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Spatial Transcriptomics Inc geomx dsp ○ high plex spatial proteomics
Geomx Dsp ○ High Plex Spatial Proteomics, supplied by Spatial Transcriptomics Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/spatial+transcriptomics+st+technologies/3d+spatial+technology+transcriptomics/pm41125076-264-74-71
Average 86 stars, based on 1 article reviews
geomx dsp ○ high plex spatial proteomics - by Bioz Stars, 2026-09
86/100 stars

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Related Articles

Selection:

Article Title: Spatial immune profiling defines a subset of human gliomas with functional tertiary lymphoid structures.
Article Snippet: .. STAR★METHODS Detailed methods are provided in the online version of this paper and include the following: • KEY RESOURCES TABLE • EXPERIMENTAL MODEL AND STUDY PARTICIPANT DETAILS ○ Sample collection and ethical approval ○ Patient selection ○ Clinical data and analysis • METHOD DETAILS ○ IHC and screening for B-cell aggregation ○ Multiplex immunofluorescence staining and digital image analysis ○ Whole exome sequencing and analysis ○ Bulk RNA-sequencing and analysis ○ Spatial transcriptomics with GeoMx® DSP ○ High-plex spatial proteomics & image analysis ○ Spatial single-cell transcriptomics (Xenium) ○ Immunoglobulin sequencing • QUANTIFICATION AND STATISTICAL ANALYSIS SUPPLEMENTAL INFORMATION Supplemental information can be found online at https://doi.org/10.1016/j. immuni.2025.09.018. ..

Article Title: Protocol for dual spatial transcriptomic profiling of infected tissues
Article Snippet: Note: Bruker Spatial Biology offers, both, mouse and human whole transcriptome atlases containing probes to detect approximately 22,000 host transcripts. .. The pathogen-specific probes were custom-designed using P. aeruginosa PA14 genomic information , , with a computational in silico preselection filters., Spatial transcriptomics workflow using GeoMx DSP instrument The procedure covers the following steps: Day1 - Slide processing using Bond RxV pipeline and probe library hybridization, Day 2 - GeoMx run consisting of staining of slides with morphology markers, GeoMx imaging, ROI selection, and sample acquisition, Day 3 - PCR-based library preparation, quantification, and sequencing, Day 4 - Data analytics. ..

Immunohistochemistry:

Article Title: Spatial immune profiling defines a subset of human gliomas with functional tertiary lymphoid structures.
Article Snippet: .. STAR★METHODS Detailed methods are provided in the online version of this paper and include the following: • KEY RESOURCES TABLE • EXPERIMENTAL MODEL AND STUDY PARTICIPANT DETAILS ○ Sample collection and ethical approval ○ Patient selection ○ Clinical data and analysis • METHOD DETAILS ○ IHC and screening for B-cell aggregation ○ Multiplex immunofluorescence staining and digital image analysis ○ Whole exome sequencing and analysis ○ Bulk RNA-sequencing and analysis ○ Spatial transcriptomics with GeoMx® DSP ○ High-plex spatial proteomics & image analysis ○ Spatial single-cell transcriptomics (Xenium) ○ Immunoglobulin sequencing • QUANTIFICATION AND STATISTICAL ANALYSIS SUPPLEMENTAL INFORMATION Supplemental information can be found online at https://doi.org/10.1016/j. immuni.2025.09.018. ..

Multiplex Assay:

Article Title: Spatial immune profiling defines a subset of human gliomas with functional tertiary lymphoid structures.
Article Snippet: .. STAR★METHODS Detailed methods are provided in the online version of this paper and include the following: • KEY RESOURCES TABLE • EXPERIMENTAL MODEL AND STUDY PARTICIPANT DETAILS ○ Sample collection and ethical approval ○ Patient selection ○ Clinical data and analysis • METHOD DETAILS ○ IHC and screening for B-cell aggregation ○ Multiplex immunofluorescence staining and digital image analysis ○ Whole exome sequencing and analysis ○ Bulk RNA-sequencing and analysis ○ Spatial transcriptomics with GeoMx® DSP ○ High-plex spatial proteomics & image analysis ○ Spatial single-cell transcriptomics (Xenium) ○ Immunoglobulin sequencing • QUANTIFICATION AND STATISTICAL ANALYSIS SUPPLEMENTAL INFORMATION Supplemental information can be found online at https://doi.org/10.1016/j. immuni.2025.09.018. ..

