Structured Review

CSPC Pharmaceutical Group β elemene
Chemical structure of  β -Elemene.
β Elemene, supplied by CSPC Pharmaceutical Group, used in various techniques. Bioz Stars score: 89/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/β elemene/product/CSPC Pharmaceutical Group
Average 89 stars, based on 3 article reviews
Price from $9.99 to $1999.99
β elemene - by Bioz Stars, 2020-09
89/100 stars

Images

1) Product Images from "Anti-Lung-Cancer Activity and Liposome-Based Delivery Systems of β-Elemene"

Article Title: Anti-Lung-Cancer Activity and Liposome-Based Delivery Systems of β-Elemene

Journal: Evidence-based Complementary and Alternative Medicine : eCAM

doi: 10.1155/2012/259523

Chemical structure of  β -Elemene.
Figure Legend Snippet: Chemical structure of β -Elemene.

Techniques Used:

2) Product Images from "β-elemene inhibits the generation of peritoneum effusion in pancreatic cancer via suppression of the HIF1A-VEGFA pathway based on network pharmacology"

Article Title: β-elemene inhibits the generation of peritoneum effusion in pancreatic cancer via suppression of the HIF1A-VEGFA pathway based on network pharmacology

Journal: Oncology Reports

doi: 10.3892/or.2019.7360

Thirty-three target genes for β-elemene against pancreatic cancer. (A) Venn diagram revealing the overlapping target genes for β-elemene against pancreatic cancer. (B) Network of target genes for β-elemene against pancreatic cancer. Red diamond represents β-elemene; red hexagon represents pancreatic cancer; blue circles represent target genes of both β-elemene and pancreatic cancer; yellow triangles represent KEGG pathway analysis of 33 target genes based on the DAVID database. KEGG, Kyoto encyclopedia of genes and genomes; DAVID, Database for Annotation, Visualization and Integrated Discovery.
Figure Legend Snippet: Thirty-three target genes for β-elemene against pancreatic cancer. (A) Venn diagram revealing the overlapping target genes for β-elemene against pancreatic cancer. (B) Network of target genes for β-elemene against pancreatic cancer. Red diamond represents β-elemene; red hexagon represents pancreatic cancer; blue circles represent target genes of both β-elemene and pancreatic cancer; yellow triangles represent KEGG pathway analysis of 33 target genes based on the DAVID database. KEGG, Kyoto encyclopedia of genes and genomes; DAVID, Database for Annotation, Visualization and Integrated Discovery.

Techniques Used:

Network of β-elemene-target genes. Red diamond represents β-elemene; blue circles represent target genes of β-elemene.
Figure Legend Snippet: Network of β-elemene-target genes. Red diamond represents β-elemene; blue circles represent target genes of β-elemene.

Techniques Used:

Antitumor effect of β-elemene in pancreatic cancer. (A) MTT assay revealed that cell viability was suppressed by β-elemene in PANC-1 cells in a dose-dependent manner. (B) MTT assay revealed that cell viability was suppressed by β-elemene in BxPC3 cells in a dose-dependent manner. (C and D) MTT assay revealed that cell viability was suppressed by β-elemene in cells isolated from peritoneum effusion of pancreatic cancer patients in a dose-dependent manner.
Figure Legend Snippet: Antitumor effect of β-elemene in pancreatic cancer. (A) MTT assay revealed that cell viability was suppressed by β-elemene in PANC-1 cells in a dose-dependent manner. (B) MTT assay revealed that cell viability was suppressed by β-elemene in BxPC3 cells in a dose-dependent manner. (C and D) MTT assay revealed that cell viability was suppressed by β-elemene in cells isolated from peritoneum effusion of pancreatic cancer patients in a dose-dependent manner.

