Journal: Frontiers in Physiology
Article Title: Long-term stimulation with alternating electric fields modulates the differentiation and mineralization of human pre-osteoblasts
doi: 10.3389/fphys.2022.965181
Figure Lengend Snippet: Results of the transcriptome analysis. (A) Heatmap of all genes with higher/lower fold change value than 1/-1 (log2), compared between unstimulated control cells and HEF stimulated cells after 7 and 28 days. (B) Heatmap of top 10 genes with highest and lowest fold changes (log2) each day. (C) Pathways influenced by the electric stimulation. Each node (circle) represents a distinct molecular or biological function, and edges (green lines) represent the number of overlapping genes, determined using a similarity coefficient . Yellow and orange circles represent upregulated molecular or biological functions after 7 (yellow) and 28 days (orange) of HEF stimulation, respectively. Green and blue circles represent downregulated molecular or biological functions after 7 (green) and 28 days (blue) of HEF stimulation, respectively.
Article Snippet: In the transcriptome analysis data set provided by ATLAS Biolabs, the signal intensity of more than 55,335 annotated probe sets, hence RNA transcripts were determined.
Techniques: Control