Immunofluorescence:

Article Title: Spatial immune profiling defines a subset of human gliomas with functional tertiary lymphoid structures.
Article Snippet: .. STAR★METHODS Detailed methods are provided in the online version of this paper and include the following: • KEY RESOURCES TABLE • EXPERIMENTAL MODEL AND STUDY PARTICIPANT DETAILS ○ Sample collection and ethical approval ○ Patient selection ○ Clinical data and analysis • METHOD DETAILS ○ IHC and screening for B-cell aggregation ○ Multiplex immunofluorescence staining and digital image analysis ○ Whole exome sequencing and analysis ○ Bulk RNA-sequencing and analysis ○ Spatial transcriptomics with GeoMx® DSP ○ High-plex spatial proteomics & image analysis ○ Spatial single-cell transcriptomics (Xenium) ○ Immunoglobulin sequencing • QUANTIFICATION AND STATISTICAL ANALYSIS SUPPLEMENTAL INFORMATION Supplemental information can be found online at https://doi.org/10.1016/j. immuni.2025.09.018. ..

Staining:

Article Title: Spatial immune profiling defines a subset of human gliomas with functional tertiary lymphoid structures.
Article Snippet: .. STAR★METHODS Detailed methods are provided in the online version of this paper and include the following: • KEY RESOURCES TABLE • EXPERIMENTAL MODEL AND STUDY PARTICIPANT DETAILS ○ Sample collection and ethical approval ○ Patient selection ○ Clinical data and analysis • METHOD DETAILS ○ IHC and screening for B-cell aggregation ○ Multiplex immunofluorescence staining and digital image analysis ○ Whole exome sequencing and analysis ○ Bulk RNA-sequencing and analysis ○ Spatial transcriptomics with GeoMx® DSP ○ High-plex spatial proteomics & image analysis ○ Spatial single-cell transcriptomics (Xenium) ○ Immunoglobulin sequencing • QUANTIFICATION AND STATISTICAL ANALYSIS SUPPLEMENTAL INFORMATION Supplemental information can be found online at https://doi.org/10.1016/j. immuni.2025.09.018. ..

Article Title: Protocol for dual spatial transcriptomic profiling of infected tissues
Article Snippet: Note: Bruker Spatial Biology offers, both, mouse and human whole transcriptome atlases containing probes to detect approximately 22,000 host transcripts. .. The pathogen-specific probes were custom-designed using P. aeruginosa PA14 genomic information , , with a computational in silico preselection filters., Spatial transcriptomics workflow using GeoMx DSP instrument The procedure covers the following steps: Day1 - Slide processing using Bond RxV pipeline and probe library hybridization, Day 2 - GeoMx run consisting of staining of slides with morphology markers, GeoMx imaging, ROI selection, and sample acquisition, Day 3 - PCR-based library preparation, quantification, and sequencing, Day 4 - Data analytics. ..

Sequencing:

Article Title: Spatial immune profiling defines a subset of human gliomas with functional tertiary lymphoid structures.
Article Snippet: .. STAR★METHODS Detailed methods are provided in the online version of this paper and include the following: • KEY RESOURCES TABLE • EXPERIMENTAL MODEL AND STUDY PARTICIPANT DETAILS ○ Sample collection and ethical approval ○ Patient selection ○ Clinical data and analysis • METHOD DETAILS ○ IHC and screening for B-cell aggregation ○ Multiplex immunofluorescence staining and digital image analysis ○ Whole exome sequencing and analysis ○ Bulk RNA-sequencing and analysis ○ Spatial transcriptomics with GeoMx® DSP ○ High-plex spatial proteomics & image analysis ○ Spatial single-cell transcriptomics (Xenium) ○ Immunoglobulin sequencing • QUANTIFICATION AND STATISTICAL ANALYSIS SUPPLEMENTAL INFORMATION Supplemental information can be found online at https://doi.org/10.1016/j. immuni.2025.09.018. ..

