Review



t type calcium channel 399 enhancers  (TargetMol)


Bioz Verified Symbol TargetMol is a verified supplier
Bioz Manufacturer Symbol TargetMol manufactures this product  
  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
  • 94

    Structured Review

    TargetMol t type calcium channel 399 enhancers
    T Type Calcium Channel 399 Enhancers, supplied by TargetMol, used in various techniques. Bioz Stars score: 94/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/system+coupling+module/Calcium+Channel+Compound+Library/pm41874002-169-12-21
    Average 94 stars, based on 3 article reviews
    t type calcium channel 399 enhancers - by Bioz Stars, 2026-11
    94/100 stars

    Images

    Related Articles

    Proliferation Assay:

    Article Title: Repurposing T-type calcium channel blocker Lomerizine as a therapeutic strategy for glioblastoma.
    Article Snippet: .. Furthermore, we 398 performed a cell proliferation assay with pretreatment using two T-type calcium channel 399 enhancers, SAK3 (Sigma–Aldrich) and ZSET1446, (TargetMol, Boston, MA, USA) to 400 investigate the involvement of T-type calcium channel activity in the cell proliferation inhibitory 401 effect of lomerizine. (28, 29) SAK3 and ZSET1446 were prepared at a final concentration of 1 402 nM and added 2 hours prior to lomerizine (5 μM) treatment. .. The relative number of viable cells 403 was determined by measuring the absorbance using a microplate reader (Bio-Rad Laboratories) 404 at 0, 24, 48, and 72 h after lomerizine addition (measurement, 590 nm; reference, 540 nm).

    Activity Assay:

    Article Title: Repurposing T-type calcium channel blocker Lomerizine as a therapeutic strategy for glioblastoma.
    Article Snippet: .. Furthermore, we 398 performed a cell proliferation assay with pretreatment using two T-type calcium channel 399 enhancers, SAK3 (Sigma–Aldrich) and ZSET1446, (TargetMol, Boston, MA, USA) to 400 investigate the involvement of T-type calcium channel activity in the cell proliferation inhibitory 401 effect of lomerizine. (28, 29) SAK3 and ZSET1446 were prepared at a final concentration of 1 402 nM and added 2 hours prior to lomerizine (5 μM) treatment. .. The relative number of viable cells 403 was determined by measuring the absorbance using a microplate reader (Bio-Rad Laboratories) 404 at 0, 24, 48, and 72 h after lomerizine addition (measurement, 590 nm; reference, 540 nm).

    Concentration Assay:

    Article Title: Repurposing T-type calcium channel blocker Lomerizine as a therapeutic strategy for glioblastoma.
    Article Snippet: .. Furthermore, we 398 performed a cell proliferation assay with pretreatment using two T-type calcium channel 399 enhancers, SAK3 (Sigma–Aldrich) and ZSET1446, (TargetMol, Boston, MA, USA) to 400 investigate the involvement of T-type calcium channel activity in the cell proliferation inhibitory 401 effect of lomerizine. (28, 29) SAK3 and ZSET1446 were prepared at a final concentration of 1 402 nM and added 2 hours prior to lomerizine (5 μM) treatment. .. The relative number of viable cells 403 was determined by measuring the absorbance using a microplate reader (Bio-Rad Laboratories) 404 at 0, 24, 48, and 72 h after lomerizine addition (measurement, 590 nm; reference, 540 nm).

    Article Title: RCN3 functions as a tumor promoter in colorectal cancer by modulating the GRP78-PI3K-AKT signaling pathway.
    Article Snippet: Colorectal cancer (CRC) remains a significant global health concern, highlighting the urgent need for novel therapeutic targets and prognostic biomarkers.. This study investigates the role of Reticulocalbin-3 (RCN3) in CRC development, focusing on its regulatory influence on calcium ion homeostasis and transport proteins, critical factors in cancer progression.. We employed bioinformatics databases, qRT-PCR, Western blotting, and immunohistochemistry to evaluate RCN3 expression levels, revealing that RCN3 is upregulated in CRC tissues and correlates with poorer patient outcomes.

    High Throughput Screening Assay:

    Article Title: Sappanchalcone suppresses NSCLC by oxidative stress-driven DNA damage and ER stress activation through PIEZO1 modulation
    Article Snippet: .. In this study, intracellular calcium signaling was dynamically monitored using the genetically encoded calcium indicator GCaMP6s, coupled with high-throughput screening of the 1880 compounds (TargetMol Natural Compound Library) via the FLIPR-Tetra fluorescence detection system ( A). ..

    Drug discovery:

    Article Title: Sappanchalcone suppresses NSCLC by oxidative stress-driven DNA damage and ER stress activation through PIEZO1 modulation
    Article Snippet: .. In this study, intracellular calcium signaling was dynamically monitored using the genetically encoded calcium indicator GCaMP6s, coupled with high-throughput screening of the 1880 compounds (TargetMol Natural Compound Library) via the FLIPR-Tetra fluorescence detection system ( A). ..

    Fluorescence:

    Article Title: Sappanchalcone suppresses NSCLC by oxidative stress-driven DNA damage and ER stress activation through PIEZO1 modulation
    Article Snippet: .. In this study, intracellular calcium signaling was dynamically monitored using the genetically encoded calcium indicator GCaMP6s, coupled with high-throughput screening of the 1880 compounds (TargetMol Natural Compound Library) via the FLIPR-Tetra fluorescence detection system ( A). ..

    Incubation:

    Article Title: RCN3 functions as a tumor promoter in colorectal cancer by modulating the GRP78-PI3K-AKT signaling pathway.
    Article Snippet: Colorectal cancer (CRC) remains a significant global health concern, highlighting the urgent need for novel therapeutic targets and prognostic biomarkers.. This study investigates the role of Reticulocalbin-3 (RCN3) in CRC development, focusing on its regulatory influence on calcium ion homeostasis and transport proteins, critical factors in cancer progression.. We employed bioinformatics databases, qRT-PCR, Western blotting, and immunohistochemistry to evaluate RCN3 expression levels, revealing that RCN3 is upregulated in CRC tissues and correlates with poorer patient outcomes.



    Similar Products

    86
    Edmund Optics fiber coupled laser module
    Fiber Coupled Laser Module, supplied by Edmund Optics, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/system+coupling+module/ccd+cooled+fluorescence+spectrometer+te/pm42270921-234-7-16
    Average 86 stars, based on 1 article reviews
    fiber coupled laser module - by Bioz Stars, 2026-11
    86/100 stars
      Buy from Supplier

    86
    Superlum Diodes Ltd fiber coupled butterfly module
    Fiber Coupled Butterfly Module, supplied by Superlum Diodes Ltd, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/system+coupling+module/butterfly+coupled+fiber+module/10__1364_slash_oe__592137-190-14-8
    Average 86 stars, based on 1 article reviews
    fiber coupled butterfly module - by Bioz Stars, 2026-11
    86/100 stars
      Buy from Supplier

    86
    Thorlabs white light fiber coupled led module
    White Light Fiber Coupled Led Module, supplied by Thorlabs, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/system+coupling+module/coupled+fiber+led/pm41946171-202-29-34
    Average 86 stars, based on 1 article reviews
    white light fiber coupled led module - by Bioz Stars, 2026-11
    86/100 stars
      Buy from Supplier

    86
    Changchun New Industries Optoelectronics fiber coupled laser module
    Fiber Coupled Laser Module, supplied by Changchun New Industries Optoelectronics, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/system+coupling+module/coupled+fiber+laser/pm41020470-172-72-76
    Average 86 stars, based on 1 article reviews
    fiber coupled laser module - by Bioz Stars, 2026-11
    86/100 stars
      Buy from Supplier

    86
    Thorlabs fiber coupled intensity modulator
    Fiber Coupled Intensity Modulator, supplied by Thorlabs, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/system+coupling+module/lithium+niobate/pmc12343765-211-13-16
    Average 86 stars, based on 1 article reviews
    fiber coupled intensity modulator - by Bioz Stars, 2026-11
    86/100 stars
      Buy from Supplier

    90
    Abaqus Inc thermal–mechanical coupling module
    Thermal–Mechanical Coupling Module, supplied by Abaqus Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/system+coupling+module/thermal+stress+analysis/pm40573011-181-5-9
    Average 90 stars, based on 1 article reviews
    thermal–mechanical coupling module - by Bioz Stars, 2026-11
    90/100 stars
      Buy from Supplier

    90
    Dilas Diode Laser conduction-cooled, single bar, fiber-coupled laser diode modules
    Conduction Cooled, Single Bar, Fiber Coupled Laser Diode Modules, supplied by Dilas Diode Laser, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/system+coupling+module/conduction+cooled++single+bar++fiber+coupled+laser+diode+modules/us12318179-400-35-43
    Average 90 stars, based on 1 article reviews
    conduction-cooled, single bar, fiber-coupled laser diode modules - by Bioz Stars, 2026-11
    90/100 stars
      Buy from Supplier

    90
    Carl Zeiss acousto-optic modulator coupled to a galvanometer scanning system zeiss 810
    Acousto Optic Modulator Coupled To A Galvanometer Scanning System Zeiss 810, supplied by Carl Zeiss, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/system+coupling+module/software+zen/pm40175691-579-7-14
    Average 90 stars, based on 1 article reviews
    acousto-optic modulator coupled to a galvanometer scanning system zeiss 810 - by Bioz Stars, 2026-11
    90/100 stars
      Buy from Supplier

    90
    ANSYS inc coupled field transient module ansys 2021r2
    Coupled Field Transient Module Ansys 2021r2, supplied by ANSYS inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/system+coupling+module/ansys+cfx/pmc12030084-153-27-27
    Average 90 stars, based on 1 article reviews
    coupled field transient module ansys 2021r2 - by Bioz Stars, 2026-11
    90/100 stars
      Buy from Supplier

    90
    ANSYS inc system coupling module
    System Coupling Module, supplied by ANSYS inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/system+coupling+module/system+coupling+module/pm40198982-172-16-21
    Average 90 stars, based on 1 article reviews
    system coupling module - by Bioz Stars, 2026-11
    90/100 stars
      Buy from Supplier

    Image Search Results