag cell neurons under whole cell voltage-clamp at a −10 mV holding potential (HP) in nASW with K+-based internal solution. A, top: in control, the response evoked by the first nicotine application was very similar to that produced 10 min later by the second application (bottom). Because there was no desensitization, antagonists were evaluated by delivering drug during the intervening period and measuring any change between the initial and latter response. Scale bars apply to both traces. B: in a separate neuron, bath delivery of 100 μM mecamylamine, a nicotinic receptor blocker, did not alter the second response evoked by pressure-applied nicotine. Scale bars apply to both traces. C: summary data showing the percentage of remaining current between the second and first nicotine applications. None of the classical nicotinic receptor blockers, i.e., mecamylamine (mec), <t>α-conotoxin</t> ImI (ImI), or hexamethonium (hex), significantly altered the magnitude of the nicotine-evoked response (ordinary ANOVA). Numbers in bars indicate number of neurons.
α Conotoxin Imi, supplied by Tocris, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/α conotoxin imi/product/Tocris
Average 94 stars, based on 1 article reviews
Price from $9.99 to $1999.99
α conotoxin imi - by Bioz Stars, 2023-02
94/100 stars

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1) Product Images from "Nicotine inhibits potassium currents in Aplysia bag cell neurons"

Article Title: Nicotine inhibits potassium currents in Aplysia bag cell neurons

Journal: Journal of Neurophysiology

doi: 10.1152/jn.00816.2015

Antagonist profile for the nicotine-evoked response at −10 mV. Shown are responses to 10 s of pressured-applied 3 mM nicotine (Nic) in cultured bag cell neurons under whole cell voltage-clamp at a −10 mV holding potential (HP) in nASW with K+-based internal solution. A, top: in control, the response evoked by the first nicotine application was very similar to that produced 10 min later by the second application (bottom). Because there was no desensitization, antagonists were evaluated by delivering drug during the intervening period and measuring any change between the initial and latter response. Scale bars apply to both traces. B: in a separate neuron, bath delivery of 100 μM mecamylamine, a nicotinic receptor blocker, did not alter the second response evoked by pressure-applied nicotine. Scale bars apply to both traces. C: summary data showing the percentage of remaining current between the second and first nicotine applications. None of the classical nicotinic receptor blockers, i.e., mecamylamine (mec), α-conotoxin ImI (ImI), or hexamethonium (hex), significantly altered the magnitude of the nicotine-evoked response (ordinary ANOVA). Numbers in bars indicate number of neurons.
Figure Legend Snippet: Antagonist profile for the nicotine-evoked response at −10 mV. Shown are responses to 10 s of pressured-applied 3 mM nicotine (Nic) in cultured bag cell neurons under whole cell voltage-clamp at a −10 mV holding potential (HP) in nASW with K+-based internal solution. A, top: in control, the response evoked by the first nicotine application was very similar to that produced 10 min later by the second application (bottom). Because there was no desensitization, antagonists were evaluated by delivering drug during the intervening period and measuring any change between the initial and latter response. Scale bars apply to both traces. B: in a separate neuron, bath delivery of 100 μM mecamylamine, a nicotinic receptor blocker, did not alter the second response evoked by pressure-applied nicotine. Scale bars apply to both traces. C: summary data showing the percentage of remaining current between the second and first nicotine applications. None of the classical nicotinic receptor blockers, i.e., mecamylamine (mec), α-conotoxin ImI (ImI), or hexamethonium (hex), significantly altered the magnitude of the nicotine-evoked response (ordinary ANOVA). Numbers in bars indicate number of neurons.

Techniques Used: Cell Culture, Produced


Structured Review

Tocris α conotoxin imi
Antagonist profile for the nicotine-evoked response at −10 mV. Shown are responses to 10 s of pressured-applied 3 mM nicotine (Nic) in cultured bag cell neurons under whole cell voltage-clamp at a −10 mV holding potential (HP) in nASW with K+-based internal solution. A, top: in control, the response evoked by the first nicotine application was very similar to that produced 10 min later by the second application (bottom). Because there was no desensitization, antagonists were evaluated by delivering drug during the intervening period and measuring any change between the initial and latter response. Scale bars apply to both traces. B: in a separate neuron, bath delivery of 100 μM mecamylamine, a nicotinic receptor blocker, did not alter the second response evoked by pressure-applied nicotine. Scale bars apply to both traces. C: summary data showing the percentage of remaining current between the second and first nicotine applications. None of the classical nicotinic receptor blockers, i.e., mecamylamine (mec), <t>α-conotoxin</t> ImI (ImI), or hexamethonium (hex), significantly altered the magnitude of the nicotine-evoked response (ordinary ANOVA). Numbers in bars indicate number of neurons.
α Conotoxin Imi, supplied by Tocris, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/α conotoxin imi/product/Tocris
Average 86 stars, based on 1 article reviews
Price from $9.99 to $1999.99
α conotoxin imi - by Bioz Stars, 2023-02
86/100 stars