Article Title: Protocol for dual spatial transcriptomic profiling of infected tissues
Article Snippet: Note: Bruker Spatial Biology offers, both, mouse and human whole transcriptome atlases containing probes to detect approximately 22,000 host transcripts. .. The pathogen-specific probes were custom-designed using P. aeruginosa PA14 genomic information , , with a computational in silico preselection filters., Spatial transcriptomics workflow using GeoMx DSP instrument The procedure covers the following steps: Day1 - Slide processing using Bond RxV pipeline and probe library hybridization, Day 2 - GeoMx run consisting of staining of slides with morphology markers, GeoMx imaging, ROI selection, and sample acquisition, Day 3 - PCR-based library preparation, quantification, and sequencing, Day 4 - Data analytics. ..

RNA sequencing:

Article Title: Spatial immune profiling defines a subset of human gliomas with functional tertiary lymphoid structures.
Article Snippet: .. STAR★METHODS Detailed methods are provided in the online version of this paper and include the following: • KEY RESOURCES TABLE • EXPERIMENTAL MODEL AND STUDY PARTICIPANT DETAILS ○ Sample collection and ethical approval ○ Patient selection ○ Clinical data and analysis • METHOD DETAILS ○ IHC and screening for B-cell aggregation ○ Multiplex immunofluorescence staining and digital image analysis ○ Whole exome sequencing and analysis ○ Bulk RNA-sequencing and analysis ○ Spatial transcriptomics with GeoMx® DSP ○ High-plex spatial proteomics & image analysis ○ Spatial single-cell transcriptomics (Xenium) ○ Immunoglobulin sequencing • QUANTIFICATION AND STATISTICAL ANALYSIS SUPPLEMENTAL INFORMATION Supplemental information can be found online at https://doi.org/10.1016/j. immuni.2025.09.018. ..

Spatial Transcriptomics:

Article Title: Spatial immune profiling defines a subset of human gliomas with functional tertiary lymphoid structures.
Article Snippet: .. STAR★METHODS Detailed methods are provided in the online version of this paper and include the following: • KEY RESOURCES TABLE • EXPERIMENTAL MODEL AND STUDY PARTICIPANT DETAILS ○ Sample collection and ethical approval ○ Patient selection ○ Clinical data and analysis • METHOD DETAILS ○ IHC and screening for B-cell aggregation ○ Multiplex immunofluorescence staining and digital image analysis ○ Whole exome sequencing and analysis ○ Bulk RNA-sequencing and analysis ○ Spatial transcriptomics with GeoMx® DSP ○ High-plex spatial proteomics & image analysis ○ Spatial single-cell transcriptomics (Xenium) ○ Immunoglobulin sequencing • QUANTIFICATION AND STATISTICAL ANALYSIS SUPPLEMENTAL INFORMATION Supplemental information can be found online at https://doi.org/10.1016/j. immuni.2025.09.018. ..

Article Title: Protocol for dual spatial transcriptomic profiling of infected tissues
Article Snippet: Note: Bruker Spatial Biology offers, both, mouse and human whole transcriptome atlases containing probes to detect approximately 22,000 host transcripts. .. The pathogen-specific probes were custom-designed using P. aeruginosa PA14 genomic information , , with a computational in silico preselection filters., Spatial transcriptomics workflow using GeoMx DSP instrument The procedure covers the following steps: Day1 - Slide processing using Bond RxV pipeline and probe library hybridization, Day 2 - GeoMx run consisting of staining of slides with morphology markers, GeoMx imaging, ROI selection, and sample acquisition, Day 3 - PCR-based library preparation, quantification, and sequencing, Day 4 - Data analytics. ..

Article Title: CXCL16 Producing Tumor Clones Are Shaping Immunosuppressive Microenvironment in Squamous Cell Carcinoma via CXCR6 Regulatory T Cell
Article Snippet: .. Spatial transcriptomics was performed using the GeoMx DSP platform of the whole‐transcriptome atlas (NanoString Technologies, Seattle, WA, USA). .. Tissue sections from formalin‐fixed paraffin‐embedded (FFPE) blocks were mounted on a charged Leica Bond slide.

Article Title: Multi-modal molecular and spatial profiling reveals NNT as a prognostic biomarker in obesity-associated colorectal cancer.
Article Snippet: .. Panels A–B illustrate the individual prognostic impact of TNM stage alone, while panels C–F show the combined analysis integrating NNT expression with TNM staging ◂ Fig. 4 Analysis of NNT expression in obese colorectal cancer (CRC) patients using GeoMx spatial transcriptomics technology. ..

Article Title: Single-cell multi-omics in cancer immunotherapy: from tumor heterogeneity to personalized precision treatment
Article Snippet: Spatial Transcriptomics + Proteomics , 2020 , DBiT-seq , 10–50 μm , [ ] . .. Spatial Transcriptomics + Proteomics , 2020 , GeoMx DSP , Single-cell , [ ] . .. Spatial Epigenome + Proteomics , 2020 , OligoFISSEQ , Single-cell , [ ] .

Article Title: So3D: a comprehensive three-dimensional spatial omics resource for decoding tissue architecture in physiology and disease
Article Snippet: .. Notably, the 3D spatial transcriptomics technology has constructed the 3D view of gene expression, cell types, and functional states within tissues and organs, revealing spatially continuous structures and biomarkers that are invisible in two-dimensional (2D) slices [ ]. ..

Article Title: So3D: a comprehensive three-dimensional spatial omics resource for decoding tissue architecture in physiology and disease.
Article Snippet: .. Notably, the 3D spatial transcriptomics technology has constructed the 3D view of gene expression, cell types, and functional states within tissues and organs, revealing spatially continuous structures and biomarkers that are invisible in two-dimensional (2D) slices [ 3 ]. ..

Spatial Proteomics:

Article Title: Spatial immune profiling defines a subset of human gliomas with functional tertiary lymphoid structures.
Article Snippet: .. STAR★METHODS Detailed methods are provided in the online version of this paper and include the following: • KEY RESOURCES TABLE • EXPERIMENTAL MODEL AND STUDY PARTICIPANT DETAILS ○ Sample collection and ethical approval ○ Patient selection ○ Clinical data and analysis • METHOD DETAILS ○ IHC and screening for B-cell aggregation ○ Multiplex immunofluorescence staining and digital image analysis ○ Whole exome sequencing and analysis ○ Bulk RNA-sequencing and analysis ○ Spatial transcriptomics with GeoMx® DSP ○ High-plex spatial proteomics & image analysis ○ Spatial single-cell transcriptomics (Xenium) ○ Immunoglobulin sequencing • QUANTIFICATION AND STATISTICAL ANALYSIS SUPPLEMENTAL INFORMATION Supplemental information can be found online at https://doi.org/10.1016/j. immuni.2025.09.018. ..

Single Cell:

Article Title: Spatial immune profiling defines a subset of human gliomas with functional tertiary lymphoid structures.
Article Snippet: .. STAR★METHODS Detailed methods are provided in the online version of this paper and include the following: • KEY RESOURCES TABLE • EXPERIMENTAL MODEL AND STUDY PARTICIPANT DETAILS ○ Sample collection and ethical approval ○ Patient selection ○ Clinical data and analysis • METHOD DETAILS ○ IHC and screening for B-cell aggregation ○ Multiplex immunofluorescence staining and digital image analysis ○ Whole exome sequencing and analysis ○ Bulk RNA-sequencing and analysis ○ Spatial transcriptomics with GeoMx® DSP ○ High-plex spatial proteomics & image analysis ○ Spatial single-cell transcriptomics (Xenium) ○ Immunoglobulin sequencing • QUANTIFICATION AND STATISTICAL ANALYSIS SUPPLEMENTAL INFORMATION Supplemental information can be found online at https://doi.org/10.1016/j. immuni.2025.09.018. ..

Article Title: Single-cell multi-omics in cancer immunotherapy: from tumor heterogeneity to personalized precision treatment
Article Snippet: Spatial Transcriptomics + Proteomics , 2020 , DBiT-seq , 10–50 μm , [ ] . .. Spatial Transcriptomics + Proteomics , 2020 , GeoMx DSP , Single-cell , [ ] . .. Spatial Epigenome + Proteomics , 2020 , OligoFISSEQ , Single-cell , [ ] .

Transcriptomics:

Article Title: Spatial immune profiling defines a subset of human gliomas with functional tertiary lymphoid structures.
Article Snippet: .. STAR★METHODS Detailed methods are provided in the online version of this paper and include the following: • KEY RESOURCES TABLE • EXPERIMENTAL MODEL AND STUDY PARTICIPANT DETAILS ○ Sample collection and ethical approval ○ Patient selection ○ Clinical data and analysis • METHOD DETAILS ○ IHC and screening for B-cell aggregation ○ Multiplex immunofluorescence staining and digital image analysis ○ Whole exome sequencing and analysis ○ Bulk RNA-sequencing and analysis ○ Spatial transcriptomics with GeoMx® DSP ○ High-plex spatial proteomics & image analysis ○ Spatial single-cell transcriptomics (Xenium) ○ Immunoglobulin sequencing • QUANTIFICATION AND STATISTICAL ANALYSIS SUPPLEMENTAL INFORMATION Supplemental information can be found online at https://doi.org/10.1016/j. immuni.2025.09.018. ..

In Silico:

Article Title: Protocol for dual spatial transcriptomic profiling of infected tissues
Article Snippet: Note: Bruker Spatial Biology offers, both, mouse and human whole transcriptome atlases containing probes to detect approximately 22,000 host transcripts. .. The pathogen-specific probes were custom-designed using P. aeruginosa PA14 genomic information , , with a computational in silico preselection filters., Spatial transcriptomics workflow using GeoMx DSP instrument The procedure covers the following steps: Day1 - Slide processing using Bond RxV pipeline and probe library hybridization, Day 2 - GeoMx run consisting of staining of slides with morphology markers, GeoMx imaging, ROI selection, and sample acquisition, Day 3 - PCR-based library preparation, quantification, and sequencing, Day 4 - Data analytics. ..

Hybridization:

Article Title: Protocol for dual spatial transcriptomic profiling of infected tissues
Article Snippet: Note: Bruker Spatial Biology offers, both, mouse and human whole transcriptome atlases containing probes to detect approximately 22,000 host transcripts. .. The pathogen-specific probes were custom-designed using P. aeruginosa PA14 genomic information , , with a computational in silico preselection filters., Spatial transcriptomics workflow using GeoMx DSP instrument The procedure covers the following steps: Day1 - Slide processing using Bond RxV pipeline and probe library hybridization, Day 2 - GeoMx run consisting of staining of slides with morphology markers, GeoMx imaging, ROI selection, and sample acquisition, Day 3 - PCR-based library preparation, quantification, and sequencing, Day 4 - Data analytics. ..

Imaging:

Article Title: Protocol for dual spatial transcriptomic profiling of infected tissues
Article Snippet: Note: Bruker Spatial Biology offers, both, mouse and human whole transcriptome atlases containing probes to detect approximately 22,000 host transcripts. .. The pathogen-specific probes were custom-designed using P. aeruginosa PA14 genomic information , , with a computational in silico preselection filters., Spatial transcriptomics workflow using GeoMx DSP instrument The procedure covers the following steps: Day1 - Slide processing using Bond RxV pipeline and probe library hybridization, Day 2 - GeoMx run consisting of staining of slides with morphology markers, GeoMx imaging, ROI selection, and sample acquisition, Day 3 - PCR-based library preparation, quantification, and sequencing, Day 4 - Data analytics. ..

Polymerase Chain Reaction:

Article Title: Protocol for dual spatial transcriptomic profiling of infected tissues
Article Snippet: Note: Bruker Spatial Biology offers, both, mouse and human whole transcriptome atlases containing probes to detect approximately 22,000 host transcripts. .. The pathogen-specific probes were custom-designed using P. aeruginosa PA14 genomic information , , with a computational in silico preselection filters., Spatial transcriptomics workflow using GeoMx DSP instrument The procedure covers the following steps: Day1 - Slide processing using Bond RxV pipeline and probe library hybridization, Day 2 - GeoMx run consisting of staining of slides with morphology markers, GeoMx imaging, ROI selection, and sample acquisition, Day 3 - PCR-based library preparation, quantification, and sequencing, Day 4 - Data analytics. ..

Expressing:

Article Title: Multi-modal molecular and spatial profiling reveals NNT as a prognostic biomarker in obesity-associated colorectal cancer.
Article Snippet: .. Panels A–B illustrate the individual prognostic impact of TNM stage alone, while panels C–F show the combined analysis integrating NNT expression with TNM staging ◂ Fig. 4 Analysis of NNT expression in obese colorectal cancer (CRC) patients using GeoMx spatial transcriptomics technology. ..

Microscopy:

Article Title: Spatial transcriptomics: a bibliometric analysis with large language model on English literatures
Article Snippet: Table S5: A Comprehensive Report on Predictions for Future Research Directions in Spatial Transcriptomics Using ChatGPT-4o Enhanced Spatial Resolution and Multi-Scale Profiling ⚫ Subcellular and Organelle-Level Profiling: Techniques like spatial-ATAC-seq and SEAM will map chromatin accessibility and metabolic heterogeneity at subcellular scales. .. ⚫ 3D Spatial Transcriptomics: Combining expansion microscopy with RNA capture to study 3D tissue architecture (e.g., liver lobules, brain circuits). ..

Construct:

Article Title: So3D: a comprehensive three-dimensional spatial omics resource for decoding tissue architecture in physiology and disease
Article Snippet: .. Notably, the 3D spatial transcriptomics technology has constructed the 3D view of gene expression, cell types, and functional states within tissues and organs, revealing spatially continuous structures and biomarkers that are invisible in two-dimensional (2D) slices [ ]. ..

Article Title: So3D: a comprehensive three-dimensional spatial omics resource for decoding tissue architecture in physiology and disease.
Article Snippet: .. Notably, the 3D spatial transcriptomics technology has constructed the 3D view of gene expression, cell types, and functional states within tissues and organs, revealing spatially continuous structures and biomarkers that are invisible in two-dimensional (2D) slices [ 3 ]. ..

Gene Expression:

Article Title: So3D: a comprehensive three-dimensional spatial omics resource for decoding tissue architecture in physiology and disease
Article Snippet: .. Notably, the 3D spatial transcriptomics technology has constructed the 3D view of gene expression, cell types, and functional states within tissues and organs, revealing spatially continuous structures and biomarkers that are invisible in two-dimensional (2D) slices [ ]. ..

Article Title: So3D: a comprehensive three-dimensional spatial omics resource for decoding tissue architecture in physiology and disease.
Article Snippet: .. Notably, the 3D spatial transcriptomics technology has constructed the 3D view of gene expression, cell types, and functional states within tissues and organs, revealing spatially continuous structures and biomarkers that are invisible in two-dimensional (2D) slices [ 3 ]. ..

Functional Assay:

Article Title: So3D: a comprehensive three-dimensional spatial omics resource for decoding tissue architecture in physiology and disease
Article Snippet: .. Notably, the 3D spatial transcriptomics technology has constructed the 3D view of gene expression, cell types, and functional states within tissues and organs, revealing spatially continuous structures and biomarkers that are invisible in two-dimensional (2D) slices [ ]. ..

Article Title: So3D: a comprehensive three-dimensional spatial omics resource for decoding tissue architecture in physiology and disease.
Article Snippet: .. Notably, the 3D spatial transcriptomics technology has constructed the 3D view of gene expression, cell types, and functional states within tissues and organs, revealing spatially continuous structures and biomarkers that are invisible in two-dimensional (2D) slices [ 3 ]. ..



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