Techniques Used: MTT Assay, Isolation

Validation of the HIF1A-VEGFA pathway inhibited by β-elemene in pancreatic cancer. (A) Western blot analysis in PANC-1 and BxPC3 pancreatic cancer cell lines and (B) corresponding histogram of protein expression levels of HIF1A and VEGFA in PANC-1 and BxPC3 pancreatic cancer cells. Three independent biological replicates were performed and data are presented as the mean ± standard deviation. *P
Figure Legend Snippet: Validation of the HIF1A-VEGFA pathway inhibited by β-elemene in pancreatic cancer. (A) Western blot analysis in PANC-1 and BxPC3 pancreatic cancer cell lines and (B) corresponding histogram of protein expression levels of HIF1A and VEGFA in PANC-1 and BxPC3 pancreatic cancer cells. Three independent biological replicates were performed and data are presented as the mean ± standard deviation. *P

Techniques Used: Western Blot, Expressing, Standard Deviation

Molecular docking simulation of β-elemene to HIF1A. Sticks represent the three-dimensional structure of β-elemene; surface represents the protein structure of HIF1A. HIF1A, hypoxia-inducible factor 1-α.
Figure Legend Snippet: Molecular docking simulation of β-elemene to HIF1A. Sticks represent the three-dimensional structure of β-elemene; surface represents the protein structure of HIF1A. HIF1A, hypoxia-inducible factor 1-α.

Techniques Used:

Related Articles

Injection:

Article Title: Anti-Lung-Cancer Activity and Liposome-Based Delivery Systems of β-Elemene
Article Snippet: .. Afterwards, an injection preparation containing 85% β -elemene developed by CSPC Pharmaceutical Limited Cooperation (China) has been approved by the SFDA, China, for the treatment of brain tumours and other carcinomas [ ]. .. Unfortunately, β -elemene, greatly suffered from poor water solubility, stability, and low bioavailability, leads to a relatively low bioavailability with oral administration, which means lots of solubilizing excipients are needed to prepare injections as well.

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    CSPC Pharmaceutical Group β elemene
    Chemical structure of  β -Elemene.
    β Elemene, supplied by CSPC Pharmaceutical Group, used in various techniques. Bioz Stars score: 89/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/β elemene/product/CSPC Pharmaceutical Group
    Average 89 stars, based on 3 article reviews
    Price from $9.99 to $1999.99
    β elemene - by Bioz Stars, 2020-09
    89/100 stars
      Buy from Supplier

    Image Search Results


    Chemical structure of  β -Elemene.

    Journal: Evidence-based Complementary and Alternative Medicine : eCAM

    Article Title: Anti-Lung-Cancer Activity and Liposome-Based Delivery Systems of β-Elemene

    doi: 10.1155/2012/259523

    Figure Lengend Snippet: Chemical structure of β -Elemene.

    Article Snippet: Afterwards, an injection preparation containing 85% β -elemene developed by CSPC Pharmaceutical Limited Cooperation (China) has been approved by the SFDA, China, for the treatment of brain tumours and other carcinomas [ ].

    Techniques:

    Thirty-three target genes for β-elemene against pancreatic cancer. (A) Venn diagram revealing the overlapping target genes for β-elemene against pancreatic cancer. (B) Network of target genes for β-elemene against pancreatic cancer. Red diamond represents β-elemene; red hexagon represents pancreatic cancer; blue circles represent target genes of both β-elemene and pancreatic cancer; yellow triangles represent KEGG pathway analysis of 33 target genes based on the DAVID database. KEGG, Kyoto encyclopedia of genes and genomes; DAVID, Database for Annotation, Visualization and Integrated Discovery.

    Journal: Oncology Reports

    Article Title: β-elemene inhibits the generation of peritoneum effusion in pancreatic cancer via suppression of the HIF1A-VEGFA pathway based on network pharmacology

    doi: 10.3892/or.2019.7360

    Figure Lengend Snippet: Thirty-three target genes for β-elemene against pancreatic cancer. (A) Venn diagram revealing the overlapping target genes for β-elemene against pancreatic cancer. (B) Network of target genes for β-elemene against pancreatic cancer. Red diamond represents β-elemene; red hexagon represents pancreatic cancer; blue circles represent target genes of both β-elemene and pancreatic cancer; yellow triangles represent KEGG pathway analysis of 33 target genes based on the DAVID database. KEGG, Kyoto encyclopedia of genes and genomes; DAVID, Database for Annotation, Visualization and Integrated Discovery.

    Article Snippet: Serial concentrations of β-elemene [CSPC Pharmaceutical Group Company Ltd. (YUANDA), Dalian, China] were added to the cells: 0, 0.5, 1, 2, 4, 8 and 16 µM.

    Techniques:

    Network of β-elemene-target genes. Red diamond represents β-elemene; blue circles represent target genes of β-elemene.

