standalone version of mtoolbox (SourceForge net)
90
Structured Review
SourceForge net
standalone version of mtoolbox
Standalone Version Of Mtoolbox, supplied by SourceForge net, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/standalone+executable+version/standalone+executable+version/pmc04698288-93-24-14
Average 90 stars, based on 1 article reviews
Standalone Version Of Mtoolbox, supplied by SourceForge net, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/standalone+executable+version/standalone+executable+version/pmc04698288-93-24-14
Average 90 stars, based on 1 article reviews
standalone version of mtoolbox - by Bioz Stars,
2026-10
90/100 stars
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1) Product Images from "A multi-parametric workflow for the prioritization of mitochondrial DNA variants of clinical interest"
Article Title: A multi-parametric workflow for the prioritization of mitochondrial DNA variants of clinical interest
Journal: Human Genetics
doi: 10.1007/s00439-015-1615-9
Figure Legend Snippet: a The histogram graphs the bimodal distribution of disease scores associated to 1872 non-synonymous variants (HmtDB, May 2014) observed in mtDNA sequences from healthy individuals and stored in HmtDB. The solid lines indicate the two gaussian components of the mixture model (McLachlan and Peel ) (46 and 54 %, respectively). The first component of the mixture model with the lowest disease score values included the most benign non-synonymous variants. The vertical dashed line is drawn at the selected Disease Score Threshold, DST, defined as 0.4311; non-synonymous variants featuring a DS above 0.4311 may, therefore, be considered potentially affecting function. b Box-plot diagram shows the disease scores of non-synonymous variants by class of ‘Neutral’ or ‘Disease’ prediction (disease scores ranging from 0.05 to 0.4311 and from 0.6565 to 0.9162, respectively, for each class) as returned by all six pathogenicity predictors implemented in MToolBox. Circles represent the outliers. c Empirical cumulative distribution function of nucleotide variability associated with the 816 non-synonymous variants, featuring a disease score above the established DST. Dashes vertical line indicates the nucleotide variability cutoff, NVC = 0.0026, defined as the third quartile of such distribution. Non-synonymous variants showing variability values below the NVC are filtered by the variant prioritization workflow
Techniques Used: Variant Assay
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