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1) Product Images from "Nicotine inhibits potassium currents in Aplysia bag cell neurons"

Article Title: Nicotine inhibits potassium currents in Aplysia bag cell neurons

Journal: Journal of Neurophysiology

doi: 10.1152/jn.00816.2015

Antagonist profile for the nicotine-evoked response at −10 mV. Shown are responses to 10 s of pressured-applied 3 mM nicotine (Nic) in cultured bag cell neurons under whole cell voltage-clamp at a −10 mV holding potential (HP) in nASW with K+-based internal solution. A, top: in control, the response evoked by the first nicotine application was very similar to that produced 10 min later by the second application (bottom). Because there was no desensitization, antagonists were evaluated by delivering drug during the intervening period and measuring any change between the initial and latter response. Scale bars apply to both traces. B: in a separate neuron, bath delivery of 100 μM mecamylamine, a nicotinic receptor blocker, did not alter the second response evoked by pressure-applied nicotine. Scale bars apply to both traces. C: summary data showing the percentage of remaining current between the second and first nicotine applications. None of the classical nicotinic receptor blockers, i.e., mecamylamine (mec), α-conotoxin ImI (ImI), or hexamethonium (hex), significantly altered the magnitude of the nicotine-evoked response (ordinary ANOVA). Numbers in bars indicate number of neurons.
Figure Legend Snippet: Antagonist profile for the nicotine-evoked response at −10 mV. Shown are responses to 10 s of pressured-applied 3 mM nicotine (Nic) in cultured bag cell neurons under whole cell voltage-clamp at a −10 mV holding potential (HP) in nASW with K+-based internal solution. A, top: in control, the response evoked by the first nicotine application was very similar to that produced 10 min later by the second application (bottom). Because there was no desensitization, antagonists were evaluated by delivering drug during the intervening period and measuring any change between the initial and latter response. Scale bars apply to both traces. B: in a separate neuron, bath delivery of 100 μM mecamylamine, a nicotinic receptor blocker, did not alter the second response evoked by pressure-applied nicotine. Scale bars apply to both traces. C: summary data showing the percentage of remaining current between the second and first nicotine applications. None of the classical nicotinic receptor blockers, i.e., mecamylamine (mec), α-conotoxin ImI (ImI), or hexamethonium (hex), significantly altered the magnitude of the nicotine-evoked response (ordinary ANOVA). Numbers in bars indicate number of neurons.

Techniques Used: Cell Culture, Produced


Structured Review

Tocris α conotoxin imi imi
α Conotoxin Imi Imi, supplied by Tocris, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/α conotoxin imi imi/product/Tocris
Average 94 stars, based on 1 article reviews
Price from $9.99 to $1999.99
α conotoxin imi imi - by Bioz Stars, 2023-02
94/100 stars

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Structured Review

Tocris α conotoxin imi imi
α Conotoxin Imi Imi, supplied by Tocris, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/α conotoxin imi imi/product/Tocris
Average 94 stars, based on 1 article reviews
Price from $9.99 to $1999.99
α conotoxin imi imi - by Bioz Stars, 2023-02
94/100 stars

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Structured Review

Tocris α conotoxin imi imi
α Conotoxin Imi Imi, supplied by Tocris, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/α conotoxin imi imi/product/Tocris
Average 86 stars, based on 1 article reviews
Price from $9.99 to $1999.99
α conotoxin imi imi - by Bioz Stars, 2023-02
86/100 stars

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Tocris α7 nachr
α7 Nachr, supplied by Tocris, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/α7 nachr/product/Tocris
Average 94 stars, based on 1 article reviews
Price from $9.99 to $1999.99
α7 nachr - by Bioz Stars, 2023-02
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Tocris α7 nachr
α7 Nachr, supplied by Tocris, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/α7 nachr/product/Tocris
Average 94 stars, based on 1 article reviews
Price from $9.99 to $1999.99
α7 nachr - by Bioz Stars, 2023-02
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    Tocris α 7 nachr agonist
    α 7 Nachr Agonist, supplied by Tocris, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/α 7 nachr agonist/product/Tocris
    Average 94 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    α 7 nachr agonist - by Bioz Stars, 2023-02
    94/100 stars
      Buy from Supplier

    94
    Tocris α7 nachr
    α7 Nachr, supplied by Tocris, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/α7 nachr/product/Tocris
    Average 94 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    α7 nachr - by Bioz Stars, 2023-02
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    Tocris α conotoxin imi
    Antagonist profile for the nicotine-evoked response at −10 mV. Shown are responses to 10 s of pressured-applied 3 mM nicotine (Nic) in cultured bag cell neurons under whole cell voltage-clamp at a −10 mV holding potential (HP) in nASW with K+-based internal solution. A, top: in control, the response evoked by the first nicotine application was very similar to that produced 10 min later by the second application (bottom). Because there was no desensitization, antagonists were evaluated by delivering drug during the intervening period and measuring any change between the initial and latter response. Scale bars apply to both traces. B: in a separate neuron, bath delivery of 100 μM mecamylamine, a nicotinic receptor blocker, did not alter the second response evoked by pressure-applied nicotine. Scale bars apply to both traces. C: summary data showing the percentage of remaining current between the second and first nicotine applications. None of the classical nicotinic receptor blockers, i.e., mecamylamine (mec), <t>α-conotoxin</t> ImI (ImI), or hexamethonium (hex), significantly altered the magnitude of the nicotine-evoked response (ordinary ANOVA). Numbers in bars indicate number of neurons.
    α Conotoxin Imi, supplied by Tocris, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/α conotoxin imi/product/Tocris
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    α conotoxin imi - by Bioz Stars, 2023-02
    86/100 stars
      Buy from Supplier

    94
    Tocris α conotoxin imi imi
    Antagonist profile for the nicotine-evoked response at −10 mV. Shown are responses to 10 s of pressured-applied 3 mM nicotine (Nic) in cultured bag cell neurons under whole cell voltage-clamp at a −10 mV holding potential (HP) in nASW with K+-based internal solution. A, top: in control, the response evoked by the first nicotine application was very similar to that produced 10 min later by the second application (bottom). Because there was no desensitization, antagonists were evaluated by delivering drug during the intervening period and measuring any change between the initial and latter response. Scale bars apply to both traces. B: in a separate neuron, bath delivery of 100 μM mecamylamine, a nicotinic receptor blocker, did not alter the second response evoked by pressure-applied nicotine. Scale bars apply to both traces. C: summary data showing the percentage of remaining current between the second and first nicotine applications. None of the classical nicotinic receptor blockers, i.e., mecamylamine (mec), <t>α-conotoxin</t> ImI (ImI), or hexamethonium (hex), significantly altered the magnitude of the nicotine-evoked response (ordinary ANOVA). Numbers in bars indicate number of neurons.
    α Conotoxin Imi Imi, supplied by Tocris, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/α conotoxin imi imi/product/Tocris
    Average 94 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    α conotoxin imi imi - by Bioz Stars, 2023-02
    94/100 stars
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    Antagonist profile for the nicotine-evoked response at −10 mV. Shown are responses to 10 s of pressured-applied 3 mM nicotine (Nic) in cultured bag cell neurons under whole cell voltage-clamp at a −10 mV holding potential (HP) in nASW with K+-based internal solution. A, top: in control, the response evoked by the first nicotine application was very similar to that produced 10 min later by the second application (bottom). Because there was no desensitization, antagonists were evaluated by delivering drug during the intervening period and measuring any change between the initial and latter response. Scale bars apply to both traces. B: in a separate neuron, bath delivery of 100 μM mecamylamine, a nicotinic receptor blocker, did not alter the second response evoked by pressure-applied nicotine. Scale bars apply to both traces. C: summary data showing the percentage of remaining current between the second and first nicotine applications. None of the classical nicotinic receptor blockers, i.e., mecamylamine (mec), α-conotoxin ImI (ImI), or hexamethonium (hex), significantly altered the magnitude of the nicotine-evoked response (ordinary ANOVA). Numbers in bars indicate number of neurons.

    Journal: Journal of Neurophysiology

    Article Title: Nicotine inhibits potassium currents in Aplysia bag cell neurons

    doi: 10.1152/jn.00816.2015

    Figure Lengend Snippet: Antagonist profile for the nicotine-evoked response at −10 mV. Shown are responses to 10 s of pressured-applied 3 mM nicotine (Nic) in cultured bag cell neurons under whole cell voltage-clamp at a −10 mV holding potential (HP) in nASW with K+-based internal solution. A, top: in control, the response evoked by the first nicotine application was very similar to that produced 10 min later by the second application (bottom). Because there was no desensitization, antagonists were evaluated by delivering drug during the intervening period and measuring any change between the initial and latter response. Scale bars apply to both traces. B: in a separate neuron, bath delivery of 100 μM mecamylamine, a nicotinic receptor blocker, did not alter the second response evoked by pressure-applied nicotine. Scale bars apply to both traces. C: summary data showing the percentage of remaining current between the second and first nicotine applications. None of the classical nicotinic receptor blockers, i.e., mecamylamine (mec), α-conotoxin ImI (ImI), or hexamethonium (hex), significantly altered the magnitude of the nicotine-evoked response (ordinary ANOVA). Numbers in bars indicate number of neurons.

    Article Snippet: In some experiments, nASW, nicotine, or the structurally similar agonist, epibatidine ( Badio and Daly 1994 ), was continuously pressured-applied for 10 s. Drugs were made up as stock solutions in water, frozen at −20°C, and then diluted down to a working concentration in the extracellular or intracellular solutions as needed: nicotine (N0257; Sigma-Aldrich), mecamylamine hydrochloride (M9020; Sigma-Aldrich), α-conotoxin ImI (3119; Tocris Bioscience), hexamethonium dichloride (H2138; Sigma-Aldrich), (±)-epibatidine dihydrochloride hydrate (E1145; Sigma-Aldrich).

    Techniques: Cell Culture, Produced