    Journal: Oncology Reports

    Article Title: β-elemene inhibits the generation of peritoneum effusion in pancreatic cancer via suppression of the HIF1A-VEGFA pathway based on network pharmacology

    doi: 10.3892/or.2019.7360

    Figure Lengend Snippet: Network of β-elemene-target genes. Red diamond represents β-elemene; blue circles represent target genes of β-elemene.

    Article Snippet: Serial concentrations of β-elemene [CSPC Pharmaceutical Group Company Ltd. (YUANDA), Dalian, China] were added to the cells: 0, 0.5, 1, 2, 4, 8 and 16 µM.

    Techniques:

    Antitumor effect of β-elemene in pancreatic cancer. (A) MTT assay revealed that cell viability was suppressed by β-elemene in PANC-1 cells in a dose-dependent manner. (B) MTT assay revealed that cell viability was suppressed by β-elemene in BxPC3 cells in a dose-dependent manner. (C and D) MTT assay revealed that cell viability was suppressed by β-elemene in cells isolated from peritoneum effusion of pancreatic cancer patients in a dose-dependent manner.

    Journal: Oncology Reports

    Article Title: β-elemene inhibits the generation of peritoneum effusion in pancreatic cancer via suppression of the HIF1A-VEGFA pathway based on network pharmacology

    doi: 10.3892/or.2019.7360

    Figure Lengend Snippet: Antitumor effect of β-elemene in pancreatic cancer. (A) MTT assay revealed that cell viability was suppressed by β-elemene in PANC-1 cells in a dose-dependent manner. (B) MTT assay revealed that cell viability was suppressed by β-elemene in BxPC3 cells in a dose-dependent manner. (C and D) MTT assay revealed that cell viability was suppressed by β-elemene in cells isolated from peritoneum effusion of pancreatic cancer patients in a dose-dependent manner.

    Article Snippet: Serial concentrations of β-elemene [CSPC Pharmaceutical Group Company Ltd. (YUANDA), Dalian, China] were added to the cells: 0, 0.5, 1, 2, 4, 8 and 16 µM.

    Techniques: MTT Assay, Isolation

    Validation of the HIF1A-VEGFA pathway inhibited by β-elemene in pancreatic cancer. (A) Western blot analysis in PANC-1 and BxPC3 pancreatic cancer cell lines and (B) corresponding histogram of protein expression levels of HIF1A and VEGFA in PANC-1 and BxPC3 pancreatic cancer cells. Three independent biological replicates were performed and data are presented as the mean ± standard deviation. *P

    Journal: Oncology Reports

    Article Title: β-elemene inhibits the generation of peritoneum effusion in pancreatic cancer via suppression of the HIF1A-VEGFA pathway based on network pharmacology

    doi: 10.3892/or.2019.7360

    Figure Lengend Snippet: Validation of the HIF1A-VEGFA pathway inhibited by β-elemene in pancreatic cancer. (A) Western blot analysis in PANC-1 and BxPC3 pancreatic cancer cell lines and (B) corresponding histogram of protein expression levels of HIF1A and VEGFA in PANC-1 and BxPC3 pancreatic cancer cells. Three independent biological replicates were performed and data are presented as the mean ± standard deviation. *P

    Article Snippet: Serial concentrations of β-elemene [CSPC Pharmaceutical Group Company Ltd. (YUANDA), Dalian, China] were added to the cells: 0, 0.5, 1, 2, 4, 8 and 16 µM.

    Techniques: Western Blot, Expressing, Standard Deviation

    Molecular docking simulation of β-elemene to HIF1A. Sticks represent the three-dimensional structure of β-elemene; surface represents the protein structure of HIF1A. HIF1A, hypoxia-inducible factor 1-α.

    Journal: Oncology Reports

    Article Title: β-elemene inhibits the generation of peritoneum effusion in pancreatic cancer via suppression of the HIF1A-VEGFA pathway based on network pharmacology

    doi: 10.3892/or.2019.7360

    Figure Lengend Snippet: Molecular docking simulation of β-elemene to HIF1A. Sticks represent the three-dimensional structure of β-elemene; surface represents the protein structure of HIF1A. HIF1A, hypoxia-inducible factor 1-α.

    Article Snippet: Serial concentrations of β-elemene [CSPC Pharmaceutical Group Company Ltd. (YUANDA), Dalian, China] were added to the cells: 0, 0.5, 1, 2, 4, 8 and 16 µM.

    Techniques: